Modeling Biomaterials

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Modeling Biomaterials

Author : Josef Málek
Publisher : Springer Nature
ISBN 13 : 3030880842
Total Pages : 281 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Modeling Biomaterials by : Josef Málek

Download or read book Modeling Biomaterials written by Josef Málek and published by Springer Nature. This book was released on 2022-01-21 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The investigation of the role of mechanical and mechano-chemical interactions in cellular processes and tissue development is a rapidly growing research field in the life sciences and in biomedical engineering. Quantitative understanding of this important area in the study of biological systems requires the development of adequate mathematical models for the simulation of the evolution of these systems in space and time. Since expertise in various fields is necessary, this calls for a multidisciplinary approach. This edited volume connects basic physical, biological, and physiological concepts to methods for the mathematical modeling of various materials by pursuing a multiscale approach, from subcellular to organ and system level. Written by active researchers, each chapter provides a detailed introduction to a given field, illustrates various approaches to creating models, and explores recent advances and future research perspectives. Topics covered include molecular dynamics simulations of lipid membranes, phenomenological continuum mechanics of tissue growth, and translational cardiovascular modeling. Modeling Biomaterials will be a valuable resource for both non-specialists and experienced researchers from various domains of science, such as applied mathematics, biophysics, computational physiology, and medicine.

Biomaterials for 3D Tumor Modeling

Author : Subhas C. Kundu
Publisher : Elsevier
ISBN 13 : 012818129X
Total Pages : 773 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biomaterials for 3D Tumor Modeling by : Subhas C. Kundu

Download or read book Biomaterials for 3D Tumor Modeling written by Subhas C. Kundu and published by Elsevier. This book was released on 2020-08-22 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Biofabrication and 3D Tissue Modeling

Author : Dong-Woo Cho
Publisher : Royal Society of Chemistry
ISBN 13 : 1788011988
Total Pages : 369 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Biofabrication and 3D Tissue Modeling by : Dong-Woo Cho

Download or read book Biofabrication and 3D Tissue Modeling written by Dong-Woo Cho and published by Royal Society of Chemistry. This book was released on 2019-01-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

Biofabrication and 3D Tissue Modeling

Author : Dong-Woo Cho
Publisher : Royal Society of Chemistry
ISBN 13 : 1788016645
Total Pages : 369 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Biofabrication and 3D Tissue Modeling by : Dong-Woo Cho

Download or read book Biofabrication and 3D Tissue Modeling written by Dong-Woo Cho and published by Royal Society of Chemistry. This book was released on 2019-01-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

Biomaterials for Skin Repair and Regeneration

Author : Elena Garcia-Gareta
Publisher : Woodhead Publishing
ISBN 13 : 0081025475
Total Pages : 372 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Biomaterials for Skin Repair and Regeneration by : Elena Garcia-Gareta

Download or read book Biomaterials for Skin Repair and Regeneration written by Elena Garcia-Gareta and published by Woodhead Publishing. This book was released on 2019-06-05 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for Skin Repair and Regeneration examines a range of materials and technologies used for regenerating or repairing skin. With a strong focus on biomaterials and scaffolds, the book also examines the testing and evaluation pathway for human clinical trials. Beginning by introducing the fundamentals on skin tissue, the book goes on to describe contemporary technology used in skin repair as well as currently available biomaterials suitable for skin tissue repair and regeneration. Skin tissue engineering and the ideal requirements to take into account when developing skin biomaterials are discussed, followed by information on the individual materials used for skin repair and regeneration. As evaluation of biomaterials in animal models is mandatory before proceeding into human clinical trials, the book also examines the different animal models available. With a strong focus on materials, engineering, and application, this book is a valuable resource for materials scientists, skin biologists, and bioengineers with an interest in tissue engineering, regeneration, and repair of skin. Provides an understanding of basic skin biology Comprehensively examines a variety of biomaterial approaches Looks at animal models for the evaluation of biomaterial-based skin constructs

Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System

Author : Zhongmin Jin
Publisher : Woodhead Publishing
ISBN 13 : 0128227621
Total Pages : 632 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System by : Zhongmin Jin

Download or read book Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System written by Zhongmin Jin and published by Woodhead Publishing. This book was released on 2020-09-29 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System: Biomaterials and Tissues, Second Edition reviews how a wide range of materials are modeled and applied. Chapters cover basic concepts for modeling of biomechanics and biotribology, the fundamentals of computational modeling of biomechanics in the musculoskeletal system, finite element modeling in the musculoskeletal system, computational modeling from a cells and tissues perspective, and computational modeling of the biomechanics and biotribology interactions, looking at complex joint structures. This book is a comprehensive resource for professionals in the biomedical market, materials scientists and biomechanical engineers, and academics in related fields. This important new edition provides an up-to-date overview of the most recent research and developments involving hydroxyapatite as a key material in medicine and its application, including new content on novel technologies, biomorphic hydroxyapatite and more. Provides detailed, introductory coverage of modeling of cells and tissues, modeling of biomaterials and interfaces, biomechanics and biotribology Discusses applications of modeling for joint replacements and applications of computational modeling in tissue engineering Offers a holistic perspective, from cells and small ligaments to complex joint interactions

Computational Modeling in Tissue Engineering

Author : Liesbet Geris
Publisher : Springer Science & Business Media
ISBN 13 : 3642325637
Total Pages : 438 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Computational Modeling in Tissue Engineering by : Liesbet Geris

Download or read book Computational Modeling in Tissue Engineering written by Liesbet Geris and published by Springer Science & Business Media. This book was released on 2012-10-30 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.

Printed Biomaterials

Author : Roger Narayan
Publisher : Springer Science & Business Media
ISBN 13 : 1441913955
Total Pages : 131 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Printed Biomaterials by : Roger Narayan

Download or read book Printed Biomaterials written by Roger Narayan and published by Springer Science & Business Media. This book was released on 2009-11-26 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have shown that novel processing and modeling techniques may be used to create patient-specific prostheses, artificial tissues, and other implants using data obtained from magnetic resonance imaging, computed tomography, or other imaging techniques. For example, customized prostheses may be fabricated that possess suitable features, including geometry, size, and weight, for a given medical condition. Many advances have been made in the development of patient-specific implants in the past decade, yet this information is not readily available to scientists and students. Printed Biomaterials: Novel Processing and Modeling Techniques for Medicine and Surgery provides the biomaterials scientist and engineer, as well as advanced undergraduate or graduate students, with a comprehensive discussion of contemporary medical implant research and development. The development of printed biomaterials is multidisciplinary, and includes concepts traditionally associated with engineering, materials science, medicine, and surgery. This text highlights important topics in these core fields in order to provide the fundamentals necessary to comprehend current processing and modeling technologies and to develop new ones.

Deformable Models

Author : Aly Farag
Publisher : Springer Science & Business Media
ISBN 13 : 0387312048
Total Pages : 592 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Deformable Models by : Aly Farag

Download or read book Deformable Models written by Aly Farag and published by Springer Science & Business Media. This book was released on 2007-08-02 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the complete spectrum of deformable models, its evolution as an imagery field and its use in many biomedical engineering and clinical application disciplines. The book focuses on the core image processing techniques, theory and biomaterials useful to research and industry. Contributors are all pioneers in the field.

Biomechanics: Trends in Modeling and Simulation

Author : Gerhard A. Holzapfel
Publisher : Springer
ISBN 13 : 3319414755
Total Pages : 319 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Biomechanics: Trends in Modeling and Simulation by : Gerhard A. Holzapfel

Download or read book Biomechanics: Trends in Modeling and Simulation written by Gerhard A. Holzapfel and published by Springer. This book was released on 2016-09-14 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models

Author : J. Miguel Oliveira
Publisher : Springer Nature
ISBN 13 : 3030365883
Total Pages : 176 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models by : J. Miguel Oliveira

Download or read book Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models written by J. Miguel Oliveira and published by Springer Nature. This book was released on 2020-04-13 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.

Patient-Specific Modeling in Tomorrow's Medicine

Author : Amit Gefen
Publisher : Springer Science & Business Media
ISBN 13 : 3642246176
Total Pages : 524 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Patient-Specific Modeling in Tomorrow's Medicine by : Amit Gefen

Download or read book Patient-Specific Modeling in Tomorrow's Medicine written by Amit Gefen and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the frontier of research and clinical applications of Patient Specific Modeling, and provides a state-of-the-art update as well as perspectives on future directions in this exciting field. The book is useful for medical physicists, biomedical engineers and other engineers who are interested in the science and technology aspects of Patient Specific Modeling, as well as for radiologists and other medical specialists who wish to be updated about the state of implementation.

Introduction to Integrative Engineering

Author : Guigen Zhang
Publisher : CRC Press
ISBN 13 : 1315388456
Total Pages : 424 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Introduction to Integrative Engineering by : Guigen Zhang

Download or read book Introduction to Integrative Engineering written by Guigen Zhang and published by CRC Press. This book was released on 2017-03-03 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is designed for an introductory course at undergraduate and graduate levels for bioengineering students. It provides a systematic way of examining bioengineering problems in a multidisciplinary computational approach. The book introduces basic concepts of multidiscipline-based computational modeling methods, provides detailed step-by-step techniques to build a model with consideration of underlying multiphysics, and discusses many important aspects of a modeling approach including results interpretation, validation, and assessment.

Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Author : Amit Gefen
Publisher : Springer Science & Business Media
ISBN 13 : 3642364829
Total Pages : 397 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Multiscale Computer Modeling in Biomechanics and Biomedical Engineering by : Amit Gefen

Download or read book Multiscale Computer Modeling in Biomechanics and Biomedical Engineering written by Amit Gefen and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

Comprehensive Biomaterials II

Author : Kevin Healy
Publisher : Elsevier
ISBN 13 : 0081006926
Total Pages : 4865 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Biomaterials II by : Kevin Healy

Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Immunomodulatory Biomaterials

Author : Stephen F. Badylak
Publisher : Woodhead Publishing
ISBN 13 : 0128214562
Total Pages : 296 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Immunomodulatory Biomaterials by : Stephen F. Badylak

Download or read book Immunomodulatory Biomaterials written by Stephen F. Badylak and published by Woodhead Publishing. This book was released on 2021-07-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Mathematical Models and Computer Simulations for Biomedical Applications

Author : Gabriella Bretti
Publisher : Springer Nature
ISBN 13 : 3031357159
Total Pages : 261 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Mathematical Models and Computer Simulations for Biomedical Applications by : Gabriella Bretti

Download or read book Mathematical Models and Computer Simulations for Biomedical Applications written by Gabriella Bretti and published by Springer Nature. This book was released on 2023-09-17 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modelling and computer simulations are playing a crucial role in the solution of the complex problems arising in the field of biomedical sciences and provide a support to clinical and experimental practices in an interdisciplinary framework. Indeed, the development of mathematical models and efficient numerical simulation tools is of key importance when dealing with such applications. Moreover, since the parameters in biomedical models have peculiar scientific interpretations and their values are often unknown, accurate estimation techniques need to be developed for parameter identification against the measured data of observed phenomena. In the light of the new challenges brought by the biomedical applications, computational mathematics paves the way for the validation of the mathematical models and the investigation of control problems. The volume hosts high-quality selected contributions containing original research results as well as comprehensive papers and survey articles including prospective discussion focusing on some topical biomedical problems. It is addressed, but not limited to: research institutes, academia, and pharmaceutical industries.