Statistical Issues

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Statistical Issues in Drug Development

Author : Stephen S. Senn
Publisher : John Wiley & Sons
ISBN 13 : 9780470723579
Total Pages : 523 pages
Book Rating : 4.7/5 (235 download)

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Book Synopsis Statistical Issues in Drug Development by : Stephen S. Senn

Download or read book Statistical Issues in Drug Development written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents anessential and thought provoking guide to the statistical issues andcontroversies involved in drug development. This highly readable second edition has been updated toinclude: Comprehensive coverage of the design and interpretation ofclinical trials. Expanded sections on missing data, equivalence, meta-analysisand dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage ofpharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9,Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue betweenstatisticians and life scientists working within the pharmaceuticalindustry. The accessible and wide-ranging coverage make itessential reading for both statisticians and non-statisticiansworking in the pharmaceutical industry, regulatory bodies andmedical research institutes. There is also much to benefitundergraduate and postgraduate students whose courses include amedical statistics component.

Controversial Statistical Issues in Clinical Trials

Author : Shein-Chung Chow
Publisher : CRC Press
ISBN 13 : 1439849625
Total Pages : 598 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Controversial Statistical Issues in Clinical Trials by : Shein-Chung Chow

Download or read book Controversial Statistical Issues in Clinical Trials written by Shein-Chung Chow and published by CRC Press. This book was released on 2016-04-19 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: In clinical trial practice, controversial statistical issues inevitably occur regardless of the compliance with good statistical practice and good clinical practice. But by identifying the causes of the issues and correcting them, the study objectives of clinical trials can be better achieved. Controversial Statistical Issues in Clinical Trials cov

Numerical Issues in Statistical Computing for the Social Scientist

Author : Micah Altman
Publisher : John Wiley & Sons
ISBN 13 : 0471475742
Total Pages : 349 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Numerical Issues in Statistical Computing for the Social Scientist by : Micah Altman

Download or read book Numerical Issues in Statistical Computing for the Social Scientist written by Micah Altman and published by John Wiley & Sons. This book was released on 2004-02-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last—a social scientist's guide through the pitfalls of modern statistical computing Addressing the current deficiency in the literature on statistical methods as they apply to the social and behavioral sciences, Numerical Issues in Statistical Computing for the Social Scientist seeks to provide readers with a unique practical guidebook to the numerical methods underlying computerized statistical calculations specific to these fields. The authors demonstrate that knowledge of these numerical methods and how they are used in statistical packages is essential for making accurate inferences. With the aid of key contributors from both the social and behavioral sciences, the authors have assembled a rich set of interrelated chapters designed to guide empirical social scientists through the potential minefield of modern statistical computing. Uniquely accessible and abounding in modern-day tools, tricks, and advice, the text successfully bridges the gap between the current level of social science methodology and the more sophisticated technical coverage usually associated with the statistical field. Highlights include: A focus on problems occurring in maximum likelihood estimation Integrated examples of statistical computing (using software packages such as the SAS, Gauss, Splus, R, Stata, LIMDEP, SPSS, WinBUGS, and MATLAB®) A guide to choosing accurate statistical packages Discussions of a multitude of computationally intensive statistical approaches such as ecological inference, Markov chain Monte Carlo, and spatial regression analysis Emphasis on specific numerical problems, statistical procedures, and their applications in the field Replications and re-analysis of published social science research, using innovative numerical methods Key numerical estimation issues along with the means of avoiding common pitfalls A related Web site includes test data for use in demonstrating numerical problems, code for applying the original methods described in the book, and an online bibliography of Web resources for the statistical computation Designed as an independent research tool, a professional reference, or a classroom supplement, the book presents a well-thought-out treatment of a complex and multifaceted field.

Statistical Issues in Drug Development

Author : Stephen S. Senn
Publisher : John Wiley & Sons
ISBN 13 : 1119238579
Total Pages : 84 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Statistical Issues in Drug Development by : Stephen S. Senn

Download or read book Statistical Issues in Drug Development written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2021-08-23 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Issues in Drug Development The revised third edition of Statistical Issues in Drug Development delivers an insightful treatment of the intersection between statistics and the life sciences. The book offers readers new discussions of crucial topics, including cluster randomization, historical controls, responder analysis, studies in children, post-hoc tests, estimands, publication bias, the replication crisis, and many more. This work presents the major statistical issues in drug development in a way that is accessible and comprehensible to life scientists working in the field, and takes pains not to gloss over significant disagreements in the field of statistics, while encouraging communication between the statistical and life sciences disciplines. In addition to new material on topics like invalid inversion, severity, random effects in network meta-analysis, and explained variation, readers will benefit from the inclusion of: A thorough introduction to basic topics in drug development and statistics, including the role played by statistics in drug development An exploration of the four views of statistics in drug development, including the historical, methodological, technical, and professional An examination of debatable and controversial topics in drug development, including the allocation of treatments to patients in clinical trials, baselines and covariate information, and the measurement of treatment effects Perfect for life scientists and other professionals working in the field of drug development, Statistical Issues in Drug Development is the ideal resource for anyone seeking a one-stop reference to enhance their understanding of the use of statistics during drug development.

Combining Information

Author :
Publisher : National Academies
ISBN 13 :
Total Pages : 234 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis Combining Information by :

Download or read book Combining Information written by and published by National Academies. This book was released on 1992-01-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistics Done Wrong

Author : Alex Reinhart
Publisher : No Starch Press
ISBN 13 : 1593276737
Total Pages : 177 pages
Book Rating : 4.5/5 (932 download)

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Book Synopsis Statistics Done Wrong by : Alex Reinhart

Download or read book Statistics Done Wrong written by Alex Reinhart and published by No Starch Press. This book was released on 2015-03-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific progress depends on good research, and good research needs good statistics. But statistical analysis is tricky to get right, even for the best and brightest of us. You'd be surprised how many scientists are doing it wrong. Statistics Done Wrong is a pithy, essential guide to statistical blunders in modern science that will show you how to keep your research blunder-free. You'll examine embarrassing errors and omissions in recent research, learn about the misconceptions and scientific politics that allow these mistakes to happen, and begin your quest to reform the way you and your peers do statistics. You'll find advice on: –Asking the right question, designing the right experiment, choosing the right statistical analysis, and sticking to the plan –How to think about p values, significance, insignificance, confidence intervals, and regression –Choosing the right sample size and avoiding false positives –Reporting your analysis and publishing your data and source code –Procedures to follow, precautions to take, and analytical software that can help Scientists: Read this concise, powerful guide to help you produce statistically sound research. Statisticians: Give this book to everyone you know. The first step toward statistics done right is Statistics Done Wrong.

Statistical Science in the Courtroom

Author : Joseph L. Gastwirth
Publisher : Springer Science & Business Media
ISBN 13 : 1461212162
Total Pages : 454 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Statistical Science in the Courtroom by : Joseph L. Gastwirth

Download or read book Statistical Science in the Courtroom written by Joseph L. Gastwirth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert testimony relying on scientific and other specialized evidence has come under increased scrutiny by the legal system. A trilogy of recent U.S. Supreme Court cases has assigned judges the task of assessing the relevance and reliability of proposed expert testimony. In conjunction with the Federal judiciary, the American Association for the Advancement of Science has initiated a project to provide judges indicating a need with their own expert. This concern with the proper interpretation of scientific evidence, especially that of a probabilistic nature, has also occurred in England, Australia and in several European countries. Statistical Science in the Courtroom is a collection of articles written by statisticians and legal scholars who have been concerned with problems arising in the use of statistical evidence. A number of articles describe DNA evidence and the difficulties of properly calculating the probability that a random individual's profile would "match" that of the evidence as well as the proper way to intrepret the result. In addition to the technical issues, several authors tell about their experiences in court. A few have become disenchanted with their involvement and describe the events that led them to devote less time to this application. Other articles describe the role of statistical evidence in cases concerning discrimination against minorities, product liability, environmental regulation, the appropriateness and fairness of sentences and how being involved in legal statistics has raised interesting statistical problems requiring further research.

Statistical Inference as Severe Testing

Author : Deborah G. Mayo
Publisher : Cambridge University Press
ISBN 13 : 1108563309
Total Pages : 503 pages
Book Rating : 4.1/5 (85 download)

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Book Synopsis Statistical Inference as Severe Testing by : Deborah G. Mayo

Download or read book Statistical Inference as Severe Testing written by Deborah G. Mayo and published by Cambridge University Press. This book was released on 2018-09-20 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mounting failures of replication in social and biological sciences give a new urgency to critically appraising proposed reforms. This book pulls back the cover on disagreements between experts charged with restoring integrity to science. It denies two pervasive views of the role of probability in inference: to assign degrees of belief, and to control error rates in a long run. If statistical consumers are unaware of assumptions behind rival evidence reforms, they can't scrutinize the consequences that affect them (in personalized medicine, psychology, etc.). The book sets sail with a simple tool: if little has been done to rule out flaws in inferring a claim, then it has not passed a severe test. Many methods advocated by data experts do not stand up to severe scrutiny and are in tension with successful strategies for blocking or accounting for cherry picking and selective reporting. Through a series of excursions and exhibits, the philosophy and history of inductive inference come alive. Philosophical tools are put to work to solve problems about science and pseudoscience, induction and falsification.

Statistical Issues in Allocating Funds by Formula

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309087104
Total Pages : 162 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Statistical Issues in Allocating Funds by Formula by : National Research Council

Download or read book Statistical Issues in Allocating Funds by Formula written by National Research Council and published by National Academies Press. This book was released on 2003-02-24 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2000, the federal government distributed over $260 billion of funding to state and local governments via 180 formula programs. These programs promote a wide spectrum of economic and social objectives, such as improving educational outcomes and increasing accessibility to medical care, and many are designed to compensate for differences in fiscal capacity that affect governments' abilities to address identified needs. Large amounts of state revenues are also distributed through formula allocation programs to counties, cities, and other jurisdictions. Statistical Issues in Allocating Funds by Formula identifies key issues concerning the design and use of these formulas and advances recommendations for improving the process. In addition to the more narrow issues relating to formula design and input data, the book discusses broader issues created by the interaction of the political process and the use of formulas to allocate funds. Statistical Issues in Allocating Funds by Formula is only up-to-date guide for policymakers who design fund allocation programs. Congress members who are crafting legislation for these programs and federal employees who are in charge of distributing the funds will find this book indispensable.

Statistical Issues in Drug Research and Development

Author : Karl E. Peace
Publisher : CRC Press
ISBN 13 : 9780824782900
Total Pages : 390 pages
Book Rating : 4.7/5 (829 download)

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Book Synopsis Statistical Issues in Drug Research and Development by : Karl E. Peace

Download or read book Statistical Issues in Drug Research and Development written by Karl E. Peace and published by CRC Press. This book was released on 1989-12-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of topics addressed by the ASA Biopharmaceutical Section work groups, including the etiology and evolution of the work groups, the work group guidelines and structure, and the statistical issues associated with clinical trials in clinical drug development programs.

Statistical Issues in Allocating Federal Funds and Estimation of Local Government Finances

Author :
Publisher :
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Statistical Issues in Allocating Federal Funds and Estimation of Local Government Finances by :

Download or read book Statistical Issues in Allocating Federal Funds and Estimation of Local Government Finances written by and published by . This book was released on 1977 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistical Issues in Machine Learning

Author : Carolin Strobl
Publisher : Cuvillier Verlag
ISBN 13 : 3867276617
Total Pages : 203 pages
Book Rating : 4.8/5 (672 download)

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Book Synopsis Statistical Issues in Machine Learning by : Carolin Strobl

Download or read book Statistical Issues in Machine Learning written by Carolin Strobl and published by Cuvillier Verlag. This book was released on 2008 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistical Modeling and Analysis for Complex Data Problems

Author : Pierre Duchesne
Publisher : Springer Science & Business Media
ISBN 13 : 0387245553
Total Pages : 330 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Statistical Modeling and Analysis for Complex Data Problems by : Pierre Duchesne

Download or read book Statistical Modeling and Analysis for Complex Data Problems written by Pierre Duchesne and published by Springer Science & Business Media. This book was released on 2005-12-05 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews some of today’s more complex problems, and reflects some of the important research directions in the field. Twenty-nine authors – largely from Montreal’s GERAD Multi-University Research Center and who work in areas of theoretical statistics, applied statistics, probability theory, and stochastic processes – present survey chapters on various theoretical and applied problems of importance and interest to researchers and students across a number of academic domains.

Assessment

Author : Harvey Goldstein
Publisher : Wiley
ISBN 13 : 9780471956686
Total Pages : 286 pages
Book Rating : 4.9/5 (566 download)

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Book Synopsis Assessment by : Harvey Goldstein

Download or read book Assessment written by Harvey Goldstein and published by Wiley. This book was released on 1996-08-16 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent books in the Wiley Series in Probability and Statistics Editors Vic Barnett J. Stuart Hunter David W. Scott Geoffrey S. Watson Ralph A. Bradley Joseph B. Kadane Adrian F.M. Smith Nicholas I. Fisher David G. Kendall Jozef L. Teugels Stochastic Geometry and Its Applications Second Edition Dietrich Stoyan, TU Bergakademie Freiberg, Germany Wilfrid S. Kendall, University of Warwick, UK Joseph Mecke, Friedrich-Schiller-Universitat Jena, Germany This standard text makes the results and methods of stochastic geometry and spatial statistics accessible to practitioners and non-theoreticians. The book is also ideal as an introduction to the subject for mathematicians. The exposition is mathematically precise and takes into account the latest results, but in many cases proofs are omitted. Topics covered include the basic theories of point processes, random sets, fibre and surface processes, random tessellations, stereology and the statistical theory of shape. The theory is illustrated by many examples drawn from different branches of science; actual data in the form of images are presented, and their statistical analysis is discussed. As well as being of great interest to statisticians, this treatment of the subject has proved useful to applied scientists working in fields such as geology, biology, microscopy and materials science, and to pure mathematicians working in geometry. 1995 Bayesian Analysis in Statistics and Econometrics. Essays in Honor of Arnold Zellner Donald A. Berry, Duke University Kathryn M. Chaloner, University of Minnesota John K. Geweke, University of Minnesota This volume affords students and professionals in statistics, econometrics, and other fields of statistical applications a unique opportunity to acquaint themselves with important current and future trends in Bayesian analytical theory and practice. Over the course of forty-eight chapters, more than one hundred authors from around the world explore a vast array of practical and theoretical issues. Topics covered include inference, estimation, prediction, regression, linear model, multivariate analysis, model selection and computation. This is a valuable working resource for statisticians, economists, and all those with a professional interest in the Bayesian approach. 1996

The Statistical Analysis of Recurrent Events

Author : Richard J. Cook
Publisher : Springer Science & Business Media
ISBN 13 : 0387698094
Total Pages : 415 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis The Statistical Analysis of Recurrent Events by : Richard J. Cook

Download or read book The Statistical Analysis of Recurrent Events written by Richard J. Cook and published by Springer Science & Business Media. This book was released on 2007-08-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents models and statistical methods for the analysis of recurrent event data. The authors provide broad, detailed coverage of the major approaches to analysis, while emphasizing the modeling assumptions that they are based on. More general intensity-based models are also considered, as well as simpler models that focus on rate or mean functions. Parametric, nonparametric and semiparametric methodologies are all covered, with procedures for estimation, testing and model checking.

Statistical Decision Problems

Author : Michael Zabarankin
Publisher : Springer Science & Business Media
ISBN 13 : 1461484715
Total Pages : 254 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Statistical Decision Problems by : Michael Zabarankin

Download or read book Statistical Decision Problems written by Michael Zabarankin and published by Springer Science & Business Media. This book was released on 2013-12-16 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Decision Problems presents a quick and concise introduction into the theory of risk, deviation and error measures that play a key role in statistical decision problems. It introduces state-of-the-art practical decision making through twenty-one case studies from real-life applications. The case studies cover a broad area of topics and the authors include links with source code and data, a very helpful tool for the reader. In its core, the text demonstrates how to use different factors to formulate statistical decision problems arising in various risk management applications, such as optimal hedging, portfolio optimization, cash flow matching, classification, and more. The presentation is organized into three parts: selected concepts of statistical decision theory, statistical decision problems, and case studies with portfolio safeguard. The text is primarily aimed at practitioners in the areas of risk management, decision making, and statistics. However, the inclusion of a fair bit of mathematical rigor renders this monograph an excellent introduction to the theory of general error, deviation, and risk measures for graduate students. It can be used as supplementary reading for graduate courses including statistical analysis, data mining, stochastic programming, financial engineering, to name a few. The high level of detail may serve useful to applied mathematicians, engineers, and statisticians interested in modeling and managing risk in various applications.

Statistical Analysis of Network Data

Author : Eric D. Kolaczyk
Publisher : Springer Science & Business Media
ISBN 13 : 0387881468
Total Pages : 397 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Statistical Analysis of Network Data by : Eric D. Kolaczyk

Download or read book Statistical Analysis of Network Data written by Eric D. Kolaczyk and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been an explosion of network data – that is, measu- ments that are either of or from a system conceptualized as a network – from se- ingly all corners of science. The combination of an increasingly pervasive interest in scienti c analysis at a systems level and the ever-growing capabilities for hi- throughput data collection in various elds has fueled this trend. Researchers from biology and bioinformatics to physics, from computer science to the information sciences, and from economics to sociology are more and more engaged in the c- lection and statistical analysis of data from a network-centric perspective. Accordingly, the contributions to statistical methods and modeling in this area have come from a similarly broad spectrum of areas, often independently of each other. Many books already have been written addressing network data and network problems in speci c individual disciplines. However, there is at present no single book that provides a modern treatment of a core body of knowledge for statistical analysis of network data that cuts across the various disciplines and is organized rather according to a statistical taxonomy of tasks and techniques. This book seeks to ll that gap and, as such, it aims to contribute to a growing trend in recent years to facilitate the exchange of knowledge across the pre-existing boundaries between those disciplines that play a role in what is coming to be called ‘network science.