Endothelial Cell Biology In Health And Disease

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Endothelial Cell Biology in Health and Disease

Author : M. Simionescu
Publisher : Springer Science & Business Media
ISBN 13 : 1461309379
Total Pages : 460 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Endothelial Cell Biology in Health and Disease by : M. Simionescu

Download or read book Endothelial Cell Biology in Health and Disease written by M. Simionescu and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although blood capillaries were first observed through a flea-lens microscope by Malpighi in 1661,200 more years elapsed before the cellular nature of the vessel wall was conclusively demonstrated. Beginning with the middle of the 19th cen tury, our knowledge of the histological organization of blood vessels has steadily increased. However, the endothelium, which for a long time was considered to be just an inert barrier lining, had been barely explored until three decades ago. Since then, there has been an upsurge of interest in the fine structure and function of endothelial cells. Intense in vivo and in vitro investigations have revealed that the endothelial cell is a key element in a wide variety of normal activities and diseases. A large number of investigators and laboratories have been attracted to endothelial cell research, thus supporting the expansion of the continuously grow ing and diversifying field of endotheliology. The number of articles published annually on this subject has increased from a few score at the beginning of the 1970s to more than a thousand in recent years, and an increasing number of journals, books, societies, and symposia focused primarily on the vascular en dothelium have marked the last decade.

Endothelial Dynamics in Health and Disease

Author : Jaap Diederik Van Buul
Publisher : Frontiers Media SA
ISBN 13 : 2889663523
Total Pages : 152 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Endothelial Dynamics in Health and Disease by : Jaap Diederik Van Buul

Download or read book Endothelial Dynamics in Health and Disease written by Jaap Diederik Van Buul and published by Frontiers Media SA. This book was released on 2021-01-06 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Vascular Endothelium in Health and Disease

Author : Shu Chien
Publisher : Springer Science & Business Media
ISBN 13 : 1468489356
Total Pages : 221 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Vascular Endothelium in Health and Disease by : Shu Chien

Download or read book Vascular Endothelium in Health and Disease written by Shu Chien and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been rapid progress in research on vascular endothelium. This has led to significant advances in our understanding of the structure and function of vascular endothelium in health and disease, including such aspects as the permeability of endothelium in relation to its ultrastructural correlates, theoretical basis, regulatory factors, and role in atherogenesis; the interaction between endothelium and blood cells; the endothelial release and processing of a number of important physiological agents, such as eicosanoids, hemostatic factors, and histamine; the cell biology of endothelium with respect to the cytoskeletal apparatus, cell activation, and cell locomotion; and the role of endothelium in microcirculatory regulation in normal and pathophysiological circumstances. A Symposium on "Vascular Endothelium in Health and Disease" was held on August 5-6, 1987, at the Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China, following the 4th World Congress for Microcirculation in Japan. Experts working on various aspects of vascular endothelium came from allover the world to participate in this two-day Symposium and gave excellent presentations. This volume, embodying the proceedings of that Symposium, is a collection of the papers given by the speakers with, in many cases, further updating and new information added subsequent to the Symposium. The Institute of Biomedical Sciences (IBMS), the site of this Symposium, is a newlJl established research institution, which has vascular endothelium as one of its areas of research emphasis.

Methods in Endothelial Cell Biology

Author : Hellmut G. Augustin
Publisher : Springer Science & Business Media
ISBN 13 : 3642187250
Total Pages : 383 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Methods in Endothelial Cell Biology by : Hellmut G. Augustin

Download or read book Methods in Endothelial Cell Biology written by Hellmut G. Augustin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial cell biology has developed into a vibrant discipline and has become a critical instrument to study several disease processes on the cellular and molecular level. It is now widely recognized that dysfunctions of normal endothelial cell homeostasis are involved in some of the most important human diseases, including ischemic heart diseases, hypertension, atherosclerosis, tumors, diabetes, arthritis, and inflammation. Further, the increasing importance and recognition of the field of vascular biology in general requires in vitro and in vivo techniques in order to address the complex questions. Methods in Endothelial Cell Biology is a comprehensive practical "how-to"-guide summarizing the most relevant established techniques as well as a number of new emerging techniques. Easy-to-follow reliable protocols provide a useful lab bench resource for the experienced researcher and newcomer to the field.

The Pulmonary Endothelium

Author : Norbert Voelkel
Publisher : John Wiley & Sons
ISBN 13 : 9780470747506
Total Pages : 532 pages
Book Rating : 4.7/5 (475 download)

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Book Synopsis The Pulmonary Endothelium by : Norbert Voelkel

Download or read book The Pulmonary Endothelium written by Norbert Voelkel and published by John Wiley & Sons. This book was released on 2009-08-25 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals – specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.

Endothelial Cells in Health and Disease

Author : William C. Aird
Publisher : CRC Press
ISBN 13 : 1135534608
Total Pages : 508 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Endothelial Cells in Health and Disease by : William C. Aird

Download or read book Endothelial Cells in Health and Disease written by William C. Aird and published by CRC Press. This book was released on 2005-02-28 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic target.

Endothelial Progenitor Cells in Health and Disease

Author : Amankeldi A. Salybekov
Publisher :
ISBN 13 : 9781685077945
Total Pages : pages
Book Rating : 4.0/5 (779 download)

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Book Synopsis Endothelial Progenitor Cells in Health and Disease by : Amankeldi A. Salybekov

Download or read book Endothelial Progenitor Cells in Health and Disease written by Amankeldi A. Salybekov and published by . This book was released on 2022-06-15 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We are delighted to offer this textbook to the scientific community, entitled Endothelial Progenitor Cells in Health and Diseases, which covers a timely topic in the rapidly evolving discipline of vascular biology. Written primarily for a life science audience and clinicians, the fundamentals of EPCs biology and the latest characterization and definition in health and diseases are introduced, followed by explanations of the most cutting-edge cell therapy methods to cure ischemic diseases. In Section One, endothelial cell progenitor isolation methods and biological characterization were reported. The discovery of this novel endothelial progenitor cells (EPC) concept has overturned the previous dogma which suggested that vasculogenesis could only occur during embryogenesis. In fact, both vasculogenesis and angiogenesis may potentially have a synergistic role in postnatal revascularization. Also, this chapter summarized recent advances in EPC biology such as biological function, origin, definition, and classification. Each EPC culture and isolation method is clearly defined to prevent confusion in EPC biology. Section Two focuses on EPC biological function alteration in cardiovascular diseases (CVD). Several large clinical trials have reported that the number and biological function are strongly associated with major adverse cardiovascular events. The diagnostic and prognostic potential of EPC is crucial in terms of CVD. In Section Three, biological dysfunction mechanisms of EPC and their scarcity in diabetic patients' peripheral blood were clearly described. Preclinical studies have shown that EPC-based therapy is feasible, safe, and efficacious in multiple disease states. Subsequently, this has led to several clinical trials demonstrating the feasibility and safety profile of EPC therapy against cardiovascular ischemic diseases. In Section Four, regenerative medicine pioneers discussed EPCs translation to the clinic and cell transplantation challenges along with their solutions. Personalized stem cell-based therapy approaches employing several clinical biomarkers, disease-related genetic-trait evaluation methods, and advanced analyses with state-of-the-art computational methods such as machine learning-based prediction can increase cell therapies' efficacy and decrease treatment costs. The last chapter in the book describes a therapeutic application of EPC-derived extracellular vesicles to cure CVD.

Cooperation of Liver Cells in Health and Disease

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Cardiovascular Biology

Author : J. F. Stoltz
Publisher : IOS Press
ISBN 13 : 9781586037758
Total Pages : 222 pages
Book Rating : 4.0/5 (377 download)

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Book Synopsis Cardiovascular Biology by : J. F. Stoltz

Download or read book Cardiovascular Biology written by J. F. Stoltz and published by IOS Press. This book was released on 2007 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular endothelial plays a significant role in regulating blood flow, and endothelial cells (EC) have highly active metabolic functions. This volume focuses on Vascular Endothelium, NO and Hypertension and is a continuum of the volumes on Mechanobiology of Cartilage and Chondrocyte.

Biology of Endothelial Cells

Author : Eric A. Jaffe
Publisher : Springer Science & Business Media
ISBN 13 : 146132825X
Total Pages : 471 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Biology of Endothelial Cells by : Eric A. Jaffe

Download or read book Biology of Endothelial Cells written by Eric A. Jaffe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The development in the early 1970's of routine and easily implemented methods for culturing human endothelial cells and the demonstration that cultured endothelial cells synthesized a physiologically relevant protein, Factor VIII/von Willebrand Factor, quickly changed this state of affairs. Over the following decade the scope of endothelial cell research rapidly widened, spreading in a number of directions. First, methods were developed to culture endothelial cells from a variety of species. Second, methods were developed to culture endothelial cells from different organs and types of blood vessels (arteries, veins, and capillaries) within a single species. Third, and most important, investigators began using cultured endothelial cells as tools to study the potential involvement of endothelial cells in a wide assortment of biologically interesting processes. The net result has been a tremendous increase in our understanding of endothelial cell function.

Endothelial Signaling in Development and Disease

Author : Mirko HH Schmidt
Publisher : Springer
ISBN 13 : 1493929070
Total Pages : 401 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Endothelial Signaling in Development and Disease by : Mirko HH Schmidt

Download or read book Endothelial Signaling in Development and Disease written by Mirko HH Schmidt and published by Springer. This book was released on 2015-10-08 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.

Angiogenesis and Vascularisation

Author : Józef Dulak
Publisher : Springer Science & Business Media
ISBN 13 : 3709114284
Total Pages : 416 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Angiogenesis and Vascularisation by : Józef Dulak

Download or read book Angiogenesis and Vascularisation written by Józef Dulak and published by Springer Science & Business Media. This book was released on 2014-02-10 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed – aggravated or impaired – vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Endothelial Dysfunction and Inflammation

Author : Shauna Dauphinee
Publisher : Springer Science & Business Media
ISBN 13 : 3034601689
Total Pages : 234 pages
Book Rating : 4.0/5 (346 download)

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Book Synopsis Endothelial Dysfunction and Inflammation by : Shauna Dauphinee

Download or read book Endothelial Dysfunction and Inflammation written by Shauna Dauphinee and published by Springer Science & Business Media. This book was released on 2010-09-24 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

Cell Movement in Health and Disease

Author : Michael Schnoor
Publisher : Academic Press
ISBN 13 : 0323901964
Total Pages : 386 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Cell Movement in Health and Disease by : Michael Schnoor

Download or read book Cell Movement in Health and Disease written by Michael Schnoor and published by Academic Press. This book was released on 2022-03-30 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Movement in Health and Disease brings the several scientific domains related to the phenomena together, establishing a consistent foundation for researchers in this exciting field. The content is presented in four main section. The first explores the foundations of Cell Movement, including overviews of cellular structure, signaling, physiology, motion-related proteins, and the interface with the cellular membrane. The second part covers the biological aspects of cellular movement, starting with chemical and mechanical sensing, describing the types of cell movement, mechanics at cell level, cell physiology, collective behavior, and the connections with the extracellular matrix. The following chapters provide an overview of the molecular machinery involved and cell-type specific movement. The third part of the book is dedicated to the translational aspects of cell movement, highlighting the key conditions associated with cell movement dysfunction, like cell invasion in cancer, wound healing, developmental issues, neurological dysfunctions, and immune response. The final part of the book covers key methods and modeling tools for cell movement research, including predictive mathematical models, in vitro and in vivo methods, biophysical and bioinformatics tools. Cell Movement in Health and Disease is the ideal reference for scientists from different backgrounds converging to expand the understanding of this key cellular process. Cellular and molecular biologists will gain a better understanding of the physical principals operating at cellular level while biophysicist and biomedical engineers will benefit from the solid biology foundation provided by the book. Combines Biology, Physics and Modeling of cellular movement in one single source Updated with the current understanding of the field Includes key research methods for cell movement investigation Cover translational aspects of cellular movement

Biology of Endothelial Cells

Author : Eric A Jaffe
Publisher :
ISBN 13 : 9781461328261
Total Pages : 476 pages
Book Rating : 4.3/5 (282 download)

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Book Synopsis Biology of Endothelial Cells by : Eric A Jaffe

Download or read book Biology of Endothelial Cells written by Eric A Jaffe and published by . This book was released on 1984-03-31 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Endothelium and Cardiovascular Diseases

Author : Protasio Lemos Da Luz
Publisher : Academic Press
ISBN 13 : 0128125519
Total Pages : 758 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Endothelium and Cardiovascular Diseases by : Protasio Lemos Da Luz

Download or read book Endothelium and Cardiovascular Diseases written by Protasio Lemos Da Luz and published by Academic Press. This book was released on 2018-02-03 with total page 758 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes