Synthesis Of Best Seller Drugs

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Synthesis of Best-Seller Drugs

Author : Ruben Vardanyan
Publisher : Academic Press
ISBN 13 : 0124115241
Total Pages : 868 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan

Download or read book Synthesis of Best-Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

The Art of Drug Synthesis

Author : Douglas S. Johnson
Publisher : John Wiley & Sons
ISBN 13 : 111867846X
Total Pages : 295 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis The Art of Drug Synthesis by : Douglas S. Johnson

Download or read book The Art of Drug Synthesis written by Douglas S. Johnson and published by John Wiley & Sons. This book was released on 2013-02-26 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Synthesis of Essential Drugs

Author : Ruben Vardanyan
Publisher : Elsevier
ISBN 13 : 9780080462127
Total Pages : 634 pages
Book Rating : 4.4/5 (621 download)

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Book Synopsis Synthesis of Essential Drugs by : Ruben Vardanyan

Download or read book Synthesis of Essential Drugs written by Ruben Vardanyan and published by Elsevier. This book was released on 2006-03-10 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references

An Introduction to Drug Synthesis

Author : Graham L. Patrick
Publisher : Oxford University Press, USA
ISBN 13 : 0198708432
Total Pages : 587 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis An Introduction to Drug Synthesis by : Graham L. Patrick

Download or read book An Introduction to Drug Synthesis written by Graham L. Patrick and published by Oxford University Press, USA. This book was released on 2015 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Contemporary Drug Synthesis

Author : Jie Jack Li
Publisher : John Wiley & Sons
ISBN 13 : 0471686735
Total Pages : 238 pages
Book Rating : 4.4/5 (716 download)

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Book Synopsis Contemporary Drug Synthesis by : Jie Jack Li

Download or read book Contemporary Drug Synthesis written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2004-12-27 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Pharmaceutical Process Chemistry for Synthesis

Author : Peter J. Harrington
Publisher : John Wiley & Sons
ISBN 13 : 0470922869
Total Pages : 815 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Pharmaceutical Process Chemistry for Synthesis by : Peter J. Harrington

Download or read book Pharmaceutical Process Chemistry for Synthesis written by Peter J. Harrington and published by John Wiley & Sons. This book was released on 2011-02-23 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

The Organic Chemistry of Drug Synthesis, Volume 7

Author : Daniel Lednicer
Publisher : John Wiley & Sons
ISBN 13 : 0470180668
Total Pages : 288 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis The Organic Chemistry of Drug Synthesis, Volume 7 by : Daniel Lednicer

Download or read book The Organic Chemistry of Drug Synthesis, Volume 7 written by Daniel Lednicer and published by John Wiley & Sons. This book was released on 2007-12-14 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

Top Drugs

Author : Jie Jack Li
Publisher : Oxford University Press
ISBN 13 : 0199362599
Total Pages : 240 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Top Drugs by : Jie Jack Li

Download or read book Top Drugs written by Jie Jack Li and published by Oxford University Press. This book was released on 2015-07-31 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.

Top Drugs

Author : John Saunders
Publisher :
ISBN 13 : 9780191848605
Total Pages : 91 pages
Book Rating : 4.8/5 (486 download)

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Book Synopsis Top Drugs by : John Saunders

Download or read book Top Drugs written by John Saunders and published by . This book was released on 2011 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of today's best selling drugs are first made in the chemical laboratory on a very small scale many years before they enter the market place. During the intervening period, organic chemists investigate alternative methods both to improve the overall yield of the process and to ensure that it operates safely on a manufacturing scale. This book describes how each drug works and then reviews the most efficient routes to their synthesis.

Innovative Drug Synthesis

Author : Jie Jack Li
Publisher : John Wiley & Sons
ISBN 13 : 1118820053
Total Pages : 358 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Innovative Drug Synthesis by : Jie Jack Li

Download or read book Innovative Drug Synthesis written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2015-12-14 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery

The Role of Natural Products in Drug Discovery

Author : J. Mulzer
Publisher : Springer Science & Business Media
ISBN 13 : 3662040425
Total Pages : 363 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis The Role of Natural Products in Drug Discovery by : J. Mulzer

Download or read book The Role of Natural Products in Drug Discovery written by J. Mulzer and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications

Author : Gouverneur Veronique
Publisher : World Scientific
ISBN 13 : 1908977892
Total Pages : 572 pages
Book Rating : 4.9/5 (89 download)

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Book Synopsis Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications by : Gouverneur Veronique

Download or read book Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications written by Gouverneur Veronique and published by World Scientific. This book was released on 2012-04-26 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging./a

Computational Drug Design

Author : D. C. Young
Publisher : John Wiley & Sons
ISBN 13 : 9780470451847
Total Pages : 344 pages
Book Rating : 4.4/5 (518 download)

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Book Synopsis Computational Drug Design by : D. C. Young

Download or read book Computational Drug Design written by D. C. Young and published by John Wiley & Sons. This book was released on 2009-01-28 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part One, The Drug Design Process, sets forth a variety of design processes suitable for a number of different drug development scenarios and drug targets. The author demonstrates how computational techniques are typically used during the design process, helping readers choose the best computational tools to meet their goals. Part Two, Computational Tools and Techniques, offers a series of chapters, each one dedicated to a single computational technique. Readers discover the strengths and weaknesses of each technique. Moreover, the book tabulates comparative accuracy studies, giving readers an unbiased comparison of all the available techniques. Part Three, Related Topics, addresses new, emerging, and complementary technologies, including bioinformatics, simulations at the cellular and organ level, synthesis route prediction, proteomics, and prodrug approaches. The book's accompanying CD-ROM, a special feature, offers graphics of the molecular structures and dynamic reactions discussed in the book as well as demos from computational drug design software companies. Computational Drug Design is ideal for both students and professionals in drug design, helping them choose and take full advantage of the best computational tools available. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

The Drug Book

Author : Michael C. Gerald
Publisher : Union Square + ORM
ISBN 13 : 1402792328
Total Pages : 882 pages
Book Rating : 4.4/5 (27 download)

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Book Synopsis The Drug Book by : Michael C. Gerald

Download or read book The Drug Book written by Michael C. Gerald and published by Union Square + ORM. This book was released on 2013-09-03 with total page 882 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A beautiful and well-researched historical guide to significant drugs” from the author of The Complete Idiot’s Guide to Prescription Drugs (Library Journal). Throughout history, humans everywhere have searched for remedies to heal our bodies and minds. Covering everything from ancient herbs to cutting-edge chemicals, this book in the hugely popular Milestones series looks at 250 of the most important moments in the development of life-altering, life-saving, and sometimes life-endangering pharmaceuticals. Illustrated entries feature ancient drugs like alcohol, opium, and hemlock; the smallpox and the polio vaccines; homeopathic cures; and controversial medical treatments like ether, amphetamines, and Xanax—while shining a light on the scientists, doctors, and companies who brought them to us. “These true tales of discovery in The Drug Book by Michael C. Gerald might change the way you think about your medicine.” —The Healthy “An excellent starting point for student researchers and is very browsable for the general reader.” —Booklist

Amphetamine Syntheses

Author : Otto Snow
Publisher :
ISBN 13 : 9780966312836
Total Pages : 0 pages
Book Rating : 4.3/5 (128 download)

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Book Synopsis Amphetamine Syntheses by : Otto Snow

Download or read book Amphetamine Syntheses written by Otto Snow and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bad Pharma

Author : Ben Goldacre
Publisher : Macmillan
ISBN 13 : 0865478066
Total Pages : 479 pages
Book Rating : 4.8/5 (654 download)

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Book Synopsis Bad Pharma by : Ben Goldacre

Download or read book Bad Pharma written by Ben Goldacre and published by Macmillan. This book was released on 2014-04 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Argues that doctors are deliberately misinformed by profit-seeking pharmaceutical companies that casually withhold information about drug efficacy and side effects, explaining the process of pharmaceutical data manipulation and its global consequences. By the best-selling author of Bad Science.

The $800 Million Pill

Author : Merrill Goozner
Publisher : Univ of California Press
ISBN 13 : 9780520246706
Total Pages : 308 pages
Book Rating : 4.2/5 (467 download)

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Book Synopsis The $800 Million Pill by : Merrill Goozner

Download or read book The $800 Million Pill written by Merrill Goozner and published by Univ of California Press. This book was released on 2005-10-10 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Goozner shows how drug innovation is driven by dedicated scientists intent on finding cures for diseases, not by pharmaceutical firms, whose bottom line often takes precedence over the advance of medicine. Stories of a university biochemist who spent twenty years searching for single blood protein that later became the best-selling biotech drug in the world, a government employee who discovered the causes for dozens of crippling genetic disorders, and the Department of Energy-funded research that made the Human Genome Project possible - these accounts illustrate how medical breakthroughs actually take place.".