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Functionalized Nanocarriers For Theranostics
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Book Synopsis Functionalized Nanocarriers for Theranostics by : Stefano Leporatti
Download or read book Functionalized Nanocarriers for Theranostics written by Stefano Leporatti and published by Frontiers Media SA. This book was released on 2020-12-31 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Design of Nanostructures for Theranostics Applications by : Alexandru Mihai Grumezescu
Download or read book Design of Nanostructures for Theranostics Applications written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-11-30 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design of Nanostructures for Theranostics Applications focuses on the theranostics applications of nanostructures. In particular, multifunctional nanoparticles for diagnostics and treatment of different diseases, including those relating to the blood-brain barrier, are discussed in detail. Chapters explore different type of nanostructures, covering design, fabrication, functionalization and optimization, helping readers obtain the desired properties. Written by a diverse range of international academics, this book is a valuable reference resource for those working in both nanoscience and the pharmaceutical industry. Explores how the design of a range of nanomaterials make them effective theranostic agents, including multifunctional core-shell nanostructures, mesoporous silica nanoparticles, and quantum dots Shows how nanomaterials are used effectively for a range of diseases, including breast cancer, prostate cancer and neurological disorders Assesses the pros and cons of using different nanomaterials for different types of treatment
Book Synopsis Handbook of Nanomaterials for Cancer Theranostics by : Joao Conde
Download or read book Handbook of Nanomaterials for Cancer Theranostics written by Joao Conde and published by Elsevier. This book was released on 2018-06-27 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nanomaterials for Cancer Theranostics focuses on recent developments in advanced theranostic nanomedicines from a chemical and biological perspective where the advantages of theranostics are achieved by combining multiple components. The authors explore the pros and cons of theranostic nanomaterials developed in cancer research in the last 15 years, with the different strategies compared and scrutinized. In addition, the book explores how nanomaterials may overcome the regulatory hurdles facing theranostic nanomedicines. This is an important research reference for postgraduates and researchers in nanomedicine and cancer research who want to learn more on how nanomaterials can help create more effective cancer treatments. Highlights the development of smart theranostic nanomaterials to tackle biomedical problems in cancer therapy and diagnostics Explores the regulatory hurdles facing theranostic nanomedicine Discusses how the use of nanomaterials can help create more effective cancer treatments
Book Synopsis Multifunctional Theranostic Nanomedicines in Cancer by : Malay K. Das
Download or read book Multifunctional Theranostic Nanomedicines in Cancer written by Malay K. Das and published by Academic Press. This book was released on 2021-03-16 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines Discusses treatment options from a pharmaceutical sciences perspective Includes translational science and targeted CNS cancer treatment
Book Synopsis Nanomedicines for Breast Cancer Theranostics by : Nanasaheb D. Thorat
Download or read book Nanomedicines for Breast Cancer Theranostics written by Nanasaheb D. Thorat and published by Elsevier. This book was released on 2020-03-08 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomedicines for Breast Cancer Theranostics addresses the translational aspects and clinical perspectives of breast cancer nanomedicine from a multidisciplinary perspective. The book summarizes research efforts at the preclinical and clinical stage of nanostructures and nanomedicine for dealing with the important challenge of nanomedicine translation in breast cancer theranostics. This book is an important resource for those working in both academia and industry, focusing on hot topics in biomaterials, biomedical engineering, drug delivery and oncology. Shows how the discovery of new nanomedicines is leading directly to an increase in the early-stage diagnosis of breast cancer Includes coverage of breast cancer nanomedicine standardization and characterization, highlighting newly developed treatments, diagnostics and treatment monitoring tools Explains why the design of nanobiomaterials make them effective drug carriers when treating breast cancer
Book Synopsis Advanced Theranostic Materials by : Ashutosh Tiwari
Download or read book Advanced Theranostic Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2015-06-30 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is covers the recent advances in the development on the regulation of such theragnosis system and their biomedical perspectives to act as a future nanomedicine. Advanced Theranostics Materialsis written by a distinguished group of contributors and provides comprehensive coverage of the current literature, up-to-date overview of all aspects of advanced theranostics materials ranging from system biology, diagnostics, imaging, image-guided therapy, therapeutics, biosensors, and translational medicine and personalized medicine, as well as the much broader task of covering most topics of biomedical research. The books focusses on the following topics: Part 1: System biology and translational medicine Aberrant Signaling Pathways: Hallmark of Cancer Cells and Target for Nanotherapeutics Application of Nanoparticles in Cancer Treatment Biomacromolecule-Gated Mesoporous Silica Drug Delivery Systems Construction of Functional DNA Nanostructures for Theranostic Applications Smart Polypeptide Nanocarriers for Malignancy Therapeutics Part 2: Imaging and therapeutics Dimercaptosuccinic acid-coated magnetic nanoparticles as a localized delivery system in cancer immunotherapy Cardiovascular nanomedicine Chitosan-based systems for sustained drug release Nanocapsules in biomedicine: promises and challenges Chitosan-based polyelectrolyte complexes: characteristics and application in formulation of particulate drug carriers Part 3: Diagnostics and featured prognostics Non-invasive Glucose Biosensors based on Nanomaterials Self/directed Assembly of Nanoparticles: A review on various approaches Ion exchangers – an open window for the development of advanced materials with pharmaceutical and medical applications New Titanium Alloys for Biomedical Applications
Book Synopsis Multi-functionalization of Micro- and Nanoparticles for Cancer Theranostics by : Ezhil Amirthalingam
Download or read book Multi-functionalization of Micro- and Nanoparticles for Cancer Theranostics written by Ezhil Amirthalingam and published by . This book was released on 2018 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis has its main focus on developing multi-functional nanomaterials, that we called nano- and microtools through two different approaches, top-down to provide support and bottom up to give functionality to prepare nanomaterials for diagnosis and therapy in cancer cells (theranostics). It includes functionalization of inorganic and or metallic nano- and microparticles with natural and synthetic receptors capable of acting as sensors to monitor different cellular parameters in living cells and deliverers specifically for diagnosis and therapy in cancer cells (theranostics). For this purpose, we used micro- and nanoparticles as substrates, made up of polysilicon or polysilicon-gold and gold nanoparticles, and functionalized them with (bio)molecules. The first objective was to develop a novel microtool for cell adhesion. For this purpose specially designed polysilicon microparticles of different shapes and sizes were chemically modified, to sense carbohydrates present on tumour cell membranes. An optimized protocol for bio-functionalization of polysilicon microparticles with lectins (WGA and Con A), both on surfaces and in suspension, was developed. Influence of different shapes in bio-functionalization of the microparticles was also observed. The final yield of the number of bio-functionalized microparticles was between 12-21 % with a major loss of approximately 50 % of microparticles during the activation step. These bio-functionalized microparticles in suspension were stable for three consecutive weeks, stored in PBS at room temperature. In vitro experiments were carried out which showed, Con A bio-functionalized Batch 2 microparticles adhered to the membrane of the Dictyostelium discoideum (Dicty) whereas, WGA bio-functionalized microparticles did not adhere to the cell membrane of Dicty or HeLa cells. Therefore, a synthetic lectin called Boronic Acids (BAs) was used and an optimized protocol for functionalization of polysilicon microparticles with 4-formylphenylboronic acid (PBA), through stable secondary amine bonds was developed. Interaction of BA functionalized surfaces with carbohydrate, N-acetylglucosamine (GlcNAc) was also studied on surfaces using ARS, which indicates stronger interaction between BA and GlcNAc. Polysilicon microparticles of different sizes functionalized using BA showed adhesion to the cell membranes of Dicty and HeLa cells. In the second objective, the primary goal is to sense intracellular pH in living cells using bi-functional microparticles (polysilicon-gold), in order to differentiate between cancer cells and normal cells. The immobilization of pH dependent fluorophores, Oregon green, pHrodo, SNARF and Alexa fluor on to polysilicon surfaces was achieved successfully. An optimized protocol for the bi-functionalization of two pH dependent fluorophores, Oregon green (on polysilicon) and pHrodo (on gold) on to a hexahedral bi-functional microparticle was achieved for pH sensing. The third objective was the generation and sensing of Reactive oxygen species (ROS) using a bio-photosensitizer for photodynamic therapy. The selected bio-photosensitizer, Cytochrome c (Cyt c) showed generation of ROS in solution. BODIPY was able to sense the production of ROS from the Cyt c in solution. An optimized protocol for immobilizing Cyt c on to the polysilicon surfaces and BODIPY on gold surfaces and microparticles was achieved. Protocol for bi-functionalization of ROS generator: Cyt c and ROS sensor: BODIPY on bi-functional microparticles was also developed for ROS sensing. The fourth objective is to deliver anionic drugs using gold nanoparticles synthesized using imidazolium based macrocycles. The ability of these gold nanoparticles to extract and incorporate ibuprofenate from an aqueous phase was calculated to be ca 85 %. The release of ibuprofenate from the gold nanoparticles system follows Fickian diffusion, which could be potentially used for local drug delivery applications.
Book Synopsis Hybrid Nanostructures for Cancer Theranostics by : Raghvendra Ashok Bohara
Download or read book Hybrid Nanostructures for Cancer Theranostics written by Raghvendra Ashok Bohara and published by Elsevier. This book was released on 2018-11-19 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hybrid nanostructures are nanoparticles which incorporate two or more structures. These structures may represent organic or inorganic material, but they synergistically improve the application of the material for end users. Hybrid Nanostructures for Cancer Theranostics explores how hybrid nanostructures are used in cancer treatment. Focusing on the properties of hybrid nanostructures, the book demonstrates how their unique characteristics can be used to create more effective treatment techniques. In the second half of the book, the chapters examine how hybrid nanostructures are currently being used in practice, assessing the pros and cons of using different types of nanostructures for different treatments. This valuable resource will allow readers to understand the core and emerging concept of functionalization, bioconjugation, hyperthermia and phototherapy of nanoparticles which allows for the greater use of hybrid nanomaterials in cancer theranostics. Shows how the use of novel hybrid nanostructures can lead to more effective cancer treatments. Explores how hybrid nanostructures are used for different treatment types, including photo thermal therapy and drug delivery. Explains how the use of hybrid nanostructures can lead to more rapid cancer diagnosis.
Book Synopsis Nano-Pharmacokinetics and Theranostics by : Nanasaheb D. Thorat
Download or read book Nano-Pharmacokinetics and Theranostics written by Nanasaheb D. Thorat and published by Academic Press. This book was released on 2021-07-28 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy addresses from a comprehensive and multidisciplinary approach the translational aspects and clinical perspectives of nano-pharmacokinetics using cancer as a model disease. Nano-pharmacokinetics is emerging as an important sub discipline of nanoscience and medical sciences because of the increasing safety issues of nanosystems on living organisms. This book reports the dynamics of nanosystems in living organisms for better understanding of nanotoxicity, pharmacology, biochemistry, physiology and medicine perspectives. It further examines current progress of state-of-the art pharmacokinetics mechanisms, which will be of great help to develop more clinical-oriented nanosystems with a wide safety margin. The book is divided into three sections: the first section focuses on the concept of pharmacokinetics with state-of-the-art Nano-Pharmacokinetics (NPK). The second section looks at the engineering of nanoparticles and pharmacokinetics clinical development. The final section focuses on Nano-Pharmacokinetics and Theranostics, elaborating the basic question of how pharmacokinetics of nanomaterials relate to their end applications such as cancer therapy. Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy will be useful to researchers in the field of nanoparticle based targeted drug delivery including pharmaceutical scientists, material scientists, chemists, nanotechnologists, biomedical scientists, and clinicians. Includes contributions from highly qualified scientists, regulatory entities, enterprises and medical practitioners to explain the long and inherently multidisciplinary pathway of nano-pharmacokinetics Describes assessment methods of nano-pharmacokinetics Examines the interface between nanomedicine and pharmacokinetics to diagnose and treat cancer
Book Synopsis Nanomaterials for Tumor Targeting Theranostics by : Mingqian Tan
Download or read book Nanomaterials for Tumor Targeting Theranostics written by Mingqian Tan and published by World Scientific. This book was released on 2016 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nanomaterials offer great potential for effective tumor diagnosis and therapy combing diagnostic agents and therapeutic drugs into one platform. In this book, the most recent progress of main nanomaterials and their applications in tumor targeting theranostics is presented. It summarizes the recent advances of current principal nanomaterials in tumor theranostics, including magnetic nanomaterials, quantum dots, mesoporous silica nanoparticles, gold nanomaterials, polymeric nanosystem, carbon nanomaterials, lipopolyplex nanoparticles, microbubbles, upconversion nanomaterials and dendrimers. It will enable readers to get a more realistic understanding of both the advantages and limitations of nanomaterials for potential tumor targeting theranosis. The publication of this book will accelerate the spread of ideas that are currently trickling through the scientific literature. Also a greater understanding of the potential and challenge of nanomaterials for tumor targeting theranostics is highly anticipated for practical clinical use."--Provided by publisher.
Book Synopsis Nanocarriers for Drug-Targeting Brain Tumors by : Lalit Kumar
Download or read book Nanocarriers for Drug-Targeting Brain Tumors written by Lalit Kumar and published by Elsevier. This book was released on 2022-06-21 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems. Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting. Provides information on the design and development of nanocarriers for targeting brain tumors Outlines the working principles of different nanocarriers for targeting brain tumors Includes case studies of different nanocarriers for targeting brain tumors
Book Synopsis Biomedical Applications of Functionalized Nanomaterials by : Bruno Sarmento
Download or read book Biomedical Applications of Functionalized Nanomaterials written by Bruno Sarmento and published by William Andrew. This book was released on 2018-03-01 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies. Provides an overview of the methodologies for biological target identification and ligand screening Includes case studies showing the development of functionalized nanomaterials and their biomedical applications Highlights the importance of functionalized nanomaterials for drug delivery, diagnostics and regenerative medicine applications
Book Synopsis SPIONs as Nano-Theranostics Agents by : Atefeh Zarepour
Download or read book SPIONs as Nano-Theranostics Agents written by Atefeh Zarepour and published by Springer. This book was released on 2017-01-20 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief introduces SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), the different synthesis approaches, their applications in the field of diagnostics and treatment and finally as theranostic agents in cancer.
Book Synopsis Biogenic Nanoparticles for Cancer Theranostics by : Chittaranjan Patra
Download or read book Biogenic Nanoparticles for Cancer Theranostics written by Chittaranjan Patra and published by Elsevier. This book was released on 2021-05-18 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biogenic Nanoparticles for Cancer Theranostics outlines the synthesis of biogenic nanoparticles to become cancer theranostic agents. The book also discusses their cellular interaction and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and other biological effects. Additionally, the book explores the mechanism of their penetration in cancerous tissue, its clearance, and its metabolism. Moreover, the in vitro and in vivo toxicological effects of biogenic nanoparticles are discussed. This book is an important reference source for materials scientists and biomedical scientists who are looking to increase their understanding of how biogenic nanoparticles are being used for a range of cancer treatment types. Metal nanoparticles have traditionally been synthesized by classical physico-chemical methods which have many drawbacks, such as high energy demand, high cost and potential ecotoxicity. As a result, the biosynthesis of metal nanoparticles is gaining increasing prominence. Biosynthesis approaches to metal nanoparticles are clean, safe, energy efficient and environment friendly. Explains the synthesis methods and applications of biogenic nanoparticles for cancer theranostics Outlines the distinctive features of biogenic nanoparticles that make them effective cancer treatment agents Assesses the major challenges of using biogenic nanoparticles on a mass scale
Book Synopsis Core-Shell Nanostructures for Drug Delivery and Theranostics by : Maria Focarete
Download or read book Core-Shell Nanostructures for Drug Delivery and Theranostics written by Maria Focarete and published by Woodhead Publishing. This book was released on 2018-06-29 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies and Prospects for Novel Carrier Systems contains valuable chapters that deal with the fundamentals of nanotechnology for drug delivery, recent developments and research in core-shell nanoparticles for drug-delivery and theranostic applications, and the potential and applications of core-shell nanofiber. This book is a highly valuable resource for scientists interested in the design and development of innovative drug delivery systems, researchers and graduate/postdoctoral students engaged in biomaterials for drug delivery, and R&D managers in the biomaterials and pharmaceutical industry. Focuses on core-shell nanoparticles and nanofiber for innovative applications, including cancer therapy, controlled release and multi-drug release Considers future prospects and potential new applications of core-shell nanostructures for drug delivery and theranostics Explains the principles and essential concepts of nanotechnology for drug delivery systems
Book Synopsis Design and Evaluation of Plasmonic/Magnetic Au-MFe2O4 (M-Fe/Co/Mn) Core-Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics by : Ravichandran Manisekaran
Download or read book Design and Evaluation of Plasmonic/Magnetic Au-MFe2O4 (M-Fe/Co/Mn) Core-Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics written by Ravichandran Manisekaran and published by Springer. This book was released on 2017-10-30 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis documents the development of a multifunctional nanoparticle system to enhance the chemotherapeutic efficiency of anti-cancer drugs, and contributes to research that helps decrease the side-effects in cancer patients while simultaneously increasing their survival rates. The work begins with an introduction to nanomedicine and cancer therapy, and contains a literature review on magnetic, gold, and core-shell nanoparticles. It also covers synthesis techniques, properties, various surface modifications, and the importance of magnetic and gold nanoparticles. The author dedicates a chapter to characterization techniques, experimental setup, and cell cultivation techniques for in-vitro studies. Further chapters describe the background, characterizations, and applications of multifunctional magnetite coated gold core-shell nanoparticles, and the doping of cobalt to magnetite and manganese to magnetite nanoparticles. The important highlight of this research was the control of the size, shape, composition, and surface chemistry of nanoparticles.
Book Synopsis Functionalized Nanomaterials for Cancer Research by : Hamed Barabadi
Download or read book Functionalized Nanomaterials for Cancer Research written by Hamed Barabadi and published by Elsevier. This book was released on 2024-03-29 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step by step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients’ overall outcomes. The book discusses the functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. It is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment. Provides comprehensive coverage on functionalized nanomaterials for cancer therapeutics and future developments Explores current trends on functionalized nanomaterials for cancer research and commercial scale opportunities Discusses real-world case studies on functionalized nanomaterials for cancer therapy and research
