Test No. 455: The Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals

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Publisher : OECD Publishing
ISBN 13 : 9264076379
Total Pages : 16 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis Test No. 455: The Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals by : OECD

Download or read book Test No. 455: The Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro assay, which provides mechanistical information, and can be used for screening and prioritization purposes. The test system utilises the hERalpha-HeLa-9903 cell line derived from a human cervical tumor and ...

Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists

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Publisher : OECD Publishing
ISBN 13 : 9264185380
Total Pages : 39 pages
Book Rating : 4.2/5 (641 download)

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Book Synopsis Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists by : OECD

Download or read book Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists written by OECD and published by OECD Publishing. This book was released on 2012-10-02 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provides the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists (ER TAs). It comprises mechanistically and functionally similar test ...

Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists

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Publisher : OECD Publishing
ISBN 13 : 9264243046
Total Pages : 53 pages
Book Rating : 4.2/5 (642 download)

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Book Synopsis Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists by : OECD

Download or read book Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists

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Author :
Publisher : OECD Publishing
ISBN 13 : 9264265295
Total Pages : 74 pages
Book Rating : 4.2/5 (642 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists

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Author :
Publisher : OECD Publishing
ISBN 13 : 9264185399
Total Pages : 26 pages
Book Rating : 4.2/5 (641 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists written by OECD and published by OECD Publishing. This book was released on 2012-10-02 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro assay, which provides concentration-response data for substances with in vitro ER agonist and antagonist activity. The test system utilises the BG1Luc4E2 cell line derived from a human ovarian adenocarcinoma ...

Hayes' Principles and Methods of Toxicology, Sixth Edition

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Author :
Publisher : CRC Press
ISBN 13 : 1842145363
Total Pages : 2186 pages
Book Rating : 4.8/5 (421 download)

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Book Synopsis Hayes' Principles and Methods of Toxicology, Sixth Edition by : A. Wallace Hayes

Download or read book Hayes' Principles and Methods of Toxicology, Sixth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2014-10-10 with total page 2186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.

Engineering Tools for Environmental Risk Management

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Publisher : CRC Press
ISBN 13 : 1315778777
Total Pages : 596 pages
Book Rating : 4.3/5 (157 download)

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Book Synopsis Engineering Tools for Environmental Risk Management by : Katalin Gruiz

Download or read book Engineering Tools for Environmental Risk Management written by Katalin Gruiz and published by CRC Press. This book was released on 2015-04-27 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical substances, physical agents and built structures exhibit various types of hazard due to their inherent toxic, mutagenic, carcinogenic, reprotoxic and sensitizing character or damaging to the immune and hormone system. The first steps in managing an environment contaminated by chemical substances are characterization of hazards and quantifi

Alternative Toxicological Methods

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Publisher : CRC Press
ISBN 13 : 0203008790
Total Pages : 616 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Alternative Toxicological Methods by : Harry Salem

Download or read book Alternative Toxicological Methods written by Harry Salem and published by CRC Press. This book was released on 2003-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist

Bioanalytical Tools in Water Quality Assessment

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Publisher : IWA Publishing
ISBN 13 : 1843393689
Total Pages : 273 pages
Book Rating : 4.8/5 (433 download)

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Book Synopsis Bioanalytical Tools in Water Quality Assessment by : Beate Escher

Download or read book Bioanalytical Tools in Water Quality Assessment written by Beate Escher and published by IWA Publishing. This book was released on 2011-12-15 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of Water Quality Set - Buy all four books and save over 30% on buying separately! Bioanalytical Tools in Water Quality Assessment reviews the application of bioanalytical tools to the assessment of water quality including surveillance monitoring. The types of water included range from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Bioanalytical Tools in Water Quality Assessment not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. Bioanalytical tools in Water Quality Assessment can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists, and toxicologists. Authors: Beate Escher, National Research Centre for Environmental Toxicology (EnTox), The University of Queensland, Australia, Frederic Leusch, Smart Water Research Facility (G51), Griffith University Gold Coast Campus, Australia. With contributions by Heather Chapman and Anita Poulsen

Toxicity and Hazard of Agrochemicals

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Publisher : BoD – Books on Demand
ISBN 13 : 9535121456
Total Pages : 172 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Toxicity and Hazard of Agrochemicals by : Marcelo Larramendy

Download or read book Toxicity and Hazard of Agrochemicals written by Marcelo Larramendy and published by BoD – Books on Demand. This book was released on 2015-07-22 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, Toxicity and Hazard of Agrochemicals, is intended to provide an overview of toxicology that examines the hazardous effects of common agrochemicals employed every day in our agricultural practices. Furthermore, it is hoped that the information in the present book will be of value to those directly engaged in the handling and use of agrochemicals and that this book will continue to meet the expectations and needs of all interested in the different aspects of human and environmental risk toxicities.

The Science of Flavonoids

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Publisher : Springer Science & Business Media
ISBN 13 : 9780387745503
Total Pages : 300 pages
Book Rating : 4.7/5 (455 download)

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Book Synopsis The Science of Flavonoids by : Erich Grotewold

Download or read book The Science of Flavonoids written by Erich Grotewold and published by Springer Science & Business Media. This book was released on 2008 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the only book of its kind to provide an overview of the science of flavonoids in plants.

Innovative Endocrinology of Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 0387788182
Total Pages : 242 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Innovative Endocrinology of Cancer by : Lev M. Berstein

Download or read book Innovative Endocrinology of Cancer written by Lev M. Berstein and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted to new developments in a huge range of topics, such as the mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and antihormonal therapy of cancer and its prevention.

OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP)

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Author :
Publisher : OECD Publishing
ISBN 13 : 9264304797
Total Pages : 206 pages
Book Rating : 4.2/5 (643 download)

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Book Synopsis OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) by : OECD

Download or read book OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) written by OECD and published by OECD Publishing. This book was released on 2018-12-10 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...

Textbook of Clinical Embryology

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Publisher : Cambridge University Press
ISBN 13 : 110727625X
Total Pages : 408 pages
Book Rating : 4.1/5 (72 download)

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Book Synopsis Textbook of Clinical Embryology by : Kevin Coward

Download or read book Textbook of Clinical Embryology written by Kevin Coward and published by Cambridge University Press. This book was released on 2013-10-31 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.

Hormonally Active Agents in the Environment

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Publisher : National Academies Press
ISBN 13 : 0309064198
Total Pages : 453 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Hormonally Active Agents in the Environment by : National Research Council

Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Steroid Hormone Resistance

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Publisher : Springer Science & Business Media
ISBN 13 : 1468451014
Total Pages : 436 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Steroid Hormone Resistance by : George P. Chrousos

Download or read book Steroid Hormone Resistance written by George P. Chrousos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and vitamin D have widely diverse roles ranging from the control of homeostasis to reproduction and bone formation. They are similar in that they share a chemical structure and that their action is in the cell nucleus where they induce transcription of specific genes leading to synthesis of function-specific proteins. Clinical syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type II) have been known for many years. Progesterone and glucocorticoid resistance syndromes have been described only recently. Resistance to estrogens has not been reported in man or in animals. It is hoped that a detailed reexamination of what is known about each of these conditions at the clinical and molecular levels will enhance our understanding of the function of these hormones and their mechanisms of action. New insight and research initiatives should result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this volume are based in part on the proceedings of an International Conference held in Bethesda in the summer of 1984. This conference was sponsored by the National Institute of Child Health and Human Development, Bethesda, Maryland.

Textbook of Organic Medicinal and Pharmaceutical Chemistry

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Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 1140 pages
Book Rating : 4.:/5 (43 download)

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Book Synopsis Textbook of Organic Medicinal and Pharmaceutical Chemistry by : Charles Owens Wilson

Download or read book Textbook of Organic Medicinal and Pharmaceutical Chemistry written by Charles Owens Wilson and published by Lippincott Williams & Wilkins. This book was released on 1977 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt: