Computational Systems Biology And Bioinformatics

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Computational Systems Biology of Cancer

Author : Emmanuel Barillot
Publisher : CRC Press
ISBN 13 : 1439831440
Total Pages : 463 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Computational Systems Biology of Cancer by : Emmanuel Barillot

Download or read book Computational Systems Biology of Cancer written by Emmanuel Barillot and published by CRC Press. This book was released on 2012-08-25 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.

Elements of Computational Systems Biology

Author : Huma M. Lodhi
Publisher : John Wiley & Sons
ISBN 13 : 0470556749
Total Pages : 435 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Elements of Computational Systems Biology by : Huma M. Lodhi

Download or read book Elements of Computational Systems Biology written by Huma M. Lodhi and published by John Wiley & Sons. This book was released on 2010-03-25 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Groundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceutical science, and physics solve complex biological problems. Written by leading experts in the field, this practical resource gives detailed descriptions of core subjects, including biological network modeling, analysis, and inference; presents a measured introduction to foundational topics like genomics; and describes state-of-the-art software tools for systems biology. Offers a coordinated integrated systems view of defining and applying computational and mathematical tools and methods to solving problems in systems biology Chapters provide a multidisciplinary approach and range from analysis, modeling, prediction, reasoning, inference, and exploration of biological systems to the implications of computational systems biology on drug design and medicine Helps reduce the gap between mathematics and biology by presenting chapters on mathematical models of biological systems Establishes solutions in computer science, biology, chemistry, and physics by presenting an in-depth description of computational methodologies for systems biology Elements of Computational Systems Biology is intended for academic/industry researchers and scientists in computer science, biology, mathematics, chemistry, physics, biotechnology, and pharmaceutical science. It is also accessible to undergraduate and graduate students in machine learning, data mining, bioinformatics, computational biology, and systems biology courses.

Systems Biology and Bioinformatics

Author : Kayvan Najarian
Publisher : CRC Press
ISBN 13 : 1439882940
Total Pages : 190 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Systems Biology and Bioinformatics by : Kayvan Najarian

Download or read book Systems Biology and Bioinformatics written by Kayvan Najarian and published by CRC Press. This book was released on 2009-04-13 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods

Systemic Approaches in Bioinformatics and Computational Systems Biology

Author : Paola Lecca
Publisher :
ISBN 13 : 9781613504352
Total Pages : 0 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Systemic Approaches in Bioinformatics and Computational Systems Biology by : Paola Lecca

Download or read book Systemic Approaches in Bioinformatics and Computational Systems Biology written by Paola Lecca and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book presents new techniques that have resulted from the application of computer science methods to the organization and interpretation of biological data, covering three subject areas: bioinformatics, computational biology, and computational systems biology"--

Computational Systems Biology

Author : Andres Kriete
Publisher : Academic Press
ISBN 13 : 0124059384
Total Pages : 549 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Computational Systems Biology by : Andres Kriete

Download or read book Computational Systems Biology written by Andres Kriete and published by Academic Press. This book was released on 2013-11-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

An Introduction to Computational Systems Biology

Author : Karthik Raman
Publisher : CRC Press
ISBN 13 : 0429944527
Total Pages : 359 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis An Introduction to Computational Systems Biology by : Karthik Raman

Download or read book An Introduction to Computational Systems Biology written by Karthik Raman and published by CRC Press. This book was released on 2021-05-30 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks—a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable understanding of concepts State-of-the-art chapters on exciting new developments, like community modelling and biological circuit design Emphasis on coding and software tools for systems biology Companion website featuring lecture videos, figure slides, codes, supplementary exercises, further reading, and appendices: https://ramanlab.github.io/SysBioBook/ An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks is highly multi-disciplinary and will appeal to biologists, engineers, computer scientists, mathematicians and others.

Simulation Algorithms for Computational Systems Biology

Author : Luca Marchetti
Publisher : Springer
ISBN 13 : 3319631136
Total Pages : 245 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Simulation Algorithms for Computational Systems Biology by : Luca Marchetti

Download or read book Simulation Algorithms for Computational Systems Biology written by Luca Marchetti and published by Springer. This book was released on 2017-09-27 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the state-of-the-art algorithms used to simulate biological dynamics. Each technique is theoretically introduced and applied to a set of modeling cases. Starting from basic simulation algorithms, the book also introduces more advanced techniques that support delays, diffusion in space, or that are based on hybrid simulation strategies. This is a valuable self-contained resource for graduate students and practitioners in computer science, biology and bioinformatics. An appendix covers the mathematical background, and the authors include further reading sections in each chapter.

Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology

Author : Hamid R Arabnia
Publisher : Morgan Kaufmann
ISBN 13 : 0128026464
Total Pages : 670 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology by : Hamid R Arabnia

Download or read book Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology written by Hamid R Arabnia and published by Morgan Kaufmann. This book was released on 2015-08-11 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology discusses the latest developments in all aspects of computational biology, bioinformatics, and systems biology and the application of data-analytics and algorithms, mathematical modeling, and simu- lation techniques. • Discusses the development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques to the study of biological and behavioral systems, including applications in cancer research, computational intelligence and drug design, high-performance computing, and biology, as well as cloud and grid computing for the storage and access of big data sets. • Presents a systematic approach for storing, retrieving, organizing, and analyzing biological data using software tools with applications to general principles of DNA/RNA structure, bioinformatics and applications, genomes, protein structure, and modeling and classification, as well as microarray analysis. • Provides a systems biology perspective, including general guidelines and techniques for obtaining, integrating, and analyzing complex data sets from multiple experimental sources using computational tools and software. Topics covered include phenomics, genomics, epigenomics/epigenetics, metabolomics, cell cycle and checkpoint control, and systems biology and vaccination research. • Explains how to effectively harness the power of Big Data tools when data sets are so large and complex that it is difficult to process them using conventional database management systems or traditional data processing applications. Discusses the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological and behavioral systems. Presents a systematic approach for storing, retrieving, organizing and analyzing biological data using software tools with applications. Provides a systems biology perspective including general guidelines and techniques for obtaining, integrating and analyzing complex data sets from multiple experimental sources using computational tools and software.

Learning and Inference in Computational Systems Biology

Author : Neil D. Lawrence
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Learning and Inference in Computational Systems Biology by : Neil D. Lawrence

Download or read book Learning and Inference in Computational Systems Biology written by Neil D. Lawrence and published by . This book was released on 2010 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tools and techniques for biological inference problems at scales ranging from genome-wide to pathway-specific. Computational systems biology unifies the mechanistic approach of systems biology with the data-driven approach of computational biology. Computational systems biology aims to develop algorithms that uncover the structure and parameterization of the underlying mechanistic model--in other words, to answer specific questions about the underlying mechanisms of a biological system--in a process that can be thought of as learning or inference. This volume offers state-of-the-art perspectives from computational biology, statistics, modeling, and machine learning on new methodologies for learning and inference in biological networks.The chapters offer practical approaches to biological inference problems ranging from genome-wide inference of genetic regulation to pathway-specific studies. Both deterministic models (based on ordinary differential equations) and stochastic models (which anticipate the increasing availability of data from small populations of cells) are considered. Several chapters emphasize Bayesian inference, so the editors have included an introduction to the philosophy of the Bayesian approach and an overview of current work on Bayesian inference. Taken together, the methods discussed by the experts in Learning and Inference in Computational Systems Biology provide a foundation upon which the next decade of research in systems biology can be built. Florence d'Alch e-Buc, John Angus, Matthew J. Beal, Nicholas Brunel, Ben Calderhead, Pei Gao, Mark Girolami, Andrew Golightly, Dirk Husmeier, Johannes Jaeger, Neil D. Lawrence, Juan Li, Kuang Lin, Pedro Mendes, Nicholas A. M. Monk, Eric Mjolsness, Manfred Opper, Claudia Rangel, Magnus Rattray, Andreas Ruttor, Guido Sanguinetti, Michalis Titsias, Vladislav Vyshemirsky, David L. Wild, Darren Wilkinson, Guy Yosiphon

Encyclopedia of Bioinformatics and Computational Biology

Author :
Publisher : Elsevier
ISBN 13 : 0128114320
Total Pages : 3421 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Bioinformatics and Computational Biology by :

Download or read book Encyclopedia of Bioinformatics and Computational Biology written by and published by Elsevier. This book was released on 2018-08-21 with total page 3421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Bioinformatics for Systems Biology

Author : Stephen Krawetz
Publisher : Springer Science & Business Media
ISBN 13 : 1597454400
Total Pages : 623 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Bioinformatics for Systems Biology by : Stephen Krawetz

Download or read book Bioinformatics for Systems Biology written by Stephen Krawetz and published by Springer Science & Business Media. This book was released on 2008-12-11 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics for Systems Biology bridges and unifies many disciplines. It presents the life scientist, computational biologist, and mathematician with a common framework. Only by linking the groups together may the true life sciences revolution move forward.

Bioinformatics and Computational Biology

Author : Basant K. Tiwary
Publisher : Springer Nature
ISBN 13 : 9811642419
Total Pages : 239 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Bioinformatics and Computational Biology by : Basant K. Tiwary

Download or read book Bioinformatics and Computational Biology written by Basant K. Tiwary and published by Springer Nature. This book was released on 2021-11-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.

Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances

Author : Lecca, Paola
Publisher : IGI Global
ISBN 13 : 1613504365
Total Pages : 335 pages
Book Rating : 4.6/5 (135 download)

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Book Synopsis Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances by : Lecca, Paola

Download or read book Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances written by Lecca, Paola and published by IGI Global. This book was released on 2011-12-31 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: The convergence of biology and computer science was initially motivated by the need to organize and process a growing number of biological observations resulting from rapid advances in experimental techniques. Today, however, close collaboration between biologists, biochemists, medical researchers, and computer scientists has also generated remarkable benefits for the field of computer science. Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances presents new techniques that have resulted from the application of computer science methods to the organization and interpretation of biological data. The book covers three subject areas: bioinformatics, computational biology, and computational systems biology. It focuses on recent, systemic approaches in computer science and mathematics that have been used to model, simulate, and more generally, experiment with biological phenomena at any scale.

Computational Biology and Bioinformatics

Author : Ka-Chun Wong
Publisher : CRC Press
ISBN 13 : 1498725007
Total Pages : 439 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Computational Biology and Bioinformatics by : Ka-Chun Wong

Download or read book Computational Biology and Bioinformatics written by Ka-Chun Wong and published by CRC Press. This book was released on 2016-04-27 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advances in biotechnology such as the next generation sequencing technologies are occurring at breathtaking speed. Advances and breakthroughs give competitive advantages to those who are prepared. However, the driving force behind the positive competition is not only limited to the technological advancement, but also to the companion data analy

Integer Linear Programming in Computational and Systems Biology

Author : Dan Gusfield
Publisher : Cambridge University Press
ISBN 13 : 1108421768
Total Pages : 431 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis Integer Linear Programming in Computational and Systems Biology by : Dan Gusfield

Download or read book Integer Linear Programming in Computational and Systems Biology written by Dan Gusfield and published by Cambridge University Press. This book was released on 2019-06-13 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This hands-on tutorial text for non-experts demonstrates biological applications of a versatile modeling and optimization technique.

Fundamentals of Bioinformatics and Computational Biology

Author : Gautam B. Singh
Publisher : Springer
ISBN 13 : 3319114034
Total Pages : 345 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Fundamentals of Bioinformatics and Computational Biology by : Gautam B. Singh

Download or read book Fundamentals of Bioinformatics and Computational Biology written by Gautam B. Singh and published by Springer. This book was released on 2014-09-24 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers comprehensive coverage of all the core topics of bioinformatics, and includes practical examples completed using the MATLAB bioinformatics toolboxTM. It is primarily intended as a textbook for engineering and computer science students attending advanced undergraduate and graduate courses in bioinformatics and computational biology. The book develops bioinformatics concepts from the ground up, starting with an introductory chapter on molecular biology and genetics. This chapter will enable physical science students to fully understand and appreciate the ultimate goals of applying the principles of information technology to challenges in biological data management, sequence analysis, and systems biology. The first part of the book also includes a survey of existing biological databases, tools that have become essential in today’s biotechnology research. The second part of the book covers methodologies for retrieving biological information, including fundamental algorithms for sequence comparison, scoring, and determining evolutionary distance. The main focus of the third part is on modeling biological sequences and patterns as Markov chains. It presents key principles for analyzing and searching for sequences of significant motifs and biomarkers. The last part of the book, dedicated to systems biology, covers phylogenetic analysis and evolutionary tree computations, as well as gene expression analysis with microarrays. In brief, the book offers the ideal hands-on reference guide to the field of bioinformatics and computational biology.

Handbook of Research on Computational and Systems Biology

Author : Limin Angela Liu
Publisher : IGI Global
ISBN 13 : 9781609604912
Total Pages : 0 pages
Book Rating : 4.6/5 (49 download)

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Book Synopsis Handbook of Research on Computational and Systems Biology by : Limin Angela Liu

Download or read book Handbook of Research on Computational and Systems Biology written by Limin Angela Liu and published by IGI Global. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book offers information on the state-of-the-art development in the fields of computational biology and systems biology, presenting methods, tools, and applications of these fields by many leading experts around the globe"--Provided by publisher.