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The Molecular Biology Of Adenoviruses I
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Book Synopsis Molecular Biology of Adenoviruses by : L. Philipson
Download or read book Molecular Biology of Adenoviruses written by L. Philipson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: I. Introduction In his biography "Arrow in the Blue" the author Arthur Koestler suggests ironically that the fate of an individual may be predicted by examining the content of the newspapers at birth. Adenoviruses were discovered in 1953 (ROWE et al. , 1953; HILLEMAN and WERNER, 1954). At this time the Salk poliomyelitis vaccine was developed (SALK et al. , 1954) and in the same year the discovery of the double helical structure of DNA (WATSON and CRICK, 1953) and the plaque assay for one animal virus (DULBECCO and VOGT, 1953) was announced. Thus, this new group of viruses was born with great hopes for progress in molecular biology and for the control of animal virus infections. In the short interval be tween 1953 and 1956 the adenoviruses were discovered, methods for laboratory diagnosis and serotyping were established, the epidemiology was clarified and a highly effective vaccine was developed and approved (for a review see HILLE MAN, 1966). Succeeding years showed, however, that the vaccines were contami nated with the oncogenic SV 40 virus and that the adenoviruses themselves were tumorigenic. Since the discovery of adenoviruses animal virology was developed into a quantitative science offering explanation for viral functions at the molecular level. Precise biochemical tools to characterize the genome and its transcription products as well as the structural proteins of these viruses are now available.
Book Synopsis The Molecular Biology of Adenoviruses by : Walter Doerfler
Download or read book The Molecular Biology of Adenoviruses written by Walter Doerfler and published by . This book was released on 1983 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adenoviral Vectors for Gene Therapy by : David T. Curiel
Download or read book Adenoviral Vectors for Gene Therapy written by David T. Curiel and published by Academic Press. This book was released on 2016-03-10 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials
Book Synopsis The Adenoviruses by : Harold S. Ginsberg
Download or read book The Adenoviruses written by Harold S. Ginsberg and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .
Book Synopsis Human Adenoviruses: From Villains To Vectors by : S Jane Flint
Download or read book Human Adenoviruses: From Villains To Vectors written by S Jane Flint and published by World Scientific. This book was released on 2016-12-21 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered.Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.
Book Synopsis Therapeutic Applications of Adenoviruses by : Philip Ng
Download or read book Therapeutic Applications of Adenoviruses written by Philip Ng and published by CRC Press. This book was released on 2016-12-12 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses.
Book Synopsis Molecular Biology of Adenoviruses by : Carl Lennart Philipson
Download or read book Molecular Biology of Adenoviruses written by Carl Lennart Philipson and published by Springer. This book was released on 1975-01-01 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Biology of Adenoviruses I by : W. Doerfler
Download or read book The Molecular Biology of Adenoviruses I written by W. Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea lized in the late 1960s and the 1970s.
Book Synopsis Molecular Biology of Adenoviruses by : L. Philipson
Download or read book Molecular Biology of Adenoviruses written by L. Philipson and published by . This book was released on 2014-01-15 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Biology of Adenoviruses 2 by : W. Doerfler
Download or read book The Molecular Biology of Adenoviruses 2 written by W. Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Repertoire of Adenoviruses I by : Walter Doerfler
Download or read book The Molecular Repertoire of Adenoviruses I written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades this virus system has served - and continues to do so - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological, and epidemiological investigations in mammalian molecular biology. In this, the first of the three volumes, an overview of adenovirus research is presented with emphasis on the structure and assembly of adenoviruses, viral infections, and viral gene products. The chapters have been written by an international group of leading experts in their respective fields of interest.
Book Synopsis The Molecular Repertoire of Adenoviruses III by : Walter Doerfler
Download or read book The Molecular Repertoire of Adenoviruses III written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigation in mammalian molecular biology. In the first of the three volumes, we present an overview of adenovirus research. In the second volume, we turn our attention to such topics as DNA replication, recombination and integration and post-trans- criptional control. This, the third volume then looks at transformation and E1A, adenovirus genetics, pathogenesis and gene therapy.
Book Synopsis The Adenoviruses by : Harold S Ginsberg
Download or read book The Adenoviruses written by Harold S Ginsberg and published by Springer. This book was released on 2014-01-15 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Biology of Adenoviruses I by : W. Doerfler
Download or read book The Molecular Biology of Adenoviruses I written by W. Doerfler and published by Springer. This book was released on 1983-12-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea lized in the late 1960s and the 1970s.
Book Synopsis The Molecular Biology of Adenoviruses 3 by : W. Doerfler
Download or read book The Molecular Biology of Adenoviruses 3 written by W. Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Human Adenoviruses: New Insights for the Healthcare Professional: 2011 Edition by :
Download or read book Human Adenoviruses: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Adenoviruses: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Human Adenoviruses in a compact format. The editors have built Human Adenoviruses: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Human Adenoviruses in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Human Adenoviruses: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis The Molecular Repertoire of Adenoviruses III by : Walter Doerfler
Download or read book The Molecular Repertoire of Adenoviruses III written by Walter Doerfler and published by Springer. This book was released on 1995-08-16 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigation in mammalian molecular biology. In the first of the three volumes, we present an overview of adenovirus research. In the second volume, we turn our attention to such topics as DNA replication, recombination and integration and post-trans- criptional control. This, the third volume then looks at transformation and E1A, adenovirus genetics, pathogenesis and gene therapy.
