Biomaterials For 3d Tumor Modeling

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Biomaterials for 3D Tumor Modeling

Author : Subhas C. Kundu
Publisher : Elsevier
ISBN 13 : 012818129X
Total Pages : 773 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biomaterials for 3D Tumor Modeling by : Subhas C. Kundu

Download or read book Biomaterials for 3D Tumor Modeling written by Subhas C. Kundu and published by Elsevier. This book was released on 2020-08-22 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Biomaterial-Assisted 3D In Vitro Tumor Models

Author : Serena Danti
Publisher : Mdpi AG
ISBN 13 : 9783036568423
Total Pages : 0 pages
Book Rating : 4.5/5 (684 download)

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Book Synopsis Biomaterial-Assisted 3D In Vitro Tumor Models by : Serena Danti

Download or read book Biomaterial-Assisted 3D In Vitro Tumor Models written by Serena Danti and published by Mdpi AG. This book was released on 2023-03-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reprint focuses on fundamental and applied research involving the combination of biomaterials and cancer cells to develop a three-dimensional (3D) tumor microenvironment in vitro, in which carcinogenesis mechanisms can be studied and therapies can be screened. Such models are becoming quite popular within the bioengineering community; thus, many technologies are being tested to obtain the best scaffold for each tumor. In any case, only a tight interaction of bioengineers with cancer biologists and oncologists can make such 3D models progress, with them finally reaching a clinical relevance. On the other hand, the medical community is approaching simpler 3D in vitro models not provided with sufficient extracellular matrix biomimicry, such as spheroids and organoids, which may not be self-exhaustive; therefore, cancer researchers could benefit from closer contact with bioengineers. The aim of this reprint is to help generate shared knowledge and promote strong interdisciplinary collaboration with the ultimate goal of contributing to the acceleration of the discovery and validation of more precise therapies to fight cancer.

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models

Author : J. Miguel Oliveira
Publisher : Springer Nature
ISBN 13 : 3030365883
Total Pages : 176 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models by : J. Miguel Oliveira

Download or read book Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models written by J. Miguel Oliveira and published by Springer Nature. This book was released on 2020-04-13 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.

Biomaterial Based Approaches to Study the Tumour Microenvironment

Author : Jessica O Winter
Publisher : Royal Society of Chemistry
ISBN 13 : 1839166029
Total Pages : 376 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Biomaterial Based Approaches to Study the Tumour Microenvironment by : Jessica O Winter

Download or read book Biomaterial Based Approaches to Study the Tumour Microenvironment written by Jessica O Winter and published by Royal Society of Chemistry. This book was released on 2022-12-07 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumour microenvironment is increasingly recognized as an important contributor to cancer progression and treatment. However, most cancer studies continue to be performed in 2D tissue culture dishes that do not capture the characteristics of the tumour niche. This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies, including scaffold design and synthesis, chemical signalling and delivery, and co-culture, microfluidics, and organ-on-a-chip tools that can be used to mimic tumour microenvironment features. This book also includes discussion of emerging imaging methods compatible with tumour microenvironment mimicking biomaterials and discusses applications of such models in immuno-oncology, metastasis, and drug screening. Edited by two leaders in the field, this book will appeal to graduate students and researchers working in biomaterials science, chemical and biomedical engineering departments.

Biofabrication and 3D Tissue Modeling

Author : Dong-Woo Cho
Publisher : Royal Society of Chemistry
ISBN 13 : 1788011988
Total Pages : 369 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Biofabrication and 3D Tissue Modeling by : Dong-Woo Cho

Download or read book Biofabrication and 3D Tissue Modeling written by Dong-Woo Cho and published by Royal Society of Chemistry. This book was released on 2019-01-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

Engineering 3D Tissue Test Systems

Author : Karen J.L. Burg
Publisher : CRC Press
ISBN 13 : 1351644548
Total Pages : 638 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Engineering 3D Tissue Test Systems by : Karen J.L. Burg

Download or read book Engineering 3D Tissue Test Systems written by Karen J.L. Burg and published by CRC Press. This book was released on 2017-07-28 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components. The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues.

Tumor Organoids

Author : Shay Soker
Publisher : Humana Press
ISBN 13 : 3319605119
Total Pages : 213 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Tumor Models in Cancer Research

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
ISBN 13 : 1592591000
Total Pages : 994 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Tumor Models in Cancer Research by : Beverly A. Teicher

Download or read book Tumor Models in Cancer Research written by Beverly A. Teicher and published by Springer Science & Business Media. This book was released on 2001-11-07 with total page 994 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Trends in Biomaterials

Author : G. P. Kothiyal
Publisher : CRC Press
ISBN 13 : 9814613991
Total Pages : 230 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Trends in Biomaterials by : G. P. Kothiyal

Download or read book Trends in Biomaterials written by G. P. Kothiyal and published by CRC Press. This book was released on 2016-02-24 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials research requires the union of materials scientists, engineers, biologists, biomedical doctors, and surgeons. Societal implications have invoked tremendous interest in this area of research in recent years. What started as a search for strong and durable implant materials has now led to path-breaking developments in tissue engineering, targeted drug delivery, and tissue scaffolds. Viable applications of mesoporous structures, polymer biocomposites, and fibers (synthetic and natural) in the areas of clinical orthopedics, controlled drug delivery, tissue engineering, orthodontics, etc., have emerged as relatively recent concepts. This book presents recent results related to both materials aspects and implant issues. The focus is on structural, magnetic, antibacterial, bioactivity/compatibility, mechanical, and other related properties and the implication of these results on biomedical applications. The book discusses technical problems faced by the surgeon during implant fixation in total hip replacement and the selection of materials based on the patient’s requirement. It also addresses recent advances in implant materials, including the reinforcement and biocompatibility issues.

Biomaterials for Cancer Therapeutics

Author : Kinam Park
Publisher : Elsevier
ISBN 13 : 0857096761
Total Pages : 530 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Biomaterials for Cancer Therapeutics by : Kinam Park

Download or read book Biomaterials for Cancer Therapeutics written by Kinam Park and published by Elsevier. This book was released on 2013-11-23 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction. This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials. A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer Discusses the fundamentals of biomaterials for cancer therapeutics Discusses synthetic vaccines, proteins and polymers for cancer therapeutics

Biomaterials in Tissue Engineering and Regenerative Medicine

Author : Birru Bhaskar
Publisher : Springer Nature
ISBN 13 : 9811600023
Total Pages : 587 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Biomaterials in Tissue Engineering and Regenerative Medicine by : Birru Bhaskar

Download or read book Biomaterials in Tissue Engineering and Regenerative Medicine written by Birru Bhaskar and published by Springer Nature. This book was released on 2021-04-29 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively explores the basic concepts and applications of biomaterials in tissue engineering and regenerative medicine. The book is divided into four sections; the first section deals with the basic concepts and different types of biomaterials used in tissue engineering. The second section discusses the functional requirements and types of materials that are used in developing state-of-the-art of scaffolds for tissue engineering applications. The third section presents the applications of biomaterials for hard and soft tissue engineering, as well as for specialized tissue engineering. The last section addresses the future prospects of nanobiomaterials, intelligent biomaterials, and 3D bioprinting biomaterials in tissue engineering and regenerative medicine. It also discusses various in vitro disease models for tissue bioengineering and regenerative medicine. As such, it offers a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

Biomaterials for Engineering Cellular Environments in Tissue Engineering

Author : Hon Fai Chan
Publisher : Frontiers Media SA
ISBN 13 : 2889716309
Total Pages : 188 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Biomaterials for Engineering Cellular Environments in Tissue Engineering by : Hon Fai Chan

Download or read book Biomaterials for Engineering Cellular Environments in Tissue Engineering written by Hon Fai Chan and published by Frontiers Media SA. This book was released on 2022-01-12 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Biomaterials for Biomedical Applications

Author : Anuj Tripathi
Publisher : Springer
ISBN 13 : 9811033285
Total Pages : 545 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Advances in Biomaterials for Biomedical Applications by : Anuj Tripathi

Download or read book Advances in Biomaterials for Biomedical Applications written by Anuj Tripathi and published by Springer. This book was released on 2017-01-24 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recent advances in the field of biomaterials design and the state of the art in biomaterials applications for biomedicine. Addressing key aspects of biomaterials, the book explores technological advances at multi-scale levels (macro, micro, and nano), which are used in applications related to cell and tissue regeneration. The book also discusses the future scope of bio-integrated systems. The contents are supplemented by illustrated examples, and schematics of molecular and cellular interactions with biomaterials/scaffolds are included to promote a better understanding of the complex biological mechanisms involved in material-to-biomolecule interactions. The book also covers factors that govern cell growth, differentiation, and regeneration in connection with the treatment and recovery of native biological systems. Tissue engineering, drug screening and delivery, and electrolyte complexes for biomedical applications are also covered in detail. This book offers a comprehensive reference guide for multi-disciplinary communities working in the area of biomaterials, and will benefit researchers and graduate students alike.

Biomaterials for Cancer Therapeutics

Author : Kinam Park
Publisher : Woodhead Publishing
ISBN 13 : 0081029845
Total Pages : 783 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Biomaterials for Cancer Therapeutics by : Kinam Park

Download or read book Biomaterials for Cancer Therapeutics written by Kinam Park and published by Woodhead Publishing. This book was released on 2020-03-05 with total page 783 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat and prevent cancer. Hence, this book is a welcomed resource to the discussion. Provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, treatment and prevention of cancer Discusses how the properties of specific biomaterials make them important in cancer treatment Covers synthetic vaccines, proteins and polymers for cancer therapeutics

Self-assembling Biomaterials

Author : Helena S. Azevedo
Publisher : Woodhead Publishing
ISBN 13 : 0081020120
Total Pages : 612 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Self-assembling Biomaterials by : Helena S. Azevedo

Download or read book Self-assembling Biomaterials written by Helena S. Azevedo and published by Woodhead Publishing. This book was released on 2018-04-17 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials

Silk Biomaterials for Tissue Engineering and Regenerative Medicine

Author : Subhas Kundu
Publisher : Elsevier
ISBN 13 : 0857097067
Total Pages : 582 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Silk Biomaterials for Tissue Engineering and Regenerative Medicine by : Subhas Kundu

Download or read book Silk Biomaterials for Tissue Engineering and Regenerative Medicine written by Subhas Kundu and published by Elsevier. This book was released on 2014-03-24 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area. Part one introduces silk biomaterials, discussing their fundamentals and how they are processed, and considering different types of silk biomaterials. Part two focuses on the properties and behavior of silk biomaterials and the implications of this for their applications in biomedicine. These chapters focus on topics including biodegradation, bio-response to silk sericin, and capillary growth behavior in porous silk films. Finally, part three discusses the applications of silk biomaterials for tissue engineering, regenerative medicine, and biomedicine, with chapters on the use of silk biomaterials for vertebral, dental, dermal, and cardiac tissue engineering. Silk Biomaterials for Tissue Engineering and Regenerative Medicine is an important resource for materials and tissue engineering scientists, R&D departments in industry and academia, and academics with an interest in the fields of biomaterials and tissue engineering. Discusses the properties and applications of silk for medical purposes Considers pharmaceutical and cosmeceutical applications

Bioinspired Biomaterials

Author : Heung Jae Chun
Publisher : Springer Nature
ISBN 13 : 9811532583
Total Pages : 231 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Bioinspired Biomaterials by : Heung Jae Chun

Download or read book Bioinspired Biomaterials written by Heung Jae Chun and published by Springer Nature. This book was released on 2020-06-29 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. Topics addressed in this volume, which is devoted to bioinspired biomaterials, range from novel biomaterials for regenerative medicine through to emerging enabling technologies with applications in, for example, drug delivery, maternal–fetal medicine, peripheral nerve repair and regeneration, and brain tumor therapy. New bioinspired hydrogels receive detailed attention in the book, and a further focus is the use of bioinspired biomaterials in the regulation of stem cell fate. Here the coverage includes the role of scaffolds in cartilage regeneration, the bioapplication of inorganic nanomaterials in tissue engineering, and guidance of cell migration to improve tissue regeneration. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.