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Author : Helen F. Cserr
Publisher :
ISBN 13 :
Total Pages : 412 pages
Book Rating : 4.F/5 ( download)
Download or read book The Neuronal Microenvironment written by Helen F. Cserr and published by . This book was released on 1986 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Wolfgang Walz
Publisher : Springer Science & Business Media
ISBN 13 : 1592591086
Total Pages : 429 pages
Book Rating : 4.5/5 (925 download)
Download or read book The Neuronal Environment written by Wolfgang Walz and published by Springer Science & Business Media. This book was released on 2001-12-26 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in neuronal demand and in blood-brain barrier function, and inflammation and the neuroimmune system. Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the only information processing system in the brain.
Author : Eva Sykova
Publisher : Springer Science & Business Media
ISBN 13 : 3642769373
Total Pages : 177 pages
Book Rating : 4.6/5 (427 download)
Download or read book Ionic and Volume Changes in the Microenvironment of Nerve and Receptor Cells written by Eva Sykova and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stability of the internal environment in which neuronal elements are situated is unquestionably an important prerequisite for the effective transmission of information in the nervous system. During the past decade our knowledge on the microenvironment of nerve cells has expanded. The conception that the microenvironment of neurones comprises a fluid with a relatively simple and stable composition is no longer accepted; the microenvironment is now envisaged as a dynamic structure whose composition, shape, and volume changes, thereby significantly influencing neuronal function and the trans mission of information in the nervous system. The modern conception of the neuronal microenvironment is based on the results of research over the last 20 years. The extracellular space (ECS) is comprehended not only as a relatively stable microenvironment containing neurones and glial cells (Bernard 1878), but also as a channel for communica tion between them. The close proximity of the neuronal elements in the CNS and the narrowness of the intercellular spaces provides a basis not only for interaction between the elements themselves, but also between the elements and their microenvironment. Substances which can cross the cell membranes can easily find their way through the microenvironment to adjacent cellular elements. In this way the microenvironment can assure non-synaptic com munication between the relevant neurones. Signalization can be coded by modulation of the chemical composition of the ECS in the vicinity of the cell membrane and does not require classic connection by axones, dendrites, and synapses.
Author : Helen F. Cserr
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (961 download)
Download or read book The Neuronal Microenvironment written by Helen F. Cserr and published by . This book was released on 1986 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alan A. Boulton
Publisher : Neuromethods
ISBN 13 :
Total Pages : 768 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Neuronal Microenvironment written by Alan A. Boulton and published by Neuromethods. This book was released on 1988-05-09 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscientists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientists and is written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routmely across the widest range of s- disciplines. Collecting these general techniques together in a single volume strikes us not only as a service, but will no doubt prove of exceptional utilitarian value as well. Volumes 2 and 3 describe all current procedures for the analyses of amines and theirmetabolites and of amino acids, respectively. These collections will clearly be of value to all neurosclentists working m or contemplating research in these fields. Similar reasons exist for Volume 4 on receptor binding techniques, since experimental details are provided for all types of ligand-receptor binding, including chapters on general principles, drug discovery and development, and a most useful appendix on computer programs for Scatchard, nonlinear, and competitive d- placement analyses. Volume 5 provides procedures for the asse- ment of enzymes involved in biogenic amine synthesis and catabolism. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physiologists, -anatomlsts, psychopharmacologists, psychiatrists, neurologists, and chemists (organic, analytical, pharmaceutical, medicinal); in fact, everyone involved in the neurosciences, both basic and clinical.
Author : Wolfgang Walz
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Neuronal Environment written by Wolfgang Walz and published by Springer Science & Business Media. This book was released on 2002 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the function of all involved components in the complex environment of the neuronal microenvironment, related them to neuronal demands, and includes their distributions during major disease states.
Author : Firas H. Kobeissy
Publisher : CRC Press
ISBN 13 : 1466565993
Total Pages : 725 pages
Book Rating : 4.4/5 (665 download)
Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.
Author : Jacqueline A. Hubbard
Publisher : Academic Press
ISBN 13 : 0128026243
Total Pages : 394 pages
Book Rating : 4.1/5 (28 download)
Download or read book Astrocytes and Epilepsy written by Jacqueline A. Hubbard and published by Academic Press. This book was released on 2016-07-05 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Author : Jan Pruszak
Publisher : Academic Press
ISBN 13 : 0128011262
Total Pages : 254 pages
Book Rating : 4.1/5 (28 download)
Download or read book Neural Surface Antigens written by Jan Pruszak and published by Academic Press. This book was released on 2015-03-23 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Surface Antigens: From Basic Biology towards Biomedical Applications focuses on the functional role of surface molecules in neural development, stem cell research, and translational biomedical paradigms. With an emphasis on human and rodent model systems, this reference covers fundamentals of neural stem cell biology and flow cytometric methodology. Addressing cell biologists as well as clinicians working in the neurosciences, the book was conceived by an international panel of experts to cover a vast array of particular surface antigen families and subtypes. It provides insight into the basic biology and functional mechanisms of neural cell surface signaling molecules influencing mammalian development, regeneration, and treatments. Introduces early phase clinical trials of neural stem cells Outlines characterization of surface molecule expression and methods for isolation which open unprecedented opportunities for functional study, quantitation & diagnostics Highlights the role of stem cells in neural surface antigen and biomarker analysis and applications
Author : P. Michael Conn
Publisher : Academic Press
ISBN 13 : 0128025964
Total Pages : 776 pages
Book Rating : 4.1/5 (28 download)
Download or read book Conn's Translational Neuroscience written by P. Michael Conn and published by Academic Press. This book was released on 2016-09-28 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment
Author : Rahul Jandial
Publisher : CRC Press
ISBN 13 : 9781587066597
Total Pages : 312 pages
Book Rating : 4.0/5 (665 download)
Download or read book Metastatic Cancer: Clinical and Biological Perspectives written by Rahul Jandial and published by CRC Press. This book was released on 2013-08-08 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.
Author : Peter C. Burger
Publisher : American Registry of Pathology
ISBN 13 :
Total Pages : 470 pages
Book Rating : 4.3/5 (91 download)
Download or read book Tumors of the Central Nervous System written by Peter C. Burger and published by American Registry of Pathology. This book was released on 1994 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 412 pages
Book Rating : 4.4/5 (987 download)
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2015-12-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Author : Marie-Ève Tremblay
Publisher : Springer
ISBN 13 : 1493914294
Total Pages : 486 pages
Book Rating : 4.4/5 (939 download)
Download or read book Microglia in Health and Disease written by Marie-Ève Tremblay and published by Springer. This book was released on 2014-09-22 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.
Author : Wolfgang Walz
Publisher : Springer Science & Business Media
ISBN 13 : 1592594794
Total Pages : 279 pages
Book Rating : 4.5/5 (925 download)
Download or read book Cerebral Ischemia written by Wolfgang Walz and published by Springer Science & Business Media. This book was released on 1999-03-25 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human brain represents about 2% of the body weight, yet it accounts for approximately 20% of aerobic metabolism. This high dependency on energy-consuming processes is mainly caused by the active transport of ions, which is necessary to compensate for the transmembrane ion currents that are part ofthe complex signaling processes in the brain. Ninety-five percent ofthe brain's ATP is derived from mitochondrial oxidative phosphorylation. Since that organ' s storage capacity for oxygen is minimal, any interruption of oxygen delivery to brain cells willlead to changes in membrane excitability and, there fore, to disruption of neuronal signaling within seconds. It seems that mamma lian brain is especially vulnerable to such an interruption, since oxygen deprivation leads to activation of ion channel mechanisms in neurons that impair their communications. Thus, the function of the brain as a coordinator of vital homeostatic reflexes, and complex body reactions to external challenges, depends critically on the rate of oxygen delivery and oxygen consumption. Oxygen delivery depends on two variables described in the Fick relation ship: volume flow rate ofblood and the arterial oxygen content. A reduction in either of these two variables will have serious effects on vital brain func tions. Reduction of arterial blood flow to the brain can be caused by cardiac arrest, shock, carotid occlusion, Of hypotension (global ischemia). Oxygen content is progressively decreased in asphyxia (including drowning).
Author : Eduardo E. Benarroch
Publisher : Oxford University Press
ISBN 13 : 0190209429
Total Pages : 850 pages
Book Rating : 4.1/5 (92 download)
Download or read book Mayo Clinic Medical Neurosciences written by Eduardo E. Benarroch and published by Oxford University Press. This book was released on 2017-11-06 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders
Author : Vladimir Parpura
Publisher : Springer Science & Business Media
ISBN 13 : 0387794921
Total Pages : 701 pages
Book Rating : 4.3/5 (877 download)
Download or read book Astrocytes in (Patho)Physiology of the Nervous System written by Vladimir Parpura and published by Springer Science & Business Media. This book was released on 2008-12-11 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.
