Chemogenomics In Drug Discovery

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Chemogenomics in Drug Discovery

Author : Hugo Kubinyi
Publisher : John Wiley & Sons
ISBN 13 : 3527604022
Total Pages : 487 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Chemogenomics in Drug Discovery by : Hugo Kubinyi

Download or read book Chemogenomics in Drug Discovery written by Hugo Kubinyi and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.

Chemogenomics

Author : Edgar Jacoby
Publisher : World Scientific
ISBN 13 : 1783260092
Total Pages : 220 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Chemogenomics by : Edgar Jacoby

Download or read book Chemogenomics written by Edgar Jacoby and published by World Scientific. This book was released on 2006-05-11 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, chemogenomics aims to identify systematically all ligands and modulators for all the gene products expressed and allows the accelerated exploration of their biological function. The subject brings together diverse disciplines including chemistry, genetics, chemo- and bioinformatics, structural biology, and biological screening in phenotypic and target-based assays. This book uniquely integrates reviews of the latest cutting-edge research by leaders in the various disciplines, providing a general, knowledge-centric overview of the different chemical, biological and informatics components. Unlike existing publications, the book focuses on how these disciplines interact efficiently for the rapid discovery of new targets and their effector molecules simultaneously. Examples of chemogenomics approaches pursued in academia as well as in biotech and pharmaceutical companies are also provided. Contents: Small Molecules for Chemogenomics-based Drug Discovery (E Jacoby et al.)Mapping the Chemogenomic Space (J Mestres)Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development (F J Dekker et al.)A Reductionist Approach to Chemogenomics in the Design of Drug Molecules and Focused Libraries (R Crossley & M Slater)In silico Screening of the Protein Structure Repertoire and of Protein Families (D Rognan)New Methods for Smilarity-based Virtual Screening (J Hert et al.)Structural Informatics: Chemogenomics In silico (D A Debe et al.)Construction of a Homogenous and Informative In vitro Profiling Database for Anticipating the Clinical Effects of Drugs (N Froloff et al.)The Inpharmatica Pharmacata Approach (J Overinghton)Target- and Cell-Based Assays and Screening: Reverse Chemogenomics (R Bouhelal & D Frabbro) Readership: Undergraduate and graduate students, and researchers in molecular pharmacology, pharmacy, medicinal chemistry, molecular and structural biology, drug discovery, genomics, bioinformatics. Key Features:Provides a unique overview of state-of-the-art chemogenomics knowledge-based approaches for target and drug identificationWritten by leading scientists in the various disciplines involved in chemogenomicsKeywords:Chemogenomics;Drug Discovery;Medicinal Chemistry;Knowledge-Based Approaches;Design of Compound Screening Collections;Natural Products;Target Families;Chemoinformatics;Bioinformatics;Mode of Action Profiling

Computational Chemogenomics

Author : Edgar Jacoby
Publisher : CRC Press
ISBN 13 : 981441140X
Total Pages : 264 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Computational Chemogenomics by : Edgar Jacoby

Download or read book Computational Chemogenomics written by Edgar Jacoby and published by CRC Press. This book was released on 2013-12-03 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead to the discovery of new medicines.

Chemogenomics

Author : Edgar Jacoby
Publisher : Methods in Molecular Biology
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Chemogenomics by : Edgar Jacoby

Download or read book Chemogenomics written by Edgar Jacoby and published by Methods in Molecular Biology. This book was released on 2009-09-17 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular BiologyTM series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.

Chemical Genomics

Author : Stefan Jaroch
Publisher : Ernst Schering Foundation Symposium Proceedings
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.X/5 (3 download)

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Book Synopsis Chemical Genomics by : Stefan Jaroch

Download or read book Chemical Genomics written by Stefan Jaroch and published by Ernst Schering Foundation Symposium Proceedings. This book was released on 2006-04-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical genomics is a field of research both in academics and in the life sciences industry. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, and more.

Chemical Genomics

Author : Stefan Jaroch
Publisher : Springer Science & Business Media
ISBN 13 : 3540376356
Total Pages : 179 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Chemical Genomics by : Stefan Jaroch

Download or read book Chemical Genomics written by Stefan Jaroch and published by Springer Science & Business Media. This book was released on 2007-05-26 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Genomics in Drug Discovery and Development

Author : Dimitri Semizarov
Publisher : John Wiley & Sons
ISBN 13 : 0470409762
Total Pages : 496 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Genomics in Drug Discovery and Development by : Dimitri Semizarov

Download or read book Genomics in Drug Discovery and Development written by Dimitri Semizarov and published by John Wiley & Sons. This book was released on 2008-11-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.

Computational Chemogenomics

Author : Edgar Jacoby
Publisher : CRC Press
ISBN 13 : 9814411396
Total Pages : 266 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Computational Chemogenomics by : Edgar Jacoby

Download or read book Computational Chemogenomics written by Edgar Jacoby and published by CRC Press. This book was released on 2013-12-03 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead to the discovery of new medicines.

Chemogenomics and Chemical Genetics

Author : ERIC MARECHAL
Publisher : Springer Science & Business Media
ISBN 13 : 3642196152
Total Pages : 256 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Chemogenomics and Chemical Genetics by : ERIC MARECHAL

Download or read book Chemogenomics and Chemical Genetics written by ERIC MARECHAL and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage and mathematical treatment of the data. “Chemogenomics and Chemical Genetics” is an introductory manual presenting methods and concepts making up the basis for this recent discipline. This book is dedicated to biologists, chemists and computer scientist beginners. It is organized in brief, illustrated chapters with practical examples. Clear definitions of biological, chemical and IT concepts are given in a glossary section to help readers who are not familiar with one of these disciplines. "Chemogenomics and Chemical Genetics" should therefore be helpful for students (from Bachelor's degree level), technological platform engineers, and researchers in biology, chemistry, bioinformatics, cheminformatics, both in biotech and academic laboratories.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Chemical Genomics

Author : Stefan Jaroch
Publisher : Springer
ISBN 13 : 9783540813255
Total Pages : 179 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Chemical Genomics by : Stefan Jaroch

Download or read book Chemical Genomics written by Stefan Jaroch and published by Springer. This book was released on 2009-09-02 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Pharmacogenomics in Drug Discovery and Development

Author : Qing Yan
Publisher : Springer Nature
ISBN 13 : 107162573X
Total Pages : 618 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Pharmacogenomics in Drug Discovery and Development by : Qing Yan

Download or read book Pharmacogenomics in Drug Discovery and Development written by Qing Yan and published by Springer Nature. This book was released on 2022-09-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Enabling Precision Medicine

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309462630
Total Pages : 145 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Enabling Precision Medicine by : National Academies of Sciences, Engineering, and Medicine

Download or read book Enabling Precision Medicine written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-11-17 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.

Chemical Genomics

Author : Dr. Anil Sehgal
Publisher : D&MD Publications
ISBN 13 : 9781579362850
Total Pages : pages
Book Rating : 4.3/5 (628 download)

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Book Synopsis Chemical Genomics by : Dr. Anil Sehgal

Download or read book Chemical Genomics written by Dr. Anil Sehgal and published by D&MD Publications. This book was released on 2004-01-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemogenomics

Author : Daniel Merk
Publisher : Springer Nature
ISBN 13 : 107163397X
Total Pages : 240 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Chemogenomics by : Daniel Merk

Download or read book Chemogenomics written by Daniel Merk and published by Springer Nature. This book was released on 2023-08-09 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents both theoretical guidance and protocols on chemogenomics including chemogenomics library assembly, compound profiling, and phenotypic assays. The chapters in this book cover topics such as the assembly and use of Kinase Chemogenomics; data mining for chemogenomic compound candidates; protocols for protein family-focused assay systems to profile chemogenomic compounds; functional and target engagement assays in cellular settings for broad characterization; and a discussion on phenotypic assays where chemogenomic sets may be applied. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chemogenomics: Methods and Protocols is a valuable resource for all researchers who are interested in learning more about this diverse and developing field.

Chemokines

Author : Nuska Tschammer
Publisher : Springer
ISBN 13 : 3319140604
Total Pages : 245 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Chemokines by : Nuska Tschammer

Download or read book Chemokines written by Nuska Tschammer and published by Springer. This book was released on 2015-03-02 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Establishing Precompetitive Collaborations to Stimulate Genomics-Driven Product Development

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309161827
Total Pages : 90 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Establishing Precompetitive Collaborations to Stimulate Genomics-Driven Product Development by : Institute of Medicine

Download or read book Establishing Precompetitive Collaborations to Stimulate Genomics-Driven Product Development written by Institute of Medicine and published by National Academies Press. This book was released on 2011-03-17 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the many basic research discoveries in genetics, relatively few gene-based treatments, drugs, or preventative measures have been developed. One way to bridge this gap may be for industry, academia, and government to develop partnerships that share resources while distributing risk. However, intellectual property protections and other barriers can inhibit collaborative efforts. The Institute of Medicine held a workshop on July 22, 2010, to explore these issues and develop solutions.