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Immunomodulatory Biomaterials
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Book Synopsis Immunomodulatory Biomaterials by : Stephen F. Badylak
Download or read book Immunomodulatory Biomaterials written by Stephen F. Badylak and published by Woodhead Publishing. This book was released on 2021-07-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area
Book Synopsis Biomaterials and Immune Response by : Nihal Engin Vrana
Download or read book Biomaterials and Immune Response written by Nihal Engin Vrana and published by CRC Press. This book was released on 2018-07-20 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area
Book Synopsis Biomaterials in Regenerative Medicine and the Immune System by : Laura Santambrogio
Download or read book Biomaterials in Regenerative Medicine and the Immune System written by Laura Santambrogio and published by Springer. This book was released on 2015-09-04 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.
Book Synopsis Biomaterials and Immune Response by : Nihal Engin Vrana
Download or read book Biomaterials and Immune Response written by Nihal Engin Vrana and published by . This book was released on 2023-09-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the role of the immune system in biomaterial applications. In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial immune system in
Book Synopsis Recent Advancements of Immunomodulatory Biomaterials in Cell Therapy and Tissue Engineering by : Sudip Mukherjee
Download or read book Recent Advancements of Immunomodulatory Biomaterials in Cell Therapy and Tissue Engineering written by Sudip Mukherjee and published by Springer. This book was released on 2024-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the recent developments in immunomodulatory biomaterials for cell-based therapies in various diseases, including diabetes, cancer, cardiovascular disease, and bone regeneration. The authors first cover the fundamentals of conventional immunology and immunomodulation, before focusing on the history, advantages, and challenges of cell therapies. Biological cell therapy has gained immense attention for various diseases due to unique advantages it has over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these cell-based therapies need an inert delivery system that can locally deliver cells and minimally elicit foreign body response. The book discusses the foreign body response to the immunomodulatory biomaterials as well as the current and future strategies for potential mitigation of considerable immune responses toward immunomodulatory biomaterials and devices.
Book Synopsis The Immune Response to Implanted Materials and Devices by : Bruna Corradetti
Download or read book The Immune Response to Implanted Materials and Devices written by Bruna Corradetti and published by Springer. This book was released on 2016-11-30 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.
Book Synopsis Host Response to Biomaterials by : Stephen F Badylak
Download or read book Host Response to Biomaterials written by Stephen F Badylak and published by Academic Press. This book was released on 2015-05-08 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices
Book Synopsis Immunomodulatory Effects of Nanomaterials by : Mahmoud Elsabahy
Download or read book Immunomodulatory Effects of Nanomaterials written by Mahmoud Elsabahy and published by Woodhead Publishing. This book was released on 2022-06-02 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunomodulatory Effects of Nanomaterials: Assessment and Analysis provides an overview of the modulatory impact of nanomaterials on the immune system, as well as evaluative and analytical methods for assessing effects. Sections cover a range of common nanomaterials for biomedical use and how different properties can elicit varied responses from the immune system. The immunomodulatory effects of these materials are then discussed, with coverage on adverse and/or toxic effects on the immune system, as well as desired modulatory effects to improve efficacy of applied therapeutics. Readers will also learn about the best evaluation methods for immunomodulatory effects of nanomaterials and associated risks. This book is a useful reference for academics and researchers with an interest in immunology, but it is also idea for those working in the fields of materials science, biomedical engineering, pharmaceutical science, immunology and toxicology. Details a range of common nanomaterials and how their specific properties and characteristics interact with the immune system Discusses the immunomodulatory effects of nanomaterials, from unintentional and potentially harmful, to intentional and desired effects on the immune system Explores methods for evaluation of immunomodulatory effects of nanomaterials, as well as precautions and risks for data analysis and interpretation
Book Synopsis Biomaterials in Regenerative Medicine and the Immune System by : Laura Santambrogio
Download or read book Biomaterials in Regenerative Medicine and the Immune System written by Laura Santambrogio and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses. Dr. Santambrogio is Professor of Pathology, Microbiology and Immunology and Orthopedic Surgery at the Albert Einstein College of Medicine. She received her M.D. from the University of Perugia and her Ph.D. from the University of Padua in Italy. She received her postdoctoral training at NYU and Harvard Medical School. One of the focuses of the research in her laboratory is the understanding of the immune responses to implanted biomaterials. .
Book Synopsis Biomaterials and Immune Response by : Nihal Engin Vrana
Download or read book Biomaterials and Immune Response written by Nihal Engin Vrana and published by CRC Press. This book was released on 2018-07-20 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area
Book Synopsis Handbook of Biomaterials Biocompatibility by : Masoud Mozafari
Download or read book Handbook of Biomaterials Biocompatibility written by Masoud Mozafari and published by Woodhead Publishing. This book was released on 2020-06-17 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology. Reviews the fundamental theories and challenges of biomaterials biocompatibility, including an overview of the standards and regulations Provides an overview on the cellular and molecular mechanisms involved in host responses to biomaterials Systematically looks at cellular response and tissue response to a wide range of biomaterials, including polymers, metals, ceramics, alloys and nanomaterials
Book Synopsis Biomaterials Associated Infection by : Fintan Moriarty
Download or read book Biomaterials Associated Infection written by Fintan Moriarty and published by Springer Science & Business Media. This book was released on 2012-09-29 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.
Book Synopsis Regenerative Medicine Applications in Organ Transplantation by : Giuseppe Orlando
Download or read book Regenerative Medicine Applications in Organ Transplantation written by Giuseppe Orlando and published by Academic Press. This book was released on 2013-10-11 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions
Book Synopsis Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy by : Anubhab Mukherjee
Download or read book Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy written by Anubhab Mukherjee and published by Springer Nature. This book was released on 2022-05-31 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.
Book Synopsis Targeted Cancer Therapy in Biomedical Engineering by : Rishabha Malviya
Download or read book Targeted Cancer Therapy in Biomedical Engineering written by Rishabha Malviya and published by Springer Nature. This book was released on 2023-04-11 with total page 949 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs. Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes. This book discusses the advancements and innovations in the field of BME that improve the diagnosis and treatment of cancer. This book is focused on bioengineering approaches to improve targeted delivery for cancer therapeutics, which include particles, targeting moieties, and stimuli-responsive drug release mechanisms. This book is a useful resource for students, researchers, and professionals in BME and medicine.
Book Synopsis In Situ Tissue Regeneration by : Sang Jin Lee
Download or read book In Situ Tissue Regeneration written by Sang Jin Lee and published by Academic Press. This book was released on 2016-07-17 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry
Book Synopsis Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and In Vitro Models for Biomaterial Testing by : Nihal Engin Vrana
Download or read book Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and In Vitro Models for Biomaterial Testing written by Nihal Engin Vrana and published by Frontiers Media SA. This book was released on 2019-05-15 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adverse immune reactions to biomaterials are important bottlenecks for translation of novel biomaterials for clinical use. Moreover, recent advances in highthrough-put biomaterial discovery and synthetic biology, while providing exciting new veues, also significantly increases potential risks related to the in vivo reactions to these new materials. For example, the novel materials might have unintended biological activities due to their natural building blocks. In this perspective, biomaterial field needs i) better understanding of cell/biomaterial interactions at systems level; ii) development of new analysis and testing tools for advanced risk assessment iii) tools and technologies for modulating reactions to biomaterials and iv) advanced in vitro models for understanding and testing of reactions to biomaterials. In the following collection of articles you will find examples of such systems,together with comprehensive reviews of current developments in in vitro model systems. The collection also contains articles that elucidate the immune reaction to biomaterials in vitro and in vitro.
