Understanding Genomic And Hereditary Cancer Risk

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Understanding Genomic and Hereditary Cancer Risk

Author : Suzanne M. Mahon
Publisher :
ISBN 13 : 9781635930498
Total Pages : 0 pages
Book Rating : 4.9/5 (34 download)

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Book Synopsis Understanding Genomic and Hereditary Cancer Risk by : Suzanne M. Mahon

Download or read book Understanding Genomic and Hereditary Cancer Risk written by Suzanne M. Mahon and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Collecting a family medical history is a regular component of the nursing assessment process that often includes information on familial cancer diagnoses, and patients may fear that they or their loved ones might be at increased risk for developing cancer because of hereditary factors. Although true inherited risk for developing cancer is much less common than acquired risk for developing cancer, approximately 10% of cancer diagnoses can be attributed to inherited risk. The identification of families exhibiting hereditary cancer syndromes enables individuals at risk to engage in increased surveillance and, in some cases, risk-reducing surgery and other preventive measures, which ultimately lead to decreasing the morbidity and mortality associated with a cancer diagnosis. The role of the nurse in helping patients to understand and manage hereditary cancer risk requires specialized knowledge of genetics and genomics concepts. Understanding Genomic and Hereditary Cancer Risk: A Handbook for Oncology Nurses provides background on basic genetic and genomic concepts, particularly those related to hereditary risk for developing cancer, to aid nurses in knowing when and why to refer patients. It also provides reliable information about how and why genetic and genomic testing can both aid in treatment decisions and also guide recommendations for cancer prevention and early detection. The nurse's role in genetic testing and counseling are discussed, as are questions and answers about types of testing, including direct-to-consumer genetic testing. Following genetic testing, most genetics professionals provide detailed information about recommendations for care, including recommendations for ongoing prevention and early detection. For patients who are found to have a harmful mutation, these recommendations can be extensive and are based on the personal and family medical history, as well as the specific variant. This book provides quick overviews of many of the more common hereditary variants as well as resources for more information. This handbook provides nurses with the essentials to understand genomic and hereditary cancer risk, to assist in facilitating interprofessional care with genetics and other oncology professionals, and to provide their patients with accurate and reassuring information"--

Understanding Genomic and Hereditary Cancer Risk

Author : Suzanne M. Mahon
Publisher :
ISBN 13 : 9781635930504
Total Pages : pages
Book Rating : 4.9/5 (35 download)

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Book Synopsis Understanding Genomic and Hereditary Cancer Risk by : Suzanne M. Mahon

Download or read book Understanding Genomic and Hereditary Cancer Risk written by Suzanne M. Mahon and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Collecting a family medical history is a regular component of the nursing assessment process that often includes information on familial cancer diagnoses, and patients may fear that they or their loved ones might be at increased risk for developing cancer because of hereditary factors. Although true inherited risk for developing cancer is much less common than acquired risk for developing cancer, approximately 10% of cancer diagnoses can be attributed to inherited risk. The identification of families exhibiting hereditary cancer syndromes enables individuals at risk to engage in increased surveillance and, in some cases, risk-reducing surgery and other preventive measures, which ultimately lead to decreasing the morbidity and mortality associated with a cancer diagnosis. The role of the nurse in helping patients to understand and manage hereditary cancer risk requires specialized knowledge of genetics and genomics concepts. Understanding Genomic and Hereditary Cancer Risk: A Handbook for Oncology Nurses provides background on basic genetic and genomic concepts, particularly those related to hereditary risk for developing cancer, to aid nurses in knowing when and why to refer patients. It also provides reliable information about how and why genetic and genomic testing can both aid in treatment decisions and also guide recommendations for cancer prevention and early detection. The nurse's role in genetic testing and counseling are discussed, as are questions and answers about types of testing, including direct-to-consumer genetic testing. Following genetic testing, most genetics professionals provide detailed information about recommendations for care, including recommendations for ongoing prevention and early detection. For patients who are found to have a harmful mutation, these recommendations can be extensive and are based on the personal and family medical history, as well as the specific variant. This book provides quick overviews of many of the more common hereditary variants as well as resources for more information. This handbook provides nurses with the essentials to understand genomic and hereditary cancer risk, to assist in facilitating interprofessional care with genetics and other oncology professionals, and to provide their patients with accurate and reassuring information"--

Principles of Clinical Cancer Genetics

Author : Daniel C. Chung
Publisher : Springer Science & Business Media
ISBN 13 : 038793846X
Total Pages : 234 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Principles of Clinical Cancer Genetics by : Daniel C. Chung

Download or read book Principles of Clinical Cancer Genetics written by Daniel C. Chung and published by Springer Science & Business Media. This book was released on 2010-07-20 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed. In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.

The Genetics of Cancer

Author : B.A. Ponder
Publisher : Springer Science & Business Media
ISBN 13 : 9401106770
Total Pages : 222 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis The Genetics of Cancer by : B.A. Ponder

Download or read book The Genetics of Cancer written by B.A. Ponder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Pediatric Cancer Genetics

Author : Nathaniel H. Robin
Publisher : Elsevier Health Sciences
ISBN 13 : 0323495966
Total Pages : 350 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Pediatric Cancer Genetics by : Nathaniel H. Robin

Download or read book Pediatric Cancer Genetics written by Nathaniel H. Robin and published by Elsevier Health Sciences. This book was released on 2017-08-22 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. Consolidates today’s available information and guidance in this timely area into one convenient resource.

A Guide to Cancer Genetics in Clinical Practice

Author : Sue Clark,
Publisher : tfm Publishing Limited
ISBN 13 : 1908986352
Total Pages : 246 pages
Book Rating : 4.9/5 (89 download)

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Book Synopsis A Guide to Cancer Genetics in Clinical Practice by : Sue Clark,

Download or read book A Guide to Cancer Genetics in Clinical Practice written by Sue Clark, and published by tfm Publishing Limited. This book was released on 2009-05-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: FIRST PRIZE Winner in the Oncology category of the 2010 BMA Medical Book Competition. Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognized, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined. This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other subspecialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions.

Genetics for Health Professionals in Cancer Care

Author : Chris Jacobs
Publisher : OUP Oxford
ISBN 13 : 0191653489
Total Pages : 384 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Genetics for Health Professionals in Cancer Care by : Chris Jacobs

Download or read book Genetics for Health Professionals in Cancer Care written by Chris Jacobs and published by OUP Oxford. This book was released on 2014-08-14 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of genetics is becoming increasingly important in all aspects of healthcare and particularly in the field of cancer care. Genetics for Health Professionals in Cancer Care: From Principles to Practice equips health professionals with the knowledge and skills required for all aspects of managing cancer family history. This includes taking an accurate cancer family history and drawing a family tree; understanding cancer biology, basic cancer genetics and the genes involved in hereditary breast, ovarian, prostate, colorectal, gastric and related gynaecological cancers and rare cancer predisposing syndromes; assessing cancer risk and communicating risk information; early detection and risk reducing measures available for those at increased risk and managing individuals with hereditary cancer. Drawing on experiences of health professionals, Genetics for Health Professionals in Cancer Care discusses the challenges raised and provides practical advice and insight into what happens when a patient is referred for genetic counselling and genetic testing, including the psychological, social and ethical issues faced by individuals and families with and at risk of hereditary cancer. The book also provides practical guidance on setting up a cancer family history clinic in primary and secondary care. Genetics for Health Professionals in Cancer Care is essential reading for healthcare professionals working with cancer patients and their families, and is an ideal reference text for non-specialists working in cancer genetics.

Understanding Disparities in Access to Genomic Medicine

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309485258
Total Pages : 127 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Understanding Disparities in Access to Genomic Medicine by : National Academies of Sciences, Engineering, and Medicine

Download or read book Understanding Disparities in Access to Genomic Medicine written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-28 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic medicine is defined as the routine use of genomic information about an individual as part of his or her clinical care as well as the health outcomes and policy implications of that clinical use. It is one approach that has the potential to improve the quality of health care by allowing practitioners to tailor prevention, diagnostic, and treatment strategies to individual patients. In recent years, research breakthroughs, technological advances, and the decreasing cost of DNA sequencing have led to the wider adoption of genomic medicine. However, as with the introduction of new technologies into health care, there are concerns that genetic and genomic testing and services will not reach all segments of the population both now and in the near future, and there remains a gap in knowledge regarding potential health care disparities in genomic medicine and precision health approaches. On June 27, 2018, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop to examine the gaps in knowledge related to access to genomic medicine and to discuss health care disparities and possible approaches to overcoming the disparate use of genomic medicine among populations. Workshop participants discussed research on access to genetics and genomics services in medically underserved areas, model programs of care for diverse patient populations, and current challenges and possible best practices for alleviating health care disparities as they relate to genomics-based approaches. This publication summarizes the presentations and discussions from the workshop.

Cancer Genomics

Author : Graham Dellaire
Publisher : Academic Press
ISBN 13 : 0123972744
Total Pages : 510 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Cancer Genomics by : Graham Dellaire

Download or read book Cancer Genomics written by Graham Dellaire and published by Academic Press. This book was released on 2013-11-21 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

The Genetic Risks of Cancer

Author : Richard Graydon
Publisher :
ISBN 13 : 9781521326534
Total Pages : 500 pages
Book Rating : 4.3/5 (265 download)

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Book Synopsis The Genetic Risks of Cancer by : Richard Graydon

Download or read book The Genetic Risks of Cancer written by Richard Graydon and published by . This book was released on 2017-05-17 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines the current understanding of the genetic basis of cancer and describes the major classes of cancer-causing genes that have relevance to clinical practice today: oncogenes, tumor suppressor genes, and DNA-damage repair genes. Oncogenes are genes, normally involved in cell growth and proliferation, that cause cancer when they are overexpressed, amplified, or mutated. Tumor suppressor genes, on the other hand, normally regulate cell growth, and only result in malignant progression when their negative regulatory controls are impaired or underexpressed. Recently, a third group of genes involved in regulating DNA repair has been implicated in hereditary human cancers. This class of DNA damage response genes shares many of the features of tumor suppressor genes. CHAPTER 2: SIGNALING PATHWAYS IN CANCERGenetic and epigenetic alterations that allow cells to overproliferate and escape mechanisms that normally control their survival and migration are major divers of carcinogenesis. Proliferation, migration and apoptosis are intricate biological processes, generally controlled by biochemical responses of cells to stimuli in their extra-cellular micro-environment. Sequences of intracellular responses, referred to as signal transduction pathways, are generally initiated following binding of extracellular ligands to cell-surface receptors. Signaling cascades incorporate protein effector molecules, which comprise the larger protein complexes of intracellular communication pathways. During intra-cellular signal transduction, signals from one source are processed and passed on to another, downstream intra-cellular protein. Aberrantly functioning intracellular signal-transduction molecules are believed to result in many of the pathologic phenotypes of cancer cells.CHAPTER 3: HEREDITARY BREAST & OVARIAN CANCER One in nine American women who live to age 85 will develop breast cancer during their lifetime. Breast cancer is expected to account for 255,180 new cases and 41,070 deaths in the United States annually (American Cancer Society 2017). Only about 3000 cases of breast cancer will be diagnosed in women age 30 or younger, and about 2,190 cases are diagnosed in males each year in the United States. CHAPTER 10: GENOMIC COUNSELING AND CANCER RISK ASSESSMENTScientific and technologic advances in genomics are revolutionizing our approach to genetic counseling and testing, targeted therapy, and cancer screening and prevention, fulfilling the promise of personalized medicine. For physicians, genetic counselors, nurses, and other members of a multidisciplinary cancer care team, the future of personalized medicine is now; however, the current enthusiasm about personalized genomics follows several decades of scientific discovery and clinical translation in human genetics. TABLE OF CONTENTSCHAPTER 1... CANCER AS A GENETIC DISORDERCHAPTER 2 ... SIGNAL TRANSDUCTION PATHWAYSCHAPTER 3 ... BREAST AND OVARIAN CANCERCHAPTER 4 ... LUNG CANCERCHAPTER 5 ... COLON CANCERCHAPTER 6 ... LEUKEMIA AND LYMPHOMACHAPTER 7... PROSTATE CANCERCHAPTER 8 ... MALIGNANT MELANOMACHAPTER 9 ... RARE HEREDITARY CANCER SYNDROMESATAXIA TELANGIECTASIABIRT-HOGG-DUBE SYNDROMEBLADDER CANCERBLOOM'S SYNDROMEBRAIN TUMORSCARNEY COMPLEXCOWDEN SYNDROMEFANCONI ANEMIAHEREDITARY DIFFUSE GASTRIC CANCERGASTROINTESTINAL STROMAL TUMORSHEREDITARY PARAGANGLIONOMAJUVENILE POLYPOSIS SYNDROMEHEREDITARY LEIOMYOMATOSISLI-FRAUMENI SYNDROME MULTIPLE ENDOCRINE NEOPLASIASNEUROBLASTOMANEUROFIBROMATOSISPANCREATIC CANCERHEREDITARY PAPILLARY THYROID CANCERPEUTZ-JEGHERS SYNDROMERETINOBLASTOMATESTICULAR CANCERTUBEROUS SCLEROSIS COMPLEXVON HIPPEL-LINDAU SYNDROMEWERNER SYNDROMEWILMS TUMOR SYNDROMEXERODERMA PIGMENTOSUMETC. CHAPTER 10 ... GENOMIC COUNSELING AND CANCER RISK ASSESSMENTCHAPTER 11 ... PSYCHOLOGICAL ISSUES IN GENETIC CANCER SYNDROMESCHAPTER 12 ... ETHICAL AND LEGAL ISSUES - CANCER RISK COUNSELING

Clinical Cancer Genetics

Author : Kenneth Offit
Publisher : Wiley-Blackwell
ISBN 13 : 9780471458937
Total Pages : 452 pages
Book Rating : 4.4/5 (589 download)

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Book Synopsis Clinical Cancer Genetics by : Kenneth Offit

Download or read book Clinical Cancer Genetics written by Kenneth Offit and published by Wiley-Blackwell. This book was released on 2030-05-07 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a world-recognized leader in this emerging field, Clinical Cancer Genetics provides an updated and expanded treatment of Kenneth Offit's seminal text on the clinical management associated with syndromes of cancer predisposition, with a thorough review of the relevant molecular genetics. This second edition features new coverage of pharmacogenetics, gene therapy trials, high throughput genotyping, and microarrays and includes a new focus on epigenetic events in carcinogenesis within background chapter on cancer genetics. Expanded coverage highlights more uncommon and rare cancer predisposition syndromes.

The Role of Genetics in Breast and Reproductive Cancers

Author : Piri Welcsh
Publisher : Springer Science & Business Media
ISBN 13 : 1441904778
Total Pages : 346 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Role of Genetics in Breast and Reproductive Cancers by : Piri Welcsh

Download or read book The Role of Genetics in Breast and Reproductive Cancers written by Piri Welcsh and published by Springer Science & Business Media. This book was released on 2009-10-03 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.

Inherited Cancer Syndromes

Author : C. Neal Ellis
Publisher : Springer Science & Business Media
ISBN 13 : 1441968210
Total Pages : 204 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Inherited Cancer Syndromes by : C. Neal Ellis

Download or read book Inherited Cancer Syndromes written by C. Neal Ellis and published by Springer Science & Business Media. This book was released on 2010-10-29 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Inherited Cancer Syndromes incorporates new genetic markers data with the clinical utility and practicality of the first edition.

Unraveling the Code

Author : Sean Harrison
Publisher : Sean P Harrison
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4./5 ( download)

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Book Synopsis Unraveling the Code by : Sean Harrison

Download or read book Unraveling the Code written by Sean Harrison and published by Sean P Harrison. This book was released on 2024-02-06 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Unraveling the Code: Decoding the Cancer Gene" is a groundbreaking exploration of cancer genetics's intricate and complex world, written by a team of leading scientists and medical experts. This comprehensive book takes readers on a captivating journey through the cutting-edge research, discoveries, and innovations that have revolutionized our understanding of cancer at the genetic level. This book's heart is the quest to decode the intricate genetic blueprint underlying cancer. The authors dive deep into the molecular mechanisms and genetic mutations that drive various cancer types' initiation, progression, and treatment. They explain complex concepts in a clear and accessible manner, making it an engaging read for both medical professionals and curious individuals with no prior background in genetics. "Unraveling the Code" is a scientific journey and a human one, as it delves into the stories of patients and families affected by cancer and the hope that genetic research brings to their lives. It emphasizes the importance of collaboration among scientists, clinicians, and patients in the fight against cancer. "Unraveling the Code: Decoding the Cancer Gene" is a groundbreaking exploration of cancer genetics's intricate and complex world, written by a team of leading scientists and medical experts. This comprehensive book takes readers on a captivating journey through the cutting-edge research, discoveries, and innovations that have revolutionized our understanding of cancer at the genetic level. This book's heart is the quest to decode the intricate genetic blueprint underlying cancer. The authors dive deep into the molecular mechanisms and genetic mutations that drive various cancer types' initiation, progression, and treatment. They explain complex concepts in a clear and accessible manner, making it an engaging read for both medical professionals and curious individuals with no prior background in genetics. "Unraveling the Code" is a scientific journey and a human one, as it delves into the stories of patients and families affected by cancer and the hope that genetic research brings to their lives. It emphasizes the importance of collaboration among scientists, clinicians, and patients in the fight against cancer.

Understanding Breast Cancer Genetics

Author : Barbara T. Zimmerman
Publisher : Univ. Press of Mississippi
ISBN 13 : 9781578065783
Total Pages : 142 pages
Book Rating : 4.0/5 (657 download)

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Book Synopsis Understanding Breast Cancer Genetics by : Barbara T. Zimmerman

Download or read book Understanding Breast Cancer Genetics written by Barbara T. Zimmerman and published by Univ. Press of Mississippi. This book was released on 2004 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health & Sickness -- Consumer Health This book by a scientist whose background is in cellular and molecular biology examines the fearsome disease that strikes one in eight women in the United States. Although women are more likely to die of heart disease or of lung cancer, a diagnosis of breast cancer is the medical pronouncement that a woman is most likely to fear. It kills more than 40,000 Americans annually. Why are some women more vulnerable than others? The interplay between genetics and environment is suspected. Thus this book for general readers will help them understand the genetic bases of both sporadic and inherited breast cancers. Although only five to ten percent of breast cancer patients have inherited mutations in these genes, all women need to understand the genetic implications of the disease. In clear, concise language Barbara T. Zimmerman guides the reader through the complexities, discussing in detail the genes that are known to increase susceptibility and the ways they are passed on. Examining the general biology of breast cancer, Zimmerman describes how sporadic and inherited forms of the disease arise and how the location of the tumors can affect the body. She discusses genetic mutations and their roles in the development of tumors and tells how these potentially cancer-inducing genes were discovered. Covered too are the issues of risk, prevention, screening, diagnosis, therapy, and genetic testing and counseling. Zimmerman concludes with a comprehensive analysis of current research and with an emphasis on how a woman's understanding of inherited breast cancer can help doctors seeking to design better methods for prevention and therapy. A useful list of resources for further information about the genetic causes of breast cancer is included. Barbara T. Zimmerman did her graduate work in experimental pathology and her post-doctoral research in the cellular and molecular processes of disease. Widely published, she is the manager of the Denver-based firm Biomedical Communication and Consulting.

Cancer Genetics: A Clinical Approach

Author : Xavier Llor
Publisher : McGraw Hill Professional
ISBN 13 : 1260440281
Total Pages : 474 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis Cancer Genetics: A Clinical Approach by : Xavier Llor

Download or read book Cancer Genetics: A Clinical Approach written by Xavier Llor and published by McGraw Hill Professional. This book was released on 2021-11-19 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultimate guide to caring for and communicating with patients suffering with hereditary cancer syndromes Providing the essential tools needed to understand clinical cancer genetics, Cancer Genetics: A Clinical Approach builds your mastery of differential diagnosis formulation, all the available genetic testing options at your disposal, interpreting results logically and accurately, and educating patients and their families about effective cancer prevention methods. This unparalleled resource walks you through the process of effectively and thoughtfully counseling patients—from pre-test counseling and relaying test results to navigating the legal implications of hereditary conditions and coping with the resulting psychological challenges. Cancer Genetics: A Clinical Approach is ideal for both specialized cancer genetics clinics or any healthcare professional seeking to improve their skills in identifying patients with possible hereditary cancer syndromes and recognizing which ones should be referred to a high-risk/clinical genetics specialty program.

Cancer Genomics

Author : David Malkin
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128061081
Total Pages : 510 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Cancer Genomics by : David Malkin

Download or read book Cancer Genomics written by David Malkin and published by Elsevier Inc. Chapters. This book was released on 2013-11-21 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is the most common cause of disease-related death in children beyond the newborn period. Most cancers are thought to arise sporadically; however, classical studies of well-defined familial cancer associations, known as cancer predisposition syndromes (CPS), together with emerging work arising from new high-resolution genomic platforms have confirmed that at least 25% of childhood cancers result from hereditary factors. The spectrum of cancers found in the diverse array of known hereditary cancer syndromes is vast. Similarly, the number of genes linked to these syndromes continues to expand. This chapter explores the genotype:phenotype correlations in several defined cancer predisposition syndromes that primarily affect children. In particular, a selection of syndromes that are caused by germline mutations in classical tumor suppressor genes (RB1, TP53, WT1) and oncogenes (RET), syndromes associated with congenital developmental anomalies (Beckwith–Wiedemann syndrome, Gorlin syndrome) and an emerging syndrome associated with microRNA processing (DICER1) provide examples of the heterogeneity that these syndromes exhibit. The chapter concludes with a discussion of the clinical impact of genetic testing and clinical surveillance for early cancer detection.