Modern Supercritical Fluid Chromatography

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Publisher : John Wiley & Sons
ISBN 13 : 1119626005
Total Pages : 442 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Modern Supercritical Fluid Chromatography by : Larry M. Miller

Download or read book Modern Supercritical Fluid Chromatography written by Larry M. Miller and published by John Wiley & Sons. This book was released on 2019-11-06 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains why modern supercritical fluid chromatography (SFC) is the leading "green" analytical and purification separations technology. Modern supercritical fluid chromatography (SFC) is the leading method used to analyze and purify chiral and achiral chemical compounds, many of which are pharmaceuticals, pharmaceutical candidates, and natural products including cannabis-related compounds. This book covers current SFC instrumentation as it relates to greater robustness, better reproducibility, and increased analytical sensitivity. Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases covers the history, instrumentation, method development and applications of SFC. The authors provided readers with an overview of analytical and preparative SFC equipment, stationary phases, and mobile phase choices. Topics covered include: Milestones of Supercritical Fluid Chromatography; Physical Properties of Supercritical Fluids; Instrumentation for SFC; Detection in SFC; Achiral SFC Method Development; Chiral SFC Method Development; and Preparative Scale SFC. The book also includes highlights of modern applications of SFC in the final chapters—namely pharmaceuticals, consumer products, foods, polymers, petroleum-related mixtures, and cannabis—and discusses the future of SFC. Provides a clear explanation of the physical and chemical properties of supercritical fluids, which gives the reader a better understanding of the basis for improved performance in SFC compared to HPLC and GC Describes the advantages of SFC as a green alternative to HPLC and GC for the analysis of both polar, water-soluble, and non-polar analytes Details both achiral and chiral SFC method development, including modifiers, additives, the impact of temperature and pressure, and stationary phase choices Details why SFC is the premier modern preparative chromatographic technique used to purify components of mixtures for subsequent uses, both from performance and economic perspectives Covers numerous detectors, with an emphasis on SFC-MS, SFC-UV, and SFC-ELSD (evaporative light scattering detection) Describes the application of SFC to numerous high-value application areas Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases will be of great interest to professionals, students, and professors involved in analytical, bioanalytical, separations science, medicinal, petroleum, and environmental chemistries. It will also appeal to pharmaceutical scientists, natural-product scientists, food and consumer-products scientists, chemical engineers, and managers in these areas.

The Use of Modern Supercritical Fluid Chromatography and Supercritical Fluid Chromatography-mass Spectrometry in Pharmaceutical Analysis

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Publisher :
ISBN 13 :
Total Pages : 225 pages
Book Rating : 4.:/5 (18 download)

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Book Synopsis The Use of Modern Supercritical Fluid Chromatography and Supercritical Fluid Chromatography-mass Spectrometry in Pharmaceutical Analysis by : Vincent Desfontaine

Download or read book The Use of Modern Supercritical Fluid Chromatography and Supercritical Fluid Chromatography-mass Spectrometry in Pharmaceutical Analysis written by Vincent Desfontaine and published by . This book was released on 2018 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Supercritical Fluid Chromatography

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Author :
Publisher : CRC Press
ISBN 13 : 9814463000
Total Pages : 420 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Supercritical Fluid Chromatography by : Gregory K. Webster

Download or read book Supercritical Fluid Chromatography written by Gregory K. Webster and published by CRC Press. This book was released on 2014-02-04 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical chemists in the pharmaceutical industry are always looking for more-efficient techniques to meet the analytical challenges of today’s pharmaceutical industry. One technique that has made steady advances in pharmaceutical analysis is supercritical fluid chromatography (SFC). SFC is meeting the chromatography needs of the industry by providing efficient and selective testing capabilities on the analytical and preparative scale. The supercritical fluid mobile phase, consisting mainly of CO2, facilitates cost reduction costs and helps the industry in meeting green chemistry standards. This book provides a comprehensive overview of the use of SFC in pharmaceutical analysis. Supercritical Fluid Chromatography reviews the use of SFC in drug-discovery applications and describes its application in drug development. When a drug is developed and brought to market, it is tested many times for impurities and degradants, enantiomeric purity, and analytical and preparative isolations—it is tested during discovery and development and for under-regulated and unregulated methodologies. The book describes the use of SFC for each of these applications and discusses more in-depth topics, such as the use of SFC in mass spectrometric and polarographic detection. The book also sheds light on the role of SFC in drug development from natural products and the advancement of SFC with new technologies and its use in pilot-scale operations as a chromatographic technique.

Supercritical Fluid Chromatography

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Author :
Publisher : Elsevier
ISBN 13 : 0128093676
Total Pages : 574 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Supercritical Fluid Chromatography by : Colin F. Poole

Download or read book Supercritical Fluid Chromatography written by Colin F. Poole and published by Elsevier. This book was released on 2017-02-16 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Significant improvements in instrumentation have rekindled interest in SFC in recent years and enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its strengths and weaknesses, but the possibilities brought to the table by SFC are less well-known and are underappreciated. Supercritical Fluid Chromatography is a thorough and encompassing reference that defines the concept of contemporary practice in SFC and how it should be implemented in laboratory science. Given the changes that have taken place in SFC, this book presents contemporary aspects and applications of the technique and introduces SFC as a natural solution in the larger field of separation science. The focus on state-of-the-art instrumental SFC distinguishes this work as the go-to reference work for those interested in implementing the technique at an advanced level. Edited and authored by world-leading chromatography experts Provides comprehensive coverage of SFC in a single source Extensive referencing facilitates identification of key research developments More than 200 figures and tables aid in the retention of key concepts

Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development

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Author :
Publisher : Elsevier
ISBN 13 : 0323884881
Total Pages : 434 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development by :

Download or read book Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development written by and published by Elsevier. This book was released on 2022-12-02 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development provides a valuable “go-to reference for many difficult-to-solve challenges using pertinent chromatographic theory, first-hand case studies, and examples provided from academic and industry experts. This text also enables professors teaching an analytical instrumental course to introduce and instruct students about one of the most sustainable and powerful separation methods currently available. While the text has broad applicability across industrial sectors, it focuses primarily on application in the pharmaceutical industry. The book is designed to allow readers to align current HPLC/UHPLC capabilities with SFC as an orthogonal tool for project specific methods in the pharmaceutical industry. It highlights where SFC falls on the spectrum of useful chromatographic tools for routine and challenging separative methods. Experienced HPLC users who are interested in developing knowledge in orthogonal separation techniques, as well as newcomers to the field of separation science, will find this text particularly useful. Chapters address where SFC may fit the analytical needs of the pharmaceutical industry and alert the readers as to where the technique will not fit. Readers will gain an understanding of how and where SFC may be applied and adapted more routinely across the pharmaceutical industry as a ‘green’ way of undertaking separation opportunities and challenges. Areas within the pharmaceutical industry include early drug discovery, process chemistry, and late stage development and manufacturing. Describes approaches to SFC column and mobile phase selection for method development for both analytical and preparative tasks Gives practical examples of how analytical SFC enables the monitoring of synthetic reactions including unstable intermediates, chiral and achiral polar reactants and products across small and large modalities Provides need-focused case studies for pharmaceutical analysts, process chemists, and contract chemistry facilities that can benefit from monitoring or purifying polar intermediates, mutagenic impurities, nitrosamines and other reaction by-products including excipients and metabolites

Unified Chromatography

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Author :
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Unified Chromatography by : J. F. Parcher

Download or read book Unified Chromatography written by J. F. Parcher and published by . This book was released on 2000 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here, authors specializing in different branches of chromatography--including gas chromatography, supercritical fluid chromatography, and high-pressure liquid chromatography--describe their fields while drawing out connections with other branches.

Supercritical Fluid Chromatography

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Author :
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 311049812X
Total Pages : 291 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Supercritical Fluid Chromatography by : Gérard Rossé

Download or read book Supercritical Fluid Chromatography written by Gérard Rossé and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-17 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supercritical Fluid Chromatography (SFC) provides a timely overview of SFC application areas which were unimaginable just a decade ago. This two-volume series opens with an overview of the history and expectant future of SFC and continues with recent applications in the pharmaceutical industry and other fascinating areas of science. SFC has found its place in the pharmaceutical industry with an increasing body of applications for chiral and achiral molecules in both the research and development phases of the drug discovery process. As illustrated in this two-volume series, the current interest in SFC extends well beyond the pharmaceutical industry. Chapters encompassing applications for polar and non-polar mixtures of importance are covering widely disparate areas in substance abuse, natural products including cannabinoids, bioactive lipids, flavor and fragrance. With its broad balance and coverage, this two-volume book constitutes a unique educational platform to students and scientists for many years to come. The major objective of this book editions is to inspire and stimulate readers to continue exploring the possibilities of exploiting supercritical fluids as a particular media for analysis, purifications and synthesis

Supercritical Fluid Chromatography

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Author :
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110619067
Total Pages : 264 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Supercritical Fluid Chromatography by : Gérard Rossé

Download or read book Supercritical Fluid Chromatography written by Gérard Rossé and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-17 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supercritical Fluid Chromatography (SFC) provides a timely overview of SFC application areas which were unimaginable just a decade ago. This two-volume series opens with an overview of the history and expectant future of SFC and continues with recent applications in the pharmaceutical industry and other fascinating areas of science. SFC has found its place in the pharmaceutical industry with an increasing body of applications for chiral and achiral molecules in both the research and development phases of the drug discovery process. As illustrated in this two-volume series, the current interest in SFC extends well beyond the pharmaceutical industry. Chapters encompassing applications for polar and non-polar mixtures of importance are covering widely disparate areas in substance abuse, natural products including cannabinoids, bioactive lipids, flavor and fragrance. With its broad balance and coverage, this two-volume book constitutes a unique educational platform to students and scientists for many years to come. The major objective of this book editions is to inspire and stimulate readers to continue exploring the possibilities of exploiting supercritical fluids as a particular media for analysis, purifications and synthesis

Modern Supercritical Fluid Chromatography

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Author :
Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Modern Supercritical Fluid Chromatography by : Curt M. White

Download or read book Modern Supercritical Fluid Chromatography written by Curt M. White and published by . This book was released on 1988 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Practical Supercritical Fluid Chromatography and Extraction

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Author :
Publisher : Routledge
ISBN 13 : 1351422502
Total Pages : 450 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Practical Supercritical Fluid Chromatography and Extraction by : Thomas Caudell

Download or read book Practical Supercritical Fluid Chromatography and Extraction written by Thomas Caudell and published by Routledge. This book was released on 2018-05-08 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of fundamental as well as practical aspects of supercritical fluid chromatography and extraction. It addresses topics such as: packed columns in SFC; detection in SFC; supercritical fluid chromatography/mass spectroscopy; and evaporative light scattering detection in SFC.

Analysis with Supercritical Fluids: Extraction and Chromatography

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Publisher : Springer Science & Business Media
ISBN 13 : 3642774741
Total Pages : 225 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Analysis with Supercritical Fluids: Extraction and Chromatography by : Bernd Wenclawiak

Download or read book Analysis with Supercritical Fluids: Extraction and Chromatography written by Bernd Wenclawiak and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of supercritical fluids in analytical chemistry is still grow ing. More and more analysts are discovering the favorable advan tages for a number of applications. Especially supercritical fluid extraction (SFE) has attracted a lot of interest in recent years due to its simplicity. Supercritical fluid chromatography (SFC) has become better established and the development of this technique has been accelerated by the many applications with capillary col umns which have been published in the literature. At first SFC equipment was based on instruments commonly used for liquid chromatography, and the first commercial in struments were derived from this technology. However, capillary columns can be much more easily interfaced to gas chromatogra phy equipment especially to the detectors commonly used for Oc. Many stationary phases both for packed micro columns and capillary columns have been designed for SFC purposes extending this technology to LC and OC. The most common fluid applied in SFC and SFE is carbon dioxide. The advantages of supercritical CO , such as having dif 2 fusivity like a gas and solvating power depending on temperature and pressure, are also valid for other fluids and modified fluids. Both properties are valuable for sample extraction and extraction selectivity.

Supercritical Fluid Extraction and Its Use in Chromatographic Sample Preparation

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Author :
Publisher : Springer
ISBN 13 :
Total Pages : 192 pages
Book Rating : 4.:/5 (51 download)

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Book Synopsis Supercritical Fluid Extraction and Its Use in Chromatographic Sample Preparation by : S.A. Westwood

Download or read book Supercritical Fluid Extraction and Its Use in Chromatographic Sample Preparation written by S.A. Westwood and published by Springer. This book was released on 1993 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last ten years have seen a marked increase in the use of supercritical fluids in analytical chemistry, mainly as mobile phases in chromatography. More recently, there has been a trend towards the application of these unusual fluids for the purpose of extraction and sample preparation. The combination of properties exhibited by supercritical fluids makes them uniquely suitable for this purpose. The automation of sample preparation using supercritical fluids will add a new dimension to existing chromatographic techniques: in addition to the time savings achieved by on-line sample preparation, there are the added benefits of improved reproduciblity and sensitivity. These developments will lead to the routine use of supercritical fluid extraction in analytical chemistry, which is the essence of this-book. Following a discussion of the use of supercritical fluid extraction as an off-line technique in analytical chemistry, authors concentrate on the highly important aspects of on-line sample preparation coupled to chromatography. Individual chapters, written by authorities in their fields, contain the maximum of practical advice in addition to covering appropriate theoretical detail. All relevant literature is reviewed in each chapter, providing a basic work of reference and a practical handbook in one volume. The book is directed at analytical chemists, pharmaceutical chemists and materials scientists in the industrial and academic sectors. It will also provide much useful information for instrument manufacturers.

Hyphenated Techniques in Supercritical Fluid Chromatography and Extraction

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Publisher : Elsevier
ISBN 13 : 0080858619
Total Pages : 345 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Hyphenated Techniques in Supercritical Fluid Chromatography and Extraction by : K. Jinno

Download or read book Hyphenated Techniques in Supercritical Fluid Chromatography and Extraction written by K. Jinno and published by Elsevier. This book was released on 1992-07-21 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to focus on the latest developments in hyphenated techniques using supercritical fluids. The advantages of SFC in hyphenation with various detection modes, such as FTIR, MS, MPD and ICP and others are clearly featured throughout the book. Special attention is paid to coupling of SFE with GC or SFC. In this edited volume, chapters are written by leading experts in the field. The book will be of interest to professionals in academia, as well as to those researchers working in an industrial environment, such as analytical instrumentation, pharmaceuticals, agriculture, food, petrochemicals and environmental.

Handbook of Advanced Chromatography /Mass Spectrometry Techniques

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Publisher : Elsevier
ISBN 13 : 0128117338
Total Pages : 522 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Handbook of Advanced Chromatography /Mass Spectrometry Techniques by : Michal Holcapek

Download or read book Handbook of Advanced Chromatography /Mass Spectrometry Techniques written by Michal Holcapek and published by Elsevier. This book was released on 2017-09-07 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Advanced Chromatography /Mass Spectrometry Techniques is a compendium of new and advanced analytical techniques that have been developed in recent years for analysis of all types of molecules in a variety of complex matrices, from foods to fuel to pharmaceuticals and more. Focusing on areas that are becoming widely used or growing rapidly, this is a comprehensive volume that describes both theoretical and practical aspects of advanced methods for analysis. Written by authors who have published the foundational works in the field, the chapters have an emphasis on lipids, but reach a broader audience by including advanced analytical techniques applied to a variety of fields. Handbook of Advanced Chromatography / Mass Spectrometry Techniques is the ideal reference for those just entering the analytical fields covered, but also for those experienced analysts who want a combination of an overview of the techniques plus specific and pragmatic details not often covered in journal reports. The authors provide, in one source, a synthesis of knowledge that is scattered across a multitude of literature articles. The combination of pragmatic hints and tips with theoretical concepts and demonstrated applications provides both breadth and depth to produce a valuable and enduring reference manual. It is well suited for advanced analytical instrumentation students as well as for analysts seeking additional knowledge or a deeper understanding of familiar techniques. Includes UHPLC, HILIC, nano-liquid chromatographic separations, two-dimensional LC-MS (LCxLC), multiple parallel MS, 2D-GC (GCxGC) methodologies for lipids analysis, and more Contains both practical and theoretical knowledge, providing core understanding for implementing modern chromatographic and mass spectrometric techniques Presents chapters on the most popular and fastest-growing new techniques being implemented in diverse areas of research

Liquid Chromatography

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Publisher : CRC Press
ISBN 13 : 9780824719364
Total Pages : 654 pages
Book Rating : 4.7/5 (193 download)

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Book Synopsis Liquid Chromatography by : Wilfried M.A. Niessen

Download or read book Liquid Chromatography written by Wilfried M.A. Niessen and published by CRC Press. This book was released on 1998-09-01 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprehensively relates developments, principles, and applications of combined liquid chromatography-mass spectrometry and other techniques such as capillary electrophoresis and supercritical fluid chromatography combined with mass spectrometry. It covers historical developments, currently important interfaces and technologies, and LC-MS applications in environmental analysis, pharmaceuticals and bioanalysis, and additional fields. It offers in-depth coverage of interfaces and technologies currently important in the laboratory, especially electrospray and APCI, contains an expanded applications section, and provides over 2200 references, tables, equations, and drawings.

Supercritical Fluid Chromatography And Micro-hplc

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Author :
Publisher : VSP
ISBN 13 : 9789067641135
Total Pages : 316 pages
Book Rating : 4.6/5 (411 download)

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Book Synopsis Supercritical Fluid Chromatography And Micro-hplc by : M. Yoshioka

Download or read book Supercritical Fluid Chromatography And Micro-hplc written by M. Yoshioka and published by VSP. This book was released on 1989 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1988. Routledge is an imprint of Taylor & Francis, an informa company.

Supercritical Fluid Extraction and Chromatography

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Author :
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (5 download)

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Book Synopsis Supercritical Fluid Extraction and Chromatography by : Bonnie A. Charpentier

Download or read book Supercritical Fluid Extraction and Chromatography written by Bonnie A. Charpentier and published by . This book was released on 1988 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: