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Expression Purification And Characterization Of Cellular Retinoic Acid Binding Protein Types I And Ii A Role In Vitamin A Metabolism
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Book Synopsis Expression, Purification and Characterization of Cellular Retinoic Acid Binding Protein Types I and II. A Role in Vitamin A Metabolism by : Paul Douglas Fiorella
Download or read book Expression, Purification and Characterization of Cellular Retinoic Acid Binding Protein Types I and II. A Role in Vitamin A Metabolism written by Paul Douglas Fiorella and published by . This book was released on 1995 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Biochemistry of Retinoid Signaling II by : Mary Ann Asson-Batres
Download or read book The Biochemistry of Retinoid Signaling II written by Mary Ann Asson-Batres and published by Springer. This book was released on 2016-11-09 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Book Synopsis The Roles of Cellular Retinol-binding Protein in the Pathway of Retinoic Acid Biosynthesis. Characterization and Purification of a Microsomal NADP-dependent Retinol Dehydrogenase by : Manja Hermina Elisabeth Maria Boerman
Download or read book The Roles of Cellular Retinol-binding Protein in the Pathway of Retinoic Acid Biosynthesis. Characterization and Purification of a Microsomal NADP-dependent Retinol Dehydrogenase written by Manja Hermina Elisabeth Maria Boerman and published by . This book was released on 1994 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Biochemical Characterization of Cellular Retinoic Acid Binding Protein Type 1 (CRABP1) by : Emma Magna
Download or read book The Biochemical Characterization of Cellular Retinoic Acid Binding Protein Type 1 (CRABP1) written by Emma Magna and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Physiological Characterization of the Interaction Between Retinoid Homeostasis and Energy Metabolism by : Alexandra Efthymios Folias
Download or read book Physiological Characterization of the Interaction Between Retinoid Homeostasis and Energy Metabolism written by Alexandra Efthymios Folias and published by . This book was released on 2008 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of Cellular Interactions by Vitamin A and Derivatives (retinoids) by : Luigi M. De Luca
Download or read book Modulation of Cellular Interactions by Vitamin A and Derivatives (retinoids) written by Luigi M. De Luca and published by . This book was released on 1981 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The proceedings of a 1980 technical conference concerning the modulation of cellular interactions by vitamin A and its derivatives are presented. Over 50 papers are included; major areas of research are: chemistry and in vivo studies; retinoid metabolism; retinoid-binding proteins; cellular interaction; biochemical models; and miscellaneous related studies. Rationale for the research derives from the observation that a major physiological role of vitamin A is to maintain normal phenotypic expression of epithelial tissues, which, in deficiency, undergo processes of squamous metaplasia and keratinization. Such processes also occur as a result of exposure to certain chemical carcinogens. Some retinoids have been demonstrated as effective protection agents of chemical carcinogenesis. Retinoids have also been observed to alter cell surface properties of neoplastically-transferred cells. The material is presented to provide a useful resource for future research in cell biology as related to the biochemical and biological roles of vitamin A and its derivatives. (wz).
Book Synopsis The Retinoid Receptors and Cellular Retinoic Acid Binding Proteins by : Anuradha Samantha Budhu
Download or read book The Retinoid Receptors and Cellular Retinoic Acid Binding Proteins written by Anuradha Samantha Budhu and published by . This book was released on 2002 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Fatty Acid-Binding Proteins II by : Jan F.C. Glatz
Download or read book Cellular Fatty Acid-Binding Proteins II written by Jan F.C. Glatz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twenty years have elapsed since cytoplasmic proteins exhibiting high-affinity binding of long-chain fatty acids were first identified (Ockner et al., Science 177:56-58, 1972). These cellular fatty acid-binding proteins (FABPs) are now well established to comprise a ligand-defined group of macromolecules belonging to a family of cytoplasmic lipid binding proteins. Unique features of the FABPs are the existence of distinct types of FABP and that these are found in a variety of tissues in remarkable abundance, with some cells expressing more than one type. The physiological significance of the FABPs has only partly been elucidated. By increasing the cytoplasmic solubilization of fatty acids, the cellular FABPs are considered to function primarily in intracellular fatty acid transport, but may also be assigned important regulatory roles in cellular lipid homeostasis as well as in the modulation of cell growth and differentiation. The broad interests in cellular FABPs has led to the organization of the 1st International Workshop on Fatty Acid-Binding Protein, held in Maastricht, the Netherlands, in 1989. Prompted by the success of the first meeting, the 2nd International Workshop on Fatty-Acid-Binding Proteins, which was held again in Maastricht, on August 31 and September 1, 1992, brought together scientific scpecialists in the field of FABP research for two days of intensive and fruitful discussion. This volume is a collection of selected papers from this conference, and thus provides the state-of-the-art knowledge of cellular FABPs. The contributors to this issue represent pioneering as well as new investigators, and also reflect the multidisciplinary nature of research in this exciting and rapidly progressing field.
Book Synopsis The Enzymes that Synthesize Retinoic Acid in Epithelial Cells Expressing Cellular Retinoic Acid Binding Protein Type II by : Brent Neil Rexer
Download or read book The Enzymes that Synthesize Retinoic Acid in Epithelial Cells Expressing Cellular Retinoic Acid Binding Protein Type II written by Brent Neil Rexer and published by . This book was released on 2001 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Fat-Soluble Vitamins by : H. DeLuca
Download or read book The Fat-Soluble Vitamins written by H. DeLuca and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first demonstration of the existence of a vitamin and the full recognition of this fact are often attributed to the work of McCollum, who found that a sub stance in butterfat and cod-liver oil was necessary for growth and health of ani mals fed purified diets. It became obvious that an organic substance present in microconcentrations was vital to growth and reproduction of animals. Following the coining of the word vitamine by Funk, McCollum named this fat-soluble sub stance vitamin A. We can, therefore, state that vitamin A was certainly one of the first known vitamins, yet its function and the function of the other fat-soluble vitamins had remained largely unknown until recent years. However, there has been an explosion of investigation and new information in this field, which had remained quiescent for at least two or three decades. It is now obvious that the fat-soluble vitamins function quite differently from their water-soluble counter parts. We have learned that vitamin D functions by virtue of its being converted in the kidney to a hormone that functions to regulate calcium and phosphorus metabolism. This new endocrine system is in the process of being elucidated in detail, and in addition, the medical use of these hormonal forms of vitamin D in the treatment of a variety of metabolic bone diseases has excited the medical com munity.
Book Synopsis Retinoids: Their Physiological Function and Therapeutic Potential by : G.V. Sherbet
Download or read book Retinoids: Their Physiological Function and Therapeutic Potential written by G.V. Sherbet and published by Elsevier. This book was released on 1997-10-30 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.
Book Synopsis Characterization of Two Distinct Cellular Retinoic Acid-binding Proteins from Rodent Tissue by : John Stuart Bailey
Download or read book Characterization of Two Distinct Cellular Retinoic Acid-binding Proteins from Rodent Tissue written by John Stuart Bailey and published by . This book was released on 1989 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1995 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expression and Function of the Cellular Retinoic Acid-binding Protein I (CRABP I) During Mouse Development by : Ana V. Perez
Download or read book Expression and Function of the Cellular Retinoic Acid-binding Protein I (CRABP I) During Mouse Development written by Ana V. Perez and published by . This book was released on 1992 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nutrient Regulation during Pregnancy, Lactation, and Infant Growth by : Lindsay Allen
Download or read book Nutrient Regulation during Pregnancy, Lactation, and Infant Growth written by Lindsay Allen and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost every aspect of energy and nutrient metabolism is altered by hormonal and other physiological changes during pregnancy and lactation. While it is evident that hormonal adjustments affect nutrient requirements, these are rarely considered when nutrient recommen dations are made for pregnant or lactating women, and often neglected during evaluation of nutritional status. In addition, changes in nutrient metabolism during the stages of pregnancy and oflactation are usually considered separately, while in reality events during pregnancy can have a major influence on nutritional status and nutrient requirements during lactation. The purpose of this volume is to describe changes in the metabolism of important nutrients during pregnancy and lactation, including the physiological basis for these changes and their implications for nutrient requirements and assessment. Authors have considered such issues as inter-relationships between endocrine changes and nutrient metabolism at the tissue, cellular and molecular level; alterations in nutrient binding proteins; the efficiency of nutrient absorp tion and retention; and the impact on maternal as well as fetal nutritional status. Another unique aspect of this book is the focus on pregnancy and lactation as a continuum.
Book Synopsis Cellular Retinoic Acid Binding Protein and Breast Cancer by :
Download or read book Cellular Retinoic Acid Binding Protein and Breast Cancer written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: In attempts to understand how the signaling by retinoic acid (the active vitamin A metabolite) is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand. The first aim is to determine the extent to which CRABP-II acts in activating different isotypes of RAR. The second aim is to dissect the mechanism by which RA-induced growth inhibition is mediated. This will then allow for closer inspection of particular target genes that are under such control. The third aim is to understand the basis for RA-resistance of mammary carcinoma cells and how CRABP-II functions to overcome this resistance.
Download or read book Vitamin A written by and published by Elsevier. This book was released on 2011-09-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
