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Translational Immunology In Trauma To Provide New Insights For Improving Outcomes
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Book Synopsis Translational immunology in trauma - to provide new insights for improving outcomes by : Klemens Horst
Download or read book Translational immunology in trauma - to provide new insights for improving outcomes written by Klemens Horst and published by Frontiers Media SA. This book was released on 2023-01-27 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Technology and Method Developments for High-throughput Translational Medicine by : Junhee Seok
Download or read book Technology and Method Developments for High-throughput Translational Medicine written by Junhee Seok and published by Stanford University. This book was released on 2011 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translation of knowledge from basic science to medicine is essential to improving both clinical research and practice. In this translation, high-throughput genomic approaches can greatly accelerate our understanding of molecular mechanisms of diseases. A successful high-throughput genomic study of disease requires, first, comprehensive and efficient platforms to collect genomic data from clinical samples, and second, computational analysis methods that utilize databases of prior biological knowledge together with experimental data to derive clinically meaningful results. In this thesis, we discuss the development of a new microarray platform as well as computational methods for knowledge-based analysis along with their applications in clinical research. First, we and other colleagues have developed a new high-density oligonucleo-tide array of the human transcriptome for high-throughput and cost-efficient analysis of patient samples in clinical studies. This array allows comprehensive examination of gene expression and genome-wide identification of alternative splicing, and also pro-vides assays for coding SNP detection and non-coding transcripts. Compared with high-throughput mRNA sequencing technology, we show that this array is highly re-producible in estimating gene and exon expression, and sensitive in detecting expres-sion changes. In addition, the exon-exon junction feature of this array is shown to im-prove detection efficiency for mRNA alternative splicing when combined with an ap-propriate computational method. We implemented the use of this array in a multi-center clinical program and have obtained comparable levels of high quality and re-producible data. With low costs and high throughputs for sample processing, we antic-ipate that this array platform will have a wide range of applications in high-throughput clinical studies. Second, we investigated knowledge-based methods that utilize prior know-ledge from biology and medicine to improve analysis and interpretation of high-throughput genomic data. We have developed knowledge-based methods to enrich our prior knowledge, illustrate dynamic response to external stimulus, and identify distur-bances in cellular pathways by chemical exposure, as well as discover hidden biological signatures for the prediction of patient outcomes. Finally, we applied a knowledge-based approach in a large scale genomic study of trauma patients. Cooperating with clinical information, prior knowledge improved the interpretation of common and dif-ferential genomic response to injury, and provided efficient risk assessment for patient outcomes. The clinical and genomic data as well as analysis results in this trauma study were systematically organized and provided to research communities as new knowledge of traumatic injury. The microarray platform and knowledge-based methods presented in this thesis provide appropriate research tools for high-throughput translational medicine in a large clinical setting. This thesis is expected to advance understanding and treatment for dis-eases, and finally, improve public health.
Book Synopsis New Insights into and Interventions of the Persistent Immune Responses in Chronic Graft Rejection, 2nd Edition by : Hao Wang
Download or read book New Insights into and Interventions of the Persistent Immune Responses in Chronic Graft Rejection, 2nd Edition written by Hao Wang and published by Frontiers Media SA. This book was released on 2022-03-09 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher’s note: This is a 2nd edition due to an article retraction.
Book Synopsis Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury by : Rajkumar Rajendram
Download or read book Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury written by Rajkumar Rajendram and published by Academic Press. This book was released on 2022-05-10 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers' understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury. - Summarizes the neuroscience of traumatic brain injury, including cellular and molecular biology - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on signaling and hormonal events - Includes plasticity and gene expression - Examines health and stress behaviors after traumatic brain injury
Book Synopsis The Neuroscience of Traumatic Brain Injury by : Rajkumar Rajendram
Download or read book The Neuroscience of Traumatic Brain Injury written by Rajkumar Rajendram and published by Academic Press. This book was released on 2022-05-27 with total page 1206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosis and Treatment of Traumatic Brain Injury will improve readers' understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers' understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury. Diagnosis and Treatment of Traumatic Brain Injury: - Covers both the diagnosis and treatment of traumatic brain cord injury - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on epidemiology and pain - Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury - Discusses pain reduction, drug delivery, and rehabilitation Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury: - Summarizes the neuroscience of traumatic brain injury, including cellular and molecular biology - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on signaling and hormonal events - Includes plasticity and gene expression - Examines health and stress behaviors after traumatic brain injury
Book Synopsis Neurological Disease: New Insights for the Healthcare Professional: 2013 Edition by :
Download or read book Neurological Disease: New Insights for the Healthcare Professional: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological Disease: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Diagnosis and Screening in a concise format. The editors have built Neurological Disease: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neurological Disease: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies by : Alessandra Stasi
Download or read book New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies written by Alessandra Stasi and published by Frontiers Media SA. This book was released on 2023-04-03 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Finding New Epigenomics and Epigenetics Biomarkers for Complex Diseases and Significant Developmental Events with Machine Learning Methods by : Lu Xie
Download or read book Finding New Epigenomics and Epigenetics Biomarkers for Complex Diseases and Significant Developmental Events with Machine Learning Methods written by Lu Xie and published by Frontiers Media SA. This book was released on 2022-03-24 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Insights on Liver Transplant and Tolerance by : Xiao-Kang Li
Download or read book New Insights on Liver Transplant and Tolerance written by Xiao-Kang Li and published by Frontiers Media SA. This book was released on 2021-11-24 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Basic and Translational Perspectives on Skin Repair by : Yiming Zhang
Download or read book New Basic and Translational Perspectives on Skin Repair written by Yiming Zhang and published by Frontiers Media SA. This book was released on 2024-09-27 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin, the largest organ of the human body, makes up the main barrier to prevent the invasion of pathogenic organisms and the loss of water. Any injuries to the skin caused by trauma, diseases, or aging will lead to skin dysfunctions, resulting in a series of physical and mental disorders. Wound healing is a complex and fragile process, accompanied by hemostasis, inflammation, proliferation, and remodeling. Any abnormality in each process may lead to delayed wound healing and/or conspicuous scars. In addition, direct contact with the outside environment and stimulation by various external factors, such as ultraviolet radiation, microorganisms, etc., will cause a series of inflammatory reactions, leading to skin cell aging, affecting stem cell activity and wound healing. Therefore, it is necessary to have a deep understanding of the mechanisms of skin injuries and to explore effective prevention and therapeutic strategies to facilitate the process of skin repair.
Book Synopsis Translational Insights into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma by : Lukas Martin
Download or read book Translational Insights into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma written by Lukas Martin and published by Frontiers Media SA. This book was released on 2020-12-15 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Community series in translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma, volume II by : Christoph Thiemermann
Download or read book Community series in translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma, volume II written by Christoph Thiemermann and published by Frontiers Media SA. This book was released on 2023-06-27 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New insights of immune cells in cardiovascular and metabolic disorders by : Yingmei Feng
Download or read book New insights of immune cells in cardiovascular and metabolic disorders written by Yingmei Feng and published by Frontiers Media SA. This book was released on 2023-10-26 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Community Series in Translational Insights into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma, volume III by : Christoph Thiemermann
Download or read book Community Series in Translational Insights into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma, volume III written by Christoph Thiemermann and published by Frontiers Media SA. This book was released on 2024-11-07 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life-threatening organ dysfunction/failure in critically ill patients suffering from sepsis or trauma is caused by a dysregulated host response to infection and/or inflammation. Despite significant advances in our understanding of some of the key signaling pathways involved in the excessive inflammation associated with sepsis/trauma, the translation of our current understanding of the underlying pathophysiology into organ-protective therapeutic strategies is still very limited. Current therapeutic approaches, hence, continue to rely on source control, antibiotics and supportive care, and particularly early goal-directed therapy.
Book Synopsis Rheumatoid Arthritis: New Insights for the Healthcare Professional: 2012 Edition by :
Download or read book Rheumatoid Arthritis: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid Arthritis: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Rheumatoid Arthritis. The editors have built Rheumatoid Arthritis: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Rheumatoid Arthritis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Rheumatoid Arthritis: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine
Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Book Synopsis Update on Translational Neuroimmunology - Research of ISNI 2018 by : Sandra Amor
Download or read book Update on Translational Neuroimmunology - Research of ISNI 2018 written by Sandra Amor and published by Frontiers Media SA. This book was released on 2020-12-29 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 14th International Congress of Neuroimmunology, ISNI 2018, was held in August 2018 in Brisbane, Australia, and is a biennial event organized by the International Society of Neuroimmunology (ISNI). The theme of ISNI 2018 was “Travelling the Neuroimmunological Translational Highway”, and the Congress highlighted many research discoveries that bridge the gap between basic and clinical sciences, and which impact our understanding of pathogenic immune-mediated mechanisms in diseases affecting the nervous system. In this Research Topic, we aim to give a comprehensive overview of topics highlighted at the Congress, showcasing the current state of the field of neuroimmunology and where it is going in the near future.
