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Author : Paul Spearman
Publisher :
ISBN 13 : 9783642021763
Total Pages : 216 pages
Book Rating : 4.0/5 (217 download)
Download or read book HIV Interactions with Host Cell Proteins written by Paul Spearman and published by . This book was released on 2011-03-04 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul Spearman
Publisher : Springer Science & Business Media
ISBN 13 : 3642021751
Total Pages : 210 pages
Book Rating : 4.6/5 (42 download)
Download or read book HIV Interactions with Host Cell Proteins written by Paul Spearman and published by Springer Science & Business Media. This book was released on 2009-12-11 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.
Author : Li Wu
Publisher : Springer Science & Business Media
ISBN 13 : 1461444330
Total Pages : 303 pages
Book Rating : 4.4/5 (614 download)
Download or read book HIV Interactions with Dendritic Cells written by Li Wu and published by Springer Science & Business Media. This book was released on 2012-09-13 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given rapid research progress and advance of the techniques in studying HIV interactions with host cells and factors, there is a critical need for a book on HIV interactions with DCs. The proposed book will aim for a broad readership to facilitate HIV/AIDS research and provide a practical tool for HIV researchers to continuously address novel questions. Specifically, the editors will summarize the literature in this field and provide critical analysis and future directions. International researchers will be invited as contributors of the book, highlighting authors who have contributed significantly to the field from different angles and aspects of virology, cell biology and immunology, etc.
Author : Tetsuo Tsukamoto
Publisher : Frontiers Media SA
ISBN 13 : 2889718050
Total Pages : 131 pages
Book Rating : 4.8/5 (897 download)
Download or read book Direct and Indirect Interactions of HIV With Host Cells written by Tetsuo Tsukamoto and published by Frontiers Media SA. This book was released on 2021-12-06 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shailendra K. Saxena
Publisher :
ISBN 13 : 9789535146025
Total Pages : 202 pages
Book Rating : 4.1/5 (46 download)
Download or read book Advances in Molecular Retrovirology written by Shailendra K. Saxena and published by . This book was released on 2016 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive overview of recent advances in Retrovirology, as well as general concepts of molecular biology of retroviral infections, immunopathology, diagnosis, and prevention, to current clinical recommendations in management of retroviruses, including endogenous retroviruses, highlighting the ongoing issues, recent advances, with future directions in diagnostic approaches and therapeutic strategies.
Author : Jay A. Levy
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.3/5 (91 download)
Download or read book HIV and the Pathogenesis of AIDS written by Jay A. Levy and published by . This book was released on 1994 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nadine Laguette
Publisher : Frontiers Media SA
ISBN 13 : 2889194841
Total Pages : 119 pages
Book Rating : 4.8/5 (891 download)
Download or read book Manipulation of the host cell by viral auxiliary proteins written by Nadine Laguette and published by Frontiers Media SA. This book was released on 2015-05-07 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of cellular factors/pathways to the benefit of the viral life cycle. To gain a foothold into host cells, HIV has to take advantage of available cellular factories and overcome the numerous potential blocks opposed to its replication while ensuring cellular survival. Viral auxiliary proteins are a perfect paradigm to illustrate the complexity of the relationship between HIV and its host. Although these accessory proteins are mostly unnecessary for viral replication in permissive cells in vitro, they play a crucial role in regulating viral spread ex vivo in non-permissive cells and in vivo in hosts. Most accessory proteins are pleiotropic and instrumental in the counteraction of restriction factors and proteins involved in innate immune response. Several proteins of the “intrinsic” immune system that detect the presence of the assailant and initiate a subsequent immune response, as well as restriction factors that are directly devoted to arresting the replication cycle at precise steps have been characterized. Despite the numerous cellular mechanisms dedicated to preventing viral replication, HIV is able to efficiently replicate in humans. Indeed, as a master regulator of cellular machineries and processes, not only has HIV evolved strategies to avoid triggering of pattern recognition receptors, but HIV has also elaborated ways to counteract host restriction factors, thereby overcoming the hurdles that oppose efficient replication. This review collection is dedicated to the manipulation of host cells by HIV-1 and HIV-2, with a particular focus on viral accessory proteins.
Author : Steven R. Bartz
Publisher :
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.:/5 (89 download)
Download or read book Host Cell Molecular Chaperone Interactions with HIV-1 written by Steven R. Bartz and published by . This book was released on 1995 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Leslie Parent
Publisher : Academic Press
ISBN 13 : 0128111933
Total Pages : 528 pages
Book Rating : 4.1/5 (281 download)
Download or read book Retrovirus-Cell Interactions written by Leslie Parent and published by Academic Press. This book was released on 2018-08-09 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems
Author : Nejat Düzgünes
Publisher : Springer Science & Business Media
ISBN 13 : 1468459767
Total Pages : 245 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms and Specificity of HIV Entry into Host Cells written by Nejat Düzgünes and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a workshop held in San Francisco, California, June 19--20, 1989
Author : Thomas J. Hope
Publisher :
ISBN 13 : 9781461496106
Total Pages : pages
Book Rating : 4.4/5 (961 download)
Download or read book Encyclopedia of AIDS written by Thomas J. Hope and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sriganesh Srihari
Publisher : Morgan & Claypool
ISBN 13 : 1970001534
Total Pages : 295 pages
Book Rating : 4.9/5 (7 download)
Download or read book Computational Prediction of Protein Complexes from Protein Interaction Networks written by Sriganesh Srihari and published by Morgan & Claypool. This book was released on 2017-05-30 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the "complexosome") is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the "interactomes") from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have enabled systematic inquiry into the identification and study of protein complexes from organisms. Computational methods have played a significant role in this context, by contributing accurate, efficient, and exhaustive ways to analyze the enormous amounts of data. These methods have helped to compensate for some of the limitations in experimental datasets including the presence of biological and technical noise and the relative paucity of credible interactions. In this book, we systematically walk through computational methods devised to date (approximately between 2000 and 2016) for identifying protein complexes from the network of protein interactions (the protein-protein interaction (PPI) network). We present a detailed taxonomy of these methods, and comprehensively evaluate them for protein complex identification across a variety of scenarios including the absence of many true interactions and the presence of false-positive interactions (noise) in PPI networks. Based on this evaluation, we highlight challenges faced by the methods, for instance in identifying sparse, sub-, or small complexes and in discerning overlapping complexes, and reveal how a combination of strategies is necessary to accurately reconstruct the entire complexosome.
Author : Nouri Neamati
Publisher : John Wiley & Sons
ISBN 13 : 1118015363
Total Pages : 710 pages
Book Rating : 4.1/5 (18 download)
Download or read book HIV-1 Integrase written by Nouri Neamati and published by John Wiley & Sons. This book was released on 2011-08-10 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.
Author : Theresa Li-Yun Chang
Publisher : IntechOpen
ISBN 13 : 9789533074429
Total Pages : 378 pages
Book Rating : 4.0/5 (744 download)
Download or read book HIV-Host Interactions written by Theresa Li-Yun Chang and published by IntechOpen. This book was released on 2011-11-02 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: HIV remains the major global health threat, and neither vaccine nor cure is available. Increasing our knowledge on HIV infection will help overcome the challenge of HIV/AIDS. This book covers several aspects of HIV-host interactions in vitro and in vivo. The first section covers the interaction between cellular components and HIV proteins, Integrase, Tat, and Nef. It also discusses the clinical relevance of HIV superinfection. The next two chapters focus on the role of innate immunity including dendritic cells and defensins in HIV infection followed by the section on the impact of host factors on HIV pathogenesis. The section of co-infection includes the impact of Human herpesvirus 6 and Trichomonas vaginalis on HIV infection. The final section focuses on generation of HIV molecular clones that can be used in macaques and the potential use of cotton rats for HIV studies.
Author : John M. Coffin
Publisher : CSHL Press
ISBN 13 : 9780879695712
Total Pages : 856 pages
Book Rating : 4.6/5 (957 download)
Download or read book Retroviruses written by John M. Coffin and published by CSHL Press. This book was released on 1997 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
Author : Bryan Cullen
Publisher : Oxford University Press
ISBN 13 : 9780199633821
Total Pages : 220 pages
Book Rating : 4.6/5 (338 download)
Download or read book Human Retroviruses written by Bryan Cullen and published by Oxford University Press. This book was released on 1993 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Author : Lawrence C. Kuo
Publisher : Gulf Professional Publishing
ISBN 13 : 9780121821425
Total Pages : 494 pages
Book Rating : 4.8/5 (214 download)
Download or read book Retroviral Proteases written by Lawrence C. Kuo and published by Gulf Professional Publishing. This book was released on 1994-09-22 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
