Tumor Organoids

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Tumor Organoids

Author : Shay Soker
Publisher : Humana Press
ISBN 13 : 3319605119
Total Pages : 213 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Tumor Organoids

Author : Shay Soker
Publisher : Humana
ISBN 13 : 9783319868745
Total Pages : 0 pages
Book Rating : 4.8/5 (687 download)

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Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana. This book was released on 2018-08-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Tumor Organoids

Author : Shay Soker
Publisher : Humana
ISBN 13 : 9783319605098
Total Pages : 0 pages
Book Rating : 4.6/5 (5 download)

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Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana. This book was released on 2017-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Immunodeficient Animals

Author : Wolfgang Arnold
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 252 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunodeficient Animals by : Wolfgang Arnold

Download or read book Immunodeficient Animals written by Wolfgang Arnold and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth characteristics and tumor markers. Special attention is given to new approaches in the fields of chemotherapy, radiation therapy and immunotherapy. Various contributors consider in vitro methods as alternative models. In addition to current data, this publication contains useful technical and methodological information and is therefore valuable not only for specialists but also for scientists entering the field of experimental cancer research.

Patient Derived Tumor Xenograft Models

Author : Rajesh Uthamanthil
Publisher : Academic Press
ISBN 13 : 0128040610
Total Pages : 486 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Patient Derived Tumor Xenograft Models by : Rajesh Uthamanthil

Download or read book Patient Derived Tumor Xenograft Models written by Rajesh Uthamanthil and published by Academic Press. This book was released on 2016-10-13 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

Ex Vivo Engineering of the Tumor Microenvironment

Author : Amir R. Aref
Publisher : Springer
ISBN 13 : 3319453971
Total Pages : 135 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Ex Vivo Engineering of the Tumor Microenvironment by : Amir R. Aref

Download or read book Ex Vivo Engineering of the Tumor Microenvironment written by Amir R. Aref and published by Springer. This book was released on 2016-12-09 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.

Patient-derived Tumor Models for Drug Development

Author : Hatim E. Sabaawy
Publisher : Frontiers Media SA
ISBN 13 : 2832530540
Total Pages : 183 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Patient-derived Tumor Models for Drug Development by : Hatim E. Sabaawy

Download or read book Patient-derived Tumor Models for Drug Development written by Hatim E. Sabaawy and published by Frontiers Media SA. This book was released on 2023-07-31 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Adult Stem Cells

Author : John Masters
Publisher : Springer
ISBN 13 : 9789048122684
Total Pages : 208 pages
Book Rating : 4.1/5 (226 download)

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Book Synopsis Human Adult Stem Cells by : John Masters

Download or read book Human Adult Stem Cells written by John Masters and published by Springer. This book was released on 2009-06-04 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of volume 7 of Human Cell Culture is to provide clear and precise methods for growing primary cultures of adult stem cells from various human tissues and describe culture conditions in which these adult stem cells differentiate along their respective lineages. The book will be of value to biomedical scientists and of special interest to stem cell biologists and tissue engineers. Each chapter is written by experts actively involved in growing human adult stem cells.

Organoids, organs-on-chip, nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment

Download Organoids, organs-on-chip, nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment PDF Online Free

Author : Fabrizio Mattei
Publisher : Frontiers Media SA
ISBN 13 : 2832531377
Total Pages : 195 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Organoids, organs-on-chip, nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment by : Fabrizio Mattei

Download or read book Organoids, organs-on-chip, nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment written by Fabrizio Mattei and published by Frontiers Media SA. This book was released on 2023-08-03 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recent 3D Tumor Models for Testing Immune-Mediated Therapies

Author : Silvia Scaglione
Publisher : Frontiers Media SA
ISBN 13 : 2889740153
Total Pages : 90 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Recent 3D Tumor Models for Testing Immune-Mediated Therapies by : Silvia Scaglione

Download or read book Recent 3D Tumor Models for Testing Immune-Mediated Therapies written by Silvia Scaglione and published by Frontiers Media SA. This book was released on 2022-01-10 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomaterials for 3D Tumor Modeling

Author : Subhas C. Kundu
Publisher : Elsevier
ISBN 13 : 012818129X
Total Pages : 773 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biomaterials for 3D Tumor Modeling by : Subhas C. Kundu

Download or read book Biomaterials for 3D Tumor Modeling written by Subhas C. Kundu and published by Elsevier. This book was released on 2020-08-22 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Intestinal Stem Cells

Author : Paloma Ordóñez-Morán
Publisher : Humana
ISBN 13 : 9781071607497
Total Pages : 350 pages
Book Rating : 4.6/5 (74 download)

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Book Synopsis Intestinal Stem Cells by : Paloma Ordóñez-Morán

Download or read book Intestinal Stem Cells written by Paloma Ordóñez-Morán and published by Humana. This book was released on 2021-08-07 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book encapsulates the most up-to-date methods of the intestinal stem cell field and provides guidance on a variety of techniques for studying intestinal stem cells properties. Beginning with a section on in vitro techniques to study different aspects of the intestinal stem cell functions by innovative imaging and functional assays, the volume continues with chapters detailing the single-cell transcriptional profiling method, the isolation of intestinal crypts to generate and establish 3D organoids, as well as different animal models of gastrointestinal cancer and examples of the use of in vivo methods for studying intestinal tumor-initiating cells or cancer stem cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and state-of-the-art, Intestinal Stem Cells: Methods and Protocols aims to provide comprehensive and easy to follow protocols designed to be helpful to both seasoned researchers and newcomers to this dynamic field.

Immune-deficient Animals

Author : Bernard Sordat
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 468 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Immune-deficient Animals by : Bernard Sordat

Download or read book Immune-deficient Animals written by Bernard Sordat and published by S. Karger AG (Switzerland). This book was released on 1984 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Prostate Cancer: Model Systems, Molecular and Cellular Mechanisms, Early Detection, and Therapies

Author : Tanya I. Stoyanova
Publisher : Frontiers Media SA
ISBN 13 : 2889767396
Total Pages : 232 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Advances in Prostate Cancer: Model Systems, Molecular and Cellular Mechanisms, Early Detection, and Therapies by : Tanya I. Stoyanova

Download or read book Advances in Prostate Cancer: Model Systems, Molecular and Cellular Mechanisms, Early Detection, and Therapies written by Tanya I. Stoyanova and published by Frontiers Media SA. This book was released on 2022-08-08 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Pancreatology for Practising Gastroenterologists and Surgeons

Author : Juan Enrique Dominguez-Munoz
Publisher : John Wiley & Sons
ISBN 13 : 111957014X
Total Pages : 752 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Clinical Pancreatology for Practising Gastroenterologists and Surgeons by : Juan Enrique Dominguez-Munoz

Download or read book Clinical Pancreatology for Practising Gastroenterologists and Surgeons written by Juan Enrique Dominguez-Munoz and published by John Wiley & Sons. This book was released on 2021-03-17 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.

FRONTIERS IN ONCOLOGY: EDITOR’S PICK 2021

Author : Giuseppe Giaccone
Publisher : Frontiers Media SA
ISBN 13 : 2889748294
Total Pages : 160 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis FRONTIERS IN ONCOLOGY: EDITOR’S PICK 2021 by : Giuseppe Giaccone

Download or read book FRONTIERS IN ONCOLOGY: EDITOR’S PICK 2021 written by Giuseppe Giaccone and published by Frontiers Media SA. This book was released on 2022-05-17 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are pleased to introduce the 2021 Frontiers in Oncology: Editor’s Pick collection, showcasing articles stimulating interest in the field, carefully selected by our Field Chief Editor, Prof. Giuseppe Giaccone, of Weill Cornell Medicine. With this ebook we aim to highlight and disseminate important findings across the domains of cancer research, capturing the multidisciplinary and inclusive approach our journal takes towards advancing the field of oncology and supporting the global effort towards improved quality of life and patient survival. 2021 was a year which saw our highest journal impact factor yet, international community growth, and a record-breaking number of articles to choose from. We wish to elevate the contributions made by authors, encourage readership and innovation through our open-access philosophies, and thank our Editorial Board for their continued hard work and collaboration.

Circulating Tumor Cells in Breast Cancer Metastatic Disease

Author : Roberto Piñeiro
Publisher : Springer Nature
ISBN 13 : 3030358054
Total Pages : 177 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Circulating Tumor Cells in Breast Cancer Metastatic Disease by : Roberto Piñeiro

Download or read book Circulating Tumor Cells in Breast Cancer Metastatic Disease written by Roberto Piñeiro and published by Springer Nature. This book was released on 2020-04-17 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed to summarise the key aspects of the role of circulating tumour cells (CTCs) in breast cancer, with special attention to their contribution to tumour progression and establishment of metastatic disease. We aim to give a clear overview of the knowledge about CTCs, framed in the context of breast cancer, by analysing basic and clinical research carried out so far. In a broader sense, we will address what are the main clinical needs of this disease based on its molecular heterogeneity (subtypes) and lay out the knowledge and understanding that CTCs are giving about it and how they are contributing and can still improve the better monitoring and management of breast cancer patients. We will discuss the evidences of the use of CTCs as a tool to monitor cancer progression and therapy response, based on the prognostic and predictive value they have, as well as a tool to unravel mechanisms of resistance to therapy and to identify new biomarkers allowing to predict therapy success. Moreover, we will analyse the main aspects of ongoing clinical trials and how they can contribute to determine the clinical utility of CTCs as a breast cancer biomarker. We will also touch upon general knowledge or basic notions of the biology of the metastatic process in epithelial cancers, in order to understand the origin and biology of CTCs. In this sense, we will pay special attention to EMT (epithelial to mesenchymal transition), dormancy and minimal residual disease, three key aspects that determine the outcome of the disease. We will also cover general aspects on the isolation and characterization techniques applies to the study of CTCs, and also the possibilities that the study of CTCs, as a biomarker with biological function, is opening in terms of understanding the biology of metastatic cells and the identification of therapeutic targets based on the functional and molecular characterization of CTCs. Lastly, we will try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine.