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Adaptive Systems In Drug Design
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Book Synopsis Adaptive Systems in Drug Design by : Gisbert Schneider
Download or read book Adaptive Systems in Drug Design written by Gisbert Schneider and published by CRC Press. This book was released on 2002-10-01 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brief history of drug design presented to make clear that there are fashions in this important field and that they change rather rapidly. This is due in part to the fact that the way that a new paradigm is accepted in a drug company often does not depend on its scientific merit alone.
Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di
Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Book Synopsis Molecular Evolutionary Models in Drug Discovery by : Juan Bueno
Download or read book Molecular Evolutionary Models in Drug Discovery written by Juan Bueno and published by Academic Press. This book was released on 2020-01-22 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies
Book Synopsis Lead Generation Approaches in Drug Discovery by : Zoran Rankovic
Download or read book Lead Generation Approaches in Drug Discovery written by Zoran Rankovic and published by John Wiley & Sons. This book was released on 2010-04-07 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Book Synopsis Chemogenomics in Drug Discovery by : Hugo Kubinyi
Download or read book Chemogenomics in Drug Discovery written by Hugo Kubinyi and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
Book Synopsis Molecular Design by : Gisbert Schneider
Download or read book Molecular Design written by Gisbert Schneider and published by John Wiley & Sons. This book was released on 2008-02-26 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kleine Moleküle für Einsteiger: Dieser für Lehre und Selbststudium gleichermaßen geeignete Band behandelt den computergestützten Entwurf von Wirkstoffen, Enzyminhibitoren, Sonden und Markern für Biomoleküle und führt den Leser bis zum ersten eigenen De-Novo-Design eines funktionellen Moleküls. Gestützt auf lange Erfahrung im Molecular-Modeling-Umfeld erläutern die Autoren, welche Fragen mit den beschriebenen Methoden beantwortet werden können (und welche nicht).
Book Synopsis Modern Biopharmaceuticals, 4 Volume Set by : Jörg Knäblein
Download or read book Modern Biopharmaceuticals, 4 Volume Set written by Jörg Knäblein and published by John Wiley & Sons. This book was released on 2005-10-28 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biopharmaceutical market has come along way since 1982 when the first biopharmaceutical product, recombinant human insulin, was launched. Over 120 such products are currently being marketed around the world including nine blockbuster drugs. The global market for biopharmaceuticals, which is currently valued at US$41 billion, has been growing at an impressive compound annual growth rate of 21% over the previous five years. With over one third of all pipe-line products in active development are biopharmaceuticals, this segment is set to continue outperforming the total pharmaceutical market and could easily reach US$100 billion by the end of this decade.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309498511 Total Pages :103 pages Book Rating :4.3/5 (94 download)
Book Synopsis The Role of NIH in Drug Development Innovation and Its Impact on Patient Access by : National Academies of Sciences, Engineering, and Medicine
Download or read book The Role of NIH in Drug Development Innovation and Its Impact on Patient Access written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-01-27 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: To explore the role of the National Institutes of Health (NIH) in innovative drug development and its impact on patient access, the Board on Health Care Services and the Board on Health Sciences Policy of the National Academies jointly hosted a public workshop on July 24â€"25, 2019, in Washington, DC. Workshop speakers and participants discussed the ways in which federal investments in biomedical research are translated into innovative therapies and considered approaches to ensure that the public has affordable access to the resulting new drugs. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Intelligent and Adaptive Systems in Medicine by : Olivier C. L. Haas
Download or read book Intelligent and Adaptive Systems in Medicine written by Olivier C. L. Haas and published by CRC Press. This book was released on 2008-03-19 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intelligent and adaptive techniques are rapidly being used in all stages of medical treatment, from the initial diagnosis to planning delivery and follow-up therapy.To realize the full potential of these techniques, developers and end users must understand both the underlying technology and the specifics of the medical application considered. Focusing on this growing area of interest, Intelligent and Adaptive Systems in Medicine clearly and concisely explains a range of adaptive and intelligent systems, highlighting their benefits and limitations with realistic medical examples. Bringing together theory and practice, this volume describes the application of adaptive and intelligent control as well as intelligent systems in the diagnosis, planning, treatment, and follow up of diseases such as cancer. Each chapter presents a family of an intelligent and adaptive system, explains the techniques and algorithms behind these systems, and explores how to solve medical and biomedical problems using intelligent and adaptive systems. The book focuses on the methods of fuzzy logic, artificial neural networks, neuro-fuzzy modeling, adaptive and predictive control, systems and statistical modeling, and image processing. By assessing the use of intelligent and adaptive techniques for medical diagnosis and therapy, this guide promotes further research in this area of “techno-medicine.” It provides researchers and clinicians with the tools and processes that are leading to the invaluable use of intelligent systems in early diagnoses and effective treatment.
Book Synopsis Advances in Swarm Intelligence by : Ying Tan
Download or read book Advances in Swarm Intelligence written by Ying Tan and published by Springer. This book was released on 2018-06-15 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume set of LNCS 10941 and 10942 constitutes the proceedings of the 9th International Conference on Advances in Swarm Intelligence, ICSI 2018, held in Shanghai, China, in June 2018. The total of 113 papers presented in these volumes was carefully reviewed and selected from 197 submissions. The papers were organized in topical sections namely: multi-agent systems; swarm robotics; fuzzy logic approaches; planning and routing problems; recommendation in social media; predication; classification; finding patterns; image enhancement; deep learning; theories and models of swarm intelligence; ant colony optimization; particle swarm optimization; artificial bee colony algorithms; genetic algorithms; differential evolution; fireworks algorithm; bacterial foraging optimization; artificial immune system; hydrologic cycle optimization; other swarm-based optimization algorithms; hybrid optimization algorithms; multi-objective optimization; large-scale global optimization.
Book Synopsis Systems Thinking in Medicine and New Drug Discovery by : Robert E. Smith
Download or read book Systems Thinking in Medicine and New Drug Discovery written by Robert E. Smith and published by Cambridge Scholars Publishing. This book was released on 2018-12-17 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Total Quality Management (TQM) and systems thinking are being used to improve all aspects of human health. This first book in a two-volume set details how the healthcare community is working with patients and their caregivers to improve healthcare and reduce its costs. Systems-based thinking encourages us to work together to look at the effects of new drugs on entire systems and not just single molecular targets. It also leads us to a better understanding of genetics and epigenetics, as well as the deep ecology of the human body. The healthcare community is developing targeted therapies that stimulate our own bodies to cure ourselves and eliminate the need for animal testing. This book will appeal to specialists, who will find recommendations on safer materials for 3D bioprinting and ways to analyze dietary supplements for toxic contaminants, and physicians, pharmacists and non-professionals, who will learn the important different ways that dietary supplements and prescription drugs are developed, sold and marketed.
Book Synopsis Advances in Nervous System Research and Application: 2012 Edition by :
Download or read book Advances in Nervous System Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nervous System Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Nervous System in a concise format. The editors have built Advances in Nervous System Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nervous System in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Nervous System Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis The Science and Business of Drug Discovery by : Edward D. Zanders
Download or read book The Science and Business of Drug Discovery written by Edward D. Zanders and published by Springer Nature. This book was released on 2020-11-09 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators
Book Synopsis Adaptive Systems in Control and Signal Processing 1992 by : L. Dugard
Download or read book Adaptive Systems in Control and Signal Processing 1992 written by L. Dugard and published by Elsevier. This book was released on 2014-06-28 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adaptive Systems remain a very interesting field of theoretical research, extended by methodological studies and an increasing number of applications. The plenary papers, invited sessions and contributed sessions focused on many aspects of adaptive systems, such as systems identification and modelling, adaptive control of nonlinear systems and theoretical issues in adaptive control. Also covered were methodological aspects and applications of adaptive control, intelligent tuning and adaptive signal processing.
Book Synopsis Computer Applications in Pharmaceutical Research and Development by : Sean Ekins
Download or read book Computer Applications in Pharmaceutical Research and Development written by Sean Ekins and published by John Wiley & Sons. This book was released on 2006-07-11 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.
Book Synopsis Platform Trial Designs in Drug Development by : Zoran Antonijevic
Download or read book Platform Trial Designs in Drug Development written by Zoran Antonijevic and published by CRC Press. This book was released on 2018-12-07 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platform trials test multiple therapies in one indication, one therapy for multiple indications, or both. These novel clinical trial designs can dramatically increase the cost-effectiveness of drug development, leading to life-altering medicines for people suffering from serious illnesses, possibly at lower cost. Currently, the cost of drug development is unsustainable. Furthermore, there are particular problems in rare diseases and small biomarker defined subsets in oncology, where the required sample sizes for traditional clinical trial designs may not be feasible. The editors recruited the key innovators in this domain. The 20 articles discuss trial designs from perspectives as diverse as quantum computing, patient’s rights to information, and international health. The book begins with an overview of platform trials from multiple perspectives. It then describes impacts of platform trials on the pharmaceutical industry’s key stakeholders: patients, regulators, and payers. Next it provides advanced statistical methods that address multiple aspects of platform trials, before concluding with a pharmaceutical executive’s perspective on platform trials. Except for the statistical methods section, only a basic qualitative knowledge of clinical trials is needed to appreciate the important concepts and novel ideas presented.
Book Synopsis Artificial Neural Network for Drug Design, Delivery and Disposition by : Munish Puri
Download or read book Artificial Neural Network for Drug Design, Delivery and Disposition written by Munish Puri and published by Academic Press. This book was released on 2015-10-15 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial Neural Network for Drug Design, Delivery and Disposition provides an in-depth look at the use of artificial neural networks (ANN) in pharmaceutical research. With its ability to learn and self-correct in a highly complex environment, this predictive tool has tremendous potential to help researchers more effectively design, develop, and deliver successful drugs. This book illustrates how to use ANN methodologies and models with the intent to treat diseases like breast cancer, cardiac disease, and more. It contains the latest cutting-edge research, an analysis of the benefits of ANN, and relevant industry examples. As such, this book is an essential resource for academic and industry researchers across the pharmaceutical and biomedical sciences. Written by leading academic and industry scientists who have contributed significantly to the field and are at the forefront of artificial neural network (ANN) research Focuses on ANN in drug design, discovery and delivery, as well as adopted methodologies and their applications to the treatment of various diseases and disorders Chapters cover important topics across the pharmaceutical process, such as ANN in structure-based drug design and the application of ANN in modern drug discovery Presents the future potential of ANN-based strategies in biomedical image analysis and much more
