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Author : C. G. Curtis
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.F/5 ( download)
Download or read book Whole-body Autoradiography written by C. G. Curtis and published by . This book was released on 1981 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. Wallace Hayes
Publisher : CRC Press
ISBN 13 : 9780849337789
Total Pages : 2304 pages
Book Rating : 4.3/5 (377 download)
Download or read book Principles and Methods of Toxicology, Fifth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2007-09-25 with total page 2304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
Author : Michael F. L'Annunziata
Publisher : Elsevier
ISBN 13 : 0323137881
Total Pages : 810 pages
Book Rating : 4.3/5 (231 download)
Download or read book Handbook of Radioactivity Analysis written by Michael F. L'Annunziata and published by Elsevier. This book was released on 2012-12-02 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Radioactivity Analysis is written by experts in the measurement of radioactivity. The book describes the broad scope of analytical methods available and instructs the reader on how to select the proper technique. It is intended as a practical manual for research which requires the accurate measurement of radioactivity at all levels, from the low levels encountered in the environment to the high levels measured in radioisotope research. This book contains sample preparation procedures, recommendations on steps to follow, necessary calculations, computer controlled analysis, and high sample throughput techniques. Each chapter includes practical techniques for application to nuclear safety, nuclear safeguards, environmental analysis, weapons disarmament, and assays required for research in biomedicine and agriculture. The fundamentals of radioactivity properties, radionuclide decay, and methods of detection are included to provide the basis for a thorough understanding of the analytical procedures described in the book. Therefore, the Handbook can also be used as a teaching text. Includes sample preparation techniques for matrices such as soil, air, plant, water, animal tissue, and surface swipes Provides procedures and guidelines for the analysis of commonly encountered na
Author : Nicholas D. Priest
Publisher : CRC Press
ISBN 13 : 9780849361906
Total Pages : 402 pages
Book Rating : 4.3/5 (619 download)
Download or read book Trace Metals and Fluoride in Bones and Teeth written by Nicholas D. Priest and published by CRC Press. This book was released on 1990-06-22 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a comprehensive introduction to the analysis, binding, uptake, metabolism, kinetics, modeling, distribution, occurrence, toxicity and chelation of metals and fluoride in the body, with special reference to mineralized tissues. Both toxic and relatively harmless polyvalent cations and anions are considered. Included are some which are stable, and others which are radioactive. While a number are essential trace elements, others have no known metabolic role. Most chapters are concerned with the uptake of bone-seeking ions by the living skeleton, but aspects of the post-mortem uptake of metals and the process of fossilization are also considered. Highlighted are the utility of modern analytical techniques and the more important bone-seeking elements including aluminum, lead, cadmium, fluorine and the radioactive heavy metals including uranium and plutonium. This important publication is of particular value to those in the fields of biochemistry, radioactive waste, geology, physiology, dentistry, orthopedics, radiology and nuclear medicine, urology, industrial hygiene, pharmacology, anthropology, paleontology, and archeology.
Author : Harry P.A. Illing
Publisher : CRC Press
ISBN 13 : 1000722384
Total Pages : 234 pages
Book Rating : 4.0/5 (7 download)
Download or read book Xenobiotic Metabolism and Disposition written by Harry P.A. Illing and published by CRC Press. This book was released on 2019-11-11 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.
Author : Donglu Zhang
Publisher : John Wiley & Sons
ISBN 13 : 1118180763
Total Pages : 622 pages
Book Rating : 4.1/5 (181 download)
Download or read book ADME-Enabling Technologies in Drug Design and Development written by Donglu Zhang and published by John Wiley & Sons. This book was released on 2012-04-13 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Author : John R.J. Baker
Publisher : Taylor & Francis
ISBN 13 : 1000942368
Total Pages : 117 pages
Book Rating : 4.0/5 (9 download)
Download or read book Autoradiography written by John R.J. Baker and published by Taylor & Francis. This book was released on 2023-05-31 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes levels of autoradiography, which is the localization within a solid specimen of a radiolabel, to help the beginner or biologist choose the correct approach for particular application. It attempts to lay emphasis on certain aspects of the appraisal of autoradiographs.
Author : Peter H. Bach
Publisher : Springer Science & Business Media
ISBN 13 : 9401130949
Total Pages : 292 pages
Book Rating : 4.4/5 (11 download)
Download or read book Histochemical and Immunohistochemical Techniques written by Peter H. Bach and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicological and pharmacological effects arise when chemicals interact with biophysiological functions in discrete cell types. There is a continuing need to screen novel compounds for their potential therapeutic effects, and once these have been "discovered" to understand their molecular actions, as the basis of using such compounds safely and for rational drug design. Pharmacology now uses all of the sophisticated molecular research techniques that are available for the development of safer and more efficacious drugs. Histochemistry has been usefully applied to developing new drugs (and assessing chemical safley) and is potentially cost effective. The need to test novel substances for their potential adverse effects has raised many questions. Toxicological pathology has moved away from the cataloging of lesions towards understanding the basis of the events that underly cell injury, especially for those secondary consequences of chemical injury that lead to malignancy and chronic disease. The focal nature of toxicologic lesions de mands the use of microtechniques to provide data to help understand these questions. Histochemistry is under-utilized, but offers one of the key ap proaches necessary to address the problem of understanding interactions between a cell population and a chemical, the modulation of cellular biochem istryor the presence of a lesion in a test animal can be rationalised in terms of species differences that have no relevance to man as opposed to those that are of clinical significance or represent a warning of dire consequences to man.
Author : H. A. Fischer
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3112318498
Total Pages : 212 pages
Book Rating : 4.1/5 (123 download)
Download or read book Autoradiography written by H. A. Fischer and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-05-18 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Autoradiography".
Author : George C. Towe
Publisher :
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.3/5 (91 download)
Download or read book High-resolution Autoradiography written by George C. Towe and published by . This book was released on 1954 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoradiography has been used only to a rather limited extent in metallurgical studies. Probably the major deterring factor has been that the autoradiographic systems have not provided the high resolution required in many investigations. A general discussion of the requirements for high-resolution autoradiography is presented in this report including detecting layer as well as radioactive-sample specifications. The need for a thin photographic emulsion in close contact with the metal surface is emphasized. The desirability of using favorable radiation (e.g., low-energy beta radioactivity) is also discussed.
Author : Gerard Morel
Publisher : CRC Press
ISBN 13 : 9780849326448
Total Pages : 458 pages
Book Rating : 4.3/5 (264 download)
Download or read book Visualization of Receptors written by Gerard Morel and published by CRC Press. This book was released on 1997-02-26 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: A multiplicity of methods for visualization are described in Visualization of Receptors. This book of techniques covers immunocytology, radioautography, in situ hybridization, plasmon resonance, RT in vitro PCR, and X-ray crystal structure analysis. Lecturers, researchers, practitioners, technicians, and students will find all the principles and protocols they require and the means of implementing them. Topics discussed include localization of ligands (in vitro or in vivo), visualization of immunoreactivities of ligand and receptor proteins, detection and quantification of mRNA expression, amplification of signals, and determination of 3-D structure. Details of protocols with illustrations of results and commentaries are provided throughout the book.
Author : Martin Braddock
Publisher : Royal Society of Chemistry
ISBN 13 : 1849730148
Total Pages : 553 pages
Book Rating : 4.8/5 (497 download)
Download or read book Biomedical Imaging written by Martin Braddock and published by Royal Society of Chemistry. This book was released on 2012 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this new book is for medicinal chemists on the chemical agents that have been used, or might be required in the future, and the methods of synthesis for inserting the reporter groups. Medicinal chemists need to know the critical issues involved in using such chemical agents with regard to the biological applications - for instance - what properties are needed chemically and why? The topics covered in the book are: PET, SPECT, contrast agents, radioimaging/radionuclide conjugates, receptor mapping, small animal imaging (eg. WBAR - whole body autoradiography); photoinduced labelling, as well as chapters on the physical techniques used including: NMR, mass spectrometry and Xray. A key reference for academics, postgraduates, researchers, industrialists and professionals working in or joining this field.
Author : Harry P.A. Illing
Publisher : CRC Press
ISBN 13 : 100071456X
Total Pages : 229 pages
Book Rating : 4.0/5 (7 download)
Download or read book Xenobiotic Metabolism and Disposition written by Harry P.A. Illing and published by CRC Press. This book was released on 2019-11-11 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.
Author : H.Gerhard Vogel
Publisher : Springer Science & Business Media
ISBN 13 : 3540898905
Total Pages : 576 pages
Book Rating : 4.5/5 (48 download)
Download or read book Drug Discovery and Evaluation: Methods in Clinical Pharmacology written by H.Gerhard Vogel and published by Springer Science & Business Media. This book was released on 2010-12-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Author : P.H. Bach
Publisher : Springer Science & Business Media
ISBN 13 : 9400933673
Total Pages : 490 pages
Book Rating : 4.4/5 (9 download)
Download or read book Nephrotoxicity in the experimental and clinical situation written by P.H. Bach and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Graham Lappin
Publisher : CRC Press
ISBN 13 : 1420004980
Total Pages : 321 pages
Book Rating : 4.4/5 (2 download)
Download or read book Radiotracers in Drug Development written by Graham Lappin and published by CRC Press. This book was released on 2006-04-03 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug's absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the b
Author :
Publisher : Elsevier
ISBN 13 : 9780080862576
Total Pages : 346 pages
Book Rating : 4.8/5 (625 download)
Download or read book Progress in Medicinal Chemistry written by and published by Elsevier. This book was released on 2011-10-10 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Medicinal Chemistry
