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Frontiers In Human Genetics
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Book Synopsis Frontiers in Human Genetics by : Eric Yap
Download or read book Frontiers in Human Genetics written by Eric Yap and published by World Scientific. This book was released on 2001 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the completion of human genome sequencing, human genetics is poised for major developments in functional genomics, molecular diagnostics, pathogenesis of complex multifactorial diseases and gene-based therapy. This book was conceived from an international symposium on human genetics and gene therapy that was held in Singapore in 1999. It includes manuscripts of the work presented as well as articles written by a selection of young researchers in the Asia Pacific region who are actively involved in a diverse range of medical problems, including cancer, infections, hypertension and myopia. New technologies being developed in gene therapy, lab-on-chips and bioinformatics are reported. The book provides a snapshot of the diverse approaches and solutions being developed at the frontiers of human genetics. It will be useful to researchers and students in molecular genetics and the life sciences, professionals in the biotechnology and pharmaceutical industries, clinicians who are interested in molecular medicine, etc.
Book Synopsis Invisible Frontiers by : Stephen S. Hall
Download or read book Invisible Frontiers written by Stephen S. Hall and published by Oxford University Press, USA. This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Author Stephen Hall weaves together the scientific, social and political threads of this story - the fierce rivalry between labs, the fateful clash of egos within labs, the invasion of academia by commerce, the public fears about genetic engineering, the threat of government regulation, and the ultimate triumph of modern biology - to give us an outstanding tale of scientific research."--BOOK JACKET.
Book Synopsis Making Sense of Genes by : Kostas Kampourakis
Download or read book Making Sense of Genes written by Kostas Kampourakis and published by Cambridge University Press. This book was released on 2017-03-30 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are genes? What do genes do? These seemingly simple questions are in fact challenging to answer accurately. As a result, there are widespread misunderstandings and over-simplistic answers, which lead to common conceptions widely portrayed in the media, such as the existence of a gene 'for' a particular characteristic or disease. In reality, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning of our life story. This comprehensive book analyses and explains the gene concept, combining philosophical, historical, psychological and educational perspectives with current research in genetics and genomics. It summarises what we currently know and do not know about genes and the potential impact of genetics on all our lives. Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals.
Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Book Synopsis Epigenetics in Health and Disease by : Igor Kovalchuk
Download or read book Epigenetics in Health and Disease written by Igor Kovalchuk and published by FT Press. This book was released on 2012 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: "After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Page 4 of cover.
Book Synopsis Mobilizing Mutations by : Daniel Navon
Download or read book Mobilizing Mutations written by Daniel Navon and published by University of Chicago Press. This book was released on 2019-09-20 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: With every passing year, more and more people learn that they or their young or unborn child carries a genetic mutation. But what does this mean for the way we understand a person? Today, genetic mutations are being used to diagnose novel conditions like the XYY, Fragile X, NGLY1 mutation, and 22q11.2 Deletion syndromes, carving out rich new categories of human disease and difference. Daniel Navon calls this form of categorization “genomic designation,” and in Mobilizing Mutations he shows how mutations, and the social factors that surround them, are reshaping human classification. Drawing on a wealth of fieldwork and historical material, Navon presents a sociological account of the ways genetic mutations have been mobilized and transformed in the sixty years since it became possible to see abnormal human genomes, providing a new vista onto the myriad ways contemporary genetic testing can transform people’s lives. Taking us inside these shifting worlds of research and advocacy over the last half century, Navon reveals the ways in which knowledge about genetic mutations can redefine what it means to be ill, different, and ultimately, human.
Book Synopsis Frontiers in the Nutrition Sciences by : Institute of Medicine
Download or read book Frontiers in the Nutrition Sciences written by Institute of Medicine and published by National Academies Press. This book was released on 1989-02-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series of individually authored chapters examines the nature and extent of scientific advances in the nutrition sciences and describes both future opportunities in the field and barriers to progress. Despite concern about declining attention to nutrition in universities and medical schools, the authors offer a bright and challenging future in nutrition research and training that should generate enthusiasm among young researchers and teachers for this indispensable component of biology.
Book Synopsis The Genetics of Neurodevelopmental Disorders by : Kevin J. Mitchell
Download or read book The Genetics of Neurodevelopmental Disorders written by Kevin J. Mitchell and published by John Wiley & Sons. This book was released on 2015-09-28 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.
Book Synopsis Frontiers in Computational and Systems Biology by : Jianfeng Feng
Download or read book Frontiers in Computational and Systems Biology written by Jianfeng Feng and published by Springer Science & Business Media. This book was released on 2010-06-14 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual’s susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.
Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council
Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Book Synopsis New Trends on Genome and Transcriptome Characterizations by :
Download or read book New Trends on Genome and Transcriptome Characterizations written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is devoted to bioinformaticians, geneticists and researchers who study or apply methods and algorithms for genomes and transcriptome analyses, aimed at understanding pathology discriminations and classifications. Papers are encouraged that use unconventional approaches and/or where mathematical and computational concepts are applied to biological and medical contexts in original ways. The contributions presented in the Topic should be of interest also to a wide class of scientists and students involved in the several fields where genomic and transcriptomic approaches are becoming essential for future investigations.
Download or read book Neuroeconomics written by Martin Reuter and published by Springer. This book was released on 2016-10-06 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents one of the cornerstones of the series Studies in Neuroscience, Psychology and Behavioral Economics. It is divided into eight sections, starting with an introduction to neuroeconomics followed by an overview of frequently applied experimental paradigms (games) in neuroeconomics research. Furthermore, it addresses the molecular basis of human decision making, environmental/situational factors and social contexts influencing human decision making, as well as translational and developmental/clinical approaches to neuroeconomics. In closing, a paper on neuro-marketing demonstrates how knowledge from neuroeconomics research can be applied in “real life.” Culminating in an extensive methods section, in which eight different neuroscience techniques are introduced, the book offers an essential resource for researchers and practitioners, and may also be beneficial for graduate students.
Book Synopsis Human Genetics and Genomics by : Bruce R. Korf
Download or read book Human Genetics and Genomics written by Bruce R. Korf and published by John Wiley & Sons. This book was released on 2012-11-19 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today’s genetics teaching, and includes updated discussion of genetic risk assessment, “single gene” disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice 'Hot topics' boxes that focus on the latest developments in testing, assessment and treatment 'Ethical issues' boxes to prompt further thought and discussion on the implications of genetic developments 'Sources of information' boxes to assist with the practicalities of clinical research and information provision Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparation Interactive Multiple Choice Questions (MCQs) with feedback on all answers Links to online resources for further study Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.
Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi
Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Book Synopsis Heritable Human Genome Editing by : The Royal Society
Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Book Synopsis Decision Neuroscience by : Jean-Claude Dreher
Download or read book Decision Neuroscience written by Jean-Claude Dreher and published by Academic Press. This book was released on 2016-09-27 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decision Neuroscience addresses fundamental questions about how the brain makes perceptual, value-based, and more complex decisions in non-social and social contexts. This book presents compelling neuroimaging, electrophysiological, lesional, and neurocomputational models in combination with hormonal and genetic approaches, which have led to a clearer understanding of the neural mechanisms behind how the brain makes decisions. The five parts of the book address distinct but inter-related topics and are designed to serve both as classroom introductions to major subareas in decision neuroscience and as advanced syntheses of all that has been accomplished in the last decade. Part I is devoted to anatomical, neurophysiological, pharmacological, and optogenetics animal studies on reinforcement-guided decision making, such as the representation of instructions, expectations, and outcomes; the updating of action values; and the evaluation process guiding choices between prospective rewards. Part II covers the topic of the neural representations of motivation, perceptual decision making, and value-based decision making in humans, combining neurcomputational models and brain imaging studies. Part III focuses on the rapidly developing field of social decision neuroscience, integrating recent mechanistic understanding of social decisions in both non-human primates and humans. Part IV covers clinical aspects involving disorders of decision making that link together basic research areas including systems, cognitive, and clinical neuroscience; this part examines dysfunctions of decision making in neurological and psychiatric disorders, such as Parkinson's disease, schizophrenia, behavioral addictions, and focal brain lesions. Part V focuses on the roles of various hormones (cortisol, oxytocin, ghrelin/leptine) and genes that underlie inter-individual differences observed with stress, food choices, and social decision-making processes. The volume is essential reading for anyone interested in decision making neuroscience. With contributions that are forward-looking assessments of the current and future issues faced by researchers, Decision Neuroscience is essential reading for anyone interested in decision-making neuroscience. - Provides comprehensive coverage of approaches to studying individual and social decision neuroscience, including primate neurophysiology, brain imaging in healthy humans and in various disorders, and genetic and hormonal influences on decision making - Covers multiple levels of analysis, from molecular mechanisms to neural-systems dynamics and computational models of how we make choices - Discusses clinical implications of process dysfunctions, including schizophrenia, Parkinson's disease, eating disorders, drug addiction, and pathological gambling - Features chapters from top international researchers in the field and full-color presentation throughout with numerous illustrations to highlight key concepts
Author :Committee on Technological Innovation in Medicine Publisher :National Academies Press ISBN 13 :0309587611 Total Pages :255 pages Book Rating :4.3/5 (95 download)
Book Synopsis Sources of Medical Technology by : Committee on Technological Innovation in Medicine
Download or read book Sources of Medical Technology written by Committee on Technological Innovation in Medicine and published by National Academies Press. This book was released on 1995-01-15 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence suggests that medical innovation is becoming increasingly dependent on interdisciplinary research and on the crossing of institutional boundaries. This volume focuses on the conditions governing the supply of new medical technologies and suggest that the boundaries between disciplines, institutions, and the private and public sectors have been redrawn and reshaped. Individual essays explore the nature, organization, and management of interdisciplinary R&D in medicine; the introduction into clinical practice of the laser, endoscopic innovations, cochlear implantation, cardiovascular imaging technologies, and synthetic insulin; the division of innovating labor in biotechnology; the government- industry-university interface; perspectives on industrial R&D management; and the growing intertwining of the public and proprietary in medical technology.
