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Expression Profiling Of Human Tumors
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Book Synopsis Expression Profiling of Human Tumors by : Marc Ladanyi
Download or read book Expression Profiling of Human Tumors written by Marc Ladanyi and published by Springer Science & Business Media. This book was released on 2003-05-01 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.
Book Synopsis Gene Expression Profiling in Cancer by : Dimitrios Vlachakis
Download or read book Gene Expression Profiling in Cancer written by Dimitrios Vlachakis and published by BoD – Books on Demand. This book was released on 2019-06-19 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer.
Book Synopsis Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes by : Luigi Marchionni
Download or read book Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes written by Luigi Marchionni and published by DIANE Publishing. This book was released on 2009-05 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assesses the evidence that three marketed gene expression-based assays improve prognostic accuracy, treatment choice, and health outcomes in women diagnosed with early stage breast cancer. Three gene expression assays were evaluated; Oncotype DX¿, MammaPrint® and the Breast Cancer Profiling (BCP or H/I ratio) test, and for gene expression signatures underlying the assays. They sought evidence on: analytic performance of tests; clinical validity; clinical utility; harms; and impact on clinical decision making and health care costs. Conclusions: Oncotype DX is furthest along the validation pathway, with retrospective evidence that it predicts distant spread and chemotherapy benefit to a clinically relevant extent over standard predictors. Illus.
Book Synopsis Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes by : Luigi Marchionni (M.D.)
Download or read book Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes written by Luigi Marchionni (M.D.) and published by . This book was released on 2008-01-01 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Diagnostic, Prognostic and Therapeutic Value of Gene Signatures by : Antonio Russo
Download or read book Diagnostic, Prognostic and Therapeutic Value of Gene Signatures written by Antonio Russo and published by Springer Science & Business Media. This book was released on 2011-11-03 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.
Book Synopsis MicroRNA Profiling in Cancer by : Yuriy Gusev
Download or read book MicroRNA Profiling in Cancer written by Yuriy Gusev and published by CRC Press. This book was released on 2019-09-06 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.
Book Synopsis Microarray Technology and Cancer Gene Profiling by : Simone Mocellin
Download or read book Microarray Technology and Cancer Gene Profiling written by Simone Mocellin and published by Springer Science & Business Media. This book was released on 2007-08-28 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.
Book Synopsis A Comparison of Gene Expression Profiling Tests for Breast Cancer by : Pam Smartt
Download or read book A Comparison of Gene Expression Profiling Tests for Breast Cancer written by Pam Smartt and published by . This book was released on 2010 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Genomics written by Ulrich Pfeffer and published by Springer Science & Business Media. This book was released on 2013-02-12 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident.
Book Synopsis Cancer Informatics in the Post Genomic Era by : Igor Jurisica
Download or read book Cancer Informatics in the Post Genomic Era written by Igor Jurisica and published by Springer Science & Business Media. This book was released on 2007-05-04 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science. This, of course, requires analytic tools. Those tools are garnered by developing and assessing methods and systems for the acquisition, processing, and interpretation of patient data, aided by scientific discovery. Key challenges in this field include integrating research and clinical care, sharing data, and establishing partnerships within and across sectors of patient diagnosis and treatment.
Book Synopsis Advances in Cancer Research by : George F. Vande Woude
Download or read book Advances in Cancer Research written by George F. Vande Woude and published by Elsevier. This book was released on 2003-11-07 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics. Provides invaluable information on the exciting and fast-moving field of cancer research. Presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics
Book Synopsis Comparing Gene Expression Profiles of Cell Culture Models with Profiles of Tumor Xenografts and Patient Tumors by : Chad Jeremy Creighton
Download or read book Comparing Gene Expression Profiles of Cell Culture Models with Profiles of Tumor Xenografts and Patient Tumors written by Chad Jeremy Creighton and published by . This book was released on 2006 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gene Profiles in Drug Design by : Brett A. Lidbury
Download or read book Gene Profiles in Drug Design written by Brett A. Lidbury and published by CRC Press. This book was released on 2008-07-10 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the successful mapping of the human genome, we have entered an age of unprecedented opportunity in which researchers are beginning to apply this vast repository of knowledge to the treatment of human disease. Gene-profiling technologies and the concept of individualized medicine are leading to the development of drugs with enhanced specificity. This promises to lead to more effective treatment of diseases with reduced risk of side effects. Gene Profiling in Drug Design provides insights from leaders in the pure sciences, biotechnology, and other arenas. It emphasizes the science that underpins gene profiling and drug development, and also includes clinical and ethical perspectives from experts in those fields. These explore the broadest health and social implications for this exciting field of science and discovery. The book begins with a discussion of the future clinical impact of genetic diagnosis and gene-based drug therapies. Virally encoded MicroRNA is reviewed, as well as the development of gene-profile-responsive antisense agents. Gene profiles are studied with respect to drug development and cancer research. RNA viruses and RNA-based drugs are also examined. Finally, ethical considerations of this groundbreaking technology are explored. The information presented in this volume provides readers with a greater understanding of the processes and technologies in gene-profile based drug design. Technologies are discussed in sufficient detail so that drug developers can use the book as a general desk reference. It also provides physicians with an important survey of emerging technologies. This book is edited by Brett A. Lidbury and Suresh Mahalingam, noted scientists from the Centre for Biomolecular and Chemical Sciences at the University of Canberra in Australia. They bring together the wisdom of numerous experts to discuss the powerful ways that these new genetic technologies can save lives and improve health.
Book Synopsis Cancer Gene Profiling by : Robert Grützmann
Download or read book Cancer Gene Profiling written by Robert Grützmann and published by Humana Press. This book was released on 2009-11-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few years, the methods for analyzing cancer-related genes on a molecular level have changed rapidly. The advent of incredible new technology, such as automated sequencing, has served as a catalyst for many advances in the area of gene profiling, and has enabled the research community to investigate populations of cells in a given tissue. Cancer Gene Profiling: Methods and Protocols examines the world of cancer gene profiling in light of these new advances, providing highly developed microarray techniques alongside modern methods for arraying tissues and proteomics. Chapters bring together the experiences of leading scientists in each method of profiling, providing a clear overview of the ground-breaking techniques used to perform these experiments effectively. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and state-of-the-art, Cancer Gene Profiling: Methods and Protocols is a fundamental guidebook for researchers in the field of cancer gene profiling, as well as for those individuals in the area of biomedical/translational research.
Book Synopsis Meta-Analysis of Gene Expression Profiles in Breast Cancer: Toward a Unified Understanding of Breast Cancer Subtyping and Prognosis Signatures by : breast breast cancer
Download or read book Meta-Analysis of Gene Expression Profiles in Breast Cancer: Toward a Unified Understanding of Breast Cancer Subtyping and Prognosis Signatures written by breast breast cancer and published by . This book was released on 2016-01-15 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer subtyping and prognosis have been studied extensively by gene expression profiling, resulting in disparate signatures with little overlap in their constituent genes. Although a previous study demonstrated a prognostic concordance among gene expression signatures, it was limited to only one dataset and did not fully elucidate how the different genes were related to one another nor did it examine the contribution of well-known biological processes of breast cancer tumorigenesis to their prognostic performance.
Book Synopsis Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes by :
Download or read book Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gene Expression Profiling by Microarrays by : Wolf-Karsten Hofmann
Download or read book Gene Expression Profiling by Microarrays written by Wolf-Karsten Hofmann and published by . This book was released on 2006 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously. This survey spans recent applications of microarrays in clinical medicine, covering malignant disease including acute leukaemias, lymphoid malignancies and breast cancer, together with diabetes and heart disease.
