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Biology Of Endothelial Cells
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Book Synopsis Biology of Endothelial Cells by : Eric A. Jaffe
Download or read book Biology of Endothelial Cells written by Eric A. Jaffe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The development in the early 1970's of routine and easily implemented methods for culturing human endothelial cells and the demonstration that cultured endothelial cells synthesized a physiologically relevant protein, Factor VIII/von Willebrand Factor, quickly changed this state of affairs. Over the following decade the scope of endothelial cell research rapidly widened, spreading in a number of directions. First, methods were developed to culture endothelial cells from a variety of species. Second, methods were developed to culture endothelial cells from different organs and types of blood vessels (arteries, veins, and capillaries) within a single species. Third, and most important, investigators began using cultured endothelial cells as tools to study the potential involvement of endothelial cells in a wide assortment of biologically interesting processes. The net result has been a tremendous increase in our understanding of endothelial cell function.
Book Synopsis Endothelial Cell Biology in Health and Disease by : M. Simionescu
Download or read book Endothelial Cell Biology in Health and Disease written by M. Simionescu and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although blood capillaries were first observed through a flea-lens microscope by Malpighi in 1661,200 more years elapsed before the cellular nature of the vessel wall was conclusively demonstrated. Beginning with the middle of the 19th cen tury, our knowledge of the histological organization of blood vessels has steadily increased. However, the endothelium, which for a long time was considered to be just an inert barrier lining, had been barely explored until three decades ago. Since then, there has been an upsurge of interest in the fine structure and function of endothelial cells. Intense in vivo and in vitro investigations have revealed that the endothelial cell is a key element in a wide variety of normal activities and diseases. A large number of investigators and laboratories have been attracted to endothelial cell research, thus supporting the expansion of the continuously grow ing and diversifying field of endotheliology. The number of articles published annually on this subject has increased from a few score at the beginning of the 1970s to more than a thousand in recent years, and an increasing number of journals, books, societies, and symposia focused primarily on the vascular en dothelium have marked the last decade.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Book Synopsis Methods in Endothelial Cell Biology by : Hellmut G. Augustin
Download or read book Methods in Endothelial Cell Biology written by Hellmut G. Augustin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial cell biology has developed into a vibrant discipline and has become a critical instrument to study several disease processes on the cellular and molecular level. It is now widely recognized that dysfunctions of normal endothelial cell homeostasis are involved in some of the most important human diseases, including ischemic heart diseases, hypertension, atherosclerosis, tumors, diabetes, arthritis, and inflammation. Further, the increasing importance and recognition of the field of vascular biology in general requires in vitro and in vivo techniques in order to address the complex questions. Methods in Endothelial Cell Biology is a comprehensive practical "how-to"-guide summarizing the most relevant established techniques as well as a number of new emerging techniques. Easy-to-follow reliable protocols provide a useful lab bench resource for the experienced researcher and newcomer to the field.
Book Synopsis Biology of Endothelial Cells by : Eric A Jaffe
Download or read book Biology of Endothelial Cells written by Eric A Jaffe and published by . This book was released on 1984-03-31 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Endothelial Cell Culture by : Roy Bicknell
Download or read book Endothelial Cell Culture written by Roy Bicknell and published by Cambridge University Press. This book was released on 1996-09-28 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.
Book Synopsis The Radiation Biology of the Vascular Endothelium by : David B. Rubin
Download or read book The Radiation Biology of the Vascular Endothelium written by David B. Rubin and published by CRC Press. This book was released on 1997-12-29 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial cells are early targets of radiation injury. Because these cells are tissues easily damaged by radiation, if we can understand the causes of radiation injury, then normal cells can be well protected and tumors can be destroyed. The Radiation Biology of the Vascular Endothelium brings together expert reviews on the biology and radiobiology of the vasculature, with emphasis on the endothelial cell component of blood vessels. The book covers both the basic aspects of endothelial cell biology and the practical consequences of this for the oncologist, with special reference to the radiation oncologist. After reading The Radiation Biology of the Vascular Endothelium, no clinical or experimental oncologist should be able to ignore the intimate relationship between tumor and normal tissue cells and endothelial cells that form the barrier to, and are the bearers of, essential nutrient supplies.
Book Synopsis Regulation of Endothelial Barrier Function by : Sarah Y. Yuan
Download or read book Regulation of Endothelial Barrier Function written by Sarah Y. Yuan and published by Biota Publishing. This book was released on 2011-02-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood–tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell–cell and cell–matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care.
Download or read book Hypertension written by Rhian M. Touyz and published by Humana. This book was released on 2017-01-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive protocols that researchers can use to dissect out fundamental principles and molecular mechanisms of hypertension, extending from genetics of experimental hypertension to biomarkers in clinical hypertension. Hypertension: Methods and Protocols guides readers through chapters on genetics and mmics of hypertension; the Renin-Angiotensin-Aldosterone System; vasoactive agents and hypertension; signal transduction and reactive oxygen species; novel cell models and approaches to study molecular mechanisms of hypertension; vascular physiology; and new approaches to manipulate mouse models to study molecular mechanisms of hypertension. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Hypertension: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Book Synopsis Endothelial Biomedicine by : William C. Aird
Download or read book Endothelial Biomedicine written by William C. Aird and published by Cambridge University Press. This book was released on 2007-09-03 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all areas of the human body. Clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. The endothelium has remarkable, though largely untapped, diagnostic and therapeutic potential. This volume bridges the bench-to-bedside gap in endothelial biomedicine, advancing research and development and improving human health. The book is the first to systematically integrate knowledge about the endothelium from different organ-specific disciplines, including neurology, pulmonary, cardiology, gastroenterology, rheumatology, infectious disease, hematology-oncology, nephrology, and dermatology. It's interdisciplinary approach, which draws on expertise from such diverse fields as evolutionary biology, comparative biology, molecular and cell biology, mathematical modeling and complexity theory, translational research, and clinical medicine.
Book Synopsis Molecular Mechanisms and Signaling in Endothelial Cell Biology and Vascular Heterogeneity by : Bin Ren
Download or read book Molecular Mechanisms and Signaling in Endothelial Cell Biology and Vascular Heterogeneity written by Bin Ren and published by Frontiers Media SA. This book was released on 2022-02-02 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cardiovascular Biology by : J. F. Stoltz
Download or read book Cardiovascular Biology written by J. F. Stoltz and published by IOS Press. This book was released on 2007 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular endothelial plays a significant role in regulating blood flow, and endothelial cells (EC) have highly active metabolic functions. This volume focuses on Vascular Endothelium, NO and Hypertension and is a continuum of the volumes on Mechanobiology of Cartilage and Chondrocyte.
Download or read book Endothelial Cells written by Una S. Ryan and published by CRC Press. This book was released on 1988-04-30 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume compendium is the most comprehensive work, to date, on endothelium cells and their important role in the functions of the internal framework. The endothelial cell is broken down into its different properties, taking into consideration its part in metabolic, hemostatic, and immunological processes, as well as their interac-tion with each other and different cell types. Numerous illustrations featured throughout help clarify the importance of endothelium in maintaining the internal status quo. These volumes are indispens-able to researchers, physicians, and others interested in endothe-lium, vascular biology, and circulatory research.
Book Synopsis Morphogenesis of Endothelium by : Werner Risau
Download or read book Morphogenesis of Endothelium written by Werner Risau and published by CRC Press. This book was released on 2003-09-02 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cardiovascular system is the first functional organ system to develop in the vertebrate embryo. Embryonic growth and differentiation essentially depend on transport of nutrients and waste through the early vasculature, and certain events in morphogenesis are thought to be influenced by the hemodynamic forces of the beating heart. The vasculature not only serves as a 'nutrient and waste pipeline' but is also a major communication system between distant organs and tissues. The vascular endothelial cell mediates vascular growth, permeability, integrity and interactions with blood cells. In most tissues the endothelium itself is highly specialized to meet the particular needs of the tissue in terms of quality and quantity of incoming and outgoing molecules and messages. The areas covered by Morphogenesis of the Endothelium include the formation of blood vessels in embryonic tissues by vasculogenesis and angiogenesis and the differentiation of endothelium in organs. The contributors are leaders in the field of cardiovascular development, biology and pathology and have written up to date chapters on the mechanisms of blood vessel formation and function in embryos and the adult.
Book Synopsis Pericyte Biology - Novel Concepts by : Alexander Birbrair
Download or read book Pericyte Biology - Novel Concepts written by Alexander Birbrair and published by Springer. This book was released on 2018-12-06 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores novel concepts of pericyte biology. The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on what we know so far about the pericytes. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology in Disease, Pericyte Biology - Novel Concepts presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific diseases.
Book Synopsis Pericyte Biology in Different Organs by : Alexander Birbrair
Download or read book Pericyte Biology in Different Organs written by Alexander Birbrair and published by Springer. This book was released on 2019-04-01 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.
