Systemic Lupus Erythematosus

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Lahita's Systemic Lupus Erythematosus

Author : Robert G. Lahita
Publisher : Elsevier
ISBN 13 : 0128205830
Total Pages : 730 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Lahita's Systemic Lupus Erythematosus by : Robert G. Lahita

Download or read book Lahita's Systemic Lupus Erythematosus written by Robert G. Lahita and published by Elsevier. This book was released on 2021-07-27 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Outcome Measures and Metrics in Systemic Lupus Erythematosus

Author : Zahi Touma
Publisher : Springer Nature
ISBN 13 : 3030733033
Total Pages : 418 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Outcome Measures and Metrics in Systemic Lupus Erythematosus by : Zahi Touma

Download or read book Outcome Measures and Metrics in Systemic Lupus Erythematosus written by Zahi Touma and published by Springer Nature. This book was released on 2021-07-22 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that manifests with a myriad of clinical and laboratory features. The assessment of SLE is comprehensive and includes different core set domains; disease activity, damage, health-related quality of life, adverse events and economic impact. This comprehensive book is focused on the instruments and outcome measures utilized in the assessment of SLE. It targets different audiences including physicians, scientists/researchers and different health professionals interested in learning about the art of measurement in SLE. The book highlights the importance of measurement in the assessment of SLE in a clinical settings, research and clinical trials. Each of the chapters provide a systematic approach to the instruments utilized in the assessment of a specific construct in SLE (e.g., disease activity, fatigue, etc.) and incorporate a comprehensive coverage of disease specific and disease generic measures. It also discusses different patient-reported outcomes that are crucial to reflect patient perceptions of their health condition and cover constructs such as fatigue, pain, anxiety and depression, cognition, frailty, and many others.

Pathogenesis of Systemic Lupus Erythematosus

Author : Alberta Hoi
Publisher : Springer Nature
ISBN 13 : 3030851613
Total Pages : 192 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Pathogenesis of Systemic Lupus Erythematosus by : Alberta Hoi

Download or read book Pathogenesis of Systemic Lupus Erythematosus written by Alberta Hoi and published by Springer Nature. This book was released on 2021-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Lupus Erythematosus

Author : Peter H. Schur
Publisher : Springer Science & Business Media
ISBN 13 : 1461411890
Total Pages : 266 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Lupus Erythematosus by : Peter H. Schur

Download or read book Lupus Erythematosus written by Peter H. Schur and published by Springer Science & Business Media. This book was released on 2012-07-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Often considered the prototypic autoimmune disease, Lupus is characterized by protean manifestations and affects a wide range of organ systems. Despite widespread availability of anti nuclear antibody testing and other technological diagnostic advances, the diagnosis of lupus can be elusive, difficult, and inexact. Treatment of the disease can also be challenging. Advances in immunology and biotechnology have led to a burgeoning world of new therapies in development that offer patients the real possibility of new therapies and physicians and scientists novel insights into the pathogenesis of this complicated immunological disease. Lupus Erythematosus: Clinical Evaluation and Treatment summarizes the clinical aspects of lupus facing the general clinician in the 21st century. In this invaluable, practical book, the reader will find introductory chapters regarding general diagnostic and treatment principles, followed by chapters addressing the lupus-specific organ manifestations. Special topics regarding pregnancy and comorbidities are also presented. Written by highly experienced physicians with special expertise in lupus, Lupus Erythematosus: Clinical Evaluation and Treatment is an indispensable reference for the common and not so common problems affecting patients with lupus.

Systemic Lupus Erythematosus

Author : Caroline Gordon
Publisher : Oxford University Press
ISBN 13 : 0198739184
Total Pages : 161 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Systemic Lupus Erythematosus by : Caroline Gordon

Download or read book Systemic Lupus Erythematosus written by Caroline Gordon and published by Oxford University Press. This book was released on 2016 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body's cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and contract research organizations.

Current Rheumatology Diagnosis & Treatment

Author : John B. Imboden
Publisher : McGraw-Hill/Appleton & Lange
ISBN 13 :
Total Pages : 532 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Rheumatology Diagnosis & Treatment by : John B. Imboden

Download or read book Current Rheumatology Diagnosis & Treatment written by John B. Imboden and published by McGraw-Hill/Appleton & Lange. This book was released on 2004 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal quick reference for primary care providers, specialists, and trainees, this accessible resource offers up-to-date assessment and management solutions for the entire range of rheumatologic diseases.

Systemic Lupus Erythematosus

Author : Paul Eggleton
Publisher : Humana
ISBN 13 : 9781493952625
Total Pages : 0 pages
Book Rating : 4.9/5 (526 download)

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Book Synopsis Systemic Lupus Erythematosus by : Paul Eggleton

Download or read book Systemic Lupus Erythematosus written by Paul Eggleton and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus: Methods and Protocols describe a number of genetic, biochemical and immunological techniques. These techniques provide an advancing understanding of the pathology, breakdown of the immune system and therapeutic challenges of SLE in both humans and animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Systemic Lupus Erythematosus: Methods and Protocols appeal to biomedical and clinical scientists in a number of pathology disciplines at the doctoral and post-doctoral level.

Dubois' Lupus Erythematosus and Related Syndromes - E-Book

Author : Daniel Wallace
Publisher : Elsevier Health Sciences
ISBN 13 : 0323550649
Total Pages : 752 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Dubois' Lupus Erythematosus and Related Syndromes - E-Book by : Daniel Wallace

Download or read book Dubois' Lupus Erythematosus and Related Syndromes - E-Book written by Daniel Wallace and published by Elsevier Health Sciences. This book was released on 2018-08-16 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

Current Research in Systemic Lupus Erythematosus

Author : Carrie Kane
Publisher :
ISBN 13 : 9781632429162
Total Pages : 237 pages
Book Rating : 4.4/5 (291 download)

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Book Synopsis Current Research in Systemic Lupus Erythematosus by : Carrie Kane

Download or read book Current Research in Systemic Lupus Erythematosus written by Carrie Kane and published by . This book was released on 2020-09-22 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus is an autoimmune disease characterized by fever, painful and swollen joints, chest pain, swollen lymph nodes, red rash, etc. This condition is caused because the immune system of the body attacks many healthy tissues of the body. It is believed to arise due to a combination of genetic and environmental factors. Some of the risk factors associated with the incidence of this disease are vitamin D deficiency, female sex hormones, smoking, certain infections and sunlight. It can be diagnosed through serologic testing. Clinically indirect immunofluorescence is the most widely used method. Testing for complement system levels, liver enzymes, electrolytes and kidney function, and complete blood count also aid in the diagnosis. The treatment of systemic lupus erythematosus involves the use of corticosteroids and anti-malarial drugs. Some forms of lupus nephritis may require intermittent cytotoxic drugs. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of systemic lupus erythematosus. It presents researches and studies performed by experts across the globe. Through this book, we attempt to enlighten the readers about the new concepts in the diagnosis and treatment of systemic lupus erythematosus.

A Clinician's Pearls & Myths in Rheumatology

Author : John H. Stone
Publisher : Springer Science & Business Media
ISBN 13 : 1848009348
Total Pages : 493 pages
Book Rating : 4.8/5 (48 download)

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Book Synopsis A Clinician's Pearls & Myths in Rheumatology by : John H. Stone

Download or read book A Clinician's Pearls & Myths in Rheumatology written by John H. Stone and published by Springer Science & Business Media. This book was released on 2009-10-03 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Important strides have been made in understanding the pathophysiologic basis of many inflammatory conditions in recent years, but rheumatology remains a discipline in which diagnosis is rooted in the medical history skillfully extracted from the patient, the careful physical examination, and the discriminating use of laboratory tests and imaging. Moreover, selection of the most appropriate therapy for patients with rheumatic diseases also remains heavily reliant upon clinical experience. Medical disciplines such as rheumatology that depend significantly upon clinical wisdom are prone to the development of systems of ‘Pearls’ and ‘Myths,’ related to the diseases they call their own, a ‘Pearl’ being a nugget of truth about the diagnosis or treatment of a particular disease that has been gained by dint of clinical experience and a ‘Myth’ being a commonly held belief that influences the practice of many clinicians – but is false. This book will pool together the clinical wisdom of seasoned, expert rheumatologists who participate in the care of patients with autoimmune diseases, systemic inflammatory disorders, and all other rheumatic conditions.

The Heart in Rheumatic, Autoimmune and Inflammatory Diseases

Author : Udi Nussinovitch
Publisher : Academic Press
ISBN 13 : 0128032685
Total Pages : 766 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Heart in Rheumatic, Autoimmune and Inflammatory Diseases by : Udi Nussinovitch

Download or read book The Heart in Rheumatic, Autoimmune and Inflammatory Diseases written by Udi Nussinovitch and published by Academic Press. This book was released on 2017-02-10 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. Presents an up-to-date “level of evidence and “strengths of recommendations for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.

Systemic Lupus Erythematosus

Author : Robert George Lahita
Publisher :
ISBN 13 :
Total Pages : 1068 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Systemic Lupus Erythematosus by : Robert George Lahita

Download or read book Systemic Lupus Erythematosus written by Robert George Lahita and published by . This book was released on 1992 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated edition which covers basic science (immunology, immunopathology and genetics), clinical and therapeutic approaches and organ systems. It contains much interdisciplinary clinical detail and has contributions from well-known specialists.

Systemic Lupus Erythematosus

Author : Carrie Kane
Publisher :
ISBN 13 : 9781632418685
Total Pages : 238 pages
Book Rating : 4.4/5 (186 download)

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Book Synopsis Systemic Lupus Erythematosus by : Carrie Kane

Download or read book Systemic Lupus Erythematosus written by Carrie Kane and published by . This book was released on 2020-09-15 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus is a chronic inflammatory disease, in which the immune system attacks healthy tissues of the body. It is one of several diseases that mimics other illnesses. Its diagnosis can thus be elusive. Some of the initial and chronic signs associated with this condition are malaise, fever, joint pains, fatigue, rashes and muscle pains. Around 70% of people with lupus have skin symptoms. Multiple genes have an influence in the development of lupus. It may also be triggered by drug reactions but is largely reversible. The severity of the disease in an individual needs to be assessed correctly to successfully treat lupus. The treatment involves the use of non-steroidal anti-inflammatory drugs and anti-malarial drugs. Certain forms of lupus nephritis require cytotoxic drugs such as mycophenolate and cyclophosphamide. This book aims to shed light on some of the unexplored aspects of systemic lupus erythematosus and the recent researches in this condition. The various studies that are constantly contributing towards advancing the diagnosis and management of lupus are examined in detail. Those in search of information to further their knowledge will be greatly assisted by this book.

Atlas of Uveitis

Author : Peizeng Yang
Publisher : Springer Nature
ISBN 13 : 9811537267
Total Pages : 855 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Atlas of Uveitis by : Peizeng Yang

Download or read book Atlas of Uveitis written by Peizeng Yang and published by Springer Nature. This book was released on 2020-11-26 with total page 855 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Atlas provides cutting-edge information on uveitis, which represents a major achievement in clinical studies on uveitis. It includes more than three thousand imaging photos of uveitis patients, showing the disease’s complete profile and the spectrum of variations commonly encountered. Numerous therapeutic regimens are also presented, each of which is designed for a specific form of uveitis. The Atlas also incorporates the latest advances in uveitis studies, making it a unique and valuable resource for a broad readership, including ophthalmologists, postgraduate students, medical students and doctors in ophthalmology.

Granulomatous diseases in Otorhinolaryngology, Head and Neck

Author : Sanjana Vijay Nemade
Publisher : Springer Nature
ISBN 13 : 9811640475
Total Pages : 329 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Granulomatous diseases in Otorhinolaryngology, Head and Neck by : Sanjana Vijay Nemade

Download or read book Granulomatous diseases in Otorhinolaryngology, Head and Neck written by Sanjana Vijay Nemade and published by Springer Nature. This book was released on 2021-09-09 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the ‘Essential features’ of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

Clinical Rheumatology

Author : Rohini Handa
Publisher : Springer Nature
ISBN 13 : 9813348852
Total Pages : 259 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Clinical Rheumatology by : Rohini Handa

Download or read book Clinical Rheumatology written by Rohini Handa and published by Springer Nature. This book was released on 2021-02-10 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Rheumatology is a book written by a clinician for clinicians. It covers all the essential clinical aspects of Rheumatology in an engaging, clear, and concise manner, thereby fulfilling an unmet need. The focus of this book is to cover clinically pertinent and practically relevant issues while pruning unnecessary detail. Patient photographs, tables, and boxes enhance readability. The bedside clinical and investigative approach is discussed in a lucid fashion illustrated by clinical photographs, flowcharts, and algorithms. The evidence-based treatment is spelt out in an easy to comprehend fashion. Key messages have been listed at the beginning of each chapter. The book is intended for undergraduate and postgraduate medical students, residents, fellows, and clinicians who want to gain practical knowledge and clinical insight into rheumatic diseases. The book is likely to appeal to internists, rheumatologists, physiatrists, physiotherapists, occupational therapists, as well as orthopaedic surgeons. They will find their day to day questions answered in a knowledge format that can be applied straight away. Senior clinicians will find it a ready reckoner and a handy manual to refresh and update their knowledge. Basic scientists will find it useful to gain clinical insight into the rheumatic diseases they research without being intimidated by the size of the text. Teachers will find it full of helpful teaching messages. Clinical Rheumatology is a must-have book for all those who deal with rheumatic musculoskeletal diseases.

Lupus

Author : Reem A. Hamdy Mohammed
Publisher :
ISBN 13 : 9781839684036
Total Pages : 0 pages
Book Rating : 4.6/5 (84 download)

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Book Synopsis Lupus by : Reem A. Hamdy Mohammed

Download or read book Lupus written by Reem A. Hamdy Mohammed and published by . This book was released on 2021-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE) is a multisystem, immune-mediated, inflammatory disease of unknown etiology. It is difficult to diagnose and thus effective intervention in SLE patients is often delayed. This book is a comprehensive guide to lupus, with chapters on diagnosis, assessment, treatment, the link between lupus and endocrinopathies, lupus and pregnancy, and advances in therapeutics. The book is presented by devoted authors who sought the latest evidence-based data to provide a well-structured display aiming at setting standards for best practice guidelines in the diagnosis and management of each and every section discussed in the 'Lupus- Need to Know.'