Regenerative Medicine Applications In Organ Transplantation

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Regenerative Medicine Applications in Organ Transplantation

Author : Giuseppe Orlando
Publisher : Academic Press
ISBN 13 : 012398520X
Total Pages : 1050 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Regenerative Medicine Applications in Organ Transplantation by : Giuseppe Orlando

Download or read book Regenerative Medicine Applications in Organ Transplantation written by Giuseppe Orlando and published by Academic Press. This book was released on 2013-10-11 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

Kidney Transplantation, Bioengineering, and Regeneration

Author : Giuseppe Orlando
Publisher : Academic Press
ISBN 13 : 0128018364
Total Pages : 1252 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Kidney Transplantation, Bioengineering, and Regeneration by : Giuseppe Orlando

Download or read book Kidney Transplantation, Bioengineering, and Regeneration written by Giuseppe Orlando and published by Academic Press. This book was released on 2017-06-08 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

Reconstructive Transplantation and Regenerative Medicine

Author : Vijay Gorantla
Publisher : CRC Press
ISBN 13 : 0429522320
Total Pages : 222 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Reconstructive Transplantation and Regenerative Medicine by : Vijay Gorantla

Download or read book Reconstructive Transplantation and Regenerative Medicine written by Vijay Gorantla and published by CRC Press. This book was released on 2021-11-12 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes rapid progress and innovation in transplantation and regenerative medicine - the merger of reconstructive plastic surgery and transplantation - called Vascularized Composite Allotransplantation. This merger includes face, hand, uteri, larynx, tongue, penis and trachea translplantations as well as other body part transplants using grafts derived from organ donors. These sorts of transplants are now performed more commonly. Cell therapies for immunomodulation are surrogates for immune responses after transplantation to non-invasive imaging of neuroregeneration for improving functional outcomes after transplant.

Stem Cells and Biomaterials for Regenerative Medicine

Author : Marek J. Los
Publisher : Academic Press
ISBN 13 : 0128122781
Total Pages : 249 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Stem Cells and Biomaterials for Regenerative Medicine by : Marek J. Los

Download or read book Stem Cells and Biomaterials for Regenerative Medicine written by Marek J. Los and published by Academic Press. This book was released on 2018-11-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine. Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials

Stem Cells and the Future of Regenerative Medicine

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309170427
Total Pages : 112 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Stem Cells and the Future of Regenerative Medicine by : Institute of Medicine

Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Organ Repair and Regeneration

Author : Giuseppe Orlando
Publisher : Academic Press
ISBN 13 : 0128194529
Total Pages : 306 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Organ Repair and Regeneration by : Giuseppe Orlando

Download or read book Organ Repair and Regeneration written by Giuseppe Orlando and published by Academic Press. This book was released on 2021-01-14 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intestines, and beyond. Chapters cover the pathophysiology of ischemia-reperfusion, repairing organs with MSC, repairing cardiac allografts in situ, and much more. The book conceptualizes the idea that the modern approach to organ preservation is ante literam, a form of organ repair and regeneration which, per se, is referred to as a field of health sciences under the umbrella of regenerative medicine. This book demonstrates the merging of regenerative medicine and organ transplantation. Covers all aspects of organ preservation, repair and regeneration Addresses the repair of organs that experience an Ischemia/Reperfusion (I/R) injury, those that are intended for transplantation, and specific issues related to each organ Presented by editors and authors who are physicians, surgeons and researchers in the field of organ transplantation and regenerative medicine

Stem Cell Transplantation

Author : Carlos López-Larrea
Publisher : Springer Science & Business Media
ISBN 13 : 1461420989
Total Pages : 342 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Stem Cell Transplantation by : Carlos López-Larrea

Download or read book Stem Cell Transplantation written by Carlos López-Larrea and published by Springer Science & Business Media. This book was released on 2012-03-28 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation has been the most important therapeutic advance in the last third of the 20th century. Its development has revolutionized medicine, as demonstrated by the fact that a large number of researchers in this field have been awarded Nobel Prizes. In the beginning of this century, we are witnessing with great expectations the emergence of a new field of medicine related to the arrival of a new player on the scene: “stem cells” and their potential use in regenerative medicine. This volume aims to cover important aspects of the various facets of organ transplantation and regenerative medicine, with leading specialists in these fields setting out their vision. We try to rigorously explain current and novel scientific research in these fields—areas which arouse great interest from society in general, due to their potential use in modern medicine for the treatment of a great number of diseases.

Principles of Regenerative Medicine

Author : Anthony Atala
Publisher : Academic Press
ISBN 13 : 9780123814234
Total Pages : 1202 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis Principles of Regenerative Medicine by : Anthony Atala

Download or read book Principles of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2010-12-16 with total page 1202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Foundations of Regenerative Medicine

Author : Anthony Atala
Publisher : Academic Press
ISBN 13 : 9780123785626
Total Pages : 824 pages
Book Rating : 4.7/5 (856 download)

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Book Synopsis Foundations of Regenerative Medicine by : Anthony Atala

Download or read book Foundations of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2009-09-04 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and developmental biology, biomaterials science, nanotechnology, physics, chemistry, physiology, molecular biology, biochemistry, bioengineering, and surgery, regenerative medicine is one of the most influential topics of biological research today. Derived from the successful Principles of Regenerative Medicine, this volume brings together the latest information on the advances in technology and medicine and the replacement of tissues and organs damaged by disease. Chapters focus on the fundamental principles of regenerative therapies that have crossover with a broad range of disciplines. From the molecular basis to therapeutic applications, this volume is an essential source for students, researchers, and technicians in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, bioengineering, and medicine to gain a comprehensive understanding of the nature and prospects for this important field. Highlights the fundamentals of regenerative medicine to relate to a variety of related science and technology fields Introductory chapter directly addresses why regenerative medicine is important to a variety of researchers by providing practical examples and references to primary literature Includes new discoveries from leading researchers on restoration of diseased tissues and organs

Technological Advances in Organ Transplantation

Author : Satish N. Nadig
Publisher : Springer
ISBN 13 : 3319621424
Total Pages : 313 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Technological Advances in Organ Transplantation by : Satish N. Nadig

Download or read book Technological Advances in Organ Transplantation written by Satish N. Nadig and published by Springer. This book was released on 2018-05-23 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an expert view into the current technologies that are revolutionizing the field of solid organ transplantation. This unique book provides insight into progress made in areas spanning robotic surgery to tissue engineering and also gives a glimpse into what may lie ahead for this innovative specialty. Topics covered include nanotherapy, machine perfusion, artificial organ development, robotics in transplant surgery, mobile health technology, stem cell therapy, and ex vivo repair of organs. This is an ideal book for biomedical engineers, physicians and surgeons, general and transplant surgeons, medical students, medical and surgical trainees, and transplant procurement technicians.

Regenerative Pharmacology

Author : George J. Christ
Publisher : Cambridge University Press
ISBN 13 : 1107354730
Total Pages : 361 pages
Book Rating : 4.1/5 (73 download)

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Book Synopsis Regenerative Pharmacology by : George J. Christ

Download or read book Regenerative Pharmacology written by George J. Christ and published by Cambridge University Press. This book was released on 2013-04-15 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.

Translating Regenerative Medicine to the Clinic

Author : Jeffrey Laurence
Publisher : Academic Press
ISBN 13 : 0128005521
Total Pages : 356 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Translating Regenerative Medicine to the Clinic by : Jeffrey Laurence

Download or read book Translating Regenerative Medicine to the Clinic written by Jeffrey Laurence and published by Academic Press. This book was released on 2015-11-18 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin. Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic. Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

Regenerative Medicine

Author : Fouad Sabry
Publisher : One Billion Knowledgeable
ISBN 13 :
Total Pages : 390 pages
Book Rating : 4.:/5 (661 download)

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Book Synopsis Regenerative Medicine by : Fouad Sabry

Download or read book Regenerative Medicine written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Regenerative Medicine The "process of replacing, altering, or regenerating human or animal cells, tissues, or organs to restore or establish normal function" is what regenerative medicine is all about. This area offers the possibility of engineering damaged tissues and organs by activating the body's own repair systems to achieve effective healing in tissues or organs that were previously irreparable. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Regenerative medicine Chapter 2: Stem cell Chapter 3: Artificial organ Chapter 4: Hematopoietic stem cell transplantation Chapter 5: Embryonic stem cell Chapter 6: Cell therapy Chapter 7: Cord blood Chapter 8: Adult stem cell Chapter 9: Stem-cell line Chapter 10: Stem cell controversy Chapter 11: Stem-cell therapy Chapter 12: Amniotic epithelial cell Chapter 13: Explant culture Chapter 14: Nova Southeastern University College of Dental Medicine Chapter 15: Neural tissue engineering Chapter 16: Dental pulp stem cell Chapter 17: Clinical uses of mesenchymal stem cells Chapter 18: Regenerative endodontics Chapter 19: Regeneration in humans Chapter 20: Spinal cord injury research Chapter 21: Shimon Slavin (II) Answering the public top questions about regenerative medicine. (III) Real world examples for the usage of regenerative medicine in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of regenerative medicine' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of regenerative medicine.

Organ Manufacturing

Author : Xiaohong Wang
Publisher : Nova Science Publishers
ISBN 13 : 9781634829571
Total Pages : 0 pages
Book Rating : 4.8/5 (295 download)

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Book Synopsis Organ Manufacturing by : Xiaohong Wang

Download or read book Organ Manufacturing written by Xiaohong Wang and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first time that human organs, such as the heart, liver, kidney, stomach, uterus, skin, lung, pancreas and breast can be manufactured automatically and precisely for clinical transplantation, drug screening and metabolism model establishment. Headed by Professor Xiaohong Wang (also the founder and director) in the Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, this group has focused on organ manufacturing for over ten years. A series of technical bottleneck problems, such as vascular and nerve system establishment in a construct, multiple cell types and material system incorporation, and stem cell sequential engagement, have been overcome one by one. Two technical approaches have been exploited extensively. One is multiple nozzle rapid prototyping (RP), additive manufacturing (AM), or three-dimension (3D) printing. The other is combined mold systems. More than 110 articles and 40 patents with a series of theories and practices have been published consequently. In the future, all the failed organs (including the brain) in the human body can be substituted easily like a small accessory part in a car. Everyone can get benefit from these techniques, which ultimately means that the lifespan of humans, therefore, can be greatly prolonged from this time point. This book examines the progress made in the field and the developments made by these researchers (and authors) in the field.

Tissue Engineering for Tissue and Organ Regeneration

Author : Daniel Eberli
Publisher : BoD – Books on Demand
ISBN 13 : 9533076887
Total Pages : 470 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Tissue Engineering for Tissue and Organ Regeneration by : Daniel Eberli

Download or read book Tissue Engineering for Tissue and Organ Regeneration written by Daniel Eberli and published by BoD – Books on Demand. This book was released on 2011-08-17 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue Engineering may offer new treatment alternatives for organ replacement or repair deteriorated organs. Among the clinical applications of Tissue Engineering are the production of artificial skin for burn patients, tissue engineered trachea, cartilage for knee-replacement procedures, urinary bladder replacement, urethra substitutes and cellular therapies for the treatment of urinary incontinence. The Tissue Engineering approach has major advantages over traditional organ transplantation and circumvents the problem of organ shortage. Tissues reconstructed from readily available biopsy material induce only minimal or no immunogenicity when reimplanted in the patient. This book is aimed at anyone interested in the application of Tissue Engineering in different organ systems. It offers insights into a wide variety of strategies applying the principles of Tissue Engineering to tissue and organ regeneration.

Biomaterials, Artificial Organs and Tissue Engineering

Author : L Hench
Publisher : Elsevier
ISBN 13 : 1845690869
Total Pages : 298 pages
Book Rating : 4.8/5 (456 download)

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Book Synopsis Biomaterials, Artificial Organs and Tissue Engineering by : L Hench

Download or read book Biomaterials, Artificial Organs and Tissue Engineering written by L Hench and published by Elsevier. This book was released on 2005-09-27 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining quality of life in an ageing population is one of the great challenges of the 21st Century. This book summarises how this challenge is being met by multi-disciplinary developments of specialty biomaterials, devices, artificial organs and in-vitro growth of human cells as tissue engineered constructs. Biomaterials, Artificial Organs and Tissue Engineering is intended for use as a textbook in a one semester course for upper level BS, MS and Meng students. The 25 chapters are organized in five parts: Part one provides an introduction to living and man-made materials for the non-specialist; Part two is an overview of clinical applications of various biomaterials and devices; Part three summarises the bioengineering principles, materials and designs used in artificial organs; Part four presents the concepts, cell techniques, scaffold materials and applications of tissue engineering; Part five provides an overview of the complex socio-economic factors involved in technology based healthcare, including regulatory controls, technology transfer processes and ethical issues. Comprehensive introduction to living and man-made materials Looks at clinical applications of various biomaterials and devices Bioengineering principles, materials and designs used in artificial organs are summarised

Biomaterials and Tissue Engineering in Urology

Author : J Denstedt
Publisher : Elsevier
ISBN 13 : 1845696379
Total Pages : 592 pages
Book Rating : 4.8/5 (456 download)

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Book Synopsis Biomaterials and Tissue Engineering in Urology by : J Denstedt

Download or read book Biomaterials and Tissue Engineering in Urology written by J Denstedt and published by Elsevier. This book was released on 2009-04-29 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Urology is the branch of medicine dealing with disorders or diseases of the male genitor-urinary tract and the female urinary tract. This important book summarises the wealth of recent research on the use of biomaterials and tissue engineering to treat urological disorders. Part one reviews the fundamentals with chapters on such topics as biofilms and encrustation formation. Part two then discusses recent advances in biomaterials and design of urological devices such as metal ureteral stents, self-lubricating catheter materials and penile implants. Chapters in Part three address urological tissue engineering with coverage of themes such as artificial and natural biomaterials, nano-technology and placental stem cells for tissue engineering the regeneration of urological tissue and organs. With its eminent editors and international team of contributors, Biomaterials and tissue engineering in urology is an invaluable resource to researchers of urological biomaterials, devices and regenerative medicine in both industry and academia, as well as an important reference for medical practitioners. Provides a comprehensive review of biomaterials and tissue engineering in urology Explores the fundamentals of urology, focusing on biofilms and encrustation and formation Discusses recent advances in biomaterials and the design of urological devices, catheters and stents