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Molecular Pharmaceutics
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Book Synopsis Computational Pharmaceutics by : Defang Ouyang
Download or read book Computational Pharmaceutics written by Defang Ouyang and published by John Wiley & Sons. This book was released on 2015-07-20 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.
Book Synopsis Molecular Pharmaceutics and Nano Drug Delivery by : Umesh Gupta
Download or read book Molecular Pharmaceutics and Nano Drug Delivery written by Umesh Gupta and published by Academic Press. This book was released on 2023-10-17 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Pharmaceutics and Nano Drug Delivery: Fundamentals and Challenges provides a thorough resource for both beginners and established scientists, bringing fundamental knowledge about key challenges of these carriers down to the molecular level. The book satisfies the need of availability of literature at single platform with the detailed knowledge to understand crucial aspects, such as regulatory, clinical, toxicological and the formulation requirements of these carriers. This is a valuable resource for graduates, pharmaceutical researchers and anyone working on aspects of pharmaceutics, molecular pharmaceutics and nano-drug/gene delivery. So called ‘novel drug delivery systems’ are numerous, with each having different approaches to their production, characterization and evaluation. The proper understanding of these dosage forms, as well as their critical attributes such as toxicity and regulatory requirements are aspects which researchers should know before they begin working on these carriers. This book provides this critical information. Provides a conceptual understanding of Molecular Pharmaceutics and drug/gene delivery systems of biological origin Presents a detailed description and discussion on nanotechnological carriers, from basics to advances, including gene delivery and protein-oriented delivery Includes regulatory and toxicological requirements for novel drug delivery systems
Book Synopsis Molecular Pharmacology by : John Dickenson
Download or read book Molecular Pharmacology written by John Dickenson and published by John Wiley & Sons. This book was released on 2012-11-30 with total page 675 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.
Book Synopsis General and Molecular Pharmacology by : Francesco Clementi
Download or read book General and Molecular Pharmacology written by Francesco Clementi and published by John Wiley & Sons. This book was released on 2015-07-01 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book
Book Synopsis Computational Pharmaceutics by : Defang Ouyang
Download or read book Computational Pharmaceutics written by Defang Ouyang and published by John Wiley & Sons. This book was released on 2015-05-18 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.
Book Synopsis MOLECULAR PHARMACEUTICS (NANO TECHNOLOGY & TARGETED DDS) by : Dr. N. G. Raghavendra Rao
Download or read book MOLECULAR PHARMACEUTICS (NANO TECHNOLOGY & TARGETED DDS) written by Dr. N. G. Raghavendra Rao and published by JEC PUBLICATION. This book was released on with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Welcome to "Molecular Pharmaceutics (Nanotechnology & Targeted DDS) (NTDS) (MPH 201T)". This book is designed to serve as a comprehensive resource for students, researchers, and professionals interested in delving into the fascinating intersection of molecular pharmaceutics, nanotechnology, and targeted drug delivery systems (DDS). In recent years, the field of molecular pharmaceutics has witnessed unprecedented growth and innovation, propelled by advancements in nanotechnology and targeted drug delivery strategies. These developments have revolutionized the way we approach drug design, delivery, and therapy, offering new avenues for personalized medicine and enhanced therapeutic outcomes. Within the pages of this book, readers will embark on a journey through the fundamental principles, cutting-edge technologies, and practical applications shaping the landscape of molecular pharmaceutics. From the basics of molecular biology and pharmaceutical chemistry to the intricacies of nanomaterial synthesis and drug delivery mechanisms, each chapter provides a comprehensive exploration of key concepts and techniques. Furthermore, this book delves into the design and development of targeted drug delivery systems, offering insights into the engineering of nanoparticles, liposomes, micelles, and other nano-carriers for precise drug delivery to specific tissues and cells. Readers will gain a deeper understanding of the principles governing drug targeting, pharmacokinetics, and bio-distribution, as well as the challenges and opportunities associated with translating these technologies from the lab to the clinic.
Book Synopsis Molecular Pharmaceutics by : Suryakanta Swain
Download or read book Molecular Pharmaceutics written by Suryakanta Swain and published by . This book was released on 2019-10-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular pharmaceutics and targeted drug delivery systems to create imagination in the mind of B. Pharm, M.Pharm students, Pharm D and Ph.D scholars. Preparing this book took longer than anticipated, and it contains more pages than expected. This present book should prove to be useful to pharma students studying in the Pharmaceutics, Industrial Pharmacy, and Pharmaceutical technology specialization, and could help to develop their career in the field of pharma industries as Formulation R&D scientists, technicians, etc.
Book Synopsis Molecular Pharmacology by : Angel Catala
Download or read book Molecular Pharmacology written by Angel Catala and published by BoD – Books on Demand. This book was released on 2020-12-16 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concentrates on recent developments related to the application of original structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology as well as basic pharmacological problems that offer mechanistic insights that are generally significant for the field of pharmacology. Written by experts, chapters cover such topics as drug transport mechanisms and drug–receptor complexes. This volume offers up-to-date, expert reviews of the fast-moving field of molecular pharmacology.
Book Synopsis Molecular Biopharmaceutics by : Bente Steffansen
Download or read book Molecular Biopharmaceutics written by Bente Steffansen and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular biopharmaceutics involves the study of drug absorption, transport and delivery at the molecular level. In particular, increasing knowledge of the molecular structure and function of membrane transporter proteins and the understanding that they play a significant role in drug transport across biological membranes has lead to growing interest in this area from the pharmaceutical industry. This emerging knowledge of membrane transporter proteins has implications for understanding drug disposition and in turn for the development of more effective drug delivery strategies. The proposed text will provide an overview of the field of molecular biopharmaceutics, and will explain its importance in drug development. It will focus on describing the interplay between the chemistry of drug molecules and membrane transporters, and will guide researchers in setting up experiments that may help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery.
Book Synopsis Foundations of Molecular Pharmacology by : J. B. Stenlake
Download or read book Foundations of Molecular Pharmacology written by J. B. Stenlake and published by A&C Black. This book was released on 1979-01-01 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Pharmacology V3 by : E.J. Ariens
Download or read book Molecular Pharmacology V3 written by E.J. Ariens and published by Elsevier. This book was released on 2012-12-02 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Pharmacology: The Model of Action of Biologically Active Compounds, Volume 1 discusses the mode of action of bioactive compounds on a molecular level. This book reviews the processes that control the uptake of drugs, their diffusion through tissues, as well as their metabolism and excretion. Comprised of three sections, this volume starts with an overview of the different aspects of drug distribution and metabolism. This text then examines the totality of intermolecular processes or reactions between drug and receptor molecules, which is known as drug-receptor interaction. Other chapters explore the actions of various pharmacodynamic agents, including hormones and substances with selective toxicity, auxins, and odorants. This book discusses as well the ways in which the actions of drugs combine with the tissues and act upon themselves. The final chapter deals with the complicated types of relations between stimulus and effect. Pharmacologists and researchers will find this book useful.
Book Synopsis Pharmaceutical Biotechnology by : Gary Walsh
Download or read book Pharmaceutical Biotechnology written by Gary Walsh and published by John Wiley & Sons. This book was released on 2013-04-25 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products. introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students includes specific ‘product category chapters’ focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products. entire chapter devoted to the principles of genetic engineering and how these drugs are developed. includes numerous relevant case studies to enhance student understanding no prior knowledge of protein structure is assumed
Book Synopsis Molecular Pharmacology V2 by : E.J. Ariens
Download or read book Molecular Pharmacology V2 written by E.J. Ariens and published by Elsevier. This book was released on 2012-12-02 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Pharmacology: The Mode of Action of Biologically Active Compound, Volume II presents the mode of action of bioactive compounds on a molecular level, which concerns a wide variety of pharmacodynamic agents. This book discusses in detail the actions of odorants, the chemotherapeutics used in the fight against cancer, as well as the interactions of substrates and enzymes. Comprised of three parts, this volume starts with an overview of the mode of action of odorants and explores the anatomical and histochemical location of the receptors. This text then explains the molecular processes that are involved olfaction. Other chapters consider the different types of chemotherapeutics used against cancer, such as the antimetabolites and radiomimetics. The final chapter deals with the structure of chemical groups that constitute the receptors and the active sites on the enzymes. This book is a valuable resource for pharmacologists and clinical researchers interested in the study of bioactive compounds.
Book Synopsis Essential Pharmaceutics by : Ashlee D. Brunaugh
Download or read book Essential Pharmaceutics written by Ashlee D. Brunaugh and published by Springer Nature. This book was released on 2019-11-05 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Particularly in healthcare fields, there is growing movement away from traditional lecture style course towards active learning and team-based activities to improve learning and build higher level thinking through application of complex problems with a strong foundation of facts and data. Essential Pharmaceutics is suited to this modern teaching style, and is the first book of its kind to provide the resources and skills needed for successful implementation of an active learning pharmaceutics course.This text offers a format that is specifically suited for integration in an active learning, team-based classroom setting. It is ideal for self-learning for the beginning pharmaceutics student, based upon the extensive utilization of figures, tables, and its overview of essential topics in pharmaceutics. Also unique to this text is the integration of case studies based upon modern pharmaceutical products which are designed to reinforce importance pharmaceutical concepts and teach essential skills in literature review and patent searching. Case studies covering all topics covered in the text have been developed by the authors that allow application of the content in the flipped-classroom pharmaceutical course.
Book Synopsis Essentials of Molecular Pharmacology by : Andrejus Korolkovas
Download or read book Essentials of Molecular Pharmacology written by Andrejus Korolkovas and published by John Wiley & Sons. This book was released on 1970 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Miktoarm Star Polymers by : Ashok Kakkar
Download or read book Miktoarm Star Polymers written by Ashok Kakkar and published by Royal Society of Chemistry. This book was released on 2017-04-13 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term ‘miktoarm polymers’ refers to asymmetric branched macromolecules, a relatively new entry to the macromolecular field. Recent advances in their synthesis and intriguing supramolecular chemistry in a desired medium has seen a fast expansion of their applications. The composition of miktoarm polymers can be tailored and even pre-defined to allow a desired combination of functions, meaning polymer chemists can have complete control of the overall architecture of these macromolecules. By carefully selecting the composition, they can create supramolecular structures with intriguing properties, particularly for applications in biology. Miktoarm Star Polymers features chapters from experts actively working in this field, and provides the reader with a unique introduction to the fundamental principles of this exciting macromolecular system. Topics covered include the design, synthesis, characterization, self-assembly and applications of miktoarm polymers. The book is an excellent overview and up to date guide to those working in research in polymer chemistry, materials science, and polymers for medical applications.
Book Synopsis Solid State Development and Processing of Pharmaceutical Molecules by : Michael Gruss
Download or read book Solid State Development and Processing of Pharmaceutical Molecules written by Michael Gruss and published by John Wiley & Sons. This book was released on 2021-08-31 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid State Development and Processing of Pharmaceutical Molecules A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors—noted experts on the topic—examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: Provides a guide for the effective development of solid drug forms Compares different characterization methods for solid state APIs Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs Includes information on automation, process control, and machine learning as an integral part of the development and production workflows Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.
