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Polymyxin Antibiotics
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Book Synopsis Polymyxin Antibiotics by : Jian Li (Pharmacologist)
Download or read book Polymyxin Antibiotics written by Jian Li (Pharmacologist) and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research.
Book Synopsis Polymyxin Antibiotics: From Laboratory Bench to Bedside by : Jian Li
Download or read book Polymyxin Antibiotics: From Laboratory Bench to Bedside written by Jian Li and published by Springer. This book was released on 2019-08-30 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’.
Book Synopsis Polymyxin Antibiotics: From Laboratory Bench to Bedside by : Jian Li
Download or read book Polymyxin Antibiotics: From Laboratory Bench to Bedside written by Jian Li and published by Springer. This book was released on 2019-07-30 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’.
Book Synopsis Microbiology and Molecular Diagnosis in Pathology by : Audrey Wanger
Download or read book Microbiology and Molecular Diagnosis in Pathology written by Audrey Wanger and published by Elsevier. This book was released on 2017-06-13 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiology and Molecular Diagnosis in Pathology: A Comprehensive Review for Board Preparation, Certification and Clinical Practice reviews all aspects of microbiology and molecular diagnostics essential to successfully passing the American Board of Pathology exam. This review book will also serve as a first resource for residents who want to become familiar with the diagnostic aspects of microbiology and molecular methods, as well as a refresher course for practicing pathologists. Opening chapters discuss issues of laboratory management, including quality control, biosafety, regulations, and proper handling and reporting of laboratory specimens. Review chapters give a quick overview of specific clinical infections as well as different types of bacteria, viruses, fungal infections, and infections caused by parasites. Following these, coverage focuses on diagnostic tools and specific tests: media for clinical microbiology, specific stains and tests for microbial identifications, susceptibility testing and use of antimicrobial agents, tests for detecting antibodies, antigens, and microbial infections. Two final chapters offer overviews on molecular diagnostics principles and methods as well as the application of molecular diagnostics in clinical practice. Takes a practical and easy-to-read approach to understanding microbiology at an appropriate level for both board preparation as well as a professional refresher course Covers all important clinical information found in larger textbooks in a more succinct and easy-to-understand manner Covers essential concepts in microbiology in such a way that residents, fellows, and clinicians understand the methods and tests without having to become specialists in the field Offers a quick overview of specific clinical infections as well as different types of bacteria, viruses, fungal infections, and infections caused by parasites
Book Synopsis Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition by :
Download or read book Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Polymyxin Antibiotics in a compact format. The editors have built Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Polymyxin Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Antibiotic Discovery and Development by : Thomas J. Dougherty
Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Book Synopsis Polymyxin Antibiotics—Advances in Research and Application: 2012 Edition by :
Download or read book Polymyxin Antibiotics—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyxin Antibiotics—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Polymyxin Antibiotics in a compact format. The editors have built Polymyxin Antibiotics—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Polymyxin Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Polymyxin Antibiotics—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Antibiotics Manual by : David L. Schlossberg
Download or read book Antibiotics Manual written by David L. Schlossberg and published by John Wiley & Sons. This book was released on 2017-08-10 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive compendium of all commonly used antibiotics, including indications, side effects, dosage information, and drug/food interactions Antibiotics Manual: A Guide to Commonly Used Antimicrobials, Second Edition is a unique, user-friendly guide made for all who prescribe antibiotics. It’s the only book available that takes a 100% drug-listed approach to 200 of the most common antibiotics prescribed to patients each day. Presented in full color, it’s also a convenient reference for every clinician to consult once the decision to use a particular antibiotic has been reached. This edition of Antibiotics Manual includes newer antibiotics that have been released since the publication of the First Edition and updates prescribing information for the older antibiotics. This all-new Second Edition: Has a color-coded interior design which provides quick and easy point of care access for the user Includes 200 of the most commonly prescribed antibiotics, listed by both brand and generic names Features important recently-released antibiotics such as ceftaroline, tedizolid, and bedaquiline Antibiotics Manual: A Guide to Commonly Used Antimicrobials, Second Edition is a welcome book for physicians in all specialties of medicine who prescribe antibiotics. It is also a handy tool for pharmacists, nurses, nurse practitioners, and physician assistants who want more information on the drugs they administer.
Book Synopsis Oxford Handbook of Infectious Diseases and Microbiology by : Estée Török
Download or read book Oxford Handbook of Infectious Diseases and Microbiology written by Estée Török and published by Oxford University Press. This book was released on 2017 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook takes an integrated approach to both infectious disease and microbiology. Referenced to national frameworks and current legislation, it covers basic principles of bacteriology and virology, specific information on diseases and conditions, and material on 'hot topics' such as bioterrorism and preventative medicine.
Book Synopsis Mechanism of Action of Antieukaryotic and Antiviral Compounds by : Fred E. Hahn
Download or read book Mechanism of Action of Antieukaryotic and Antiviral Compounds written by Fred E. Hahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.
Download or read book ICU Protocols written by Rajesh Chawla and published by Springer Nature. This book was released on 2019-12-31 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this highly successful book includes up-to-date notes on the step-wise management of clinical emergencies encountered in everyday intensive care units (ICU). Each thoroughly revised chapter provides concise information for point-of-care treatment, making it a practical guide clinicians can refer to on a daily basis at work or while traveling, or just to expand their knowledge. Volume 1 of ICU Protocols covers topics in pulmonology, cardiology, neurology, gastroenterology, nephrology and infectious diseases. The endocrine and metobolic systems, oncology, trauma, toxicology, envenomation and thermodysregulation, obstetrics, and perioperative care are covered in the second volume of ICU Protocols. This two-volume book is a must-read for intensivists, critical care specialists, junior trainees and residents working in ICUs. It is also relevant as course material for workshops on critical care, and essential for all hospital-based libraries. “This book provides junior trainees with an introduction to the management of problems common to the critical care unit.” David J Dries, Doody’s Book Reviews, March, 2013, for the first edition of ICU Protocols.
Book Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan
Download or read book Synthesis of Best-Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
Book Synopsis Photonanotechnology for Therapeutics and Imaging by : Seok Ki Choi
Download or read book Photonanotechnology for Therapeutics and Imaging written by Seok Ki Choi and published by Elsevier. This book was released on 2020-02-14 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photonanotechnology for Therapeutics and Imaging surveys major concepts and recent advances in the use of photonanotechnology with nanomaterials reported in various interdisciplinary fields, including chemistry, materials science, biomedical engineering and biomedicine. This book discusses the impact of this technology on the advancement of therapeutic modalities and imaging methods in cancers, infectious diseases and other serious diseases. Photonanotechnology studies the design principle, application and development of photoactive nanomaterials. It applies light-controlled strategies for the development of nanotherapeutics, imaging agents and diagnostic nanodevices. Provides the latest information on photocontrolled drug delivery systems Details how photoactive nanomaterials are designed to release reactive oxygen species (ROS) for photodynamic therapy (PDT) Explains how photoactive nanomaterials have the ability to induce surface plasmonic heating for photothermal therapeutic (PTT) effects
Book Synopsis Core Topics in Cardiothoracic Critical Care by : Kamen Valchanov
Download or read book Core Topics in Cardiothoracic Critical Care written by Kamen Valchanov and published by Cambridge University Press. This book was released on 2018-07-05 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most patients with critical cardiac or thoracic conditions will at some stage pass through the cardiothoracic critical care unit. Critical care presents more complex clinical data than any other area of medicine. The new edition of Core Topics in Cardiothoracic Critical Care focuses on the latest practise in the management of patients in cardiothoracic intensive care. The practice of cardiothoracic critical care medicine is constantly evolving, and this new edition reflects the modernized learning styles for trainees. Each chapter includes key learning points as well as sample multiple choice questions and answers to assist in exam preparation. This edition also features updated chapters on ECMO, perioperative management of patients undergoing emergency cardiothoracic surgery, and advanced modes of organ support for patients. This text provides key knowledge in a concise and accessible manner for trainees, clinicians and consultants from specialities and disciplines such as cardiology and anaesthesia, and nursing and physiotherapy.
Book Synopsis Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods by : Sahra Kırmusaoğlu
Download or read book Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods written by Sahra Kırmusaoğlu and published by BoD – Books on Demand. This book was released on 2019-04-03 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: To prevent bacterial adherence, invasion and infection, antimicrobials such as antibiotics are being used and vastly researched nowdays. Several factors such as natural selection, mutations in genes, the presence of efflux pumps, impermeability of the cell wall, structural changes in enzymes and receptors, biofilm formation, and quorum sensing cause microorganisms to develop resistance against antimicrobials. Isolates that synthesize extended spectrum-β-lactamases (ESBL), induced β-lactamases (IBL), carbapenamases, metallo-β-lactamases (MBLs), and New Delhi metallo-β-lactamases (NDM) have emerged. Determining virulence factors such as biofilms and the level of antimicrobial activities of antimicrobial agents alone and in combination with appropriate doses against microorganisms is very important for the diagnosis, inhibition, and prevention of microbial infection. The goal of this book is to provide information on all these topics.
Book Synopsis Antibiotic Pharmacodynamics by : John C. Rotschafer
Download or read book Antibiotic Pharmacodynamics written by John C. Rotschafer and published by Humana. This book was released on 2016-03-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.
Book Synopsis Antimicrobial Stewardship by : Céline Pulcini
Download or read book Antimicrobial Stewardship written by Céline Pulcini and published by Academic Press. This book was released on 2017-04-05 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial Stewardship (AMS), Volume Two includes the experience of ESGAP workshops and courses on antibiotic stewardship since 2012. It combines clinical and laboratory information about AMS, with a focus on human medicine. The ESCMID study group on antibiotic policies (ESGAP) is one of the most productive groups in the field, organizing courses and workshops. This book is an ideal tool for the participants of these workshops. With short chapters (around 1500 words) written on different topics, the authors insisted on the following points: A ‘hands on’, practical approach, tips to increase success, a description of the most common mistakes, a global picture (out- and inpatient settings, all countries) and a short list of 10-20 landmark references. Focuses on the most recent antimicrobial stewardship strategies Provides a detailed description of laboratory support Offers a balanced synthesis of basic and clinical sciences for each individual case, presenting clinical courses of the cases in parallel with the pathogenesis and detailed microbiological information for each infection Describes the prevalence and incidence of the global issues and current therapeutic approaches Presents the measures for infection control
