Quasispecies From Theory To Experimental Systems

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Quasispecies: From Theory to Experimental Systems

Author : Esteban Domingo
Publisher : Springer
ISBN 13 : 3319238981
Total Pages : 357 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Quasispecies: From Theory to Experimental Systems by : Esteban Domingo

Download or read book Quasispecies: From Theory to Experimental Systems written by Esteban Domingo and published by Springer. This book was released on 2016-03-18 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

Virus as Populations

Author : Esteban Domingo
Publisher : Academic Press
ISBN 13 : 0128163321
Total Pages : 426 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Virus as Populations by : Esteban Domingo

Download or read book Virus as Populations written by Esteban Domingo and published by Academic Press. This book was released on 2019-11-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes

Origin and Evolution of Viruses

Author : Esteban Domingo
Publisher : Elsevier
ISBN 13 : 0080564968
Total Pages : 573 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Origin and Evolution of Viruses by : Esteban Domingo

Download or read book Origin and Evolution of Viruses written by Esteban Domingo and published by Elsevier. This book was released on 2008-06-23 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts

Quasispecies and RNA Virus Evolution

Author : Esteban Domingo
Publisher :
ISBN 13 : 9781587060106
Total Pages : 188 pages
Book Rating : 4.0/5 (61 download)

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Book Synopsis Quasispecies and RNA Virus Evolution by : Esteban Domingo

Download or read book Quasispecies and RNA Virus Evolution written by Esteban Domingo and published by . This book was released on 2001 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Quasispecies: Concept and Implications for Virology

Author : Esteban Domingo
Publisher : Springer Science & Business Media
ISBN 13 : 3540263977
Total Pages : 413 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Quasispecies: Concept and Implications for Virology by : Esteban Domingo

Download or read book Quasispecies: Concept and Implications for Virology written by Esteban Domingo and published by Springer Science & Business Media. This book was released on 2006-02-19 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.

Advanced Mathematical Methods in Biosciences and Applications

Author : Faina Berezovskaya
Publisher : Springer Nature
ISBN 13 : 3030157156
Total Pages : 268 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Advanced Mathematical Methods in Biosciences and Applications by : Faina Berezovskaya

Download or read book Advanced Mathematical Methods in Biosciences and Applications written by Faina Berezovskaya and published by Springer Nature. This book was released on 2019-09-19 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring contributions from experts in mathematical biology and biomedical research, this edited volume covers a diverse set of topics on mathematical methods and applications in the biosciences. Topics focus on advanced mathematical methods, with chapters on the mathematical analysis of the quasispecies model, Arnold’s weak resonance equation, bifurcation analysis, and the Tonnelier-Gerstner model. Special emphasis is placed on applications such as natural selection, population heterogeneity, polyvariant ontogeny in plants, cancer dynamics, and analytical solutions for traveling pulses and wave trains in neural models. A survey on quasiperiodic topology is also presented in this book. Carefully peer-reviewed, this volume is suitable for students interested in interdisciplinary research. Researchers in applied mathematics and the biosciences will find this book an important resource on the latest developments in the field. In keeping with the STEAM-H series, the editors hope to inspire interdisciplinary understanding and collaboration.

The Evolution and Emergence of RNA Viruses

Author : Edward C. Holmes
Publisher : Oxford University Press
ISBN 13 : 0199211124
Total Pages : 267 pages
Book Rating : 4.1/5 (992 download)

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Book Synopsis The Evolution and Emergence of RNA Viruses by : Edward C. Holmes

Download or read book The Evolution and Emergence of RNA Viruses written by Edward C. Holmes and published by Oxford University Press. This book was released on 2009-06-25 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the study of viral evolution has developed rapidly in the last 30 years, little attention has been directed toward linking the mechanisms of viral evolution to the epidemiological outcomes of these processes. This book intends to fill this gap by considering the patterns and processes of viral evolution at all its spatial and temporal scales.

Systems Immunology

Author : Jayajit Das
Publisher : CRC Press
ISBN 13 : 1351646141
Total Pages : 405 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Systems Immunology by : Jayajit Das

Download or read book Systems Immunology written by Jayajit Das and published by CRC Press. This book was released on 2018-09-03 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.

Viruses: Essential Agents of Life

Author : Günther Witzany
Publisher : Springer Science & Business Media
ISBN 13 : 940074899X
Total Pages : 432 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Viruses: Essential Agents of Life by : Günther Witzany

Download or read book Viruses: Essential Agents of Life written by Günther Witzany and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.

Mathematical Models in the Biosciences II

Author : Michael Frame
Publisher : Yale University Press
ISBN 13 : 0300263791
Total Pages : 493 pages
Book Rating : 4.3/5 (2 download)

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Book Synopsis Mathematical Models in the Biosciences II by : Michael Frame

Download or read book Mathematical Models in the Biosciences II written by Michael Frame and published by Yale University Press. This book was released on 2021-10-12 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume Two of an award-winning professor’s introduction to essential concepts of calculus and mathematical modeling for students in the biosciences This is the second of a two-part series exploring essential concepts of calculus in the context of biological systems. Building on the essential ideas and theories of basic calculus taught in Mathematical Models in the Biosciences I, this book focuses on epidemiological models, mathematical foundations of virus and antiviral dynamics, ion channel models and cardiac arrhythmias, vector calculus and applications, and evolutionary models of disease. It also develops differential equations and stochastic models of many biomedical processes, as well as virus dynamics, the Clancy-Rudy model to determine the genetic basis of cardiac arrhythmias, and a sketch of some systems biology. Based on the author’s calculus class at Yale, the book makes concepts of calculus less abstract and more relatable for science majors and premedical students.

An Introduction to Computational Systems Biology

Author : Karthik Raman
Publisher : CRC Press
ISBN 13 : 0429944527
Total Pages : 359 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis An Introduction to Computational Systems Biology by : Karthik Raman

Download or read book An Introduction to Computational Systems Biology written by Karthik Raman and published by CRC Press. This book was released on 2021-05-30 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasises a hands-on approach to modelling Strong emphasis on coding and software tools for systems biology Covers the entire spectrum of modelling, from static networks, to dynamic models Thoughtful exercises to test and enable student understanding of concepts Current chapters on exciting new developments like whole-cell modelling and community modelling

Stochasticity in Processes

Author : Peter Schuster
Publisher : Springer
ISBN 13 : 3319395025
Total Pages : 728 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Stochasticity in Processes by : Peter Schuster

Download or read book Stochasticity in Processes written by Peter Schuster and published by Springer. This book was released on 2016-10-14 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has developed over the past fifteen years from a modern course on stochastic chemical kinetics for graduate students in physics, chemistry and biology. The first part presents a systematic collection of the mathematical background material needed to understand probability, statistics, and stochastic processes as a prerequisite for the increasingly challenging practical applications in chemistry and the life sciences examined in the second part. Recent advances in the development of new techniques and in the resolution of conventional experiments at nano-scales have been tremendous: today molecular spectroscopy can provide insights into processes down to scales at which current theories at the interface of physics, chemistry and the life sciences cannot be successful without a firm grasp of randomness and its sources. Routinely measured data is now sufficiently accurate to allow the direct recording of fluctuations. As a result, the sampling of data and the modeling of relevant processes are doomed to produce artifacts in interpretation unless the observer has a solid background in the mathematics of limited reproducibility. The material covered is presented in a modular approach, allowing more advanced sections to be skipped if the reader is primarily interested in applications. At the same time, most derivations of analytical solutions for the selected examples are provided in full length to guide more advanced readers in their attempts to derive solutions on their own. The book employs uniform notation throughout, and a glossary has been added to define the most important notions discussed.

The Computability of the World

Author : Bernd-Olaf Küppers
Publisher : Springer
ISBN 13 : 3319673696
Total Pages : 200 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis The Computability of the World by : Bernd-Olaf Küppers

Download or read book The Computability of the World written by Bernd-Olaf Küppers and published by Springer. This book was released on 2017-11-28 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thought-provoking book Küppers, an internationally renowned physicist, philosopher and theoretical biologist, addresses a number of science's deepest questions: Can physics advance to the origin of all things and explain the unique phenomena of life, time and history? Are there unsolvable enigmas of the world? How did life originate? Is language a general phenomenon of Nature? What is time? Is it possible to express the history of the world in formulae? Where is science leading us? These and other provocative questions essential for a deeper understanding of the world are treated here in a refreshing and stimulating manner.

Viral Fitness and Evolution

Author : Esteban Domingo
Publisher : Springer Nature
ISBN 13 : 3031156404
Total Pages : 350 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Viral Fitness and Evolution by : Esteban Domingo

Download or read book Viral Fitness and Evolution written by Esteban Domingo and published by Springer Nature. This book was released on 2023-01-02 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book unifies general concepts of plant and animal virus evolution and covers a broad range of topics related to theoretical and experimental aspects of virus population dynamics and viral fitness. Timely topics such as viral mechanisms to cope with antiviral agents, the adaptability of the virus to new hosts, emergence of new viral phenotypes, and the connections between short- and long-term virus evolution are included. By comparing plant and animal viruses, universal mechanisms responsible for fitness variations, viral emergence and disease mechanisms are explored. Although emphasis is put on specific plant and human viral pathogens, relevant similarities and differences to other viruses are highlighted. Additionally, readers will learn more about the adaptability of coronaviruses, including the recently emerged SARS-CoV-2, the causative agent of the COVID-19 pandemic. The book is aimed at students and scientists interested in basic and applied aspects of plant and animal virus population dynamics and evolution.

The Language of Living Matter

Author : Bernd-Olaf Küppers
Publisher : Springer Nature
ISBN 13 : 3030803198
Total Pages : 525 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis The Language of Living Matter by : Bernd-Olaf Küppers

Download or read book The Language of Living Matter written by Bernd-Olaf Küppers and published by Springer Nature. This book was released on 2022-06-01 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, by an eminent scientist and philosopher, provides strong evidence for the claim that language is a general principle of Nature, rooted exclusively in physical and chemical laws. The author’s radical idea inevitably leads us to view the essence, origin and evolution of life in a completely new light. It shifts the coordinates of our scientific world-view in favor of an overarching concept of language that is able to bridge the gap between matter and mind. At the same time, it removes a blind spot in the Darwinian concept of evolution. To justify this far-reaching idea, the book takes a long and deep look at our scientific and philosophical thinking, at language as such, at science’s claim to truth, and at its methods, unity, limits and perspectives. These are the cornerstones structuring the book into six thematically self-contained chapters, rounded off by an epilogue that introduces the new topic of Nature’s semantics. The range of issues covered is a testimony to how progress in the life sciences is transforming the whole edifice of science, from physics to biology and beyond. The book is aimed at a broad academic and general readership; it requires no mathematical expertise.

The Quasispecies Equation and Classical Population Models

Author : Raphaël Cerf
Publisher : Springer Nature
ISBN 13 : 3031086635
Total Pages : 236 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis The Quasispecies Equation and Classical Population Models by : Raphaël Cerf

Download or read book The Quasispecies Equation and Classical Population Models written by Raphaël Cerf and published by Springer Nature. This book was released on 2022-08-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph studies a series of mathematical models of the evolution of a population under mutation and selection. Its starting point is the quasispecies equation, a general non-linear equation which describes the mutation-selection equilibrium in Manfred Eigen’s famous quasispecies model. A detailed analysis of this equation is given under the assumptions of finite genotype space, sharp peak landscape, and class-dependent fitness landscapes. Different probabilistic representation formulae are derived for its solution, involving classical combinatorial quantities like Stirling and Euler numbers. It is shown how quasispecies and error threshold phenomena emerge in finite population models, and full mathematical proofs are provided in the case of the Wright–Fisher model. Along the way, exact formulas are obtained for the quasispecies distribution in the long chain regime, on the sharp peak landscape and on class-dependent fitness landscapes. Finally, several other classical population models are analyzed, with a focus on their dynamical behavior and their links to the quasispecies equation. This book will be of interest to mathematicians and theoretical ecologists/biologists working with finite population models.

The Dark Matter of Childrens 'Fantastika' Literature

Author : Chloe Germaine
Publisher : Bloomsbury Publishing
ISBN 13 : 1350167029
Total Pages : 233 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis The Dark Matter of Childrens 'Fantastika' Literature by : Chloe Germaine

Download or read book The Dark Matter of Childrens 'Fantastika' Literature written by Chloe Germaine and published by Bloomsbury Publishing. This book was released on 2023-09-21 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the material turn in the humanities, this book brings perspectives from science and ecology into dialogue with children's fiction written and published in the UK and the USA in the 21st century. It develops the concept of entanglement, which originated in 20th-century quantum physics but has been applied to cultural critique, through a reading of Fantastika literature. Surveying a wide-ranging scope of literary texts, this book covers the gothic, fantasy, the Weird, and other forms of speculative fiction to argue that Fantastika positions entanglement as an ethical imperative that transforms our imaginative relationship with materiality. In so doing, it synthesizes perspectives from a similarly diverse range of areas, including ecology, physics, anthropology, and literary studies, to examine the storied matter of children's Fantastika as ground from which we might begin to imagine an as-yet-unrealised future that addresses the problems of our present.