Biased Signaling In Physiology Pharmacology And Therapeutics

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Biased Signaling in Physiology, Pharmacology and Therapeutics

Author : Brian J Arey
Publisher : Elsevier
ISBN 13 : 0124115071
Total Pages : 316 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Biased Signaling in Physiology, Pharmacology and Therapeutics by : Brian J Arey

Download or read book Biased Signaling in Physiology, Pharmacology and Therapeutics written by Brian J Arey and published by Elsevier. This book was released on 2014-06-05 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

GPCRs

Author : Beata Jastrzebska
Publisher : Academic Press
ISBN 13 : 9780128162286
Total Pages : 0 pages
Book Rating : 4.1/5 (622 download)

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Book Synopsis GPCRs by : Beata Jastrzebska

Download or read book GPCRs written by Beata Jastrzebska and published by Academic Press. This book was released on 2019-09-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer's disease, Parkinson's disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth.

The Orexin System. Basic Science and Role in Sleep Pathology

Author : M.A. Steiner
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318068446
Total Pages : 165 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis The Orexin System. Basic Science and Role in Sleep Pathology by : M.A. Steiner

Download or read book The Orexin System. Basic Science and Role in Sleep Pathology written by M.A. Steiner and published by Karger Medical and Scientific Publishers. This book was released on 2021-05-28 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Pharmacology and Therapeutics of Constitutively Active Receptors

Author : Ya-Xiong Tao
Publisher : Elsevier
ISBN 13 : 0124172067
Total Pages : 440 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Pharmacology and Therapeutics of Constitutively Active Receptors by : Ya-Xiong Tao

Download or read book Pharmacology and Therapeutics of Constitutively Active Receptors written by Ya-Xiong Tao and published by Elsevier. This book was released on 2014-06-11 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Advances in Pharmacology provides a rich collection of reviews on timely topics. The series places emphasis on the molecular bases of drug action, both applied and experimental. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

Neurobiology and Physiology of the Endocannabinoid System

Author : Vinood B. Patel
Publisher : Elsevier
ISBN 13 : 0323908780
Total Pages : 602 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Neurobiology and Physiology of the Endocannabinoid System by : Vinood B. Patel

Download or read book Neurobiology and Physiology of the Endocannabinoid System written by Vinood B. Patel and published by Elsevier. This book was released on 2023-06-02 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology and Physiology of the Endocannabinoid System offers readers a comprehensive reference on the neurobiology of this system and the use of cannabimimetic compounds to induce neurological changes and confer symptom relief. With sections on both natural and synthetic compounds, the book's broad coverage allows readers to learn about their use with multiple conditions, as well as the working biology of the endocannabinoid system, its receptors and its ligands. This volume provides a platform for research on the effects of this system and its modulation in brain function and neurological dysfunction. Summarizes research on the working neurobiology of the endocannabinoid system Contains chapter abstracts, key facts, a dictionary and a summary Covers both natural cannabinoids and synthetic or exogenous cannabimimetics Includes conditions like headache, anxiety, stress and neuroinflammation Discusses system modulation in the context of pain, traumatic brain injury and obesity

APPNING: Animal Population Imaging

Author : Michel Dojat
Publisher : Frontiers Media SA
ISBN 13 : 2889668657
Total Pages : 111 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis APPNING: Animal Population Imaging by : Michel Dojat

Download or read book APPNING: Animal Population Imaging written by Michel Dojat and published by Frontiers Media SA. This book was released on 2021-07-14 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Calving Management and Newborn Calf Care

Author : João Simões
Publisher : Springer Nature
ISBN 13 : 3030681688
Total Pages : 297 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Calving Management and Newborn Calf Care by : João Simões

Download or read book Calving Management and Newborn Calf Care written by João Simões and published by Springer Nature. This book was released on 2021-08-28 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive textbook provides detailed information on calving management in dairy and beef cattle. Enriched with diverse learning opportunities, it conveys the fundamentals of reproductive anatomy and physiology, parturition, birth complications and various obstetrical manoeuvres, as well as dam and calf care. In order to promote best practices in this specialized subject, the book covers all significant points from conception to calving and the perinatal period. Clear chapter structures, a wealth of illustrations and videos, obstetrical case studies, and question-and-answer lists round out the reading experience, making the book a unique source of information on how to support mother cows and obtain viable offspring. In addition, readers can download the free Springer Nature Flashcards App and benefit from 77 digital study questions to test their knowledge. Calving is a significant event in terms of providing care and nutrition for mother cows and calves. The reproductive health status in cattle farms is crucial to immediately initiate lactation and new conception. Assistance by technical personnel, dystocia and stillbirth occurrences can reach ca. 50%, 14% and 6% of parturitions, respectively. Hence, zootechnical and veterinary management of calving is of great importance for animal welfare. This textbook makes a valuable contribution to teaching and everyday practice in cattle medicine and obstetrics. Veterinary students, residents, practitioners and technical personnel will discover it to be a rich learning and reference resource.

Introduction to Modern Biophysics

Author : Mohammad Ashrafuzzaman
Publisher : CRC Press
ISBN 13 : 1003821642
Total Pages : 603 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Introduction to Modern Biophysics by : Mohammad Ashrafuzzaman

Download or read book Introduction to Modern Biophysics written by Mohammad Ashrafuzzaman and published by CRC Press. This book was released on 2023-12-15 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an introduction to the fundamental and applied aspects of biophysics for advanced undergraduate and graduate students of physics, chemistry, and biology. The application of physics principles and techniques in exploring biological systems has long been a tradition in scientific research. Biological systems hold naturally inbuilt physical principles and processes which are popularly explored. Systematic discoveries help us understand the structures and functions of individual biomolecules, biomolecular systems, cells, organelles, tissues, and even the physiological systems of animals and plants. Utilizing a physics- based scientific understanding of biological systems to explore disease is at the forefront of applied scientific research. This textbook covers key breakthroughs in biophysics whilst looking ahead to future horizons and directions of research. It contains models based on both classical and quantum mechanical treatments of biological systems. It explores diseases related to physical alterations in biomolecular structures and organizations alongside drug discovery strategies. It also discusses the cutting- edge applications of nanotechnologies in manipulating nanoprocesses in biological systems. Key Features: • Presents an accessible introduction to how physics principles and techniques can be used to understand biological and biochemical systems. • Addresses natural processes, mutations, and their purposeful manipulation. • Lays the groundwork for vitally important natural scientific, technological, and medical advances. Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing physics principles and techniques. He is a professor of biophysics at King Saud University’s Biochemistry Department in the College of Science, Riyadh, Saudi Arabia; the co- founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada. He has authored Biophysics and Nanotechnology of Ion Channels, Nanoscale Biophysics of the Cell, and Membrane Biophysics. He has also published about 50 peer- reviewed articles and several patents, edited two books, and has been serving on the editorial boards of Elsevier and Bentham Science journals. Dr. Ashrafuzzaman has held research and academic ranks at Bangladesh University of Engineering & Technology, University of Neuchatel (Switzerland), Helsinki University of Technology (Finland), Weill Medical College of Cornell University (USA), and University of Alberta (Canada). During 2013– 2018 he also served as a Visiting Professor at the Departments of Oncology, and Medical Microbiology and Immunology, of the University of Alberta. Dr. Ashrafuzzaman earned his highest academic degree, Doctor of Science (D.Sc.) in condensed matter physics from the University of Neuchatel, Switzerland in 2004.

Ion Channels as Targets in Drug Discovery

Author : Gary Stephens
Publisher : Springer Nature
ISBN 13 : 3031521978
Total Pages : 540 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Ion Channels as Targets in Drug Discovery by : Gary Stephens

Download or read book Ion Channels as Targets in Drug Discovery written by Gary Stephens and published by Springer Nature. This book was released on with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders

Author : Heba Mohamed Mansour
Publisher : Elsevier
ISBN 13 : 0443186782
Total Pages : 606 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders by : Heba Mohamed Mansour

Download or read book Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders written by Heba Mohamed Mansour and published by Elsevier. This book was released on 2023-06-06 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders. Provides a thorough overview of RTKs biology and their role in health and disease progression and modulation Highlights RTK families and the numerous receptors within each subfamily Examines RTKIs and other protein kinase inhibitors in pre-clinical and clinical trials in both neurodegenerative and psychiatric disorders Gives future directions of possible safe effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in various neurodegenerative and psychiatric disorders Includes chapter contributions from renowned experts in biology, pharmacology, neurology, psychiatry, and oncology

New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications

Author : Marc J.M. Abadie
Publisher : Springer Nature
ISBN 13 : 3030574563
Total Pages : 371 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications by : Marc J.M. Abadie

Download or read book New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications written by Marc J.M. Abadie and published by Springer Nature. This book was released on 2021-05-26 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.

Concepts and Principles of Pharmacology

Author : James E. Barrett
Publisher : Springer Nature
ISBN 13 : 3030353621
Total Pages : 466 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Concepts and Principles of Pharmacology by : James E. Barrett

Download or read book Concepts and Principles of Pharmacology written by James E. Barrett and published by Springer Nature. This book was released on 2019-12-24 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

GPCR Signaling in Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0128202300
Total Pages : 164 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis GPCR Signaling in Cancer by :

Download or read book GPCR Signaling in Cancer written by and published by Academic Press. This book was released on 2020-03-06 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more. G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics. Covers the latest concepts in GPCR signaling and their relevancy to cancer biology Presents new indications for anti-cancer therapeutic programs Includes sections on cross-talk and signaling networks of GPCRs and effectors in molecular oncology and therapeutics

Cannabinoid Pharmacology

Author :
Publisher : Academic Press
ISBN 13 : 0128112336
Total Pages : 492 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cannabinoid Pharmacology by :

Download or read book Cannabinoid Pharmacology written by and published by Academic Press. This book was released on 2017-08-18 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cannabinoid Pharmacology, Volume 80 is a new volume in the Advances in Pharmacology that presents reviews of recent breakthroughs. This volume aims to present current knowledge of the endogenous cannabinoid system, and looks at molecular, cellular, tissue and organismal effects of endogenous and exogenous cannabinoids. Topics of note in this new volume include Endocannabinoids and their congeners, Endocannabinoid turnover, Plant cannabinoids, Synthetic cannabinoids and ‘legal highs’, CB1 and CB2 cannabinoid receptors, Novel signaling modalities, Novel cannabinoid receptors, and Ion channel regulation by cannabinoids. There is a broad coverage of the essential elements associated with the cannabinoid system. The Editors have sought to include authors who represent authoritative voices on these themes, but have not previously worked together to allow a fresh approach to the individual aspects covered. Presents reviews of recent breakthroughs in the cannabinoid system Features chapters from the best authors in the field Provides an essential resource for scientists, advanced undergraduate students through to established faculty members

Protein Degradation

Author : R. John Mayer
Publisher : Wiley-VCH
ISBN 13 : 9783527308378
Total Pages : 393 pages
Book Rating : 4.3/5 (83 download)

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Book Synopsis Protein Degradation by : R. John Mayer

Download or read book Protein Degradation written by R. John Mayer and published by Wiley-VCH. This book was released on 2005-04-15 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Allosteric Modulation of G Protein-Coupled Receptors

Author : Robert Laprairie
Publisher : Academic Press
ISBN 13 : 0128197722
Total Pages : 214 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Allosteric Modulation of G Protein-Coupled Receptors by : Robert Laprairie

Download or read book Allosteric Modulation of G Protein-Coupled Receptors written by Robert Laprairie and published by Academic Press. This book was released on 2022-02-05 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not – as we once believed – unique to a few receptor subfamilies. Introduces background on core concepts of molecular pharmacology, including statistical analyses, non-linear regression, complex models and GPCR-dependent signal transduction as they relate to allosteric modulation Discusses critical advances and landmark studies, including discoveries in the area of GPCR allosteric modulation, which are reviewed for their importance in positive and negative regulation, protein-protein interactions, and small molecule drug discovery Includes key methodologies used to study allosteric modulation at the in silico, in vitro, and in vivo levels of drug discovery and characterization

Physiology of Neurons

Author : Anne Feltz
Publisher : Garland Science
ISBN 13 : 100076155X
Total Pages : 776 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Physiology of Neurons by : Anne Feltz

Download or read book Physiology of Neurons written by Anne Feltz and published by Garland Science. This book was released on 2020-04-09 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to tremendous technical advances in molecular biology and cellular imaging after those in electrophysiology, there is now a deep understanding of the physiology of nerve cells and their synaptic interconnections. The complexity of the brain emerges from the communication and interaction between billions of these elements. This book explores systematically and didactically the details of neuronal physiology, covering membrane biophysics, receptor physiology, sensory transduction and synaptic transmission with its selective pharmacology. Readers of the book will be fully equipped to understand the functions and possibilities of the key units of the brain’s parallel computations.