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Author : Habib Driouch
Publisher :
ISBN 13 : 9783869558080
Total Pages : 151 pages
Book Rating : 4.5/5 (58 download)
Download or read book Systems Biotechnology of Recombinant Protein Production in Aspergillus Niger written by Habib Driouch and published by . This book was released on 2011 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lifang Liu
Publisher :
ISBN 13 : 9789175970387
Total Pages : pages
Book Rating : 4.9/5 (73 download)
Download or read book Systems Biology of Recombinant Protein Production by Fungi written by Lifang Liu and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Monika Schmoll
Publisher : Springer
ISBN 13 : 3319279513
Total Pages : 499 pages
Book Rating : 4.3/5 (192 download)
Download or read book Gene Expression Systems in Fungi: Advancements and Applications written by Monika Schmoll and published by Springer. This book was released on 2016-04-04 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology has emerged as one of the key environmentally safe technologies for the future which enables use of biomass to develop novel smart materials and to replace oil derived products. Fungi are the most efficient producers of the enzymes needed for this purpose and in addition they produce a plethora of secondary metabolites, among which novel antibiotics can be found. Industrial application and exploitation of the metabolic capacities of fungi requires highly productive and robust gene expression systems, which can be achieved by selection of appropriate species and strain improvement. In this book we aim to summarize homologous and heterologous gene expression systems of fungi for production of enzymes and secondary metabolites. A broad overview on requirements, challenges and successful applications shall serve as a basis for further development of fungi as biotechnological workhorses in research and industry.
Author : Gerd Gellissen
Publisher : John Wiley & Sons
ISBN 13 : 3527604413
Total Pages : 429 pages
Book Rating : 4.5/5 (276 download)
Download or read book Production of Recombinant Proteins written by Gerd Gellissen and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the choices of microbial and eukaryotic expression systems for production of recombinant proteins are many, most researchers in academic and industrial settings do not have ready access to pertinent biological and technical information since it is normally scattered throughout the scientific literature. This book closes the gap by providing information on the general biology of the host organism, a description of the expression platform, a methodological section -- with strains, genetic elements, vectors and special methods, where applicable -- as well as examples of proteins produced with the respective platform. The systems thus described are well balanced by the inclusion of three prokaryotes (two Gram-negatives and one Gram-positive), four yeasts, two filamentous fungi and two higher eukaryotic cell systems -- mammalian and plant cells. Throughout, the book provides valuable practical and theoretical information on the criteria and schemes for selecting the appropriate expression platform, the possibility and practicality of a universal expression vector, and on comparative industrial-scale fermentation, with the production of a recombinant Hepatitis B vaccine chosen as an industrial example. With a foreword by Herbert P. Schweizer, Colorado State University, USA: "As a whole, this book is a valuable and overdue resource for a varied audience. It is a practical guide for academic and industrial researchers who are confronted with the design of the most suitable expression platform for their favorite protein for technical or pharmaceutical purposes. In addition, the book is also a valuable study resource for professors and students in the fields of applied biology and biotechnology."
Author : Vijai Kumar Gupta
Publisher : Elsevier
ISBN 13 : 0444635130
Total Pages : 315 pages
Book Rating : 4.4/5 (446 download)
Download or read book New and Future Developments in Microbial Biotechnology and Bioengineering written by Vijai Kumar Gupta and published by Elsevier. This book was released on 2016-10-27 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and Future Developments in Microbial Biotechnology and Bioengineering: Aspergillus System Properties and Applications provides information on emerging issues related to recent advancements in aspergillus research and its applications in bioprocess technology, chemical engineering, genome biology, molecular taxonomy, secondary and metabolite production, industrial process and biofuels/bioenergy research, and alternative fuel development. The book covers the various novel enzymes secreted by these fungi and their specific use in the food, textile, pulp and paper, biocellulosic ethanol production, and other industries. The book describes research and experimentation on aspergillus activity and directly connects them to their use in bioprocess technology, chemical engineering, bioremediation process, secondary metabolite production, pharmaceutical processes, protein production, industrial process, biofuels/bioenergy research, and alternative fuel development. Readers will find this book to be an indispensable resource for biotechnologists, biochemical engineers, biochemists, microbiologists, bioinformatics researchers, and other biologists who are interested in learning about the potential applications of these fungi. Compiles available, up-to-date information on recent developments made in the study of aspergillus system properties Contains global content from pioneering international authors Presents current research efforts and links them to various applications, including uses in foods, textiles, pulp and paper, and in biocellulosic ethanol production Provides an indispensable resource for biologists who are interested in learning about the potential applications of the fungi aspergillus
Author : Christoph Wittmann
Publisher : Springer
ISBN 13 : 3642142311
Total Pages : 250 pages
Book Rating : 4.6/5 (421 download)
Download or read book Biosystems Engineering I written by Christoph Wittmann and published by Springer. This book was released on 2010-08-18 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: -Integration of Systems Biology with Bioprocess Engineering: L-Threonine Production by Systems Metabolic Engineering of Escherichia Coli, By Sang Yup Lee and Jin Hwan Park; -Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum, By Christoph Wittmann; -Systems Biology of Industrial Microorganisms, Marta Papini, Margarita Salazar, and Jens Nielsen; -De Novo Metabolic Engineering and the Promise of Synthetic DNA, By Daniel Klein-Marcuschamer, Vikramaditya G. Yadav, Adel Ghaderi, and Gregory N. Stephanopoulos; -Systems Biology of Recombinant Protein Production in Bacillus megaterium, Rebekka Biedendieck, Boyke Bunk, Tobias Fürich, Ezequiel Franco-Lara, Martina Jahn, and Dieter Jahn; -Extending Synthetic Routes for Oligosaccharides by Enzyme, Substrate and Reaction Engineering; By Jürgen Seibel, Hans-Joachim Jördening, and Klaus Buchholz; -Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds; By Andrea Weckbecker, Harald Gröger, and Werner Hummel;
Author : Christoph Wittmann
Publisher : Springer
ISBN 13 : 3642138667
Total Pages : 166 pages
Book Rating : 4.6/5 (421 download)
Download or read book Biosystems Engineering II written by Christoph Wittmann and published by Springer. This book was released on 2010-08-18 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: -Morphology of Filamentous Fungi: Linking Cellular Biology to Process Engineering Using Aspergillus niger, By Rainer Krull, Christiana Cordes, Harald Horn, Ingo Kampen, Arno Kwade, Thomas R. Neu, and Bernd Nörtemann; -Multi-Scale Spatio-Temporal Modeling: Lifelines of Microorganisms in Bioreactors and Tracking Molecules in Cells, By Alexei Lapin, Michael Klann, and Matthias Reuss; -Impact of Profiling Technologies in the Understanding of Recombinant Protein Production, By Chandran Vijayendran and Erwin Flaschel -Engineering the Escherichia coli Fermentative Metabolism, By M. Orencio-Trejo, J. Utrilla, M.T. Fernàndez-Sandoval, G. Huerta-Beristain, G. Gosset, and A. Martinez; -Modeling Languages for Biochemical Network Simulation: Reaction vs Equation Based Approaches, By Wolfgang Wiechert, Stephan Noack, and Atya Elsheikh; -Impact of Thermodynamic Principles in Systems Biology, By J.J. Heijnen;
Author : Brigitte Gasser
Publisher : Humana Press
ISBN 13 : 9781493990238
Total Pages : 431 pages
Book Rating : 4.9/5 (92 download)
Download or read book Recombinant Protein Production in Yeast written by Brigitte Gasser and published by Humana Press. This book was released on 2019-02-09 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of the main yeast production platforms currently used and future yeast cell factories for recombinant protein production. Chapters detail approaches of genetic and metabolic engineering, co-factor containing proteins and virus-like particles, glycoproteins, and post-translational modifications of proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Recombinant Protein Production in Yeast: Methods and Protocols aims to provide state of the art background and methods for protein producing yeast platforms, as well as case studies for special applications.
Author : Ghasem Najafpour
Publisher : Elsevier
ISBN 13 : 0444633774
Total Pages : 668 pages
Book Rating : 4.4/5 (446 download)
Download or read book Biochemical Engineering and Biotechnology written by Ghasem Najafpour and published by Elsevier. This book was released on 2015-02-24 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Engineering and Biotechnology, 2nd Edition, outlines the principles of biochemical processes and explains their use in the manufacturing of every day products. The author uses a diirect approach that should be very useful for students in following the concepts and practical applications. This book is unique in having many solved problems, case studies, examples and demonstrations of detailed experiments, with simple design equations and required calculations. Covers major concepts of biochemical engineering and biotechnology, including applications in bioprocesses, fermentation technologies, enzymatic processes, and membrane separations, amongst others Accessible to chemical engineering students who need to both learn, and apply, biological knowledge in engineering principals Includes solved problems, examples, and demonstrations of detailed experiments with simple design equations and all required calculations Offers many graphs that present actual experimental data, figures, and tables, along with explanations
Author : Yoshikatsu Murooka
Publisher : CRC Press
ISBN 13 : 1000105687
Total Pages : 894 pages
Book Rating : 4.0/5 (1 download)
Download or read book Recombinant Microbes for Industrial and Agricultural Applications written by Yoshikatsu Murooka and published by CRC Press. This book was released on 2020-08-26 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between laboratory observations and industrial practices, this work presents detailed information on recombinant micro-organisms and their applications in industry and agriculture. All recombinant microbes, bacteria, yeasts and fungi are covered.
Author : Bernard R. Glick
Publisher : John Wiley & Sons
ISBN 13 : 1683673646
Total Pages : 903 pages
Book Rating : 4.6/5 (836 download)
Download or read book Molecular Biotechnology written by Bernard R. Glick and published by John Wiley & Sons. This book was released on 2022-03-15 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biotechnology Molecular Biotechnology Principles and Applications of Recombinant DNA SIXTH EDITION An authoritative introduction to the fast-changing world of molecular biotechnology In continuous publication since 1994 and now in its sixth edition, Molecular Biotechnology: Principles and Applications of Recombinant DNA has been effective in introducing this complex field to students for more than 25 years. This textbook covers essentially every aspect of the field of molecular biotechnology, which is constantly changing and adapting in light of new advances. This edition includes the latest techniques in DNA sequencing and genetic engineering of microbial, plant, and animal genomes, including human genome editing, as well as updates across many areas, such as: Immunological assays for disease diagnosis, more effective bacteriophage therapy, and new ways of dealing with antibiotic-resistant bacteria New and developing vaccines for influenza, tuberculosis, and emerging viral threats, including Zika and SARS-CoV-2 Engineering bacteria to perform plastic degradation and green algae to produce hydrogen, altering amino acid biosynthesis, and creating designer cellulosomes Production of humanized monoclonal antibodies in plants, modifying hybrid plants to produce clonal hybrids, and protecting plants from viral and fungal diseases Molecular Biotechnology features nearly 600 detailed figures and is an ideal textbook for undergraduate and graduate courses in introductory biotechnology, as well as courses dedicated to utilizing this technology, such as medical, agricultural, environmental, and industrial biotechnology applications.
Author : Eduardo A. Ceccarelli
Publisher : Frontiers E-books
ISBN 13 : 2889192946
Total Pages : 103 pages
Book Rating : 4.8/5 (891 download)
Download or read book Recombinant protein expression in microbial systems written by Eduardo A. Ceccarelli and published by Frontiers E-books. This book was released on 2014-10-02 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of recombinant DNA technology, expressing heterologous proteins in microorganisms rapidly became the method of choice for their production at laboratory and industrial scale. Bacteria, yeasts and other hosts can be grown to high biomass levels efficiently and inexpensively. Obtaining high yields of recombinant proteins from this material was only feasible thanks to constant research on microbial genetics and physiology that led to novel strains, plasmids and cultivation strategies. Despite the spectacular expansion of the field, there is still much room for progress. Improving the levels of expression and the solubility of a recombinant protein can be quite challenging. Accumulation of the product in the cell can lead to stress responses which affect cell growth. Buildup of insoluble and biologically inactive aggregates (inclusion bodies) lowers the yield of production. This is particularly true for obtaining membrane proteins or high-molecular weight and multi-domain proteins. Also, obtaining eukaryotic proteins in a prokaryotic background (for example, plant or animal proteins in bacteria) results in a product that lack post-translational modifications, often required for functionality. Changing to a eukaryotic host (yeasts or filamentous fungi) may not be a proper solution since the pattern of sugar modifications is different than in higher eukaryotes. Still, many advances in the last couple of decades have provided to researchers a wide variety of strategies to maximize the production of their recombinant protein of choice. Everything starts with the careful selection of the host. Be it bacteria or yeast, a broad list of strains is available for overcoming codon use bias, incorrect disulfide bond formation, protein toxicity and lack of post-translational modifications. Also, a huge catalog of plasmids allows choosing for different fusion partners for improving solubility, protein secretion, chaperone co-expression, antibiotic resistance and promoter strength. Next, controlling culture conditions like temperature, inducer and media composition can bolster recombinant protein production. With this Research Topic, we aim to provide an encyclopedic account of the existing approaches to the expression of recombinant proteins in microorganisms, highlight recent discoveries and analyze the future prospects of this exciting and ever-growing field.
Author : Andreas Vogel
Publisher : John Wiley & Sons
ISBN 13 : 3527343857
Total Pages : 430 pages
Book Rating : 4.5/5 (273 download)
Download or read book Industrial Enzyme Applications written by Andreas Vogel and published by John Wiley & Sons. This book was released on 2019-10-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a "must-read": It explains how an effective and economically viable enzymatic process in industry is developed and presents numerous successful examples which underline the efficiency of biocatalysis.
Author : Manely Eslahpazir Esfandabadi
Publisher : Cuvillier Verlag
ISBN 13 : 3736944497
Total Pages : 146 pages
Book Rating : 4.7/5 (369 download)
Download or read book Numerical Characterization of Mechanical Stress and Flow Patterns in Stirred Tank Bioreactors written by Manely Eslahpazir Esfandabadi and published by Cuvillier Verlag. This book was released on 2013-06-24 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das Ziel der Arbeit bestand darin, die lokalen und globalen mechanischen Beanspruchungsparameter in einem Rührkesselbioreaktor mit Hilfe der numerischen Strömungssimulation (CFD) nachzubilden und die Ergebnisse mit experimentellen Daten der Pellet-kultivierung bzgl. Fluiddynamik und Rheolgie des rekombinanten Stammes A. niger SKAn1015 zu validieren. Ausgehend von der einphasigen Strömungssimulation eines 2L-Bioreaktors werden zunächst Simultionsdaten über Strömungsgeschwindigkeit und mechanische Beanspruchung diskutiert. Aßerdem erfolgt eine Validierung der einphasigen Simulationsdaten mit der Particle Image Velocimetry. In weiteren Untersuchungen wird die Strömungssimulation auch auf nicht-newtonsche Flüssigkeiten, so wie sie bei der Kultivierung filamentöser Pilze üblicherweise auftreten, mit dem Ostwald - de Waele-Ansatz erweitert und die mechanische Beanspruchung in Abhängigkeit zu den rheologischen Prozessparametern korreliert. Die Untersuchung des Einflusses unterschiedlicher Rührergeometrien auf die Strömungsfelder und die mechanische Beanspruchung mittels CFD bildet den Abschluss, so dass die Auswahl eines geeigneten Rührers für den Kultivierungsprozess mit schesensitiven biologischen Systemen eindeutig getroffen wird. Die Arbeit validiert die numerische Strömungssimulation in einem Bioreaktor mit experimentell gnerierten biologischen und fluiddynamischen Prozessdaten und gibt praktische Hinweise darüber, wie biotechnologische Prozesse mit filamentösen Mikroorganismen hinsichtlich der Minimierung der mechanischen Beanspruchung zu betreiben sind.
Author : Pey-Jin Lin
Publisher : Cuvillier Verlag
ISBN 13 : 3736941811
Total Pages : 126 pages
Book Rating : 4.7/5 (369 download)
Download or read book Effect of fluid dynamics on pellet morphology and product formation of "Aspergillus niger" written by Pey-Jin Lin and published by Cuvillier Verlag. This book was released on 2012-08-13 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The product formation of the biopellets of filamentous fungi, such as Aspergillus niger, is closely linked with the pellet morphology. Therefore, investigations were carried out to determine the influence of fluid dynamic conditions on the growth of fungal pellets. During the present study, important information about the evolution of morphological changes during the cultivation process in stirred tank reactors was gathered from cultivations at different volumetric power inputs by agitation and aeration. The quantification of the pellet morphology was accomplished by the digital image analysis and the laser diffraction technique tracing parameters like the pellet diameter and the pellet concentration. The property of the pellet surface structure was determined by the microscopic image analysis of the pellet slices and verified by sedimentation velocity measurements. Results revealed a notable variation in morphological data among pellets cultivated at different volumetric power inputs by agitation and aeration, by which the production yields of the model product glucoamylase were correspondingly altered. Furthermore, without raising the total energy input, by utilizing of the different impact of aeration- and agitation-induced volumetric power input on the fungal pellet morphology, the product formation could be consequentially improved. Die Produktbildung der Biopellets von filamentösen Pilzen, wie Aspergillus niger, ist eng mit der Pelletmorphologie verknüpft. Daher wurden Untersuchungen durchgeführt, um den Einfluss von fluiddynamischen Bedingungen auf das Wachstum von Pilzpellets zu bestimmen. In der vorliegenden Arbeit wurden wichtige Informationen über die Entwicklung der morphologischen Veränderungen von Kultivierungen bei verschiedenen Leistungseinträgen durch Rühren und Begasen gesammelt. Die Quantifizierung der Pelletmorphologie wurde, zur Erfassung verschiedener Parameter wie zum Beispiel des Pelletdurchmessers oder der Pelletkonzentration, mit Hilfe von Bildanalyse und Laserbeugung durchgeführt. Die Qualifizierung der Pelletoberflächenstruktur wurde durch die mikroskopische Bildanalyse von Pelletschnitten bestimmt und durch Sinkgeschwindigkeitsmessungen verifiziert. Die Ergebnisse zeigten eine bemerkenswerte Variation in morphologischen Daten bei Pellets, die unter verschiedenen Leistungseinträgen durch Rühren und Begasen kultiviert wurden, wodurch sich die Ausbeuten des Modellprodukts Glucoamylase entsprechend veränderten. Weiterhin konnte ohne Erhöhung des Gesamtenergieeintrags bei Variation des begasungs- und rührerinduzierten Leistungseintrags die Pelletmorphologie verändert und die Produktbildung verbessert werden.
Author : Andres R. Alcantara
Publisher : MDPI
ISBN 13 : 3036511261
Total Pages : 174 pages
Book Rating : 4.0/5 (365 download)
Download or read book Applied Biocatalysis in Europe written by Andres R. Alcantara and published by MDPI. This book was released on 2021-08-30 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied biocatalysis and biotransformation, that is, the use of enzymes and whole-cell systems in manufacturing processes for synthetic purposes, has been experiencing a clear boom in recent years, which has led to the start of the so-called “fourth wave”. In fact, the latest advances in bioinformatics, system biology, process intensification, and, in particular, enzyme-directed evolution (encouraged by the 2018 Nobel Prize awarded to F. Arnold), are widening the range of the efficacy of biocatalysts and accelerating the rate at which new enzymes are becoming available, even for activities not previously known. European scientists have been very actively involved in different aspects of this field. Nine contributions dealing with different aspects of applied biocatalysis developed by European researchers are gathered in this Special Issue
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464920699
Total Pages : 1746 pages
Book Rating : 4.4/5 (649 download)
Download or read book Proteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1746 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Amino Acids, Peptides, and Proteins. The editors have built Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Amino Acids, Peptides, and Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
