Understanding The Oncolytic Virus Ov Basis Therapy

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Understanding the “Oncolytic Virus (OV) Basis & Therapy.”

Author : Dr. Hakim. K. Saboowala
Publisher : Dr.Hakim Saboowala
ISBN 13 :
Total Pages : 40 pages
Book Rating : 4./5 ( download)

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Book Synopsis Understanding the “Oncolytic Virus (OV) Basis & Therapy.” by : Dr. Hakim. K. Saboowala

Download or read book Understanding the “Oncolytic Virus (OV) Basis & Therapy.” written by Dr. Hakim. K. Saboowala and published by Dr.Hakim Saboowala. This book was released on with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the “Oncolytic Virus (OV) Basis & Therapy.” Oncolytic viruses (OVs) are an emerging class of cancer therapeutics that offer the: · Benefits of selective replication in tumour cells, · Delivery of multiple eukaryotic transgene payloads, · Induction of immunogenic cell death and promotion of antitumour immunity, and · Tolerable safety profile that largely does not overlap with that of other cancer therapeutics. To date, four OVs and one non-oncolytic virus have been approved for the treatment of cancer globally although talimogene laherparepvec (T-VEC) remains the only widely approved therapy. Despite increasing research interest, a better understanding of the underlying biology of OVs is needed to enable the full therapeutic potential of these agents in patients with cancer. Thus, it is strived in this Booklet to precisely describe: ü Time-line History of oncolytic virus development, ü Mechanisms of Tumour Tropism, ü Mechanisms of action of virus destroying tumour cells and ü Inherent and engineered oncolytic viruses. Further, it is also attempted to describe on optimization of the use of OVs in clinical practice along with plenty of relevant IMAGES for better understanding. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Gene Therapy of Cancer

Author : Edmund C. Lattime
Publisher : Academic Press
ISBN 13 : 0123946328
Total Pages : 554 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Gene Therapy of Cancer by : Edmund C. Lattime

Download or read book Gene Therapy of Cancer written by Edmund C. Lattime and published by Academic Press. This book was released on 2013-08-28 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Oncolytic Viruses - Genetically Engineering the Future of Cancer Therapy

Author : Benjamin Gesundheit
Publisher : Frontiers Media SA
ISBN 13 : 2889453588
Total Pages : 195 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Oncolytic Viruses - Genetically Engineering the Future of Cancer Therapy by : Benjamin Gesundheit

Download or read book Oncolytic Viruses - Genetically Engineering the Future of Cancer Therapy written by Benjamin Gesundheit and published by Frontiers Media SA. This book was released on 2016-11-22 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.

Oncolytic Virus

Author : Fouad Sabry
Publisher : One Billion Knowledgeable
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.:/5 (661 download)

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Book Synopsis Oncolytic Virus by : Fouad Sabry

Download or read book Oncolytic Virus written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Oncolytic Virus A virus is said to be oncolytic if it targets cancer cells for infection and then proceeds to destroy those cells. As a result of the oncolysis, infected cancer cells are being eliminated, which results in the production of additional infectious virus particles called virions, which further contribute to the elimination of the residual tumor. It is believed that oncolytic viruses not only induce the direct killing of tumor cells, but also activate the host's anti-tumor immune system responses. [Citation needed] [Citation needed] In addition to this, oncolytic viruses are able to influence the microenvironment of the tumor in a variety of different ways. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Oncolytic virus Chapter 2: Virotherapy Chapter 3: Virus latency Chapter 4: Herpes simplex virus Chapter 5: Tony Minson Chapter 6: Genetically modified virus Chapter 7: Pelareorep Chapter 8: Pexastimogene devacirepvec Chapter 9: Herpes simplex research Chapter 10: Jennerex Chapter 11: Talimogene laherparepvec Chapter 12: Oncolytic herpes virus Chapter 13: Oncolytic adenovirus Chapter 14: GL-ONC1 Chapter 15: Genelux Corporation Chapter 16: ONCOS-102 Chapter 17: Akseli Hemminki Chapter 18: Infected cell protein 34.5 Chapter 19: Oncolytic AAV Chapter 20: HSV epigenetics Chapter 21: Transgene (company) (II) Answering the public top questions about oncolytic virus. (III) Real world examples for the usage of oncolytic virus in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of oncolytic virus' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of oncolytic virus.

Handbook of Oncobiology: From Basic to Clinical Sciences

Author : R. C. Sobti
Publisher : Springer Nature
ISBN 13 : 9819962633
Total Pages : 1584 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Handbook of Oncobiology: From Basic to Clinical Sciences by : R. C. Sobti

Download or read book Handbook of Oncobiology: From Basic to Clinical Sciences written by R. C. Sobti and published by Springer Nature. This book was released on with total page 1584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cell Biology of Viral Infections

Author : Pierre-Yves Lozach
Publisher : MDPI
ISBN 13 : 3036501460
Total Pages : 418 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Cell Biology of Viral Infections by : Pierre-Yves Lozach

Download or read book Cell Biology of Viral Infections written by Pierre-Yves Lozach and published by MDPI. This book was released on 2021-01-25 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses exhibit an elegant simplicity as they are so basic, but so frightening. Although only a few are life threatening, they have substantial implications for human health and the economy, as exempliﬁed by the ongoing coronavirus pandemic. Viruses are rather small infectious agents found in all types of life forms, from animals and plants to prokaryotes and archaebacteria. They are obligate intracellular parasites, and as such, subvert many molecular and cellular processes of the host cell to ensure their own replication, ampliﬁcation, and subsequent spread. This Special Issue addresses the cell biology of viral infections based on a collection of original research articles, communications, opinions, and reviews on various aspects of virus–host cell interactions. Together, these articles not only provide a glance into the latest research on the cell biology of viral infections but also include novel technological developments.

Identification, function and mechanisms of interferon induced genes associated with viruses

Author : Chang Li
Publisher : Frontiers Media SA
ISBN 13 : 2832514693
Total Pages : 157 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Identification, function and mechanisms of interferon induced genes associated with viruses by : Chang Li

Download or read book Identification, function and mechanisms of interferon induced genes associated with viruses written by Chang Li and published by Frontiers Media SA. This book was released on 2023-02-15 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Intraperitoneal Cancer Therapy

Author : Wim P. Ceelen
Publisher : CRC Press
ISBN 13 : 1482261197
Total Pages : 423 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Intraperitoneal Cancer Therapy by : Wim P. Ceelen

Download or read book Intraperitoneal Cancer Therapy written by Wim P. Ceelen and published by CRC Press. This book was released on 2015-10-22 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraperitoneal Cancer Therapy: Principles and Practice is one of the first books to combine the latest clinical developments in the treatment of patients with peritoneal surface disease and the scientific principles that underlie the concept of intraperitoneal cancer therapy. The book covers basic concepts such as anatomy, physiology, pharmacology

Virus Bioinformatics

Author : Dmitrij Frishman
Publisher : CRC Press
ISBN 13 : 1000426548
Total Pages : 296 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Virus Bioinformatics by : Dmitrij Frishman

Download or read book Virus Bioinformatics written by Dmitrij Frishman and published by CRC Press. This book was released on 2021-08-18 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses are the most numerous and deadliest biological entities on the planet, infecting all types of living organisms—from bacteria to human beings. The constantly expanding repertoire of experimental approaches available to study viruses includes both low-throughput techniques, such as imaging and 3D structure determination, and modern OMICS technologies, such as genome sequencing, ribosomal profiling, and RNA structure probing. Bioinformatics of viruses faces significant challenges due to their seemingly unlimited diversity, unusual lifestyle, great variety of replication strategies, compact genome organization, and rapid rate of evolution. At the same time, it also has the potential to deliver decisive clues for developing vaccines and medications against dangerous viral outbreaks, such as the recent coronavirus pandemics. Virus Bioinformatics reviews state-of-the-art bioinformatics algorithms and recent advances in data analysis in virology. FEATURES Contributions from leading international experts in the field Discusses open questions and urgent needs Covers a broad spectrum of topics, including evolution, structure, and function of viruses, including coronaviruses The book will be of great interest to computational biologists wishing to venture into the rapidly advancing field of virus bioinformatics as well as to virologists interested in acquiring basic bioinformatics skills to support their wet lab work.

Viral Therapy of Cancer

Author : Kevin J. Harrington
Publisher : John Wiley & Sons
ISBN 13 : 047098578X
Total Pages : 432 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Viral Therapy of Cancer by : Kevin J. Harrington

Download or read book Viral Therapy of Cancer written by Kevin J. Harrington and published by John Wiley & Sons. This book was released on 2008-05-23 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they give an up-to-date and realistic evaluation of a therapy’s potential utility for the cancer patient. Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer Describes the use of viruses as oncolytic agents, killing cells directly Editors are experts in the field, with experience of both laboratory and clinical research Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.

The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application

Author : Martin Villalba
Publisher : Frontiers Media SA
ISBN 13 : 2889638219
Total Pages : 148 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application by : Martin Villalba

Download or read book The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application written by Martin Villalba and published by Frontiers Media SA. This book was released on 2020-07-02 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oncolytic Virotherapy

Author : Ahmed Majeed Al-Shammari
Publisher : Frontiers Media SA
ISBN 13 : 2832539424
Total Pages : 213 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Oncolytic Virotherapy by : Ahmed Majeed Al-Shammari

Download or read book Oncolytic Virotherapy written by Ahmed Majeed Al-Shammari and published by Frontiers Media SA. This book was released on 2023-11-20 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using viruses to treat cancer is an established concept, and many viruses have shown promising anti-tumor efficacies. Oncolytic viruses are safe and well-characterized pathogens with a stable genome. The outstanding clinical results for oncolytic virotherapy deserve serious attention and consideration to make it a treatment option alongside classical cancer therapeutics. Virotherapy uses replication-competent oncolytic viruses to replicate and destroy cancer cells selectively. The transformed nature of cancer cells offers a permissive environment for some viruses’ replication and to complement viral mutations. The in situ amplification and spread within the tumor mass is the key benefit of such replication-competent viruses. Oncolytic virotherapy is divided into two main groups, according to tumor specificity: naturally oncolytic viruses to replicate in human cancer cells; and gene-modified viruses engineered to accomplish selective oncolysis.

Cancer Immunology

Author : Nima Rezaei
Publisher : Springer
ISBN 13 : 3662449463
Total Pages : 525 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Cancer Immunology by : Nima Rezaei

Download or read book Cancer Immunology written by Nima Rezaei and published by Springer. This book was released on 2014-12-29 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.

Basic Immunology: Functions and Disorders of the Immune System, 6e: Sae-E-Book

Author : Abul K Abbas, Mbbs
Publisher : Elsevier India
ISBN 13 : 8131259587
Total Pages : 337 pages
Book Rating : 4.1/5 (312 download)

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Book Synopsis Basic Immunology: Functions and Disorders of the Immune System, 6e: Sae-E-Book by : Abul K Abbas, Mbbs

Download or read book Basic Immunology: Functions and Disorders of the Immune System, 6e: Sae-E-Book written by Abul K Abbas, Mbbs and published by Elsevier India. This book was released on 2019-06-28 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Immunology: Functions and Disorders of the Immune System, 6e: SAE-E-book

Basic Immunology E-Book

Author : Abul K. Abbas
Publisher : Elsevier Health Sciences
ISBN 13 : 0323639097
Total Pages : 336 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Basic Immunology E-Book by : Abul K. Abbas

Download or read book Basic Immunology E-Book written by Abul K. Abbas and published by Elsevier Health Sciences. This book was released on 2019-01-25 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meticulously reviewed and updated for today’s medical students, Basic Immunology, 6th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases—all designed to help students master this complex topic in the most efficient, effective manner possible. Emphasizes clinical aspects of immunology, including disease pathogenesis, the development of novel therapies based on basic science, and an appendix of clinical cases for real-world application. Provides top-notch instruction from experienced teachers, course directors, and lecturers led by well-known editor and author Dr. Abul Abbas. Features a highly readable writing style and practical organization, now with fully revised content and updated images to reflect recent important advances in today’s understanding of the immune system. Presents information in a format and style that maximizes usefulness to students and teachers studying medicine, allied health fields, and biology. Contains numerous features designed to help students understand key immunologic concepts: high-quality illustrations, practical tables, chapter outlines, bolded key points, and focus questions in every chapter for self-assessment and review. Evolve Instructor site with a downloadable image bank is available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com

Cancer-Causing Viruses and Their Inhibitors

Author : Satya Prakash Gupta
Publisher : CRC Press
ISBN 13 : 1466589787
Total Pages : 502 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Cancer-Causing Viruses and Their Inhibitors by : Satya Prakash Gupta

Download or read book Cancer-Causing Viruses and Their Inhibitors written by Satya Prakash Gupta and published by CRC Press. This book was released on 2014-05-16 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who di

Targeted Cancer Treatment in Silico

Author : Natalia L. Komarova
Publisher : Springer Science & Business Media
ISBN 13 : 1461483018
Total Pages : 235 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Targeted Cancer Treatment in Silico by : Natalia L. Komarova

Download or read book Targeted Cancer Treatment in Silico written by Natalia L. Komarova and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.