Nano And Microparticle Induced Cell Death Inflammation And Immune Responses

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Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses

Author : Shrikant R. Mulay
Publisher : Frontiers Media SA
ISBN 13 : 2889459217
Total Pages : 242 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses by : Shrikant R. Mulay

Download or read book Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses written by Shrikant R. Mulay and published by Frontiers Media SA. This book was released on 2019-07-19 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano- and microparticles including crystals, synthetic biomaterials, misfolded proteins or environmental particulates are involved in a wide range of biological processes and diseases. They may present as intrinsic or environmental toxins but may also be applied intentionally, e.g. as immune adjuvants, drug carriers or ion exchangers. The discovery that a wide range of nano- and microparticles share the capacity to induce IL-1β secretion via activation of the NLRP3 inflammasome in dendritic cells and macrophages has led to the hypothesis that nano- and microparticles may contribute in a uniform mechanistic manner to different disease entities. Other molecular mechanisms triggered by a range nano- and microparticles have also recently been identified including (i) the induction of regulated necrosis; (ii) neutrophil extracellular trap (NET) formation and (iii) foreign body granuloma formation as a mechanism of persistent tissue inflammation and scarring. Research on the biology of nano- and microparticle handling is currently under intense investigation. The cell type-specific responses of nano- and microparticle exposure deserves careful attention as well as the related secondary responses to these particles that lead to tissue remodeling. The immune system is at the center of these processes in terms of particle clearance, particle-induced cell death and inflammation, thereby limiting particle-related inflammation and orchestrating wound healing responses. In this Research Topic, we welcomed the submission of Original Research, Review and Mini-Review articles that addressed the significance of the immune system in particle-induced cell death, inflammation and immune responses. These findings will help facilitate new approaches to the prevention and management of particle-related diseases.

Biomedical Nanomaterials

Author : Rostyslav S. Stoika
Publisher : Springer Nature
ISBN 13 : 3030762351
Total Pages : 324 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Biomedical Nanomaterials by : Rostyslav S. Stoika

Download or read book Biomedical Nanomaterials written by Rostyslav S. Stoika and published by Springer Nature. This book was released on 2021-09-11 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book characterizes how to design and synthesize nanomaterials of an organic and mineral nature. The book also discusses the visualization of developed nanomaterials and their bio-applications, as well as describes the biomedical effects and environmental impact of nanomaterials. This is an ideal book for students studying biomedicine or the life sciences, as well as researchers and professionals in medicine, environmental protection, biotechnology, agriculture, and the food industry. More specifically, this book addresses the important nanomaterials and nanobiotechnologies that are used in those fields in biomedicine and life sciences.

Toxicity of Nanomaterials

Author : Suresh C. Pillai
Publisher :
ISBN 13 : 9780429265471
Total Pages : 0 pages
Book Rating : 4.2/5 (654 download)

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Book Synopsis Toxicity of Nanomaterials by : Suresh C. Pillai

Download or read book Toxicity of Nanomaterials written by Suresh C. Pillai and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Choice Recommended Title, April 2020 This comprehensive book, edited by two leading experts in nanotechnology and bioengineering with contributions from a global team of specialists, provides a detailed overview of the environmental and health impacts associated with the toxicology of nanomaterials. Special attention is given to nanomaterial toxicity during synthesis, production and application, and chapters throughout are focused on key areas that are important for future research and development of nanomaterials. This book will be of interest to advanced students studying biomedical engineering and materials science, PhD researchers, post-docs and academics working in the area of nanotechnology, medicine, manufacturing and regulatory bodies. Features: Collates and critically evaluates various aspects of the toxicology of nanomaterials in one comprehensive text Discusses the various effects of nanocrystals including the morphologies on cytotoxicity, in addition to the environmental and cytotoxicity risks of graphene and 2D nanomaterials Explores practical methods of detection and quantification, with applications in the environmental and healthcare fields

Polymer Particles

Author : Masayoshi Okubo
Publisher : Springer Science & Business Media
ISBN 13 : 9783540229230
Total Pages : 388 pages
Book Rating : 4.2/5 (292 download)

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Book Synopsis Polymer Particles by : Masayoshi Okubo

Download or read book Polymer Particles written by Masayoshi Okubo and published by Springer Science & Business Media. This book was released on 2005-02-10 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this special volume on polymer particles, recent trends and developments in the synthesis of nano- to micron-sized polymer particles by radical polymerization (Emulsion, Miniemulsion, Microemulsion, and Dispersion Polymerizations) of vinyl monomers in environmentally friendly heterogeneous aqueous and supercritical carbon dioxide fluid media are reviewed by prominent worldwide researchers. In addition to the important challenges and possibilities with regards to design and preparation of functionalized polymer particles of controlled size, the topics described are of great current interest due to the increased awareness of environmental issues.

Marine Anthropogenic Litter

Author : Melanie Bergmann
Publisher : Springer
ISBN 13 : 3319165100
Total Pages : 456 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Marine Anthropogenic Litter by : Melanie Bergmann

Download or read book Marine Anthropogenic Litter written by Melanie Bergmann and published by Springer. This book was released on 2015-06-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how man-made litter, primarily plastic, has spread into the remotest parts of the oceans and covers all aspects of this pollution problem from the impacts on wildlife and human health to socio-economic and political issues. Marine litter is a prime threat to marine wildlife, habitats and food webs worldwide. The book illustrates how advanced technologies from deep-sea research, microbiology and mathematic modelling as well as classic beach litter counts by volunteers contributed to the broad awareness of marine litter as a problem of global significance. The authors summarise more than five decades of marine litter research, which receives growing attention after the recent discovery of great oceanic garbage patches and the ubiquity of microscopic plastic particles in marine organisms and habitats. In 16 chapters, authors from all over the world have created a universal view on the diverse field of marine litter pollution, the biological impacts, dedicated research activities, and the various national and international legislative efforts to combat this environmental problem. They recommend future research directions necessary for a comprehensive understanding of this environmental issue and the development of efficient management strategies. This book addresses scientists, and it provides a solid knowledge base for policy makers, NGOs, and the broader public.

Innate Immunity: Platelets and their Interaction with other Cellular Elements in Host Defense and Disease Pathogenesis

Author : Meganathan Kannan
Publisher : Frontiers Media SA
ISBN 13 : 283253872X
Total Pages : 133 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Innate Immunity: Platelets and their Interaction with other Cellular Elements in Host Defense and Disease Pathogenesis by : Meganathan Kannan

Download or read book Innate Immunity: Platelets and their Interaction with other Cellular Elements in Host Defense and Disease Pathogenesis written by Meganathan Kannan and published by Frontiers Media SA. This book was released on 2023-11-08 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomedical Nanomaterials

Author : Rostyslav S. Stoika
Publisher : Springer
ISBN 13 : 9783030762377
Total Pages : 0 pages
Book Rating : 4.7/5 (623 download)

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Book Synopsis Biomedical Nanomaterials by : Rostyslav S. Stoika

Download or read book Biomedical Nanomaterials written by Rostyslav S. Stoika and published by Springer. This book was released on 2022-09-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book characterizes how to design and synthesize nanomaterials of an organic and mineral nature. The book also discusses the visualization of developed nanomaterials and their bio-applications, as well as describes the biomedical effects and environmental impact of nanomaterials. This is an ideal book for students studying biomedicine or the life sciences, as well as researchers and professionals in medicine, environmental protection, biotechnology, agriculture, and the food industry. More specifically, this book addresses the important nanomaterials and nanobiotechnologies that are used in those fields in biomedicine and life sciences.

Mucosal Vaccines

Author : Hiroshi Kiyono
Publisher : Elsevier
ISBN 13 : 0080537057
Total Pages : 501 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Mucosal Vaccines by : Hiroshi Kiyono

Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization

Nanoscience and Nanotechnology for Human Health

Author : Bert Müller
Publisher : John Wiley & Sons
ISBN 13 : 3527338608
Total Pages : 416 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Nanoscience and Nanotechnology for Human Health by : Bert Müller

Download or read book Nanoscience and Nanotechnology for Human Health written by Bert Müller and published by John Wiley & Sons. This book was released on 2017-04-10 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique in combining the expertise of practitioners from university hospitals and that of academic researchers, this timely monograph presents selected topics catering specifically to the needs and interests of natural scientists and engineers as well as physicians who are concerned with developing nanotechnology-based treatments to improve human health. To this end, the book cover the materials aspects of nanomedicine, such as the hierarchical structure of biological materials, the imaging of hard and soft tissues and, in particular, concrete examples of nanotechnology-based approaches in modern medical treatments. The whole is rounded off by a discussion of the opportunities and risks of using nanotechnology and nanomaterials in medicine, backed by case studies taken from real life.

Micro- and Nanotechnology in Vaccine Development

Author : Mariusz Skwarczynski
Publisher : William Andrew
ISBN 13 : 0323400299
Total Pages : 462 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Micro- and Nanotechnology in Vaccine Development by : Mariusz Skwarczynski

Download or read book Micro- and Nanotechnology in Vaccine Development written by Mariusz Skwarczynski and published by William Andrew. This book was released on 2016-09-20 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. - Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development - Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development - Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

The Basics of Cancer Immunotherapy

Author : Haidong Dong
Publisher : Springer
ISBN 13 : 3319706225
Total Pages : 164 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Basics of Cancer Immunotherapy by : Haidong Dong

Download or read book The Basics of Cancer Immunotherapy written by Haidong Dong and published by Springer. This book was released on 2018-01-05 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today’s daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors’ expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.

Cancer Immunology and Immunotherapy

Author : Glenn Dranoff
Publisher : Springer Science & Business Media
ISBN 13 : 3642141366
Total Pages : 313 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Cancer Immunology and Immunotherapy by : Glenn Dranoff

Download or read book Cancer Immunology and Immunotherapy written by Glenn Dranoff and published by Springer Science & Business Media. This book was released on 2011-04-11 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Nanotoxicity

Author : Susai Rajendran
Publisher : Elsevier
ISBN 13 : 012819944X
Total Pages : 487 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Nanotoxicity by : Susai Rajendran

Download or read book Nanotoxicity written by Susai Rajendran and published by Elsevier. This book was released on 2020-04-09 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotoxicity: Prevention, and Antibacterial Applications of Nanomaterials focuses on the fundamental concepts for cytotoxicity and genotoxicity of nanomaterials. It sheds more light on the underlying phenomena and fundamental mechanisms through which nanomaterials interact with organisms and physiological media. The book provides good guidance for toxic prevention methods and management in the manufacture/application/disposal. The book also discusses the potential applications of nanomaterials-based antibiotics. The potential toxic effects of nanomaterials result not only from the type of base materials, but also from their size/ ligands/surface chemical modifications. This book discusses why different classes of nanomaterials display toxic properties, and what can be done to mitigate this toxicity. It also explores how nanomaterials are being used as antimicrobial agents, being used to purify air and water, and counteract a range of infectious diseases. This is an important reference for materials scientists, environmental scientists and biomedical scientists, who are seeking to gain a greater understanding of how nanomaterials can be used to combat toxic agents, and how the toxicity of nanomaterials themselves can best be mitigated. - Explains the underlying phenomena and fundamental mechanisms through which nanomaterials interact with organisms and physiological media - Outlines major methods for mitigating and prevention of nanotoxicity - Discusses the applications of nanomaterials-based antibiotics

Fundamentals of Pharmaceutical Nanoscience

Author : Ijeoma F. Uchegbu
Publisher : Springer Science & Business Media
ISBN 13 : 1461491649
Total Pages : 602 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Fundamentals of Pharmaceutical Nanoscience by : Ijeoma F. Uchegbu

Download or read book Fundamentals of Pharmaceutical Nanoscience written by Ijeoma F. Uchegbu and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscience or the science of the very small offers the pharmaceutical scientist a wealth of opportunities. By fabricating at the nanoscale, it is possible to exert unprecedented control on drug activity. This textbook will showcase a variety of nanosystems working from their design and construction to their application in the field of drug delivery. The book is intended for graduate students in drug delivery, physical and polymer chemistry, and applied pharmaceutical sciences courses that involve fundamental nanoscience. The purpose of the text is to present physicochemical and biomedical properties of synthetic polymers with an emphasis on their application in polymer therapeutics i.e., pharmaceutical nanosystems, drug delivery and biological performance. There are two main objectives of this text. The first is to provide advanced graduate students with knowledge of the principles of nanosystems and polymer science including synthesis, structure, and characterization of solution and solid state properties. The second is to describe the fundamentals of therapeutic applications of polymers in drug delivery, targeting, response modifiers as well as regulatory issues. The courses, often listed as Advanced Drug Delivery and Applied Pharmaceutics; Polymer Therapeutics; or Nanomedicine, are designed as an overview of the field specifically for graduate students in the Department of Pharmaceutical Sciences Graduate Programs. However, the course content may also be of interest for graduate students in related biomedical research programs. These courses generally include a discussion of the major principles of polymer science and fundamental concepts of application of polymers as modern therapeutics. All courses are moving away from the above mentioned course names and going by ‘pharmaceutical nanoscience or nanosystems’. This area of research and technology development has attracted tremendous attention during the last two decades and it is expected that it will continue to grow in importance. However, the area is just emerging and courses are limited but they are offered.

Handbook of Immunological Properties of Engineered Nanomaterials

Author : Marina Dobrovolskaia
Publisher : World Scientific
ISBN 13 : 9814390259
Total Pages : 721 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Handbook of Immunological Properties of Engineered Nanomaterials by : Marina Dobrovolskaia

Download or read book Handbook of Immunological Properties of Engineered Nanomaterials written by Marina Dobrovolskaia and published by World Scientific. This book was released on 2013 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilization. Each chapter presents a broad literature review of the given focus area, describes protocols and resources available to support research in the individual focus areas, highlights challenges, and outlines unanswered questions and future directions. In addition, the Handbook includes an overview of and serves a guide to the physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. Regulations related to immunotoxicity testing of materials prior to their translation into the clinic are also reviewed.The Handbook is written by top experts in the field of nanomedicine, nanotechnology, and translational bionanotechnology, representing academia, government, industry, and consulting organizations, and regulatory agencies. The Handbook is designed to serve as a textbook for students, a practical guide for research laboratories, and an informational resource for scientific consultants, reviewers, and policy makers. It is written such that both experts and beginners will find the information highly useful and applicable.

Biomaterials Science

Author : Buddy D. Ratner
Publisher : Academic Press
ISBN 13 : 008087780X
Total Pages : 1610 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Biomaterials Science by : Buddy D. Ratner

Download or read book Biomaterials Science written by Buddy D. Ratner and published by Academic Press. This book was released on 2012-12-31 with total page 1610 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. - Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today - Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials - Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank

Nanoparticle–Protein Corona

Author : Ashutosh Kumar
Publisher : Royal Society of Chemistry
ISBN 13 : 1788018532
Total Pages : 310 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Nanoparticle–Protein Corona by : Ashutosh Kumar

Download or read book Nanoparticle–Protein Corona written by Ashutosh Kumar and published by Royal Society of Chemistry. This book was released on 2019-07-26 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles have numerous biomedical applications including drug delivery, bone implants and imaging. A protein corona is formed when proteins existing in a biological system cover the nanoparticle surface. The formation of a nanoparticle–protein corona, changes the behaviour of the nanoparticle, resulting in new biological characteristics and influencing the circulation lifetime, accumulation, toxicity, cellular uptake and agglomeration. This book provides a detailed understanding of nanoparticle–protein corona formation, its biological significance and the factors that govern the formation of coronas. It also explains the impact of nanoparticle–protein interactions on biological assays, ecotoxicity studies and proteomics research. It will be of interest to researchers studying the application of nanoparticles as well as toxicologists and pharmaceutical chemists.