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The Effects Of Soluble Epidermal Growth Factor Receptor In Mammary Epithelial Cells
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Book Synopsis The Effects of Soluble Epidermal Growth Factor Receptor in Mammary Epithelial Cells by : Jennifer J. Gavinski
Download or read book The Effects of Soluble Epidermal Growth Factor Receptor in Mammary Epithelial Cells written by Jennifer J. Gavinski and published by . This book was released on 2008 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Role of Epidermal Growth Factor Receptors and Their Ligands in Normal Mammary Epithelial and Breast Cancer Cells by :
Download or read book Role of Epidermal Growth Factor Receptors and Their Ligands in Normal Mammary Epithelial and Breast Cancer Cells written by and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidermal growth factor (EGF) and transforming growth factor a (TGFalpha) acting through EGF receptors (EGFR) regulate the development of normal mammary epithelial cells (MEC) and breast cancer. Primary culture studies examined the effects of EGF and TGFalpha in MEC. PD158780, a selective inhibitor of the tyrosine kinase domain of EGFR, helped demonstrate that EGFR signaling was required for the proliferation and functional differentiation of immature MEC from days 0-7 of culture, and survival of terminally differentiated MEC from days 17.5-21 of the study. EGFR levels were expressed at high levels in non-functional MEC and MEC undergoing apoptosis whereas functionally differentiated MEC expressed relatively low levels of EGFR. In EGF medium, cultured MEC expressed peak levels of erbB2 and erbB3 from day 7-14 of culture, whereas erbB4 levels were only detected within MEC cultured for 7 and 10.5 days. MEC isolated from mammary glands expressed high levels of erbB2 and erbB3 in virgin rats and rats during pregnancy and involution, and relatively low levels during lactation, whereas erbB4 appeared to be uniformly expressed throughout the developmental stages analyzed. These findings will help in the development of therapies to treat aggressive human breast cancers that often overexpress EGFR and/or other erbB receptors.
Book Synopsis The Role of Epidermal Growth Factor Receptor in Hepatocyte Growth Factor Signaling in Mammary Epithelial Cells by : Alyssa Rowena Bonine-Summers
Download or read book The Role of Epidermal Growth Factor Receptor in Hepatocyte Growth Factor Signaling in Mammary Epithelial Cells written by Alyssa Rowena Bonine-Summers and published by . This book was released on 2006 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deregulated hepatocyte growth factor (HGF) and c-Met signaling leads to increased tumor cell invasion and growth that is observed in mammary carcinogenesis. Determining the specific role of HGF/c-Met signaling in breast cancer has been compounded by the fact that c-Met communicates with a number other receptor pathways that lead to various pathological outcomes. In the present study we show that the epidermal growth factor receptor (EGFR) plays a direct role in HGF/c-Met mediated biological activities. We used the clinically relevant EGFR inhibitors gefitinib and erlotinib to determine the role of EGFR in mediating HGF signaling. Inhibition of EGFR through these small molecule inhibitors significantly reduces the ability of HGF to induce proliferation, cell motility and invasion as well as cell scattering in various mammary epithelial cells. Furthermore, our data indicate that gefitinib and erlotinib negatively regulate the ability of HGF to activate its cognate receptor c-Met and that this action is EGFR-dependent. Our results provide a novel mechanism of action for EGFR as a mediator of HGF signaling thereby linking EGFR to the oncogenic potential of c-Met in mammary carcinomas cells.
Book Synopsis Growth Factors in Reproduction by : David W. Schomberg
Download or read book Growth Factors in Reproduction written by David W. Schomberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critical role of growth factors in normal as well as abnormal cellular growth and function has become overwhelmingly apparent in recent years. The significant advances in reproductive biology within this rapidly expanding field were highlighted at the Serono Symposia, USA, symposium entitled Growth Factors in Reproduc tion. The conference focused on growth factors as polyfunctional regulators of growth and development in the reproductive system. The program was organized into five areas: (1) growth factors as polyfunctional regulators of growth and development, (2) growth factors and gonadal function, (3) regulation of normal and neoplastic mammary growth, (4) regulatory peptides in reproductive tract development and function, and (5) embryo-maternal signaling. This volume constitutes the contributions ofthe invited symposium speakers and is organized into sections representing the five topic areas of the sessions. Drs. Eli Y. Adashi, Robert B. Dickson, David C. Lee, James Hammond, John A. McLachlan, and R. Michael Roberts, who served as chairmen ofthese sessions, not only provided invaluable advice and assistance in organizing the symposium, but contributed significantly to its content. The enthusiasm and esprit de corps of the poster presenters and discussion participants also helped make this symposium succeed as the first of its kind. Finally, special thanks are due Drs. James Posillico and Lisa Kern ofSerono Symposia, USA, for their guidance and support in the conception and planning of the symposium and in the publication of this volume.
Book Synopsis Regulated Trafficking and Spatially Restricted Signaling of the Epidermal Growth Factor Receptor in Human Mammary Epithelial Cells by : Patrick Martin Burke
Download or read book Regulated Trafficking and Spatially Restricted Signaling of the Epidermal Growth Factor Receptor in Human Mammary Epithelial Cells written by Patrick Martin Burke and published by . This book was released on 2000 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Growth Factors and Oncogenes in Breast Cancer by : Mels Sluyser
Download or read book Growth Factors and Oncogenes in Breast Cancer written by Mels Sluyser and published by John Wiley & Sons. This book was released on 1987 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hormone, Growth Factor and Fatty Acid Effects on Differentiation of Mouse Mammary Epithelial Cells in Collagen Gel Culture by : Brett Kingsley Young
Download or read book Hormone, Growth Factor and Fatty Acid Effects on Differentiation of Mouse Mammary Epithelial Cells in Collagen Gel Culture written by Brett Kingsley Young and published by . This book was released on 1987 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis In Vitro Hormonal Regulation of Epidermal Growth Factor and Glucocorticoid Receptors in a Rat Mammary Tumor Clonal Line by : Ladan Basiripour
Download or read book In Vitro Hormonal Regulation of Epidermal Growth Factor and Glucocorticoid Receptors in a Rat Mammary Tumor Clonal Line written by Ladan Basiripour and published by . This book was released on 1986 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Requirement of Proto-oncogene C-myc in Epidermal Growth Factor Stimulated Proliferation of Mammary Epithelial Cells by : Sharyl Jeanne Nass
Download or read book Requirement of Proto-oncogene C-myc in Epidermal Growth Factor Stimulated Proliferation of Mammary Epithelial Cells written by Sharyl Jeanne Nass and published by . This book was released on 1991 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer by : David Salomon
Download or read book The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer written by David Salomon and published by . This book was released on 1997 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family which binds to and activates the EGF receptor. Its role in breast cancer, however, is unclear. We have studied the mechanism of induction of HB-EGF(by EGF(in the spontaneously immortalized mammary epithelial cell line MCF-10A and in MCF-10A cells that have been transformed with oncogenic Ha-ras. The levels of EGFR, erbB-2 and erbB-3 were very similar in the nontransformed and in the transformed MCF-10A cells. However, the levels of mitogen- activated protein kinase (MAPK) were elevated in the MCF-10A cells transformed with the Ha-ras oncogene. Neutralizing antibodies and inhibitors against the EGFR were able to inhibit the induction of HE-EUF mRNA levels in the nontransformed MCF-10A cells but not in the MCF- lOA cells transfected with oncogenic Ha-ras. However, an inhibitor of MAPK kinase (MEK) completely blocked the EOF induction of HB-EOF mRNA levels in the parental MCF-10A cells as well as in transformed MCF-10A cells, which suggests that EUF may be operating through other erbB receptors such as erbB-2/erbB-3 heterodimers and that MAPK is involved in the i, of induction in nontransformed and transformed human mammary.
Book Synopsis Mechanisms of Estrogen-independent Allometric Mammary Growth Induced by Diet by : Grace Ellen Berryhill
Download or read book Mechanisms of Estrogen-independent Allometric Mammary Growth Induced by Diet written by Grace Ellen Berryhill and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammary glands are unique in that most of their development occurs postnatally coordinate with reproductive maturation, where secretion of estrogen (E) by the ovaries stimulates allometric ductal growth and terminal end bud (TEB) formation during puberty. Insulin-like growth factor-1 (IGF-1) synthesized by the mammary stroma synergizes with E to potentiate mammary epithelial cell (MEC) proliferation and ductal elongation. In parallel, activation of the epidermal growth factor receptor (EGFR) in the mammary stroma is also indispensable for pubertal ductal development, highlighting a role for reciprocal signaling between the stromal and epithelial compartments. As part a part of this dissertation, we made the surprising finding that ductal elongation and TEB formation is induced in ovariectomized mice fed trans-10, cis-12 conjugated linoleic acid (10,12 CLA), but not cis-9, trans-11 conjugated linoleic acid, independent of E and its receptor. This novel finding was also recapitulated as increased tumorigenesis in mice carrying the polyomavirus middle T antigen transgene. These effects of 10,12 CLA were accompanied by dysregulated metabolic function manifest as lipoatrophy and inflammation of the mammary fat pad, hyperinsulinemia, and hepatic steatosis. We implicated activity of the IGF-1 receptor and the EGFR in concert with metabolic disturbances and concomitant inflammation as mediators of 10,12 CLA-stimulated mammary growth. Proliferation of MEC in response to 10,12 CLA was spatially-restricted with significant MEC mitosis in TEB, similarly to that induced by E. The proliferation of MEC and ductal expansion stimulated by 10,12 CLA was delayed and temporally uncoupled versus that elicited by E. Transcriptomic analysis of allometric mammary growth and TEB formation revealed a subset of genes that was similarly regulated by either E or 10,12 CLA, consistent with their roles during cell cycle progression. In parallel, 10,12 CLA also regulated a unique subset of genes associated with inflammation and immune cell infiltration along with components of the EGFR pathway. We speculate that stromal inflammation increased EGFR activation leading to MEC proliferation and TEB formation. Taken together, these experiments highlight a role for diet in normal mammary development and tumorigenesis, and implicate local inflammation as a potential mediator of E-independent mammary growth.
Book Synopsis Sturkie's Avian Physiology by : G. Causey Whittow
Download or read book Sturkie's Avian Physiology written by G. Causey Whittow and published by Elsevier. This book was released on 1999-10-14 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sturkie's Avian Physiology is the classic comprehensive single volume on the physiology of domestic as well as wild birds. The Fifth Edition is thoroughly revised and updated, and includes new chapters on the physiology of incubation and growth. Chapters on the nervous system and sensory organs have been greatly expanded due to the many recent advances in the field. The text also covers the physiology of flight, reproduction in both male and female birds, and the immunophysiology of birds. The Fifth Edition, like the earlier editions, is a must for anyone interested in comparative physiology, poultry science, veterinary medicine, and related fields. This volume establishes the standard for those who need the latest and best information on the physiology of birds. Thoroughly updated and revised Coverage of both domestic and wild birds New larger format Only comprehensive, single volume devoted to birds
Book Synopsis The Effect of Transforming Growth Factor-ß on P27 in Human Mammary Epithelial Cells by :
Download or read book The Effect of Transforming Growth Factor-ß on P27 in Human Mammary Epithelial Cells written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pancreatic Cancer by : Douglas B. Evans
Download or read book Pancreatic Cancer written by Douglas B. Evans and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.
Book Synopsis Spatial Distribution of the EGF Receptor System in the Regulation of Breast Epithelia Cell Growth and Organization by :
Download or read book Spatial Distribution of the EGF Receptor System in the Regulation of Breast Epithelia Cell Growth and Organization written by and published by . This book was released on 1995 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: 184A1 human mammary epithelial cells (HMECs) form organotypic structures when plated on Matrigel. However, the organotypic structures differentiate into squamous, not glandular, epithelia. They can not be used to examine the functional significance of a polarized epidermal growth factor receptor system in a glandular epithelia. This experimental system may be useful for investigating cell-extracellular matrix interactions that control EGF-R expression. 184A1s and subclones of the 184A1 cell line express proteins necessary for structural and functional polarization on Transwells, but do not assemble these proteins into tight junctions. MCF-7 cells express ZO-1 and assemble the protein into tight junctions when plated onto Transwells. MCF-7s also segregate B-1 integrin into the basal-lateral membrane coppartment. NCF-7 cells respond mitogenicly to EGF-R occupancy and may provide an experimental system with which to address the primary aim of my proposal: to determine if the loss of the correct spatial organization or inappropriate expression of the EGF-R system provides a growth advantage, enhances cell motility, or ochanges the differentiated state of normally organized epithelial cells.
Book Synopsis Regulation of the Epidermal Growth Factor Receptor in Rat Tracheal Epithelial Cells by : Margaret Mary Doherty
Download or read book Regulation of the Epidermal Growth Factor Receptor in Rat Tracheal Epithelial Cells written by Margaret Mary Doherty and published by . This book was released on 1994 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
