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Author : Thomas Peters
Publisher : Springer Science & Business Media
ISBN 13 : 3540490779
Total Pages : 317 pages
Book Rating : 4.5/5 (44 download)
Download or read book Bioactive Conformation I written by Thomas Peters and published by Springer Science & Business Media. This book was released on 2007-01-05 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Author : Arun K. Ghosh
Publisher : John Wiley & Sons
ISBN 13 : 3527333657
Total Pages : 474 pages
Book Rating : 4.5/5 (273 download)
Download or read book Structure-based Design of Drugs and Other Bioactive Molecules written by Arun K. Ghosh and published by John Wiley & Sons. This book was released on 2014-08-11 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Author : Shaoping Nie
Publisher : Academic Press
ISBN 13 : 0128114517
Total Pages : 568 pages
Book Rating : 4.1/5 (281 download)
Download or read book Bioactive Polysaccharides written by Shaoping Nie and published by Academic Press. This book was released on 2017-10-19 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Polysaccharides offers a comprehensive review of the structures and bioactivities of bioactive polysaccharides isolated from traditional herbs, fungi, and seaweeds. It describes and discusses specific topics based on the authors' rich experience, including extraction technologies, practical techniques required for purification and fractionation, strategies and skills for elucidating the fine structures, in-vitro and in-vivo protocols, and methodologies for evaluating the specific bioactivities, including immune-modulating activities, anti-cancer activities, anti-oxidant activities, and others. This unique book also discusses partial structure-functionality (bioactivities) relationships based on conformational studies. This comprehensive work can be used as a handbook to explore potential applications in foods, pharmaceuticals, and nutraceutical areas for commercial interests. - Serves as a comprehensive review on extraction technologies, and as a practical guide for the purification and fractionation of bioactive polysaccharides - Brings step-by-step strategies for elucidating the fine structures and molecular characterizations of bioactive polysaccharides - Includes detailed experimental design and methodologies for investigation bioactivities using both in-vitro and in-vivo protocols - Clarifies how to extract, purify, and fractionate bioactive polysaccharides, also exploring health benefits - Useful as a guide to explore the commercial potentials of bioactive polysaccharides as pharmaceuticals, medicine, and functional foods
Author : Thomas Peters
Publisher : Springer
ISBN 13 : 3540490809
Total Pages : 244 pages
Book Rating : 4.5/5 (44 download)
Download or read book Bioactive Conformation II written by Thomas Peters and published by Springer. This book was released on 2009-11-04 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The volume is still valid and useful after five or ten years. More information, as well as the electronic version of the whole content, is available at: springerlink.com.
Author : Eric Marsault
Publisher : John Wiley & Sons
ISBN 13 : 1119092566
Total Pages : 617 pages
Book Rating : 4.1/5 (19 download)
Download or read book Practical Medicinal Chemistry with Macrocycles written by Eric Marsault and published by John Wiley & Sons. This book was released on 2017-09-12 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Author : Javier Luque
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733538
Total Pages : 443 pages
Book Rating : 4.8/5 (497 download)
Download or read book Physico-chemical and Computational Approaches to Drug Discovery written by Javier Luque and published by Royal Society of Chemistry. This book was released on 2012 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title covers a wide range of topics relevant to the development of drugs. It provides a comprehensive description of the major methodological strategies available for rational drug discovery.
Author :
Publisher :
ISBN 13 :
Total Pages : 40 pages
Book Rating : 4.3/5 (91 download)
Download or read book STD Interchange written by and published by . This book was released on 1984 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Camille Georges Wermuth
Publisher : Elsevier
ISBN 13 : 0080497772
Total Pages : 792 pages
Book Rating : 4.0/5 (84 download)
Download or read book The Practice of Medicinal Chemistry written by Camille Georges Wermuth and published by Elsevier. This book was released on 2003-06-11 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. - The only book available dealing with the practical aspects of medicinal chemistry - Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production - Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry
Author : Sasadhar Majhi
Publisher : Elsevier
ISBN 13 : 0443152705
Total Pages : 484 pages
Book Rating : 4.4/5 (431 download)
Download or read book Semisynthesis of Bioactive Compounds and their Biological Activities written by Sasadhar Majhi and published by Elsevier. This book was released on 2023-11-25 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented. Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development. - Focuses on the current resistance mechanisms of antibiotics, chemical derivatization of antibiotics, and clinical applications of semisynthetic derivatives. - Includes discussion of the semisynthesis of natural products using green tools, green solvents, and eco-friendly catalysts. - Illustrates the concept of toxicity, the merits of transition-metal-free reactions, and the semisynthesis of natural products by introducing the oxygen atom(s) under transition-metal-free conditions.
Author : Valentin Wittmann
Publisher : Springer
ISBN 13 : 3540367616
Total Pages : 271 pages
Book Rating : 4.5/5 (43 download)
Download or read book Glycopeptides and Glycoproteins written by Valentin Wittmann and published by Springer. This book was released on 2007-01-30 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Author : G.D. Fasman
Publisher : Springer Science & Business Media
ISBN 13 : 1475725086
Total Pages : 739 pages
Book Rating : 4.4/5 (757 download)
Download or read book Circular Dichroism and the Conformational Analysis of Biomolecules written by G.D. Fasman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''Excellent and very timely....It will undoubtedly become a standard reference for the application of circular dichroism (CD) to biomolecules.'' --- Quarterly Review of Biology, March 1997 ''[T]estament to the book's utility is the fact that during the course of my review I had to 'rescue' it from the desks of graduate students on an almost daily basis. In summary, this is a great book.'' --- American Scientist ''Well documented chapters provide a very good insight into the problems surrounding the conformation of biomacromolecules...An indispensible source of information.'' --- Nahrung, 42(2), 1998 Renowned experts present the first state-of-the-art description of circular dichroism spectroscopy (CD). Chapters present in-depth discussions of the history of the field, the theory of CD for application to globular proteins, membrane proteins, peptides, nucleic acids and their interactions, carbohydrates, and instrumentation. Discussions also feature new techniques using synchrotron radiation, vibrational Raman optical activity, and vibrational CD. More than 250 illustrations supplement the text.
Author : Hugo Kubinyi
Publisher : Springer Science & Business Media
ISBN 13 : 9789072199140
Total Pages : 796 pages
Book Rating : 4.1/5 (991 download)
Download or read book 3D QSAR in Drug Design written by Hugo Kubinyi and published by Springer Science & Business Media. This book was released on 1993-12-31 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in medicinal chemistry and in drug design depends on our ability to understand the interactions of drugs with their biological targets. Classical QSAR studies describe biological activity in terms of physicochemical properties of substituents in certain positions of the drug molecules. The purpose of this book is twofold: On the one hand, both the novice and the experienced user will be introduced to the theory and application of 3D QSAR analyses, and on the other, a comprehensive overview of the scope and limitations of these methods is given. The detailed discussion of the present state of the art should enable scientists to further develop and improve these powerful new tools. The greater part of the book is dedicated to the theoretical background of 3D QSAR and to a discussion of CoMFA applications. In addition, various other 3D QSAR approaches and some CoMFA-related methods are described in detail. Thus, the book should be valuable for medicinal, agricultural and theoretical chemists, biochemists and biologists, as well as for other scientists interested in drug design. Its content, starting at a very elementary level and proceeding to the latest methodological results, the strengths and limitations of 3D QSAR approaches, makes the book also appropriate as a text for teaching and for graduate student courses.
Author : G A Webb
Publisher : Royal Society of Chemistry
ISBN 13 : 1847551025
Total Pages : 515 pages
Book Rating : 4.8/5 (475 download)
Download or read book Nuclear Magnetic Resonance written by G A Webb and published by Royal Society of Chemistry. This book was released on 2009-10-16 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: ""NMR of Proteins and Nucleic Acids"" and ""NMR of Carbohydrates, Lipids and Membranes"". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications.
Author : Kwen-Jen Chang
Publisher : CRC Press
ISBN 13 : 0824758587
Total Pages : 522 pages
Book Rating : 4.8/5 (247 download)
Download or read book The Delta Receptor written by Kwen-Jen Chang and published by CRC Press. This book was released on 2003-12-11 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Delta Receptor spans current research in delta receptor biology, pharmacology, physiology, and chemistry to identify, advance, and inspire the development of novel drug candidates. It demonstrates the potential significance and impact of the delta receptor in the therapy and treatment of medical conditions such as pain, gastrointestinal disorders, bladder dysfunction, and depression, as well as heart attack prevention. This reference examines the pathophysiological functions and mechanisms of receptor-selective drugs. Documenting key advances in the field, The Delta Receptor represents the most comprehensive and up-to-date studies on receptor applications currently available.
Author :
Publisher :
ISBN 13 :
Total Pages : 390 pages
Book Rating : 4.3/5 (91 download)
Download or read book NIDA Research Monograph written by and published by . This book was released on 1976 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rao S. Rapaka
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (327 download)
Download or read book Opioid Peptides written by Rao S. Rapaka and published by . This book was released on 1986 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ernst Schaumann
Publisher : Springer
ISBN 13 : 3540680985
Total Pages : 195 pages
Book Rating : 4.5/5 (46 download)
Download or read book Sulfur-Mediated Rearrangements I written by Ernst Schaumann and published by Springer. This book was released on 2007-01-30 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:
