Statistical Issues

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Statistical Issues in Drug Development

Author : Stephen S. Senn
Publisher : John Wiley & Sons
ISBN 13 : 9780470723579
Total Pages : 523 pages
Book Rating : 4.7/5 (235 download)

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Book Synopsis Statistical Issues in Drug Development by : Stephen S. Senn

Download or read book Statistical Issues in Drug Development written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents anessential and thought provoking guide to the statistical issues andcontroversies involved in drug development. This highly readable second edition has been updated toinclude: Comprehensive coverage of the design and interpretation ofclinical trials. Expanded sections on missing data, equivalence, meta-analysisand dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage ofpharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9,Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue betweenstatisticians and life scientists working within the pharmaceuticalindustry. The accessible and wide-ranging coverage make itessential reading for both statisticians and non-statisticiansworking in the pharmaceutical industry, regulatory bodies andmedical research institutes. There is also much to benefitundergraduate and postgraduate students whose courses include amedical statistics component.

Controversial Statistical Issues in Clinical Trials

Author : Shein-Chung Chow
Publisher : CRC Press
ISBN 13 : 1439849625
Total Pages : 598 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Controversial Statistical Issues in Clinical Trials by : Shein-Chung Chow

Download or read book Controversial Statistical Issues in Clinical Trials written by Shein-Chung Chow and published by CRC Press. This book was released on 2016-04-19 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: In clinical trial practice, controversial statistical issues inevitably occur regardless of the compliance with good statistical practice and good clinical practice. But by identifying the causes of the issues and correcting them, the study objectives of clinical trials can be better achieved. Controversial Statistical Issues in Clinical Trials cov

Numerical Issues in Statistical Computing for the Social Scientist

Author : Micah Altman
Publisher : John Wiley & Sons
ISBN 13 : 0471475742
Total Pages : 349 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Numerical Issues in Statistical Computing for the Social Scientist by : Micah Altman

Download or read book Numerical Issues in Statistical Computing for the Social Scientist written by Micah Altman and published by John Wiley & Sons. This book was released on 2004-02-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last—a social scientist's guide through the pitfalls of modern statistical computing Addressing the current deficiency in the literature on statistical methods as they apply to the social and behavioral sciences, Numerical Issues in Statistical Computing for the Social Scientist seeks to provide readers with a unique practical guidebook to the numerical methods underlying computerized statistical calculations specific to these fields. The authors demonstrate that knowledge of these numerical methods and how they are used in statistical packages is essential for making accurate inferences. With the aid of key contributors from both the social and behavioral sciences, the authors have assembled a rich set of interrelated chapters designed to guide empirical social scientists through the potential minefield of modern statistical computing. Uniquely accessible and abounding in modern-day tools, tricks, and advice, the text successfully bridges the gap between the current level of social science methodology and the more sophisticated technical coverage usually associated with the statistical field. Highlights include: A focus on problems occurring in maximum likelihood estimation Integrated examples of statistical computing (using software packages such as the SAS, Gauss, Splus, R, Stata, LIMDEP, SPSS, WinBUGS, and MATLAB®) A guide to choosing accurate statistical packages Discussions of a multitude of computationally intensive statistical approaches such as ecological inference, Markov chain Monte Carlo, and spatial regression analysis Emphasis on specific numerical problems, statistical procedures, and their applications in the field Replications and re-analysis of published social science research, using innovative numerical methods Key numerical estimation issues along with the means of avoiding common pitfalls A related Web site includes test data for use in demonstrating numerical problems, code for applying the original methods described in the book, and an online bibliography of Web resources for the statistical computation Designed as an independent research tool, a professional reference, or a classroom supplement, the book presents a well-thought-out treatment of a complex and multifaceted field.

Combining Information

Author :
Publisher : National Academies
ISBN 13 :
Total Pages : 234 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis Combining Information by :

Download or read book Combining Information written by and published by National Academies. This book was released on 1992-01-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistics Done Wrong

Author : Alex Reinhart
Publisher : No Starch Press
ISBN 13 : 1593276206
Total Pages : 177 pages
Book Rating : 4.5/5 (932 download)

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Book Synopsis Statistics Done Wrong by : Alex Reinhart

Download or read book Statistics Done Wrong written by Alex Reinhart and published by No Starch Press. This book was released on 2015-03-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific progress depends on good research, and good research needs good statistics. But statistical analysis is tricky to get right, even for the best and brightest of us. You'd be surprised how many scientists are doing it wrong. Statistics Done Wrong is a pithy, essential guide to statistical blunders in modern science that will show you how to keep your research blunder-free. You'll examine embarrassing errors and omissions in recent research, learn about the misconceptions and scientific politics that allow these mistakes to happen, and begin your quest to reform the way you and your peers do statistics. You'll find advice on: –Asking the right question, designing the right experiment, choosing the right statistical analysis, and sticking to the plan –How to think about p values, significance, insignificance, confidence intervals, and regression –Choosing the right sample size and avoiding false positives –Reporting your analysis and publishing your data and source code –Procedures to follow, precautions to take, and analytical software that can help Scientists: Read this concise, powerful guide to help you produce statistically sound research. Statisticians: Give this book to everyone you know. The first step toward statistics done right is Statistics Done Wrong.

Statistical Inference as Severe Testing

Author : Deborah G. Mayo
Publisher : Cambridge University Press
ISBN 13 : 1108563309
Total Pages : 503 pages
Book Rating : 4.1/5 (85 download)

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Book Synopsis Statistical Inference as Severe Testing by : Deborah G. Mayo

Download or read book Statistical Inference as Severe Testing written by Deborah G. Mayo and published by Cambridge University Press. This book was released on 2018-09-20 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mounting failures of replication in social and biological sciences give a new urgency to critically appraising proposed reforms. This book pulls back the cover on disagreements between experts charged with restoring integrity to science. It denies two pervasive views of the role of probability in inference: to assign degrees of belief, and to control error rates in a long run. If statistical consumers are unaware of assumptions behind rival evidence reforms, they can't scrutinize the consequences that affect them (in personalized medicine, psychology, etc.). The book sets sail with a simple tool: if little has been done to rule out flaws in inferring a claim, then it has not passed a severe test. Many methods advocated by data experts do not stand up to severe scrutiny and are in tension with successful strategies for blocking or accounting for cherry picking and selective reporting. Through a series of excursions and exhibits, the philosophy and history of inductive inference come alive. Philosophical tools are put to work to solve problems about science and pseudoscience, induction and falsification.

Statistical Issues in Machine Learning

Author : Carolin Strobl
Publisher : Cuvillier Verlag
ISBN 13 : 3867276617
Total Pages : 203 pages
Book Rating : 4.8/5 (672 download)

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Book Synopsis Statistical Issues in Machine Learning by : Carolin Strobl

Download or read book Statistical Issues in Machine Learning written by Carolin Strobl and published by Cuvillier Verlag. This book was released on 2008 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistical Issues in Allocating Funds by Formula

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309087104
Total Pages : 162 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Statistical Issues in Allocating Funds by Formula by : National Research Council

Download or read book Statistical Issues in Allocating Funds by Formula written by National Research Council and published by National Academies Press. This book was released on 2003-02-24 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2000, the federal government distributed over $260 billion of funding to state and local governments via 180 formula programs. These programs promote a wide spectrum of economic and social objectives, such as improving educational outcomes and increasing accessibility to medical care, and many are designed to compensate for differences in fiscal capacity that affect governments' abilities to address identified needs. Large amounts of state revenues are also distributed through formula allocation programs to counties, cities, and other jurisdictions. Statistical Issues in Allocating Funds by Formula identifies key issues concerning the design and use of these formulas and advances recommendations for improving the process. In addition to the more narrow issues relating to formula design and input data, the book discusses broader issues created by the interaction of the political process and the use of formulas to allocate funds. Statistical Issues in Allocating Funds by Formula is only up-to-date guide for policymakers who design fund allocation programs. Congress members who are crafting legislation for these programs and federal employees who are in charge of distributing the funds will find this book indispensable.

Statistical Issues in Allocating Federal Funds and Estimation of Local Government Finances

Author :
Publisher :
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Statistical Issues in Allocating Federal Funds and Estimation of Local Government Finances by :

Download or read book Statistical Issues in Allocating Federal Funds and Estimation of Local Government Finances written by and published by . This book was released on 1977 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistical Issues in Drug Research and Development

Author : Karl E. Peace
Publisher : CRC Press
ISBN 13 : 9780824782900
Total Pages : 390 pages
Book Rating : 4.7/5 (829 download)

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Book Synopsis Statistical Issues in Drug Research and Development by : Karl E. Peace

Download or read book Statistical Issues in Drug Research and Development written by Karl E. Peace and published by CRC Press. This book was released on 1989-12-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of topics addressed by the ASA Biopharmaceutical Section work groups, including the etiology and evolution of the work groups, the work group guidelines and structure, and the statistical issues associated with clinical trials in clinical drug development programs.

Statistical Software Engineering

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309176085
Total Pages : 83 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Statistical Software Engineering by : National Research Council

Download or read book Statistical Software Engineering written by National Research Council and published by National Academies Press. This book was released on 1996-03-15 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book identifies challenges and opportunities in the development and implementation of software that contain significant statistical content. While emphasizing the relevance of using rigorous statistical and probabilistic techniques in software engineering contexts, it presents opportunities for further research in the statistical sciences and their applications to software engineering. It is intended to motivate and attract new researchers from statistics and the mathematical sciences to attack relevant and pressing problems in the software engineering setting. It describes the "big picture," as this approach provides the context in which statistical methods must be developed. The book's survey nature is directed at the mathematical sciences audience, but software engineers should also find the statistical emphasis refreshing and stimulating. It is hoped that the book will have the effect of seeding the field of statistical software engineering by its indication of opportunities where statistical thinking can help to increase understanding, productivity, and quality of software and software production.

Statistical Analysis of Network Data

Author : Eric D. Kolaczyk
Publisher : Springer Science & Business Media
ISBN 13 : 0387881468
Total Pages : 397 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Statistical Analysis of Network Data by : Eric D. Kolaczyk

Download or read book Statistical Analysis of Network Data written by Eric D. Kolaczyk and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been an explosion of network data – that is, measu- ments that are either of or from a system conceptualized as a network – from se- ingly all corners of science. The combination of an increasingly pervasive interest in scienti c analysis at a systems level and the ever-growing capabilities for hi- throughput data collection in various elds has fueled this trend. Researchers from biology and bioinformatics to physics, from computer science to the information sciences, and from economics to sociology are more and more engaged in the c- lection and statistical analysis of data from a network-centric perspective. Accordingly, the contributions to statistical methods and modeling in this area have come from a similarly broad spectrum of areas, often independently of each other. Many books already have been written addressing network data and network problems in speci c individual disciplines. However, there is at present no single book that provides a modern treatment of a core body of knowledge for statistical analysis of network data that cuts across the various disciplines and is organized rather according to a statistical taxonomy of tasks and techniques. This book seeks to ll that gap and, as such, it aims to contribute to a growing trend in recent years to facilitate the exchange of knowledge across the pre-existing boundaries between those disciplines that play a role in what is coming to be called ‘network science.

Statistical Science in the Courtroom

Author : Joseph L. Gastwirth
Publisher : Springer Science & Business Media
ISBN 13 : 1461212162
Total Pages : 454 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Statistical Science in the Courtroom by : Joseph L. Gastwirth

Download or read book Statistical Science in the Courtroom written by Joseph L. Gastwirth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert testimony relying on scientific and other specialized evidence has come under increased scrutiny by the legal system. A trilogy of recent U.S. Supreme Court cases has assigned judges the task of assessing the relevance and reliability of proposed expert testimony. In conjunction with the Federal judiciary, the American Association for the Advancement of Science has initiated a project to provide judges indicating a need with their own expert. This concern with the proper interpretation of scientific evidence, especially that of a probabilistic nature, has also occurred in England, Australia and in several European countries. Statistical Science in the Courtroom is a collection of articles written by statisticians and legal scholars who have been concerned with problems arising in the use of statistical evidence. A number of articles describe DNA evidence and the difficulties of properly calculating the probability that a random individual's profile would "match" that of the evidence as well as the proper way to intrepret the result. In addition to the technical issues, several authors tell about their experiences in court. A few have become disenchanted with their involvement and describe the events that led them to devote less time to this application. Other articles describe the role of statistical evidence in cases concerning discrimination against minorities, product liability, environmental regulation, the appropriateness and fairness of sentences and how being involved in legal statistics has raised interesting statistical problems requiring further research.

The Statistical Analysis of Recurrent Events

Author : Richard J. Cook
Publisher : Springer Science & Business Media
ISBN 13 : 0387698094
Total Pages : 415 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis The Statistical Analysis of Recurrent Events by : Richard J. Cook

Download or read book The Statistical Analysis of Recurrent Events written by Richard J. Cook and published by Springer Science & Business Media. This book was released on 2007-08-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents models and statistical methods for the analysis of recurrent event data. The authors provide broad, detailed coverage of the major approaches to analysis, while emphasizing the modeling assumptions that they are based on. More general intensity-based models are also considered, as well as simpler models that focus on rate or mean functions. Parametric, nonparametric and semiparametric methodologies are all covered, with procedures for estimation, testing and model checking.

Statistical Topics and Stochastic Models for Dependent Data with Applications

Author : Vlad Stefan Barbu
Publisher : John Wiley & Sons
ISBN 13 : 1786306034
Total Pages : 288 pages
Book Rating : 4.7/5 (863 download)

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Book Synopsis Statistical Topics and Stochastic Models for Dependent Data with Applications by : Vlad Stefan Barbu

Download or read book Statistical Topics and Stochastic Models for Dependent Data with Applications written by Vlad Stefan Barbu and published by John Wiley & Sons. This book was released on 2020-12-03 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collective volume authored by leading scientists in the field of stochastic modelling, associated statistical topics and corresponding applications. The main classes of stochastic processes for dependent data investigated throughout this book are Markov, semi-Markov, autoregressive and piecewise deterministic Markov models. The material is divided into three parts corresponding to: (i) Markov and semi-Markov processes, (ii) autoregressive processes and (iii) techniques based on divergence measures and entropies. A special attention is payed to applications in reliability, survival analysis and related fields.

Statistical Evaluation of Diagnostic Performance

Author : Kelly H. Zou
Publisher : CRC Press
ISBN 13 : 1439812233
Total Pages : 243 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Statistical Evaluation of Diagnostic Performance by : Kelly H. Zou

Download or read book Statistical Evaluation of Diagnostic Performance written by Kelly H. Zou and published by CRC Press. This book was released on 2016-04-19 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are releva

An Introduction to Statistical Learning

Author : Gareth James
Publisher : Springer Nature
ISBN 13 : 3031387473
Total Pages : 617 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis An Introduction to Statistical Learning by : Gareth James

Download or read book An Introduction to Statistical Learning written by Gareth James and published by Springer Nature. This book was released on 2023-08-01 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Statistical Learning provides an accessible overview of the field of statistical learning, an essential toolset for making sense of the vast and complex data sets that have emerged in fields ranging from biology to finance, marketing, and astrophysics in the past twenty years. This book presents some of the most important modeling and prediction techniques, along with relevant applications. Topics include linear regression, classification, resampling methods, shrinkage approaches, tree-based methods, support vector machines, clustering, deep learning, survival analysis, multiple testing, and more. Color graphics and real-world examples are used to illustrate the methods presented. This book is targeted at statisticians and non-statisticians alike, who wish to use cutting-edge statistical learning techniques to analyze their data. Four of the authors co-wrote An Introduction to Statistical Learning, With Applications in R (ISLR), which has become a mainstay of undergraduate and graduate classrooms worldwide, as well as an important reference book for data scientists. One of the keys to its success was that each chapter contains a tutorial on implementing the analyses and methods presented in the R scientific computing environment. However, in recent years Python has become a popular language for data science, and there has been increasing demand for a Python-based alternative to ISLR. Hence, this book (ISLP) covers the same materials as ISLR but with labs implemented in Python. These labs will be useful both for Python novices, as well as experienced users.