The Orexin System Basic Science And Role In Sleep Pathology

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The Orexin System. Basic Science and Role in Sleep Pathology

Author : M.A. Steiner
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318068446
Total Pages : 165 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis The Orexin System. Basic Science and Role in Sleep Pathology by : M.A. Steiner

Download or read book The Orexin System. Basic Science and Role in Sleep Pathology written by M.A. Steiner and published by Karger Medical and Scientific Publishers. This book was released on 2021-05-28 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

The Orexin System

Author : Michel Steiner
Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783318068436
Total Pages : 154 pages
Book Rating : 4.0/5 (684 download)

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Book Synopsis The Orexin System by : Michel Steiner

Download or read book The Orexin System written by Michel Steiner and published by S. Karger AG (Switzerland). This book was released on 2021 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer's disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Hypocretins

Author : Luis De Lecea
Publisher : Springer Science & Business Media
ISBN 13 : 0387254463
Total Pages : 438 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Hypocretins by : Luis De Lecea

Download or read book Hypocretins written by Luis De Lecea and published by Springer Science & Business Media. This book was released on 2007-04-25 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

Sleep and Mental Illness

Author : S. R. Pandi-Perumal
Publisher : Cambridge University Press
ISBN 13 : 1139483706
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Sleep and Mental Illness by : S. R. Pandi-Perumal

Download or read book Sleep and Mental Illness written by S. R. Pandi-Perumal and published by Cambridge University Press. This book was released on 2010-04-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.

Foundations of Psychiatric Sleep Medicine

Author : John W. Winkelman
Publisher : Cambridge University Press
ISBN 13 : 1139494341
Total Pages : 435 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Foundations of Psychiatric Sleep Medicine by : John W. Winkelman

Download or read book Foundations of Psychiatric Sleep Medicine written by John W. Winkelman and published by Cambridge University Press. This book was released on 2010-12-23 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.

Sleep Disorders and Sleep Deprivation

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309101115
Total Pages : 425 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Sleep Disorders and Sleep Deprivation by : Institute of Medicine

Download or read book Sleep Disorders and Sleep Deprivation written by Institute of Medicine and published by National Academies Press. This book was released on 2006-10-13 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

Neuroimaging of Sleep and Sleep Disorders

Author : Eric Nofzinger
Publisher : Cambridge University Press
ISBN 13 : 1107018633
Total Pages : 445 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Neuroimaging of Sleep and Sleep Disorders by : Eric Nofzinger

Download or read book Neuroimaging of Sleep and Sleep Disorders written by Eric Nofzinger and published by Cambridge University Press. This book was released on 2013-03-07 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date, superbly illustrated practical guide to the effective use of neuroimaging in the patient with sleep disorders. The only book to date to provide comprehensive coverage of this topic. A must for all healthcare workers interested in understanding the causes, consequences and treatment of sleep disorders.

Encyclopedia of Sleep

Author :
Publisher : Academic Press
ISBN 13 : 0123786118
Total Pages : 2626 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Encyclopedia of Sleep by :

Download or read book Encyclopedia of Sleep written by and published by Academic Press. This book was released on 2013-01-17 with total page 2626 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a world of 24-hour media saturation, sleep has become an increasingly fraught enterprise. The award-winning four-volume Encyclopedia of Sleep, Four Volume Set is the largest reference, either online or in print, on the subject of sleep. Written to be useful for the novice and the established researcher and clinician, Topic areas will include sleep across the life cycle and in other species, sleep and women, sleep and the elderly, pediatric sleep, sleep deprivation and loss, sleep mechanisms, sleep physiology and pathophysiology, sleep disorders, neurobiology, chronobiology, pharmacology, and impact of other disorders on sleep. Recognizing the many fields that are connected to sleep science, the editorial team has been carefully chosen to do justice to this highly interdisciplinary field of study. The steady growth of researchers and clinicians in the sleep field attests to the continued interest in the scientific study of sleep and the management of patients with sleep disorders, and anyone involved in this exciting field should find this work to be an invaluable reference. 2013 PROSE Award winner for Multivolume Reference in Science from the Association of American Publishers Thoroughly interdisciplinary: looks at sleep throughout the life cycle, with exceptional coverage of basic sleep concepts, the physiology of sleep as well as sleep disorders of all descriptions Excellent coverage of sleep and special populations, covering the lifespan, as well as gender and ethnic differences, among others Chapters focusing on sleep disorders are grouped under the broad categories classified in the ICSD-2 for clear organization so that the reader can effectively access the steps involved in diagnosing and treating these disorders Online version is linked both within the encyclopedia (to related content) and to external sources (such as primary journal content) so that users have easy access to more detailed information if needed

Orexin/Hypocretin System

Author : Anantha Shekhar
Publisher : Elsevier
ISBN 13 : 0444594892
Total Pages : 208 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Orexin/Hypocretin System by : Anantha Shekhar

Download or read book Orexin/Hypocretin System written by Anantha Shekhar and published by Elsevier. This book was released on 2012-09-05 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations." "Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding and body weight regulation."--Résumé de l'éditeur.

Principles and Practice of Geriatric Sleep Medicine

Author : S. R. Pandi-Perumal
Publisher : Cambridge University Press
ISBN 13 : 1139483625
Total Pages : 471 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Principles and Practice of Geriatric Sleep Medicine by : S. R. Pandi-Perumal

Download or read book Principles and Practice of Geriatric Sleep Medicine written by S. R. Pandi-Perumal and published by Cambridge University Press. This book was released on 2009-11-26 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep disorders cause considerable morbidity and distress in the aging population. By highlighting the clinical diagnosis and management of sleep disorders, this volume provides a valuable resource for all those involved in health care of older individuals. The changes in sleep patterns that occur during normal aging are described, followed by authoritative chapters on the presentation of various age-related sleep disorders. The book deals with the range of therapeutic measures available for managing these disorders and gives insight to potential areas of research that have emerged in the last few years, such as the study of circadian rhythms in later life, sleep patterns associated with co-morbidities and the use of quality-of-life measurement tools to determine sleep quality as we age. This volume is relevant to sleep disorders specialists, psychiatrists, geriatricians and gerontologists, and any professionals and researchers working in the interdisciplinary areas of sleep and aging.

Sleep Disorders

Author : Sue Wilson
Publisher : OUP Oxford
ISBN 13 : 0191662089
Total Pages : 160 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Sleep Disorders by : Sue Wilson

Download or read book Sleep Disorders written by Sue Wilson and published by OUP Oxford. This book was released on 2013-09-26 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep dysfunction is one of the primary symptoms reported by patients with psychiatric disorders, and specifically those suffering from anxiety and depressive disorders. Conversely, primary insomnia and other sleep disorders produce symptoms of mood disturbance that are quite similar to those reported by patients with psychiatric disorders. Because of this overlap in the symptoms and treatments for insomnias and psychiatric disorders, it is important for clinicians to be able to accurately identify the root cause of sleep dysfunction in individual patients in order to optimize treatment. Part of the Oxford Psychiatry Library series, Sleep Disorders provides clinicians with an overview of current understanding of sleep physiology, the pathophysiology of sleep disturbance, and the diagnosis and treatment of sleep disorders. This second edition includes new sections covering sleep problems in children, sleep in the elderly, and sleep in pregnancy and menopause, as well as new algorithms from the British Association of Psychopharmacology's (BAP's) new Consensus Guidelines on the management of sleep disorders.

Prescription Sleep Aid Use Among Adults

Author : Yinong Chong
Publisher :
ISBN 13 :
Total Pages : 10 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Prescription Sleep Aid Use Among Adults by : Yinong Chong

Download or read book Prescription Sleep Aid Use Among Adults written by Yinong Chong and published by . This book was released on 2013 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sleep Disorders in Children

Author : Soňa Nevšímalová
Publisher : Springer
ISBN 13 : 3319286404
Total Pages : 422 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Sleep Disorders in Children by : Soňa Nevšímalová

Download or read book Sleep Disorders in Children written by Soňa Nevšímalová and published by Springer. This book was released on 2016-10-03 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is both an exam guide to children ́s sleep medicine and a practical manual for diagnosis and management of sleep disorders in children. An overview of the most frequent sleep disorders encountered in newborns, infants, children and adolescents is provided. This book discusses the main sleep disorders in detail, including insomnia, respiratory disturbances, movement disorders during sleep, circadian rhythm disorders, parasomnias, and disorders associated with increased sleepiness. It also covers sleep disorders associated with neurological, psychiatric, and medical diseases. This book is divided into two parts. The first part is an introduction to childhood sleep physiology and pathology, epidemiology of sleep disorders, and diagnostic procedures. The second part describes the most frequent sleep disorders in greater depth. Sleep Disorders in Children is aimed at sleep researchers, pediatricians, child neurologists and child psychiatrists, as well as patient organizations and families with affected children.

Fundamentals of Sleep Technology

Author : Teofilo Lee-Chiong, M.D.
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451132034
Total Pages : 681 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Fundamentals of Sleep Technology by : Teofilo Lee-Chiong, M.D.

Download or read book Fundamentals of Sleep Technology written by Teofilo Lee-Chiong, M.D. and published by Lippincott Williams & Wilkins. This book was released on 2012-06-01 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Sleep Technology provides a thorough understanding of the use of polysomnography and other technologies in the evaluation and management of sleep disorders. Coverage includes in-depth reviews of the neurophysiology and cardiopulmonary aspects of sleep, along with the pathophysiology of sleep disorders. Detailed sections on polysomnography include recording procedures, identifying and scoring sleep stages and sleep-related events, and report generation. Chapters discuss therapeutic interventions including positive airway pressure, supplemental oxygen, surgical and pharmacologic treatments, and patient education. A section focuses on pediatric sleep disorders and polysomnography. Also included are chapters on establishing and managing a sleep center and accrediting a sleep program. Fundamentals of Sleep Technology is endorsed by American Association of Sleep Technologists (AAST). AAST committees oversaw the development of this book, defining the table of contents, recruiting the Editors, and providing most of the contributors.

Oxford Textbook of Sleep Disorders

Author : Sudhansu Chokroverty
Publisher : Oxford University Press
ISBN 13 : 0199682003
Total Pages : 561 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Oxford Textbook of Sleep Disorders by : Sudhansu Chokroverty

Download or read book Oxford Textbook of Sleep Disorders written by Sudhansu Chokroverty and published by Oxford University Press. This book was released on 2017 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a rapid global increase in the number of individuals making sleep medicine their career, resulting in an explosive growth in the number of sleep centres and programmes, as well as an increasing number of sleep societies and journals. Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Sleep Disorders covers the rapid advances in scientific, technical, clinical, and therapeutic aspects of sleep medicine which have captivated sleep scientists and clinicians. This text aims to introduce sleep disorders within the context of classical neurological diseases, giving an in-depth coverage of the topic in a logical and orderly way, while emphasizing the practical aspects in a succinct and lucid manner. Divided into 12 sections, this book begins by discussing the basic science (Section 1), before moving onto the laboratory evaluation (Section 2) and the clinical science (Section 3). The remainder of the book focuses on specific sleep disorders (Sections 4-12), from insomnias and parasomnias to sleep neurology and sleep and psychiatric disorders. Chapters are supplemented by tables, case reports, and illustrations intended to succinctly provide relevant information in a practical manner for diagnosis and treatment of sleep disorders, while always emphasizing clinical-behavioural-laboratory correlations.

Case Studies in Sleep Neurology

Author : Antonio Culebras
Publisher : Cambridge University Press
ISBN 13 : 1139489887
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Case Studies in Sleep Neurology by : Antonio Culebras

Download or read book Case Studies in Sleep Neurology written by Antonio Culebras and published by Cambridge University Press. This book was released on 2010-09-23 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep disorders are increasingly recognized as a major clinical problem, with significant morbidity and considerable economic importance. This compendium of case studies presents a diverse range of situations which challenge the problem-solving abilities of all those interested in sleep disorders, covering both common and unusual cases. Each case begins with a clinical history, followed by examination findings and special investigations and culminating in diagnosis, treatment and management, with discussion of differential diagnosis where appropriate. Focusing attention on the major categories of sleep medicine, including insomnia, hypersomnias, sleep-breathing disorders, parasomnias, movement disorders, circadian dysrhythmias and the neurology of sleep, this clinical guide promotes integrative thinking and diagnostic skill. Historical and review citations, illustrations and concise real-life stories stimulate memory and facilitate learning. Written and edited by an international cadre of sleep professionals, this book will inform and challenge established specialists and provide a stimulating teaching tool for those in training.

Sleep and ADHD

Author : Harriet Hiscock
Publisher : Academic Press
ISBN 13 : 0128141816
Total Pages : 394 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Sleep and ADHD by : Harriet Hiscock

Download or read book Sleep and ADHD written by Harriet Hiscock and published by Academic Press. This book was released on 2019-03-19 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep and ADHD begins with an overview of sleep (normal sleep, sleep cues, developmental phases, etc.) and continues with the epidemiology of ADHD and sleep problems, including medical issues (e.g. sleep apnea), parasomnias, behavioral insomnias (i.e. limit setting, sleep onset association disorders, circadian rhythm disorders and anxiety-related insomnia). It then covers the etiology of sleep problems, including the role of sleep hygiene and habits, the developing child, and the role of stimulants and medications used in the management of ADHD sleep problems. As the first book of its kind, users will find this reference an invaluable addition to the literature on ADHD. Covers both the pharmacological and non-pharmacological management of sleep problems Addresses sleep issues in younger children, but also addresses adolescents and adults Discusses the impact of sleep problems on the family as well as the child with ADHD Reviews the evidence around the neurobiology of sleep and systems regulating sleep in ADHD