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Metallomics And The Cell
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Book Synopsis Metallomics and the Cell by : Lucia Banci
Download or read book Metallomics and the Cell written by Lucia Banci and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.
Download or read book Metallomics written by Wolfgang Maret and published by World Scientific Publishing Company. This book was released on 2016-05-12 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallomics is an integrated biometal science as it unifies different disciplines into a mainstream subject that can be taught to students of the biological and biomedical sciences. Metallomics bridges chemistry and the biological sciences from a global and quantitative systems approach, while the biological context provides new insights into the functions of metals in biological cells. The book challenges the traditional view of relating biochemistry only to organic chemistry, and discusses the structure and function of metal ions in the context of their environment in organisms. This is an essential read for undergraduate and graduate students in the fields of biochemistry, cell biology, nutrition (trace element research), toxicology, pharmacology and ecology.
Download or read book Metallomics written by Yasumitsu Ogra and published by Springer. This book was released on 2017-03-01 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.
Book Synopsis Metals in Cells by : Valeria Culotta
Download or read book Metals in Cells written by Valeria Culotta and published by John Wiley & Sons. This book was released on 2016-03-16 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
Download or read book Applied Metallomics written by Yu-Feng Li and published by John Wiley & Sons. This book was released on 2024-05-22 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Metallomics A groundbreaking survey of a field that unites the sciences The metallome of a cellular compartment, such as an enzyme, is the variety and arrangement of its metal ions. Metallomics is the multidisciplinary study of the metallome and its many important interactions with biological molecules and systems. It exists at the intersection of biochemistry and materials science, offering crucial insights into biological processes in which iron, for instance, plays a pivotal role. Applied Metallomics is an up-to-the-minute overview of research developments in metallomics, offering both analysis and applications in a vast array of scientific and industrial areas. Moving freely between material science, environmental science, health science, and more, it offers a comprehensive survey of this interdisciplinary research area. As the field of metallomics continues to develop and its applications expand, this book will only be a need of the hour Applied Metallomics readers will also find: Detailed treatment of nanometallomics, environmetallomics, agrometallomics, and many more Coverage of machine learning and artificial intelligence techniques with applications in metallomics An author team with vast international research experiences Applied Metallomics is ideal for researchers in many areas touched by metallomics, that include chemistry, biochemistry, biotechnology, bioinorganic chemistry, and more.
Book Synopsis Metallomics by : Marco Aurélio Zezzi Arruda
Download or read book Metallomics written by Marco Aurélio Zezzi Arruda and published by Springer. This book was released on 2018-06-08 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.
Book Synopsis Toxicological Profile for Silver by :
Download or read book Toxicological Profile for Silver written by and published by . This book was released on 1990 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Binding, Transport and Storage of Metal Ions in Biological Cells by : Wolfgang Maret
Download or read book Binding, Transport and Storage of Metal Ions in Biological Cells written by Wolfgang Maret and published by Royal Society of Chemistry. This book was released on 2014-07-09 with total page 938 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.
Download or read book Metallomics written by Bernhard Michalke and published by John Wiley & Sons. This book was released on 2016-09-12 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Latest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health.
Book Synopsis Plant Metallomics and Functional Omics by : Gaurav Sablok
Download or read book Plant Metallomics and Functional Omics written by Gaurav Sablok and published by Springer. This book was released on 2019-07-04 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major portion of the planet earth is covered by seas and oceans representing 96.5% of the planet’s water, playing a detrimental role in sustaining the plant including crop diversity and productivity for human consumption. Water resources contain both soluble and transition metals, which are easily absorbed by plants through roots as a first point of contact and subsequently play important physiological and biological functions in plants. Transition metals such as copper (Cu), iron (Fe), manganese (Mn) and zinc (Zn) contribute to the plant productivity by playing key functional roles in the photosynthesis. In addition, to their major role in regulating the plant productivity, they also play an important role by acting as homeostatic regulators in uni-parentally inherited chloroplasts and maintains the flow of the electron transfer. It is worthwhile to mention that they play a critical role as transporters, which acts as electron balancing units for managing the electrostatic potential across the membranes. In contrast, some metals such as Cd, As play a significant role in inducing the stress mechanism and influencing either directly or in-directly Haber-Weiss reactions either through the production of the reactive oxygen species (ROS) or through the membrane damage thus leading to leakage of membrane transporters. However, besides playing a detrimental role as transporters in plant system, excessive accumulation of these metals due to the increasing contamination in the marginal soil and water are posing important threats to the plant system. Realizing the toxic effects of the metals, several physiological evidences have been laid for the credence of the metal toxicity and their concurrent effect on plant productivity. Increasing effects of the metals as toxicants can have three adverse effects on the populations: population can move, persist via local adaptation or phenotypic plasticity, or die. Next generation sequencing studies have revolutionized our abilities to detect the changes in expression profiles across an array of genes, which can in-turn help to develop early markers of metal induced stress. Plant Metallomics and Functional Omics: A System-Wide Perspective focuses on the applications of the system wide understanding of the biological and functional interplay occurring at the juncture of the metalloid induced stress and toxicity. The main goal of this book is to familiarize the readers with the most up-to-date information on metal-induced physiological changes in plant species.
Book Synopsis The Biological Chemistry of Nickel by : Deborah Zamble
Download or read book The Biological Chemistry of Nickel written by Deborah Zamble and published by Royal Society of Chemistry. This book was released on 2017-04-04 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.
Book Synopsis Metabolomics: From Fundamentals to Clinical Applications by : Alessandra Sussulini
Download or read book Metabolomics: From Fundamentals to Clinical Applications written by Alessandra Sussulini and published by Springer. This book was released on 2017-01-28 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.
Book Synopsis Trace Metals and Infectious Diseases by : Jerome O. Nriagu
Download or read book Trace Metals and Infectious Diseases written by Jerome O. Nriagu and published by MIT Press. This book was released on 2024-06-11 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang
Book Synopsis Metal Ions in Biological Systems by : Sanat Dhar
Download or read book Metal Ions in Biological Systems written by Sanat Dhar and published by Springer. This book was released on 2012-11-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles published in this volume are based on the papers del ivered at a conference on the Role of Metal Ions in Biological Systems held November 20 and 21, 1972, at Argonne National Laboratory. The purpose of the conference was to present to an interdiscipl inary audience of physical scientists some recent developments illustrating the chemical and environ mental participation of the heavy metal ions in the biological system. The invited speakers at the conference are special ists in the fields they describe, and the articles presented here are at a level of interest to readers with backgrounds in physical sciences who are not necessari Iy doing research in the areas described. The articles are referenced through 1972, and in some cases early 1973, and thus should also be of value to research workers. It is hoped that the book wi II be of particular interest to chemists, biologists, workers in the fields of en vironmental science and publ ic health, as wei I as graduate and senior undergraduate students in these discipl ines. The conference was sponsored by the Central States Universities, Inc. , a consortium of sixteen midwestern univer sities, the Center for Educational Affairs, Argonne National Laboratory, and the United States Atomic Energy Commission. It is my pleasure to thank the members of the conference committee for their ideas and active help in organizing the conference.
Book Synopsis Yeast Stress Responses by : Stefan Hohmann
Download or read book Yeast Stress Responses written by Stefan Hohmann and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every cell has developed mechanisms to respond to changes in its environment and to adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast has long proven as a particularly useful model system for the analysis of cellular stress responses, and the completion of the yeast genome sequence has only added to its power This volume comprehensively reviews both the basic features of the yeast genral stress response and the specific adapations to different stress types (nutrient depletion, osmotic and heat shock as well as salt and oxidative stress). It includes the latest findings in the field and discusses the implications for the analysis of stress response mechanisms in higher eukaryotes as well.
Book Synopsis Advances in Metallodrugs by : Shahid Ul-Islam
Download or read book Advances in Metallodrugs written by Shahid Ul-Islam and published by John Wiley & Sons. This book was released on 2020-07-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.
Book Synopsis Solubilities of Inorganic and Organic Compounds. A Compilation of Quantitative Solubility Data from the Periodical Literature by : Atherton Seidell
Download or read book Solubilities of Inorganic and Organic Compounds. A Compilation of Quantitative Solubility Data from the Periodical Literature written by Atherton Seidell and published by . This book was released on 1928 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
