The Evaluation Of New Antiarrhythmic Drugs

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The Evaluation of New Antiarrhythmic Drugs

Author : J. Morganroth
Publisher : Springer Science & Business Media
ISBN 13 : 9400982704
Total Pages : 324 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis The Evaluation of New Antiarrhythmic Drugs by : J. Morganroth

Download or read book The Evaluation of New Antiarrhythmic Drugs written by J. Morganroth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thus, there are now several chronic canine myocardial infarction ventricular tachyarrhythmia models which are available for the evaluation of new antiarrhythmic drugs (Table I). The available models fulfill many, but not all of the requirements for an ideal chronic arrhythmia model (Table 11). The sustained arrhythmias initiated in these models using programmed pacing presumably have the same localized reentrant mechanism that characterizes chronic human myocardial infarction and chronic coronary 26 artery disease. However, these models are not suitable for determining whether a new drug will abolish spontaneous ly-occurring PVCs. In addition, these models are of unproven value in the study of acute spontaneously occurring sudden death; although recently initiated, provocative work may shed further light on this subject. Most importantly, the available models do seem well-suited to the evaluation of new drugs intended for use in chronic coronary artery disease patients at risk for sustained reentrant ventricular tachycardia or VF. Notably, the results of preliminary electropharmacologic studies in these canine models parallel closely those findings reported in human patients with sustained life-threatening ventricu lar tachyarrhythmias (Table Ill). Therefore, increased use of these chronic models for new antiarrhythmic drug testing is strongly recommended. TABLE II Ideal vs Available Chronic Canine - Arrhythmia Models Ideal Available 1. (a) Arrhythmia mechanism comparable to Yes patients with chronic CAD: Reentry (b) Pathophysiology similar (e. g. , atherogenic CAD) No 2. Susceptible to: (a) spontaneous PVCs No l No (b) spontaneous VT/VF (c) inducible VT/VF Yes 3.

The Evaluation of New Antiarrhythmic Drugs

Author : Joel Morganroth
Publisher :
ISBN 13 : 9789024723362
Total Pages : pages
Book Rating : 4.7/5 (233 download)

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Book Synopsis The Evaluation of New Antiarrhythmic Drugs by : Joel Morganroth

Download or read book The Evaluation of New Antiarrhythmic Drugs written by Joel Morganroth and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Evaluation of New Antiarrhythmic Drugs

Author :
Publisher :
ISBN 13 : 9789024723362
Total Pages : 323 pages
Book Rating : 4.7/5 (233 download)

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Book Synopsis The Evaluation of New Antiarrhythmic Drugs by :

Download or read book The Evaluation of New Antiarrhythmic Drugs written by and published by . This book was released on 1981 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guidelines for the Clinical Evaluation of Anti-arrhythmic Drugs

Author : United States. Food and Drug Administration
Publisher :
ISBN 13 :
Total Pages : 16 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Guidelines for the Clinical Evaluation of Anti-arrhythmic Drugs by : United States. Food and Drug Administration

Download or read book Guidelines for the Clinical Evaluation of Anti-arrhythmic Drugs written by United States. Food and Drug Administration and published by . This book was released on 1977 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiac Arrhythmias: New Therapeutic Drugs and Devices

Author : J. Morganroth
Publisher : Springer Science & Business Media
ISBN 13 : 1461325951
Total Pages : 359 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Cardiac Arrhythmias: New Therapeutic Drugs and Devices by : J. Morganroth

Download or read book Cardiac Arrhythmias: New Therapeutic Drugs and Devices written by J. Morganroth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .

Pediatric Cardiac Surgery

Author : Constantine Mavroudis
Publisher : John Wiley & Sons
ISBN 13 : 1405196521
Total Pages : 978 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Pediatric Cardiac Surgery by : Constantine Mavroudis

Download or read book Pediatric Cardiac Surgery written by Constantine Mavroudis and published by John Wiley & Sons. This book was released on 2013-02-04 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric cardiac surgery is a dynamic, fast-moving field. Busy practitioners, like you, need clear and comprehensive guidance you can rely on to ensure optimal patient care. For over 25 years Pediatric Cardiac Surgery has been the gold-standard reference for pediatric and adult congenital heart surgeons, pediatric and congenital cardiologists, intensivists, anesthesiologists, residents and nurses. Now, in this thoroughly revised fourth edition, you again get trusted, complete coverage of the field with timely new features and expert reviews of critical topics including heart transplantation, emerging modalities for diagnosing congenital heart and tracheal defects, the surgical technique of Fontan conversion with arrhythmia surgery, the medical challenges of managing adult CHD patients, and more. This new edition includes: Contributions from over 65 world-renowned experts More beautiful illustrations, by renowned medical illustrator Rachid Idriss, which have brought acclaim to previous editions Reviews of the embryology, physical findings, diagnostic criteria, and therapeutic choices for each disease entity and describes the latest in surgical techniques in each chapter All-new chapters that guide readers through new treatment options and other key developments since the publication of the third edition highlighting recent advances in congenital heart surgery. All-new new chapters that review advances in right ventricular to pulmonary artery conduits, arrhythmia surgery, double outlet ventricles, and adult congenital heart disease, among other key topics.

Perspectives on Antiarrhythmic Drug Therapy: Disappointing Past, Current Efforts and Faint Hopes

Author : Peter P. Nanasi
Publisher : Frontiers Media SA
ISBN 13 : 2889639967
Total Pages : 241 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Perspectives on Antiarrhythmic Drug Therapy: Disappointing Past, Current Efforts and Faint Hopes by : Peter P. Nanasi

Download or read book Perspectives on Antiarrhythmic Drug Therapy: Disappointing Past, Current Efforts and Faint Hopes written by Peter P. Nanasi and published by Frontiers Media SA. This book was released on 2020-09-08 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Clinical Evaluation of New Antiarrhythmic Agents

Author : Francesco Furlanello
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (953 download)

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Book Synopsis Clinical Evaluation of New Antiarrhythmic Agents by : Francesco Furlanello

Download or read book Clinical Evaluation of New Antiarrhythmic Agents written by Francesco Furlanello and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Arrhythmia Treatment and Therapy

Author : Raymond Woosley
Publisher : CRC Press
ISBN 13 : 9780824781644
Total Pages : 0 pages
Book Rating : 4.7/5 (816 download)

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Book Synopsis Arrhythmia Treatment and Therapy by : Raymond Woosley

Download or read book Arrhythmia Treatment and Therapy written by Raymond Woosley and published by CRC Press. This book was released on 2000-02-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This vitally important reference traces the progress of antiarrhythmic drug trials and treatment methods-from the vantage point of the clinicians who designed and conducted the studies to objective views of the strengths and weaknesses of the results, identifying unresolved questions or newly created issues. Reviews significant studies in chronological order-providing a clear, informative account of how current thinking about arrhythmia treatment has evolved. Written by over 35 leading experts in the field, Clinical Trials on the Treatment of Arrhythmias emphasizes the need for science-based therapeutics and rigorously controlled clinical trials of drugs and implantable devices compares electrocardiographic monitoring with electrophysiological techniques for arrhythmia management analyzes the landmark Cardiac Arrhythmia Suppression Trial (CAST) evaluates the effectiveness of amiodarone describes sodium and potassium channel blockers and the development of drugs that slow conduction velocity and prolong repolarization and refractoriness investigates the effects of the d-isomer of sotalol on mortality critiques studies on the established efficacy of implantable devices versus amiodarone to benefit post-bypass surgery patients and more! Containing over 600 literature citations, Clinical Trials on the Treatment of Arrhythmias is an invaluable resource for cardiologists and cardiovascular specialists, pharmacologists, pharmaceutical researchers, and graduate and medical school students in these disciplines.

Antiarrhythmic Drugs

Author : Richard N. Fogoros, MD
Publisher : Wiley-Blackwell
ISBN 13 : 9780865425323
Total Pages : 192 pages
Book Rating : 4.4/5 (253 download)

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Book Synopsis Antiarrhythmic Drugs by : Richard N. Fogoros, MD

Download or read book Antiarrhythmic Drugs written by Richard N. Fogoros, MD and published by Wiley-Blackwell. This book was released on 1997-03-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to cardiac arrythmias and their treatment, Antiarrhythmic Drugs: A Practical Guide offers a concise, easily understood framework enabling the reader to become confident in the evaluation and treatment of patients with cardiac arrhythmias. Because most clinicians, technicians and nurses find this area confusing, both in terms of diagnosis and management, this manual provides a route map for understanding mechanisms and selecting appropriate drug therapies. Focusing on the choice of drug for specific conditions, this book covers dosages, interactions and side effects.

Experimental Evaluation of Antiarrhythmic Drugs

Author : Martin Joshua Kerr
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (598 download)

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Book Synopsis Experimental Evaluation of Antiarrhythmic Drugs by : Martin Joshua Kerr

Download or read book Experimental Evaluation of Antiarrhythmic Drugs written by Martin Joshua Kerr and published by . This book was released on 1987 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antiarrhythmic Drugs

Author : Antoni Martínez-Rubio
Publisher : Springer Nature
ISBN 13 : 3030348938
Total Pages : 433 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Antiarrhythmic Drugs by : Antoni Martínez-Rubio

Download or read book Antiarrhythmic Drugs written by Antoni Martínez-Rubio and published by Springer Nature. This book was released on 2020-02-03 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis.

Invasive Cardiac Electrophysiology in the Evaluation of Antiarrhythmic Drug Therapy

Author : L. K. Atkinson
Publisher :
ISBN 13 :
Total Pages : 167 pages
Book Rating : 4.:/5 (188 download)

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Book Synopsis Invasive Cardiac Electrophysiology in the Evaluation of Antiarrhythmic Drug Therapy by : L. K. Atkinson

Download or read book Invasive Cardiac Electrophysiology in the Evaluation of Antiarrhythmic Drug Therapy written by L. K. Atkinson and published by . This book was released on 1980 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Basis and Treatment of Cardiac Arrhythmias

Author : Robert E. Kass
Publisher : Springer Science & Business Media
ISBN 13 : 3540297154
Total Pages : 360 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Basis and Treatment of Cardiac Arrhythmias by : Robert E. Kass

Download or read book Basis and Treatment of Cardiac Arrhythmias written by Robert E. Kass and published by Springer Science & Business Media. This book was released on 2006-01-03 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Incorporating the information related to mechanisms and treatment of cardiac arrhythmia, this book discusses genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These approaches and implementations of anti-arrhythmic therapy derive from many decades of research.

Neurocritical Care Pharmacotherapy

Author : Eelco F. M. Wijdicks
Publisher : Oxford University Press
ISBN 13 : 0190684747
Total Pages : 353 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Neurocritical Care Pharmacotherapy by : Eelco F. M. Wijdicks

Download or read book Neurocritical Care Pharmacotherapy written by Eelco F. M. Wijdicks and published by Oxford University Press. This book was released on 2018 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurocritical Care Pharmacotherapy: A Clinican's Guide is a practical, succinct but comprehensive pharmacy handbook provides up-to-date clinical guidance on the effective selection, prescription, and usage of neurocritical care drugs for patients with acute neurologic illnesses. The treatment of the critically ill neurologic patient is often difficult, specialized, and includes drugs infrequently used in other intensive care units such as antiepileptic drugs, osmotic agents or acute immunotherapy such as intravenous immunoglobulin and plasma exchange. This text discusses choosing the right combination of drugs; how to correctly prescribe and administer the drugs; how to monitor drug efficacy and side effects; how neurocritical care drugs interact with other medications; and comprehensive coverage of current treatment options. Key Feature of this Manual Include - A brief discussion of the basic pharmacology of each neurocritical drug, with an emphasis on how to select and use these drugs in multiple clinical contexts. - 150 drugs accompanied by a diagram for quick comprehension and drug administration guides. - Unique blending of expertise of neurointensivist with a critical care pharmacist to provide a vital resource for both specialities - References for further reading that are oriented toward utility in clinical practice.

Evaluation of a new antiarrhythmic drug

Author : Lars Rydén
Publisher :
ISBN 13 :
Total Pages : 40 pages
Book Rating : 4.:/5 (462 download)

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Book Synopsis Evaluation of a new antiarrhythmic drug by : Lars Rydén

Download or read book Evaluation of a new antiarrhythmic drug written by Lars Rydén and published by . This book was released on 1974 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Symposium, Clinical Evaluation of Response to Antiarrhythmic Therapy

Author : Symposium Clinical Evaluation of Response to Antiarrhythmic Therapy (1988, Atlanta, Ga.)
Publisher :
ISBN 13 :
Total Pages : 49 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis A Symposium, Clinical Evaluation of Response to Antiarrhythmic Therapy by : Symposium Clinical Evaluation of Response to Antiarrhythmic Therapy (1988, Atlanta, Ga.)

Download or read book A Symposium, Clinical Evaluation of Response to Antiarrhythmic Therapy written by Symposium Clinical Evaluation of Response to Antiarrhythmic Therapy (1988, Atlanta, Ga.) and published by . This book was released on 1988 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: