Statistical Evaluation Of Diagnostic Performance

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Statistical Evaluation of Diagnostic Performance

Author : Kelly H. Zou
Publisher : CRC Press
ISBN 13 : 1439812233
Total Pages : 245 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Statistical Evaluation of Diagnostic Performance by : Kelly H. Zou

Download or read book Statistical Evaluation of Diagnostic Performance written by Kelly H. Zou and published by CRC Press. This book was released on 2016-04-19 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are relevant to a wide variety of applications, including medical imaging, cancer research, epidemiology, and bioinformatics. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis covers areas including monotone-transformation techniques in parametric ROC analysis, ROC methods for combined and pooled biomarkers, Bayesian hierarchical transformation models, sequential designs and inferences in the ROC setting, predictive modeling, multireader ROC analysis, and free-response ROC (FROC) methodology. The book is suitable for graduate-level students and researchers in statistics, biostatistics, epidemiology, public health, biomedical engineering, radiology, medical imaging, biomedical informatics, and other closely related fields. Additionally, clinical researchers and practicing statisticians in academia, industry, and government could benefit from the presentation of such important and yet frequently overlooked topics.

Saving Women's Lives

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309165946
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Saving Women's Lives by : National Research Council

Download or read book Saving Women's Lives written by National Research Council and published by National Academies Press. This book was released on 2005-03-18 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.

Assessment of Diagnostic Technology in Health Care

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030904099X
Total Pages : 152 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Assessment of Diagnostic Technology in Health Care by : Institute of Medicine

Download or read book Assessment of Diagnostic Technology in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 1989-02-01 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technology assessment can lead to the rapid application of essential diagnostic technologies and prevent the wide diffusion of marginally useful methods. In both of these ways, it can increase quality of care and decrease the cost of health care. This comprehensive monograph carefully explores methods of and barriers to diagnostic technology assessment and describes both the rationale and the guidelines for meaningful evaluation. While proposing a multi-institutional approach, it emphasizes some of the problems involved and defines a mechanism for improving the evaluation and use of medical technology and essential resources needed to enhance patient care.

The Statistical Evaluation of Medical Tests for Classification and Prediction

Author : Margaret Sullivan Pepe
Publisher : OUP Oxford
ISBN 13 : 019158861X
Total Pages : 319 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis The Statistical Evaluation of Medical Tests for Classification and Prediction by : Margaret Sullivan Pepe

Download or read book The Statistical Evaluation of Medical Tests for Classification and Prediction written by Margaret Sullivan Pepe and published by OUP Oxford. This book was released on 2003-03-13 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes statistical techniques for the design and evaluation of research studies on medical diagnostic tests, screening tests, biomarkers and new technologies for classification and prediction in medicine.

Diagnostic Meta-Analysis

Author : Giuseppe Biondi-Zoccai
Publisher : Springer
ISBN 13 : 331978966X
Total Pages : 319 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Diagnostic Meta-Analysis by : Giuseppe Biondi-Zoccai

Download or read book Diagnostic Meta-Analysis written by Giuseppe Biondi-Zoccai and published by Springer. This book was released on 2018-07-24 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first exclusively devoted to the systematic synthesis of diagnostic test accuracy studies. It builds upon the major recent developments in reporting standards, search methods, and, in particular, statistical tools specifically devoted to diagnostic studies. In addition, it borrows extensively from the latest advances in systematic reviews and meta-analyses of intervention studies. After a section dedicated to methods for designing reviews, synthesizing evidence and appraising inconsistency in research, the application of these approaches is demonstrated in the context of case studies from various clinical disciplines. Diagnosis is central in medical decision-making, and in many other fields of human endeavor, such as education and psychology. The plurality of sources of evidence on diagnostic test accuracy poses a huge challenge for practitioners and researchers, as do the multiple dimensions of evidence validity, which include sensitivity, specificity, predictive values, and likelihood ratios. This book offers an invaluable resource for anyone aiming to improve decision-making processes in diagnosis, classification or risk prognostication, from epidemiologists to biostatisticians, radiologists, laboratory physicians and graduate students, as any physician interested in refining his methodological skills in clinical diagnosis.

Statistical Methods in Diagnostic Medicine

Author : Xiao-Hua Zhou
Publisher : John Wiley & Sons
ISBN 13 : 1118626044
Total Pages : 592 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Statistical Methods in Diagnostic Medicine by : Xiao-Hua Zhou

Download or read book Statistical Methods in Diagnostic Medicine written by Xiao-Hua Zhou and published by John Wiley & Sons. This book was released on 2014-08-21 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition " . . . the book is a valuable addition to the literature in thefield, serving as a much-needed guide for both clinicians andadvanced students."—Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests inmedical research In recent years, a considerable amount of research has focusedon evolving methods for designing and analyzing diagnostic accuracystudies. Statistical Methods in Diagnostic Medicine, Second Editioncontinues to provide a comprehensive approach to the topic, guidingreaders through the necessary practices for understanding thesestudies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy andstudy design, the authors successfully define various measures ofdiagnostic accuracy, describe strategies for designing diagnosticaccuracy studies, and present key statistical methods forestimating and comparing test accuracy. Topics new to the SecondEdition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values andsample size calculations Correcting techniques for verification and imperfect standardbiases Sample size calculation for multiple reader studies when pilotdata are available Updated meta-analysis methods, now incorporating randomeffects Three case studies thoroughly showcase some of the questions andstatistical issues that arise in diagnostic medicine, with allassociated data provided in detailed appendices. A related web sitefeatures Fortran, SAS®, and R software packages so thatreaders can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is anexcellent supplement for biostatistics courses at the graduatelevel. It also serves as a valuable reference for clinicians andresearchers working in the fields of medicine, epidemiology, andbiostatistics.

Evaluation of diagnostic systems

Author : John Swets
Publisher : Elsevier
ISBN 13 : 0323141641
Total Pages : 270 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Evaluation of diagnostic systems by : John Swets

Download or read book Evaluation of diagnostic systems written by John Swets and published by Elsevier. This book was released on 2012-12-02 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluation of Diagnostic Systems: Methods from Signal Detection Theory addresses the many issues that arise in evaluating the performance of a diagnostic system, across the wide range of settings in which such systems are used. These settings include clinical medicine, industrial quality control, environmental monitoring and investigation, machine and metals inspection, military monitoring, information retrieval, and crime investigation. The book is divided into three parts encompassing 11 chapters that emphasize the interpretation of diagnostic visual images by human observers. The first part of the book describes quantitative methods for measuring the accuracy of a system and the statistical techniques for drawing inferences from performance tests. The subsequent part covers study design and includes a detailed description of the form and conduct of an image-interpretation test. The concluding part examines the case study of a medical imaging system that serves as an example of both simple and complex applications. In this part, three mammographic modalities are used: industrial film radiography, low-dose film radiography, and xeroradiography. The case study focuses on the overall reliability of accuracy indices made by its main components, that is, the variabilities across cases, across readers, and within individual readers. The supplementary texts provide study protocols, a computer program for processing test results, and an extensive list of references that will assist the reader in applying those evaluative methods to diagnostic systems in any setting. This book is of value to scientists and engineers, as well as to applied, quantitative, or experimental psychologists who are engaged in the study of the human processes of discrimination and decision making in either perceptual or cognitive tasks.

Improving Diagnosis in Health Care

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309377722
Total Pages : 473 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Improving Diagnosis in Health Care by : National Academies of Sciences, Engineering, and Medicine

Download or read book Improving Diagnosis in Health Care written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2015-12-29 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.

ROC Curves for Continuous Data

Author : Wojtek J. Krzanowski
Publisher : CRC Press
ISBN 13 : 9781439800225
Total Pages : 232 pages
Book Rating : 4.8/5 (2 download)

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Book Synopsis ROC Curves for Continuous Data by : Wojtek J. Krzanowski

Download or read book ROC Curves for Continuous Data written by Wojtek J. Krzanowski and published by CRC Press. This book was released on 2009-05-21 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since ROC curves have become ubiquitous in many application areas, the various advances have been scattered across disparate articles and texts. ROC Curves for Continuous Data is the first book solely devoted to the subject, bringing together all the relevant material to provide a clear understanding of how to analyze ROC curves. The fundamental theory of ROC curves The book first discusses the relationship between the ROC curve and numerous performance measures and then extends the theory into practice by describing how ROC curves are estimated. Further building on the theory, the authors present statistical tests for ROC curves and their summary statistics. They consider the impact of covariates on ROC curves, examine the important special problem of comparing two ROC curves, and cover Bayesian methods for ROC analysis. Special topics The text then moves on to extensions of the basic analysis to cope with more complex situations, such as the combination of multiple ROC curves and problems induced by the presence of more than two classes. Focusing on design and interpretation issues, it covers missing data, verification bias, sample size determination, the design of ROC studies, and the choice of optimum threshold from the ROC curve. The final chapter explores applications that not only illustrate some of the techniques but also demonstrate the very wide applicability of these techniques across different disciplines. With nearly 5,000 articles published to date relating to ROC analysis, the explosive interest in ROC curves and their analysis will continue in the foreseeable future. Embracing this growth of interest, this timely book will undoubtedly guide present and future users of ROC analysis.

Diagnostic Tests Toolkit

Author : Matthew Thompson
Publisher : John Wiley & Sons
ISBN 13 : 1119951801
Total Pages : 114 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Diagnostic Tests Toolkit by : Matthew Thompson

Download or read book Diagnostic Tests Toolkit written by Matthew Thompson and published by John Wiley & Sons. This book was released on 2011-09-29 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic Tests Toolkit Diagnostic Tests Toolkit Finding the evidence for diagnostic tests Establishing an evidence-based methodology to assess the effectiveness of diagnostic tests has posed problems for many years. Now that the framework is in place health professionals can find and appraise the evidence for themselves. With Diagnostic Tests Toolkit clinicians and junior researchers can interpret the evidence for the effectiveness of different types of diagnostic tests, or develop their own research using the successful ‘step-by-step’ format of the Toolkit series. Written by renowned clinical researchers, this is the first basic guide to evidence-based diagnosis. It is equally valuable to starters in clinical research and those needing a quick refresher on the core elements of evidence-based diagnosis.

Occupational Outlook Handbook

Author : United States. Bureau of Labor Statistics
Publisher :
ISBN 13 :
Total Pages : 740 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Occupational Outlook Handbook by : United States. Bureau of Labor Statistics

Download or read book Occupational Outlook Handbook written by United States. Bureau of Labor Statistics and published by . This book was released on 1957 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Diagnostic Classification Models

Author : Matthias von Davier
Publisher : Springer Nature
ISBN 13 : 3030055841
Total Pages : 656 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Handbook of Diagnostic Classification Models by : Matthias von Davier

Download or read book Handbook of Diagnostic Classification Models written by Matthias von Davier and published by Springer Nature. This book was released on 2019-10-11 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides an overview of major developments around diagnostic classification models (DCMs) with regard to modeling, estimation, model checking, scoring, and applications. It brings together not only the current state of the art, but also the theoretical background and models developed for diagnostic classification. The handbook also offers applications and special topics and practical guidelines how to plan and conduct research studies with the help of DCMs. Commonly used models in educational measurement and psychometrics typically assume a single latent trait or at best a small number of latent variables that are aimed at describing individual differences in observed behavior. While this allows simple rankings of test takers along one or a few dimensions, it does not provide a detailed picture of strengths and weaknesses when assessing complex cognitive skills. DCMs, on the other hand, allow the evaluation of test taker performance relative to a potentially large number of skill domains. Most diagnostic models provide a binary mastery/non-mastery classification for each of the assumed test taker attributes representing these skill domains. Attribute profiles can be used for formative decisions as well as for summative purposes, for example in a multiple cut-off procedure that requires mastery on at least a certain subset of skills. The number of DCMs discussed in the literature and applied to a variety of assessment data has been increasing over the past decades, and their appeal to researchers and practitioners alike continues to grow. These models have been used in English language assessment, international large scale assessments, and for feedback for practice exams in preparation of college admission testing, just to name a few. Nowadays, technology-based assessments provide increasingly rich data on a multitude of skills and allow collection of data with respect to multiple types of behaviors. Diagnostic models can be understood as an ideal match for these types of data collections to provide more in-depth information about test taker skills and behavioral tendencies.

Principles and Practice of Clinical Trials

Author : Steven Piantadosi
Publisher : Springer Nature
ISBN 13 : 3319526367
Total Pages : 2573 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Principles and Practice of Clinical Trials by : Steven Piantadosi

Download or read book Principles and Practice of Clinical Trials written by Steven Piantadosi and published by Springer Nature. This book was released on 2022-07-19 with total page 2573 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.

Finite Mixture Models

Author : Geoffrey McLachlan
Publisher : John Wiley & Sons
ISBN 13 : 047165406X
Total Pages : 419 pages
Book Rating : 4.4/5 (716 download)

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Book Synopsis Finite Mixture Models by : Geoffrey McLachlan

Download or read book Finite Mixture Models written by Geoffrey McLachlan and published by John Wiley & Sons. This book was released on 2004-03-22 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date, comprehensive account of major issues in finitemixture modeling This volume provides an up-to-date account of the theory andapplications of modeling via finite mixture distributions. With anemphasis on the applications of mixture models in both mainstreamanalysis and other areas such as unsupervised pattern recognition,speech recognition, and medical imaging, the book describes theformulations of the finite mixture approach, details itsmethodology, discusses aspects of its implementation, andillustrates its application in many common statisticalcontexts. Major issues discussed in this book include identifiabilityproblems, actual fitting of finite mixtures through use of the EMalgorithm, properties of the maximum likelihood estimators soobtained, assessment of the number of components to be used in themixture, and the applicability of asymptotic theory in providing abasis for the solutions to some of these problems. The author alsoconsiders how the EM algorithm can be scaled to handle the fittingof mixture models to very large databases, as in data miningapplications. This comprehensive, practical guide: * Provides more than 800 references-40% published since 1995 * Includes an appendix listing available mixture software * Links statistical literature with machine learning and patternrecognition literature * Contains more than 100 helpful graphs, charts, and tables Finite Mixture Models is an important resource for both applied andtheoretical statisticians as well as for researchers in the manyareas in which finite mixture models can be used to analyze data.

Clinical Prediction Models

Author : Ewout W. Steyerberg
Publisher : Springer
ISBN 13 : 3030163997
Total Pages : 558 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Clinical Prediction Models by : Ewout W. Steyerberg

Download or read book Clinical Prediction Models written by Ewout W. Steyerberg and published by Springer. This book was released on 2019-07-22 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this volume provides insight and practical illustrations on how modern statistical concepts and regression methods can be applied in medical prediction problems, including diagnostic and prognostic outcomes. Many advances have been made in statistical approaches towards outcome prediction, but a sensible strategy is needed for model development, validation, and updating, such that prediction models can better support medical practice. There is an increasing need for personalized evidence-based medicine that uses an individualized approach to medical decision-making. In this Big Data era, there is expanded access to large volumes of routinely collected data and an increased number of applications for prediction models, such as targeted early detection of disease and individualized approaches to diagnostic testing and treatment. Clinical Prediction Models presents a practical checklist that needs to be considered for development of a valid prediction model. Steps include preliminary considerations such as dealing with missing values; coding of predictors; selection of main effects and interactions for a multivariable model; estimation of model parameters with shrinkage methods and incorporation of external data; evaluation of performance and usefulness; internal validation; and presentation formatting. The text also addresses common issues that make prediction models suboptimal, such as small sample sizes, exaggerated claims, and poor generalizability. The text is primarily intended for clinical epidemiologists and biostatisticians. Including many case studies and publicly available R code and data sets, the book is also appropriate as a textbook for a graduate course on predictive modeling in diagnosis and prognosis. While practical in nature, the book also provides a philosophical perspective on data analysis in medicine that goes beyond predictive modeling. Updates to this new and expanded edition include: • A discussion of Big Data and its implications for the design of prediction models • Machine learning issues • More simulations with missing ‘y’ values • Extended discussion on between-cohort heterogeneity • Description of ShinyApp • Updated LASSO illustration • New case studies

The Evidence Base of Clinical Diagnosis

Author : J. Andre Knottnerus
Publisher : BMJ Books
ISBN 13 : 144430058X
Total Pages : 320 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis The Evidence Base of Clinical Diagnosis by : J. Andre Knottnerus

Download or read book The Evidence Base of Clinical Diagnosis written by J. Andre Knottnerus and published by BMJ Books. This book was released on 2009-01-26 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book presents a framework for the strategy and methodology of diagnostic research, in relation to its relevance for practice. Now in its second edition The Evidence Base of Clinical Diagnosis has been fully revised and extended with new chapters covering the STARD guidelines (STAndards for the Reporting of Diagnostic accuracy studies) and the multivariable analysis of diagnostic data. With contributions from leading international experts in evidence-based medicine, this book is an indispensable guide on how to conduct and interpret studies in clinical diagnosis. It will serve as a valuable resource for all investigators who want to embark on diagnostic research and for clinicians, practitioners and students who want to learn more about its principles and the relevant methodological options available.

Biostatistics for Radiologists

Author : Francesco Sardanelli
Publisher : Springer Science & Business Media
ISBN 13 : 8847011337
Total Pages : 244 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Biostatistics for Radiologists by : Francesco Sardanelli

Download or read book Biostatistics for Radiologists written by Francesco Sardanelli and published by Springer Science & Business Media. This book was released on 2009-03-31 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to present statistical problems and methods in a friendly way to radiologists, emphasizing statistical issues and methods most frequently used in radiological studies (e.g., nonparametric tests, analysis of intra- and interobserver reproducibility, comparison of sensitivity and specificity among different imaging modality, difference between clinical and screening application of diagnostic tests, ect.). The tests will be presented starting from a radiological "problem" and all examples of statistical methods applications will be "radiological".