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Studies Towards The Synthesis Of Ebelactone A And Maurenone
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Book Synopsis Studies Towards the Synthesis of -Ebelactone-A And -Maurenone by : Ravindar Kontham
Download or read book Studies Towards the Synthesis of -Ebelactone-A And -Maurenone written by Ravindar Kontham and published by LAP Lambert Academic Publishing. This book was released on 2012-03 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph features the studies directed towards the total synthesis of architecturally and biologically interesting polypropionate natural products (-)-Ebelactone-A and (-)-Maurenone utilizing desymmetrization as a key strategy. ( )-Ebelactone A, show structural characteristics in common with macrolide antibiotics. Ebelactones act as potent inhibitors of esterase s, lipases and N-formylmethionine amino peptidases, and they have shown to produce enhance immune responses. They are also reported to inhibit cutinases produced by fungal pathogens. Novel biological activity combined with unique and challenging structure of Ebelactone, made this compound an exciting target for the total synthesis. Secondly, this book described an efficient synthetic protocol for polypropionate natural product (-)-Maurenone, which was isolated by Faulkner et al. in 1986 from specimens of the pulmonate mollusc Siphonaria maura. This monograph is unique in dealing with many interesting synthetic protocols including full experimental procedures, analytical data for all synthetic materials and complete reference sections. This monograph can be served as a good hand book for synthetic organic chemists.
Book Synopsis Studies Towards the Synthesis of Ebelactone B. by : Rhonan Lee Ford
Download or read book Studies Towards the Synthesis of Ebelactone B. written by Rhonan Lee Ford and published by . This book was released on 1999 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Directed Towards the Synthesis of (-)-ebelactone-A. by : David James Barden
Download or read book Studies Directed Towards the Synthesis of (-)-ebelactone-A. written by David James Barden and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Directed Towards the Synthesis of ( - )-Ebelactone-A. by : Colin Frederick Foster
Download or read book Studies Directed Towards the Synthesis of ( - )-Ebelactone-A. written by Colin Frederick Foster and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes work concerning the total synthesis of ebelactone-a 16, and in particular the synthesis of one of the retrosynthetic fragments (fragment A 20) and its coupling to the combined fragment BC 115 formed from the other two. We repeated the synthesis of enantiomerically enriched 20 devised by Williams, employing a Mukaiyama aldol reaction directed by Oppolzer's sultam to establish the anti-anti stereotriad of the fragment. We modelled the coupling of this to 115 using isobutyraldehyde in place of 20 and vinyl iodide 133 in place of 115, and verified that the Nozaki-Kishi method using chromium(II) chloride and catalytic nickel(II) chloride was effective. By this method, we successfully coupled 133 to 20. Model work was unsuccessful in establishing a methodology for removing the hydroxy group from alcohols 188/189 without disrupting either the position or geometry of the adjacent C=C bond. We also established a completely new route to fragment A, utilising the features of organosilicon chemistry to control the stereochemistry. An intermediate 213 containing two different silyl groups, in which we hoped to transform one selectively into a hydroxy group with retention of configuration by Fleming's method, proved too unstable for synthesis, but we were able to modify the route and produce alcohol 254 in enantiomerically pure form (Oppolzer's sultam was once again used as the chiral auxiliary), and we expect future workers to be able to take this through to fragment A.
Book Synopsis Approaches Towards the Synthesis of Ebelactone-a Using Organosilicon Chemistry by : Sarah Catherine Archibald
Download or read book Approaches Towards the Synthesis of Ebelactone-a Using Organosilicon Chemistry written by Sarah Catherine Archibald and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Approaches to the Synthesis of Ebelactone-A by : Anna Beatrice Zwicky
Download or read book Approaches to the Synthesis of Ebelactone-A written by Anna Beatrice Zwicky and published by . This book was released on 1993 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
