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Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances

Author : Lecca, Paola
Publisher : IGI Global
ISBN 13 : 1613504365
Total Pages : 471 pages
Book Rating : 4.6/5 (135 download)

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Book Synopsis Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances by : Lecca, Paola

Download or read book Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances written by Lecca, Paola and published by IGI Global. This book was released on 2011-12-31 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The convergence of biology and computer science was initially motivated by the need to organize and process a growing number of biological observations resulting from rapid advances in experimental techniques. Today, however, close collaboration between biologists, biochemists, medical researchers, and computer scientists has also generated remarkable benefits for the field of computer science. Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances presents new techniques that have resulted from the application of computer science methods to the organization and interpretation of biological data. The book covers three subject areas: bioinformatics, computational biology, and computational systems biology. It focuses on recent, systemic approaches in computer science and mathematics that have been used to model, simulate, and more generally, experiment with biological phenomena at any scale.

Systemic Approaches in Bioinformatics and Computational Systems Biology

Author : Paola Lecca
Publisher :
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.:/5 (794 download)

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Book Synopsis Systemic Approaches in Bioinformatics and Computational Systems Biology by : Paola Lecca

Download or read book Systemic Approaches in Bioinformatics and Computational Systems Biology written by Paola Lecca and published by . This book was released on with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systems Biology and Bioinformatics

Author : Kayvan Najarian
Publisher : CRC Press
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Systems Biology and Bioinformatics by : Kayvan Najarian

Download or read book Systems Biology and Bioinformatics written by Kayvan Najarian and published by CRC Press. This book was released on 2009-04-13 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing computational methods, Systems Biology and Bioinformatics provides an introduction to systems biology and its impact on biology and medicine. It reviews basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The methods presented include techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. It also explains applications for system-oriented models to predict the behavior of biological systems.

Elements of Computational Systems Biology

Author : Huma M. Lodhi
Publisher : John Wiley & Sons
ISBN 13 : 0470556749
Total Pages : 435 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Elements of Computational Systems Biology by : Huma M. Lodhi

Download or read book Elements of Computational Systems Biology written by Huma M. Lodhi and published by John Wiley & Sons. This book was released on 2010-03-25 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Groundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceutical science, and physics solve complex biological problems. Written by leading experts in the field, this practical resource gives detailed descriptions of core subjects, including biological network modeling, analysis, and inference; presents a measured introduction to foundational topics like genomics; and describes state-of-the-art software tools for systems biology. Offers a coordinated integrated systems view of defining and applying computational and mathematical tools and methods to solving problems in systems biology Chapters provide a multidisciplinary approach and range from analysis, modeling, prediction, reasoning, inference, and exploration of biological systems to the implications of computational systems biology on drug design and medicine Helps reduce the gap between mathematics and biology by presenting chapters on mathematical models of biological systems Establishes solutions in computer science, biology, chemistry, and physics by presenting an in-depth description of computational methodologies for systems biology Elements of Computational Systems Biology is intended for academic/industry researchers and scientists in computer science, biology, mathematics, chemistry, physics, biotechnology, and pharmaceutical science. It is also accessible to undergraduate and graduate students in machine learning, data mining, bioinformatics, computational biology, and systems biology courses.

Transactions on Computational Systems Biology I

Author :
Publisher : Springer
ISBN 13 : 3540321268
Total Pages : 112 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Transactions on Computational Systems Biology I by :

Download or read book Transactions on Computational Systems Biology I written by and published by Springer. This book was released on 2005-03-10 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thisisthe?rstissueofanewjournaloftheLNCSjournalsubline.Theaimofthe journal is to encourage inter- and multidisciplinary research in the ?elds of c- puter science and life sciences. The recent paradigmatic shift in biology towards a system view of biological phenomena requires a corresponding paradigmatic shift in the techniques from computer science that can face the new challenges. Classical tools usually used in bioinformatics are no longer up to date and new ideas are needed. The convergence of sciences and technologies we are experiencing these days is changing the classical terms of reference for research activities. In fact clear distinctions between disciplines no longer exist because advances in one ?eld permit advances in others and vice versa, thus establishing a positive feedback loop between sciences. The potential impact of the convergence of sciences and technologies is so huge that we must consider how to control and correctly drive our future activities. International and national funding agencies are looking at interdisciplinary research as a key issue for the coming years, especially in the intersection of life sciences and information technology. To speed up this process, we surely need to establish relationships between researchers of di?erent communities and to de?ne a common language that will allow them to exchange ideas and - sults. Furthermore, expectations of di?erent communities can be merged only by running activities like common projects and experiences. TheTransactionsonComputationalSystemsBiologycouldbeagoodforumto helplifescientistsandcomputerscientiststodiscusstogethertheircommongoals.

Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology

Author : Hamid R Arabnia
Publisher : Morgan Kaufmann
ISBN 13 : 0128026464
Total Pages : 670 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology by : Hamid R Arabnia

Download or read book Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology written by Hamid R Arabnia and published by Morgan Kaufmann. This book was released on 2015-08-11 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology discusses the latest developments in all aspects of computational biology, bioinformatics, and systems biology and the application of data-analytics and algorithms, mathematical modeling, and simu- lation techniques. • Discusses the development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques to the study of biological and behavioral systems, including applications in cancer research, computational intelligence and drug design, high-performance computing, and biology, as well as cloud and grid computing for the storage and access of big data sets. • Presents a systematic approach for storing, retrieving, organizing, and analyzing biological data using software tools with applications to general principles of DNA/RNA structure, bioinformatics and applications, genomes, protein structure, and modeling and classification, as well as microarray analysis. • Provides a systems biology perspective, including general guidelines and techniques for obtaining, integrating, and analyzing complex data sets from multiple experimental sources using computational tools and software. Topics covered include phenomics, genomics, epigenomics/epigenetics, metabolomics, cell cycle and checkpoint control, and systems biology and vaccination research. • Explains how to effectively harness the power of Big Data tools when data sets are so large and complex that it is difficult to process them using conventional database management systems or traditional data processing applications. Discusses the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological and behavioral systems. Presents a systematic approach for storing, retrieving, organizing and analyzing biological data using software tools with applications. Provides a systems biology perspective including general guidelines and techniques for obtaining, integrating and analyzing complex data sets from multiple experimental sources using computational tools and software.

Systems Biology

Author : Jens Nielsen
Publisher : John Wiley & Sons
ISBN 13 : 3527696172
Total Pages : 600 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Systems Biology by : Jens Nielsen

Download or read book Systems Biology written by Jens Nielsen and published by John Wiley & Sons. This book was released on 2017-03-15 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems. Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression. This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.

Advances in Computational Biology

Author : Hamid R. Arabnia
Publisher : Springer Science & Business Media
ISBN 13 : 1441959130
Total Pages : 759 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Advances in Computational Biology by : Hamid R. Arabnia

Download or read book Advances in Computational Biology written by Hamid R. Arabnia and published by Springer Science & Business Media. This book was released on 2010-09-24 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of The 2009 International Conference on Bioinformatics and Computational Biology in Las Vegas, NV, July 13-16, 2009. Recent advances in Computational Biology are covered through a variety of topics. Both inward research (core areas of computational biology and computer science) and outward research (multi-disciplinary, Inter-disciplinary, and applications) will be covered during the conferences. These include: Gene regulation, Gene expression databases, Gene pattern discovery and identification, Genetic network modeling and inference, Gene expression analysis, RNA and DNA structure and sequencing, Biomedical engineering, Microarrays, Molecular sequence and structure databases, Molecular dynamics and simulation, Molecular sequence classification, alignment and assembly, Image processing In medicine and biological sciences, Sequence analysis and alignment, Informatics and Statistics in Biopharmaceutical Research, Software tools for computational biology and bioinformatics, Comparative genomics; and more.

Computational Systems Biology

Author : Andres Kriete
Publisher : Academic Press
ISBN 13 : 0124059384
Total Pages : 548 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Computational Systems Biology by : Andres Kriete

Download or read book Computational Systems Biology written by Andres Kriete and published by Academic Press. This book was released on 2013-11-26 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Computational Systems Biology Approaches in Cancer Research

Author : Inna Kuperstein
Publisher : CRC Press
ISBN 13 : 1000682927
Total Pages : 167 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Computational Systems Biology Approaches in Cancer Research by : Inna Kuperstein

Download or read book Computational Systems Biology Approaches in Cancer Research written by Inna Kuperstein and published by CRC Press. This book was released on 2019-09-09 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and faculty." — Trey Ideker, Professor of Medicine, UC Xan Diego, School of Medicine "This volume is attractive because it addresses important and timely topics for research and teaching on computational methods in cancer research. It covers a broad variety of approaches, exposes recent innovations in computational methods, and provides acces to source code and to dedicated interactive web sites." — Yves Moreau, Department of Electrical Engineering, SysBioSys Centre for Computational Systems Biology, University of Leuven With the availability of massive amounts of data in biology, the need for advanced computational tools and techniques is becoming increasingly important and key in understanding biology in disease and healthy states. This book focuses on computational systems biology approaches, with a particular lens on tackling one of the most challenging diseases - cancer. The book provides an important reference and teaching material in the field of computational biology in general and cancer systems biology in particular. The book presents a list of modern approaches in systems biology with application to cancer research and beyond. It is structured in a didactic form such that the idea of each approach can easily be grasped from the short text and self-explanatory figures. The coverage of topics is diverse: from pathway resources, through methods for data analysis and single data analysis to drug response predictors, classifiers and image analysis using machine learning and artificial intelligence approaches. Features Up to date using a wide range of approaches Applicationexample in each chapter Online resources with useful applications’

Biomolecular Networks

Author : Luonan Chen
Publisher : John Wiley & Sons
ISBN 13 : 9780470488058
Total Pages : 416 pages
Book Rating : 4.4/5 (88 download)

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Book Synopsis Biomolecular Networks by : Luonan Chen

Download or read book Biomolecular Networks written by Luonan Chen and published by John Wiley & Sons. This book was released on 2009-06-29 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alternative techniques and tools for analyzing biomolecular networks With the recent rapid advances in molecular biology, high-throughput experimental methods have resulted in enormous amounts of data that can be used to study biomolecular networks in living organisms. With this development has come recognition of the fact that a complicated living organism cannot be fully understood by merely analyzing individual components. Rather, it is the interactions of components or biomolecular networks that are ultimately responsible for an organism's form and function. This book addresses the important need for a new set of computational tools to reveal essential biological mechanisms from a systems biology approach. Readers will get comprehensive coverage of analyzing biomolecular networks in cellular systems based on available experimental data with an emphasis on the aspects of network, system, integration, and engineering. Each topic is treated in depth with specific biological problems and novel computational methods: GENE NETWORKS—Transcriptional regulation; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networks PROTEIN INTERACTION NETWORKS—Prediction of protein-protein interactions; topological structure of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein function METABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and applications of metabolic networks; modeling and inference of signaling networks; and other topics and new trends In addition to theoretical results and methods, many computational software tools are referenced and available from the authors' Web sites. Biomolecular Networks is an indispensable reference for researchers and graduate students in bioinformatics, computational biology, systems biology, computer science, and applied mathematics.

Computational Systems Biology in Medicine and Biotechnology

Author : Sonia Cortassa
Publisher : Springer Nature
ISBN 13 : 1071618318
Total Pages : 494 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Computational Systems Biology in Medicine and Biotechnology by : Sonia Cortassa

Download or read book Computational Systems Biology in Medicine and Biotechnology written by Sonia Cortassa and published by Springer Nature. This book was released on 2022-05-23 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses the latest state-of-the-art systems biology-oriented approaches that--driven by big data and bioinformatics--are utilized by Computational Systems Biology, an interdisciplinary field that bridges experimental tools with computational tools to tackle complex questions at the frontiers of knowledge in medicine and biotechnology. The chapters in this book are organized into six parts: systems biology of the genome, epigenome, and redox proteome; metabolic networks; aging and longevity; systems biology of diseases; spatiotemporal patterns of rhythms, morphogenesis, and complex dynamics; and genome scale metabolic modeling in biotechnology. In every chapter, readers will find varied methodological approaches applied at different levels, from molecular, cellular, organ to organisms, genome to phenome, and health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics; criteria utilized for applying specific methodologies; lists of the necessary materials, reagents, software, databases, algorithms, mathematical models, and dedicated analytical procedures; step-by-step, readily reproducible laboratory, bioinformatics, and computational protocols all delivered in didactic and clear style and abundantly illustrated with express case studies and tutorials; and tips on troubleshooting and advice for achieving reproducibility while avoiding mistakes and misinterpretations. The overarching goal driving this volume is to excite the expert and stimulate the newcomer to the field of Computational Systems Biology. Cutting-edge and authoritative, Computational Systems Biology in Medicine and Biotechnology: Methods and Protocols is a valuable resource for pre- and post-graduate students in medicine and biotechnology, and in diverse areas ranging from microbiology to cellular and organismal biology, as well as computational and experimental biologists, and researchers interested in utilizing comprehensive systems biology oriented methods.

Computational Systems Bioinformatics

Author : Xiaobo Zhou
Publisher : World Scientific
ISBN 13 : 9812707042
Total Pages : 398 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Computational Systems Bioinformatics by : Xiaobo Zhou

Download or read book Computational Systems Bioinformatics written by Xiaobo Zhou and published by World Scientific. This book was released on 2008 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields. This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.

Introduction to Systems Biology

Author : Sangdun Choi
Publisher : Springer Science & Business Media
ISBN 13 : 1597455318
Total Pages : 549 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Introduction to Systems Biology by : Sangdun Choi

Download or read book Introduction to Systems Biology written by Sangdun Choi and published by Springer Science & Business Media. This book was released on 2008-05-17 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors offer a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches. The final sections provide ideas for theoretical and modeling optimization in systemic biological researches. The book is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.

Computational Systems Bioinformatics - Methods And Biomedical Applications

Author : Wong Stephen Tin Chi
Publisher : World Scientific Publishing Company
ISBN 13 : 9813106999
Total Pages : 400 pages
Book Rating : 4.8/5 (131 download)

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Book Synopsis Computational Systems Bioinformatics - Methods And Biomedical Applications by : Wong Stephen Tin Chi

Download or read book Computational Systems Bioinformatics - Methods And Biomedical Applications written by Wong Stephen Tin Chi and published by World Scientific Publishing Company. This book was released on 2008-01-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields.This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.

Systems Biology and Bioinformatics

Author : Kayvan Najarian
Publisher : CRC Press
ISBN 13 : 9781138118034
Total Pages : 190 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Systems Biology and Bioinformatics by : Kayvan Najarian

Download or read book Systems Biology and Bioinformatics written by Kayvan Najarian and published by CRC Press. This book was released on 2017-05-31 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods used in what is being coined the digital eraof biology. Written by field experts with proven track records, this authoritative textbook first provides an introduction to systems biology and its impact on biology and medicine. The book then reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The text includes techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. The book also explains how to use system-oriented models to predict the behavior of biological systems for important applications such as rational drug design. The numerous examples and problem sets allow students to confidently explore practical systems biology applications using real examples with real biological data, making Systems Biology and Bioinformatics: A Computational Approachan ideal text for senior undergraduate and first-year graduate students.

A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations

Author : Vishwesh V. Kulkarni
Publisher : Springer
ISBN 13 : 9401790418
Total Pages : 332 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations by : Vishwesh V. Kulkarni

Download or read book A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations written by Vishwesh V. Kulkarni and published by Springer. This book was released on 2014-07-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume I provides a panoramic view that illustrates the potential of such mathematical methods in systems and synthetic biology. Recent advances in systems and synthetic biology have clearly demonstrated the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources. In Volume I, some of the leading researchers in the field of systems and synthetic biology demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in order to understand how biological systems function. As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.