The Role Of Apoptosis In Development Tissue Homeostasis And Malignancy

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The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy

Author : R.M. Dexter
Publisher : Springer Science & Business Media
ISBN 13 : 9401105537
Total Pages : 101 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy by : R.M. Dexter

Download or read book The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy written by R.M. Dexter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past five years have witnessed a remarkable development of interest in cell death 'from inside out'. After 30 years of relative obscurity, its quantitative importance in the building and maintenance of normal tissues, the subtle strategies involved in its regulation, and its significance in the pathogenesis of diseases of major social importance are becoming clear. Moreover, because a distinct set of biological events is involved in this death, these events themselves become reason able targets for new pharmacological agents in the treatment of cancer. The articles in this volume summarize the contents of a discussion meeting held at the Royal Society on 23 and 24 February 1994. The authors are a distinguished international group from a variety of disciplines in biology and medicine and hopefully their articles will convey something of the excitement of this fast-moving field. The three organizers are enormously indebted to all the contributors for the enthusiasm with which they delivered their talks, shared in discussion, and finally committed their contributions to these printed pages. We would also like to acknowledge the gracious way in which the Royal Society hosted the meeting, and in particular Mary Manning for making it the trouble-free and enjoyable experience that it was, and Janet Clifford and Simon Gribbin for skillfully managing the editorial processing of this volume. Michael Dexter June 1994 Martin Raff Andrew Wyllie x 1 Death from inside out: an overVIew ANDREW H.

The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy

Author : R. M. Dexter
Publisher :
ISBN 13 : 9789401105545
Total Pages : 116 pages
Book Rating : 4.1/5 (55 download)

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Book Synopsis The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy by : R. M. Dexter

Download or read book The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy written by R. M. Dexter and published by . This book was released on 1995-06-30 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy

Author : Christopher D. Gregory
Publisher : Springer
ISBN 13 : 3319394061
Total Pages : 247 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy by : Christopher D. Gregory

Download or read book Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy written by Christopher D. Gregory and published by Springer. This book was released on 2016-08-24 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

Cell Apoptosis

Author : Lawrence B. Shultz
Publisher : Nova Publishers
ISBN 13 : 9781600215087
Total Pages : 228 pages
Book Rating : 4.2/5 (15 download)

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Book Synopsis Cell Apoptosis by : Lawrence B. Shultz

Download or read book Cell Apoptosis written by Lawrence B. Shultz and published by Nova Publishers. This book was released on 2007 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer.A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book deals with cell apoptosis regulation and environmental factors.

Cell Apoptosis and Cancer

Author : Albina W. Taylor
Publisher : Nova Publishers
ISBN 13 : 9781600215063
Total Pages : 208 pages
Book Rating : 4.2/5 (15 download)

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Book Synopsis Cell Apoptosis and Cancer by : Albina W. Taylor

Download or read book Cell Apoptosis and Cancer written by Albina W. Taylor and published by Nova Publishers. This book was released on 2007 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. Cancer and cell apoptosis is the central focus of this significant book.

Apoptosis and Cancer

Author : Seamus J. Martin
Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805565790
Total Pages : 0 pages
Book Rating : 4.5/5 (657 download)

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Book Synopsis Apoptosis and Cancer by : Seamus J. Martin

Download or read book Apoptosis and Cancer written by Seamus J. Martin and published by S. Karger AG (Switzerland). This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past five years have witnessed an explosion of research efforts in the study of how cells die. This book provides an up-to-date overview of our current knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. By synthesizing many of the recent developments in this area and placing them in perspective, it fulfills an important need. All the contributions are written by experts in their respective fields. The first two chapters give a basic introduction to the cell death machinery and its role in tumor development and progression; subsequent chapters cover current aspects of apoptosis research, including the involvement of cell cycle-related proteins (e.g. cyclin-dependent kinases) in apoptosis, the role of Bcl-2, Bcr-Abl, Rb, p53 and myc in the regulation of cell death, and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukemia and neuroblastoma. It is also discussed how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells. Compiling the most recent research results on the relationship between apoptosis and cancer in one handy volume, this book will provide a valuable reference for scientists working in cancer research as well as newcomers to the field.

Cell Apoptosis Research Trends

Author :
Publisher : Nova Publishers
ISBN 13 : 9781600214240
Total Pages : 312 pages
Book Rating : 4.2/5 (142 download)

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Book Synopsis Cell Apoptosis Research Trends by :

Download or read book Cell Apoptosis Research Trends written by and published by Nova Publishers. This book was released on 2007 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book presents exciting research in this related field.

Cellular Signaling and Apoptosis Research

Author : Alex R. Demasi
Publisher : Nova Publishers
ISBN 13 : 9781600215650
Total Pages : 280 pages
Book Rating : 4.2/5 (156 download)

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Book Synopsis Cellular Signaling and Apoptosis Research by : Alex R. Demasi

Download or read book Cellular Signaling and Apoptosis Research written by Alex R. Demasi and published by Nova Publishers. This book was released on 2007 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer s disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book focuses on cell apoptotic signalling.

Apoptosis in Normal Development and Cancer

Author : M Sluyser
Publisher : CRC Press
ISBN 13 : 0203483154
Total Pages : 275 pages
Book Rating : 4.2/5 (34 download)

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Book Synopsis Apoptosis in Normal Development and Cancer by : M Sluyser

Download or read book Apoptosis in Normal Development and Cancer written by M Sluyser and published by CRC Press. This book was released on 2002-09-11 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: In apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die. This book addresses the

New Cell Apoptosis Research

Author : Rafe G. Valentino
Publisher : Nova Science Publishers
ISBN 13 :
Total Pages : 262 pages
Book Rating : 4.X/5 (3 download)

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Book Synopsis New Cell Apoptosis Research by : Rafe G. Valentino

Download or read book New Cell Apoptosis Research written by Rafe G. Valentino and published by Nova Science Publishers. This book was released on 2007 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer.A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. The aim of this book is to provide new studies in the field of apoptosis research.

Genetics of Apoptosis

Author : Stefan Grimm
Publisher : Garland Science
ISBN 13 : 1135325030
Total Pages : 328 pages
Book Rating : 4.1/5 (353 download)

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Book Synopsis Genetics of Apoptosis by : Stefan Grimm

Download or read book Genetics of Apoptosis written by Stefan Grimm and published by Garland Science. This book was released on 2003-12-16 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is an essential process in embryonic development and tissue homeostasis, particularly in the prevention of disease. Written from a genetic viewpoint, Genetics of Apoptosis first describes the molecular and cell biology of apoptosis, then examines the process in more detail in several model systems. This volume brings together contributions from internationally renowned authors, and will be a valuable reference to all researchers studying apoptosis.

Apoptosis

Author : Ning Yang
Publisher : Biota Publishing
ISBN 13 : 1615045392
Total Pages : 112 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Apoptosis by : Ning Yang

Download or read book Apoptosis written by Ning Yang and published by Biota Publishing. This book was released on 2013-04-01 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multi-cellular organisms eliminate individual cells through a self-destruct process known as apoptosis. Apoptosis is critical for proper development and maintenance of tissue homeostasis. The importance of this process is highlighted by the fact that too much or too little apoptosis is the underlying cause of pathologies such as cancer, autoimmune diseases (e.g., lupus, arthritis), and neurodegenerative disorders (e.g., Parkinson's, Alzheimer's). In the early days, apoptotic cells were identified strictly by cell morphology. Now we know that biochemical signatures define a number of death programs, of which apoptosis is the most widely understood. In this review, we discuss genetic insights gained from C. elegans, the importance of caspases, engulfment of apoptotic cells, apoptotic signals, the role of mitochondria, the Bcl-2 family, and the link between dysfunctional apoptosis and disease. Within each topic, we highlight landmark studies that contributed to our current understanding of apoptosis. All together, this research exemplifies tremendous scientific synergy between the disciplines of genetics, biochemistry, developmental cell biology, and structural biology. Continued exploration into mechanisms that regulate apoptosis will undoubtedly lead to insights into disease processes with potential therapeutic strategies.

Apoptosis, Senescence and Cancer

Author : David A. Gewirtz
Publisher : Springer Science & Business Media
ISBN 13 : 1588295273
Total Pages : 596 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Apoptosis, Senescence and Cancer by : David A. Gewirtz

Download or read book Apoptosis, Senescence and Cancer written by David A. Gewirtz and published by Springer Science & Business Media. This book was released on 2007-12-17 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides insight into established practices and research into apoptosis and senescence by examining techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. This book concludes with established cancer therapies.

New Developments in Cell Apoptosis Research

Author : Alan J. Corvin
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.X/5 (3 download)

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Book Synopsis New Developments in Cell Apoptosis Research by : Alan J. Corvin

Download or read book New Developments in Cell Apoptosis Research written by Alan J. Corvin and published by . This book was released on 2007 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer s disease and cancer. fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. The aim of this book is to provide new studies in the field of apoptosis research.

When Cells Die

Author : Richard A. Lockshin
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 538 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis When Cells Die by : Richard A. Lockshin

Download or read book When Cells Die written by Richard A. Lockshin and published by Wiley-Liss. This book was released on 1998-04-13 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Cells Die A Comprehensive Evaluation of Apoptosis and Programmed Cell Death Edited by Richard A. Lockshin, Zahra Zakeri, and Jonathan L. Tilly Cell death is fast becoming one of the most dynamic areas of biological research -involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods -making it difficult for scientists to get an overview of the field. When Cells Die establishes a coherent framework for the study of cell death -cutting across viewpoints and disciplines and consolidating disparate research efforts. Leading international researchers describe a wide range of topics, including evaluation methods for programmed cell death and apoptosis in numerous tissues and circumstances; genetic mechanism, signal transduction, and observed manifestations of physiological cell death; model systems ranging from nematodes to humans; relevant work in cancer research, AIDS, immune disorders, fertility, eye disease, and Alzheimer's disease; and more. Written to provide an in-depth overview of cell death, the book is divided into five major parts: * The phenomenon of cell death * Themes and approaches to cell death * Cell death where mitosis is high and evanescence is desirable * Cell death in long-lived cells * The clinical relevance of apoptosis. When Cells Die offers a comprehensive introduction to an intriguing discipline, insight into areas in need of exploration, and information on new techniques and therapeutic applications -all supported with diagrams and flowcharts and a fully cross-referenced and indexed text. It is important reading for anyone working in cell and developmental biology, neuroscience, immunology, cancer research, and virology. It is also useful for advanced undergraduate and graduate-level students, postdoctoral fellows, and researchers just entering the field.

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

Author : Salvatore V. Pizzo
Publisher : Academic Press
ISBN 13 : 0128123524
Total Pages : 144 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cell Surface GRP78, a New Paradigm in Signal Transduction Biology by : Salvatore V. Pizzo

Download or read book Cell Surface GRP78, a New Paradigm in Signal Transduction Biology written by Salvatore V. Pizzo and published by Academic Press. This book was released on 2018-03-20 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease Provides four-color illustrations that facilitate the narrative

Clinical Perspectives and Targeted Therapies in Apoptosis

Author : Rupinder K. Sodhi
Publisher : Academic Press
ISBN 13 : 9780128157626
Total Pages : 0 pages
Book Rating : 4.1/5 (576 download)

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Book Synopsis Clinical Perspectives and Targeted Therapies in Apoptosis by : Rupinder K. Sodhi

Download or read book Clinical Perspectives and Targeted Therapies in Apoptosis written by Rupinder K. Sodhi and published by Academic Press. This book was released on 2020-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research.