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Divergent Regulation And Function Of Wnt Catenin Signaling And Tcf Transcription Factors In Pancreatic Cancer
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Book Synopsis Divergent Regulation and Function of Wnt/β-catenin Signaling and TCF Transcription Factors in Pancreatic Cancer by : Kathleen Kershaw
Download or read book Divergent Regulation and Function of Wnt/β-catenin Signaling and TCF Transcription Factors in Pancreatic Cancer written by Kathleen Kershaw and published by . This book was released on 2018 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: With steadily increasing incidence and an 8-9% 5-year survival rate, pancreatic ductal adenocarcinoma (PDA) treatment represents an urgent, unmet clinical need. Hindered by long asymptomatic growth, methods of early detection are not yet available, resulting in frequent late-stage patient presentation at which point treatment options are extremely limited. Current standards of care offer only modest increases in survival, and molecular targeted therapies have underperformed in the clinic, likely due in part to the high degree of genetic heterogeneity within PDA. Increased efforts to sequence large numbers of tumors have revealed a short list of highly mutated pathways within that heterogeneity, including the Wnt/ -catenin signaling pathway. A highly detailed understanding of the regulation and function of Wnt/ -catenin signaling in PDA however, is lacking. Here we use an unbiased approach to uncover the existence of discrete patterns of expression for T-cell factor/lymphoid enhancer factor (TCF/LEF) family members that are linked to divergent Wnt activity and function in PDA. Importantly, these distinct patterns were also observed in resected patient tumors where they are correlated with survival outcomes. TCF expression was found to define distinct subtypes of PDA with differential phenotypic responses to similar stimuli. Furthermore, patterns of TCF expression corresponded to differing Wnt niche growth requirements. The predictive power of TCFs may serve as a more sensitive biomarker for stratifying patients into relevant groups for targeted clinical therapies. Additionally, the effect of Wnt manipulation on TCF-mediated control of particular gene programs reveals vulnerabilities that could be targeted by novel therapeutics alongside Wnt, pushing PDA treatment one step closer to effective, personalized medicine.
Book Synopsis Targeting the Wnt Pathway in Cancer by : Kathleen H. Goss
Download or read book Targeting the Wnt Pathway in Cancer written by Kathleen H. Goss and published by Springer Science & Business Media. This book was released on 2011-01-25 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Book Synopsis Molecular Diagnostics by : Wayne W. Grody
Download or read book Molecular Diagnostics written by Wayne W. Grody and published by Academic Press. This book was released on 2009-11-06 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. Molecular Diagnostics provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting. - Serves as the definitivereference for molecular pathologists worldwide - Covers a variety of molecular techniques including next generation sequencing, tumor somatic cell genotyping, infectious and genetic disease tecting, and pharmacogenetics - Discusses in the detail issues concerning quality assurance, regulation, ethics, and future directions for the science
Download or read book Intestinal Stem Cell Niche written by and published by Academic Press. This book was released on 2018-04-24 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication
Book Synopsis Pancreatic Cancer by : Douglas B. Evans
Download or read book Pancreatic Cancer written by Douglas B. Evans and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.
Book Synopsis The Unfolded Protein Response in Cancer by : Robert Clarke
Download or read book The Unfolded Protein Response in Cancer written by Robert Clarke and published by Springer. This book was released on 2019-03-01 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
Book Synopsis Aspects Cell Motility by : Society for Experimental Biology (Great Britain)
Download or read book Aspects Cell Motility written by Society for Experimental Biology (Great Britain) and published by . This book was released on 1968 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Kinases in Development and Disease by :
Download or read book Protein Kinases in Development and Disease written by and published by Academic Press. This book was released on 2017-02-22 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease. - Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms - Includes a broad scope of topics that are addressed - Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge
Book Synopsis Activity-Based Protein Profiling by : Benjamin F. Cravatt
Download or read book Activity-Based Protein Profiling written by Benjamin F. Cravatt and published by Springer. This book was released on 2019-01-25 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
Book Synopsis Signaling Pathways in Cancer Pathogenesis and Therapy by : David A. Frank
Download or read book Signaling Pathways in Cancer Pathogenesis and Therapy written by David A. Frank and published by Springer Science & Business Media. This book was released on 2011-11-12 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.
Book Synopsis Oxidative Stress and Chronic Degenerative Diseases by : Jose Antonio Morales-Gonzalez
Download or read book Oxidative Stress and Chronic Degenerative Diseases written by Jose Antonio Morales-Gonzalez and published by BoD – Books on Demand. This book was released on 2013-05-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.
Book Synopsis New Prognostic and Predictive Markers in Cancer Progression by : Susan Costantini Alfredo Budillon
Download or read book New Prognostic and Predictive Markers in Cancer Progression written by Susan Costantini Alfredo Budillon and published by MDPI. This book was released on 2021-02-12 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient’s outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.
Book Synopsis Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability by : Carlo Sala
Download or read book Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability written by Carlo Sala and published by Academic Press. This book was released on 2016-04-30 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. - Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities - Describes the genes implicated in autistic spectrum disorders and their function - Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies - Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture
Download or read book Prostate Cancer written by Scott M. Dehm and published by Springer Nature. This book was released on 2020-01-03 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.
Book Synopsis Tumor Suppressor Genes in Human Cancer by : David E. Fisher
Download or read book Tumor Suppressor Genes in Human Cancer written by David E. Fisher and published by Springer Science & Business Media. This book was released on 2000-10-26 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Book Synopsis Yamada's Textbook of Gastroenterology by : Daniel K. Podolsky
Download or read book Yamada's Textbook of Gastroenterology written by Daniel K. Podolsky and published by John Wiley & Sons. This book was released on 2015-10-22 with total page 16819 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seit 20 Jahren ist Yamada's Textbook of Gastroenterology das umfassendste und weltweit anerkannte Lehrwerk für das Fachgebiet und vereint in Form einer Enzyklopädie die wissenschaftlichen Grundlagen von Magen-Darm- und Lebererkrankungen mit den neuesten klinischen Erkenntnissen, vor allem Entwicklungen in den Bereichen Diagnose und Therapie. Zu dem Herausgeberteam unter der Leitung von Tachi Yamada, einer der weltweit führenden Forscher des Fachgebiets, gehörten schon immer herausragende Namen. Gleiches gilt für die Autoren vieler Beiträge, die zu den Experten ihres Fachbereichs gehören. Mit dem neuen Chefherausgeber Dan Podolsky, Professor für Innere Medizin an dem Southwestern Medical Center der University of Texas, wurde die 6. Auflage dieses führenden Lehrbuchs aktualisiert und in vielerlei Hinsicht verbessert - Jetzt beim Kauf der Printversion mit kostenlosem Zugriff auf die digitale Ausgabe mit umfassenden Suchfunktionen. - Einheitliche Darstellung der einzelnen Themenabschnitte, unterteilt in wissenschaftliche Grundlagen, Krankheiten und deren Symptome, und damit eine Vereinheitlichung in Aufbau, Inhalt und Länge. - Neuer Abschnitt "Principles of Clinical Gastroenterology" mit Schwerpunkt auf klinische Aspekte. In 14 Kapiteln wird auf die jeweiligen Krankheitssymptome eingegangen. Ärzte können so ihre Patienten in der Klinik noch besser beurteilen und behandeln. - Wichtige Themen werden noch ausführlicher erläutert (autoimmune Pankreatitis, fäkale Biomarker, Genetik, chronisch-entzündliche Darmerkrankungen, systemische IgG4-assoziierte Erkrankungen, Morbus Crohn, Colitis ulcerosa und eosinophile Ösophagitis). - Podcasts international führender Experten zu aktuellen Themen. - Stärkerer Schwerpunkt auf klinische Studien/Versuchsreihen, evidenzbasierte Praxis, Richtlinien von Fachverbänden und Regierungsstellen. - Verweise auf Online-Referenzwerke, Hyperlinks zu Pubmed/CrossRef. Die wichtigsten Verweise sind weiterhin in der Printversion enthalten. - Noch internationaler und global: Neben den führenden Experten aus Nordamerika kommen renommierte Fachärzte aus Europa und Asien zu Wort. Yamada's Textbook of Gastroenterology ist das umfassende Standardwerk der Gastroenterologie. Die 6. Auflage orientiert sich noch stärker am Klinikalltag, ist aufgrund der Fülle an Informationen zu wissenschaftlichen Grundlagen nach wie vor Marktführer und gleichzeitig ein herausragendes Referenzwerk zum klinischen Management von Erkrankungen des Magen-Darm-Trakts. Jetzt noch besser: Kostenloser Online-Zugang zu allen Inhalten der Printausgabe mit weitreichenden Suchfunktionen. Genau das Richtige für Gastroenterologen, ob erfahrener Praktiker oder Berufsanfänger.
Book Synopsis Poly(ADP-Ribosyl)ation by : Alexander Bürkle
Download or read book Poly(ADP-Ribosyl)ation written by Alexander Bürkle and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
