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Effect Of Fluid Dynamics On Pellet Morphology And Product Formation Of Aspergillus Niger
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Book Synopsis Effect of fluid dynamics on pellet morphology and product formation of "Aspergillus niger" by : Pey-Jin Lin
Download or read book Effect of fluid dynamics on pellet morphology and product formation of "Aspergillus niger" written by Pey-Jin Lin and published by Cuvillier Verlag. This book was released on 2012-08-13 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The product formation of the biopellets of filamentous fungi, such as Aspergillus niger, is closely linked with the pellet morphology. Therefore, investigations were carried out to determine the influence of fluid dynamic conditions on the growth of fungal pellets. During the present study, important information about the evolution of morphological changes during the cultivation process in stirred tank reactors was gathered from cultivations at different volumetric power inputs by agitation and aeration. The quantification of the pellet morphology was accomplished by the digital image analysis and the laser diffraction technique tracing parameters like the pellet diameter and the pellet concentration. The property of the pellet surface structure was determined by the microscopic image analysis of the pellet slices and verified by sedimentation velocity measurements. Results revealed a notable variation in morphological data among pellets cultivated at different volumetric power inputs by agitation and aeration, by which the production yields of the model product glucoamylase were correspondingly altered. Furthermore, without raising the total energy input, by utilizing of the different impact of aeration- and agitation-induced volumetric power input on the fungal pellet morphology, the product formation could be consequentially improved. Die Produktbildung der Biopellets von filamentösen Pilzen, wie Aspergillus niger, ist eng mit der Pelletmorphologie verknüpft. Daher wurden Untersuchungen durchgeführt, um den Einfluss von fluiddynamischen Bedingungen auf das Wachstum von Pilzpellets zu bestimmen. In der vorliegenden Arbeit wurden wichtige Informationen über die Entwicklung der morphologischen Veränderungen von Kultivierungen bei verschiedenen Leistungseinträgen durch Rühren und Begasen gesammelt. Die Quantifizierung der Pelletmorphologie wurde, zur Erfassung verschiedener Parameter wie zum Beispiel des Pelletdurchmessers oder der Pelletkonzentration, mit Hilfe von Bildanalyse und Laserbeugung durchgeführt. Die Qualifizierung der Pelletoberflächenstruktur wurde durch die mikroskopische Bildanalyse von Pelletschnitten bestimmt und durch Sinkgeschwindigkeitsmessungen verifiziert. Die Ergebnisse zeigten eine bemerkenswerte Variation in morphologischen Daten bei Pellets, die unter verschiedenen Leistungseinträgen durch Rühren und Begasen kultiviert wurden, wodurch sich die Ausbeuten des Modellprodukts Glucoamylase entsprechend veränderten. Weiterhin konnte ohne Erhöhung des Gesamtenergieeintrags bei Variation des begasungs- und rührerinduzierten Leistungseintrags die Pelletmorphologie verändert und die Produktbildung verbessert werden.
Book Synopsis Numerical Characterization of Mechanical Stress and Flow Patterns in Stirred Tank Bioreactors by : Manely Eslahpazir Esfandabadi
Download or read book Numerical Characterization of Mechanical Stress and Flow Patterns in Stirred Tank Bioreactors written by Manely Eslahpazir Esfandabadi and published by Cuvillier Verlag. This book was released on 2013-06-24 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das Ziel der Arbeit bestand darin, die lokalen und globalen mechanischen Beanspruchungsparameter in einem Rührkesselbioreaktor mit Hilfe der numerischen Strömungssimulation (CFD) nachzubilden und die Ergebnisse mit experimentellen Daten der Pellet-kultivierung bzgl. Fluiddynamik und Rheolgie des rekombinanten Stammes A. niger SKAn1015 zu validieren. Ausgehend von der einphasigen Strömungssimulation eines 2L-Bioreaktors werden zunächst Simultionsdaten über Strömungsgeschwindigkeit und mechanische Beanspruchung diskutiert. Aßerdem erfolgt eine Validierung der einphasigen Simulationsdaten mit der Particle Image Velocimetry. In weiteren Untersuchungen wird die Strömungssimulation auch auf nicht-newtonsche Flüssigkeiten, so wie sie bei der Kultivierung filamentöser Pilze üblicherweise auftreten, mit dem Ostwald - de Waele-Ansatz erweitert und die mechanische Beanspruchung in Abhängigkeit zu den rheologischen Prozessparametern korreliert. Die Untersuchung des Einflusses unterschiedlicher Rührergeometrien auf die Strömungsfelder und die mechanische Beanspruchung mittels CFD bildet den Abschluss, so dass die Auswahl eines geeigneten Rührers für den Kultivierungsprozess mit schesensitiven biologischen Systemen eindeutig getroffen wird. Die Arbeit validiert die numerische Strömungssimulation in einem Bioreaktor mit experimentell gnerierten biologischen und fluiddynamischen Prozessdaten und gibt praktische Hinweise darüber, wie biotechnologische Prozesse mit filamentösen Mikroorganismen hinsichtlich der Minimierung der mechanischen Beanspruchung zu betreiben sind.
Book Synopsis Production of labyrinthopeptin A1 with Actinomadura namibiensis by : Sebastian Tesche
Download or read book Production of labyrinthopeptin A1 with Actinomadura namibiensis written by Sebastian Tesche and published by Cuvillier Verlag. This book was released on 2020-12-21 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The filamentous actinomycete Actinomadura namibiensis is the only known producer of labyrinthopeptins, a class of ribosomally synthesized and posttranslationally modified peptides (RiPPs) displaying highly attractive bioactive properties. In order to increase the labyrinthopeptin A1 productivity in shaking flask cultivations of A. namibiensis, a new cultivation method called salt-enhanced cultivation was used. Compared to the unsupplemented control, labyrinthopeptin A1 productivity was enhanced the most by addition of 50 mM (NH4)2SO4, reaching a 7-fold higher yield of 325 mg L-1 within 10 cultivation days. Salt-enhanced cultivation affected growth and product formation mechanisms, cell morphology characteristics and rheological characteristics of cultivation broth. An image analysis method was developed to quantify both the macro-morphology (pellet size and shape) and the micro-morphology (hyphal network structure) of the heterogeneous filamentous biomass in detail. Productivity-related morphological parameters were in particular the size and circularity of pellets and the degree of hyphal interweaving (hyphal network spacing). It was shown that the time-dependent change in morphology linked to the rheological properties of the cultivation broth. The results presented in this work provide new insights into the cultivation aspects of A. namibiensis and illustrate the challenges on the way to a comprehensive understanding of the complex relationship between productivity, morphology and rheology in filamentous cultivations.
Book Synopsis Micro- and Macroparticle enhanced cultivation of filamentous Lentzea aerocolonigenes for increased rebeccamycin production by : Kathrin Schrinner
Download or read book Micro- and Macroparticle enhanced cultivation of filamentous Lentzea aerocolonigenes for increased rebeccamycin production written by Kathrin Schrinner and published by Cuvillier Verlag. This book was released on 2020-12-28 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: The filamentous actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. However, the complex morphology of actinomycetes leads to challenges during the cultivation often accompanied by low product titers. In the recent past, the to date low rebeccamycin titers were increased by particle addition to cultivations of L. aerocolonigenes. In this thesis the addition of micro-, macro- and adsorbent particles to cultivations of L. aerocolonigenes were investigated in more detail. Furthermore, the scale-up to a bubble-free bioreactor was conducted. The addition of glass microparticles (x50 = 7.9 μm, 10 g L-1) to shake flask cultivations increased the rebeccamycin titer up to 3.6-fold compared to an unsupplemented approach. Pellet slices showed the incorporation of microparticles. With different surface modifications of the microparticles, specific incorporation patterns of the microparticles appeared. The incorporation of microparticles causes looser and smaller pellets allowing an increased nutrient and oxygen supply in the pellet core. With addition of larger (glass) macroparticles (ø = 0.2 – 2.1 mm, 100 g L-1) mechanical stress was induced on the biopellets. The additional supplementation of 5 g L-1 soy lecithin and glass beads (ø = 969 μm, 100 g L-1) resulted in a rebeccamycin titer of 388 mg L-1, one of the highest rebeccamycin titers ever achieved. For the scale-up of L. aerocolonigenes cultivations a bubble-free membrane aeration system was developed. The tubular membrane aeration system can additionally be pressurized to increase the oxygen transfer. First cultivations of L. aerocolonigenes successfully provided 18 mg L-1 rebeccamycin, a concentration similar to that of unsupplemented shake flask cultivations. XAD adsorbent particles were added to cultivations to facilitate rebeccamycin recovery. However, the XAD particles additionally increased the rebeccamycin titer which was likely to be caused by the adsorption of the rebeccamycin precursor tryptophan to the resins which in turn directly transferred the tryptophan to the microorganism.
Book Synopsis Filaments in Bioprocesses by : Rainer Krull
Download or read book Filaments in Bioprocesses written by Rainer Krull and published by Springer. This book was released on 2015-06-12 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Book Synopsis Biosystems Engineering II by : Christiana Cordes
Download or read book Biosystems Engineering II written by Christiana Cordes and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosystems Engineering I explores all aspects of biotechnology, which blends aspects of chemistry, biochemistry, microbiology, genetics, chemical engineering and computer sciences. Topics include the systems biology of industrial microorganisms, modeling languages for biochemical network simulation, and more.
Book Synopsis Multiphase Bioreactor Design by : Joaquim M.S. Cabral
Download or read book Multiphase Bioreactor Design written by Joaquim M.S. Cabral and published by CRC Press. This book was released on 2001-09-20 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreaction engineering is fundamental to the optimization of biotechnological processes and the production of biochemicals by enzymes, microbial, plant and animal cells and higher organisms. A reference text for postgraduate students and researchers in biochemical engineering and bioreactor design, Multiphase Bioreactor Design describes the
Author :Michael A. Winkler Publisher :Springer Science & Business Media ISBN 13 :9781851664542 Total Pages :390 pages Book Rating :4.6/5 (645 download)
Book Synopsis Chemical Engineering Problems in Biotechnology by : Michael A. Winkler
Download or read book Chemical Engineering Problems in Biotechnology written by Michael A. Winkler and published by Springer Science & Business Media. This book was released on 1990-04-30 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Citric Acid Biotechnology by : Bjorn Kristiansen
Download or read book Citric Acid Biotechnology written by Bjorn Kristiansen and published by CRC Press. This book was released on 2002-04-12 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers citric acid fermentation methods including recent advances and approaches. The book looks at all aspects of the fermentation process and should be of interest to those working in biotechnology, microbiology and biochemistry.
Book Synopsis Immobilized Cells: Basics and Applications by : R.M. Buitelaar
Download or read book Immobilized Cells: Basics and Applications written by R.M. Buitelaar and published by Elsevier. This book was released on 1996-03-21 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication contains full papers of both oral and poster presentations of the symposium "Immobilized Cells: Basics and Applications" that was held in Noordwijkerhout, The Netherlands, 26-29 November 1995. This volume covers recent developments in the field of immobilization e.g.: new support materials, characterization of support materials, kinetic characterizations, dynamic modelling, bioreactor types, scale up and applications are also given. Applications in the field of medicine, fermentation technology, food technology and environmental technology are described. Guidelines for research with immobilized cells. Based on the scientific sessions a strategy of research and methods for characterization of immobilized cells, especially in view of applications are given. The goal was to relate basic research to applications and to extract guidelines for characterization of immobilized cells in view of process design and application from the contributions. The manuscripts presented in these proceedings give an extensive and recent overview of the research and applications of immobilized-cell technology.
Book Synopsis 21st Century Guidebook to Fungi by : David Moore
Download or read book 21st Century Guidebook to Fungi written by David Moore and published by Cambridge University Press. This book was released on 2020-05-08 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mysterious world of fungi is once again unearthed in this expansive second edition. This textbook provides readers with an all-embracing view of the kingdom fungi, ranging in scope from ecology and evolution, diversity and taxonomy, cell biology and biochemistry, to genetics and genomics, biotechnology and bioinformatics. Adopting a unique systems biology approach - and using explanatory figures and colour illustrations - the authors emphasise the diverse interactions between fungi and other organisms. They outline how recent advances in molecular techniques and computational biology have fundamentally changed our understanding of fungal biology, and have updated chapters and references throughout the book in light of this. This is a fascinating and accessible guide, which will appeal to a broad readership - from aspiring mycologists at undergraduate and graduate level to those studying related disciplines. Online resources are hosted on a complementary website.
Book Synopsis Current Developments in Biotechnology and Bioengineering by : Mohammad Taherzadeh
Download or read book Current Developments in Biotechnology and Bioengineering written by Mohammad Taherzadeh and published by Elsevier. This book was released on 2022-11-18 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filamentous Fungi Biorefinery, the latest release in the Current Developments in Biotechnology and Bioengineering series, builds on knowledge on the classification of filamentous fungi and presence and roles played in ecosystems. The importance of filamentous fungi is then further corroborated through a description of their present applications in biotechnological processes. Knowledge on fungal biology is extended through discussion on structure and composition together with a description of growth potentialities of filamentous fungi in/on a wide range of substrates. In addition, the morphology of filamentous fungi is then described and its implications during integration in industrial processes is discussed. The book then provides an overview on the use of filamentous fungi for the production of a wide range of value-added products, including feed and food products, alcohols, organic acids, pigments, enzymes, antibiotics and biopolymers. All provided state-of-arts are extended to a description of the present degree of application of filamentous fungi towards the production of those products using low-value substrates, identification of research gaps, and proposes future research avenues. Presents the first book dedicated to the use of filamentous fungi for process development within waste management Discusses the transfer of research knowledge into industrial processes and marketable products Includes industrial applications of filamentous fungi towards valorization of low-value substrates Provides up-to-date knowledge on research and application fields that can benefit from the integration of filamentous fungi
Book Synopsis Biotechnology in Space by : Günter Ruyters
Download or read book Biotechnology in Space written by Günter Ruyters and published by Springer. This book was released on 2017-12-21 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the early successes, drawbacks and accomplishments in cell biology and cell biotechnology achieved by the latest projects performed on the International Space Station ISS. It also depicts outcomes of experiments in tissue engineering, cancer research and drug design and reveals the chances that research in Space offers for medical application on Earth. This SpringerBriefs volume provides an overview on the latest international activities in Space and gives an outlook on the potential of biotechnological research in Space in future. This volume is written for students and researchers in Biomedicine, Biotechnology and Pharmacology and may specifically be of interest to scientists with focus on protein sciences, crystallization, tissue engineering, drug design and cancer research.
Book Synopsis Genetic Transformation Systems in Fungi, Volume 2 by : Marco A. van den Berg
Download or read book Genetic Transformation Systems in Fungi, Volume 2 written by Marco A. van den Berg and published by Springer. This book was released on 2014-10-31 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are an economic very important class of microbes. Not only do they host a range of versatile enzymes used in industrial applications (biofuels, laundry, food processing), as well do they produce several very important pharmaceutical drugs (statins and penicillins). Moreover, fungal pathogens can cause great damage in agricultural production (Phytophthora and Botrytis) and during mammalian infections (Penicillium marneffei and Candida). Transformation of DNA is used to understand the genetic basis behind these traits. Several different techniques have been developed over the years and readily shown to be decisive methods to improve fungal biotechnology. This book will cover the basics behind the most commonly used transformation methods, as well as associated tools and techniques. Each chapter will provide protocols along with examples to be used in laboratories worldwide.
Download or read book ASEAN Food Journal written by and published by . This book was released on 1993 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of Fermentation and Bioengineering by :
Download or read book Journal of Fermentation and Bioengineering written by and published by . This book was released on 1993 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book CJChE written by and published by . This book was released on 1999-08 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt:
