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Author : Spiros I. Liras
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (23 download)
Download or read book Studies Directed to the Total Synthesis of Biologically Active Natural Products written by Spiros I. Liras and published by . This book was released on 1990 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Goutam Brahmachari
Publisher : Elsevier
ISBN 13 : 0081028237
Total Pages : 352 pages
Book Rating : 4.0/5 (81 download)
Download or read book Total Synthesis of Bioactive Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2019-04-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. - Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules - Outlines each step of the process in detail, with full experimental information supported by extensive schemes - Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule
Author : Jie Jack Li
Publisher : Springer Science & Business Media
ISBN 13 : 3642340652
Total Pages : 292 pages
Book Rating : 4.6/5 (423 download)
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Author : Sasadhar Majhi
Publisher : World Scientific
ISBN 13 : 9811268703
Total Pages : 469 pages
Book Rating : 4.8/5 (112 download)
Download or read book Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products written by Sasadhar Majhi and published by World Scientific. This book was released on 2023-04-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.
Author : Pei-Qiang Huang
Publisher : John Wiley & Sons
ISBN 13 : 1118605403
Total Pages : 512 pages
Book Rating : 4.1/5 (186 download)
Download or read book Efficiency in Natural Product Total Synthesis written by Pei-Qiang Huang and published by John Wiley & Sons. This book was released on 2018-10-16 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals
Author : John ApSimon
Publisher : John Wiley & Sons
ISBN 13 : 0470129581
Total Pages : 483 pages
Book Rating : 4.4/5 (71 download)
Download or read book The Total Synthesis of Natural Products, Volume 7 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The appearance of the seventh volume of The Total Synthesis of Natural Products signals the continued health of the art and science of organic synthesis. This new volume contains a chapter updating monoterpene synthesis and reviews the newer areas of leukotrienes and macro-cyclic lactones. The Total Synthesis of Natural Products, Volume Seven forms an integral part of the invaluable working reference begun in Volumes One through Six, to which chemists may turn for the available data on the total synthesis of complex molecules. Lessons learned from the synthetic challenges presented here by various natural products will serve as a sound base for this continually evolving field.
Author : Shinsuke Inuki
Publisher : Springer
ISBN 13 : 9784431540441
Total Pages : 106 pages
Book Rating : 4.5/5 (44 download)
Download or read book Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds written by Shinsuke Inuki and published by Springer. This book was released on 2011-11-30 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.
Author : Joji Hayashida
Publisher :
ISBN 13 :
Total Pages : 730 pages
Book Rating : 4.:/5 (42 download)
Download or read book Synthetic Studies on Bioactive Natural Products written by Joji Hayashida and published by . This book was released on 2009 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John ApSimon
Publisher : John Wiley & Sons
ISBN 13 : 047012959X
Total Pages : 720 pages
Book Rating : 4.4/5 (71 download)
Download or read book The Total Synthesis of Natural Products written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic chemistry's innovative breadth is especially noteworthy in the area of natural products synthesis. Since the early 1970s, this landmark chemical reference has been documenting the newest and most important of these, in a readily understood format, that clearly traces each of their synthetic routes. Volume Eight, the latest in the series, contains a long-awaited look at the synthesis of tri- and tetracyclic diterpenes, along with the synthesis of naturally occurring quinones. Recent interest in the biologically important polysaccharides has led to a detailed consideration of that compound class. Finally, this new volume contains a look at the strategies and methods specific to natural products containing the spiroketal functional group. The Total Synthesis of Natural Products, Volume Eight, continues the meticulous work of the series, providing chemists with an entirely up-to-date and convenient guide to the critical new syntheses essential to organic chemistry's continuing evolution.
Author : Masahisa Nakada
Publisher : Springer Nature
ISBN 13 : 9819716195
Total Pages : 518 pages
Book Rating : 4.8/5 (197 download)
Download or read book Modern Natural Product Synthesis written by Masahisa Nakada and published by Springer Nature. This book was released on with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Goutam Brahmachari
Publisher : Elsevier
ISBN 13 : 0128157240
Total Pages : 461 pages
Book Rating : 4.1/5 (281 download)
Download or read book Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases written by Goutam Brahmachari and published by Elsevier. This book was released on 2019-04-15 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. - Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery - Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases - Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases
Author : U. Beifuss
Publisher : Springer Science & Business Media
ISBN 13 : 9783540211242
Total Pages : 284 pages
Book Rating : 4.2/5 (112 download)
Download or read book Natural Product Synthesis II written by U. Beifuss and published by Springer Science & Business Media. This book was released on 2005-02-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: T. Heckrodt and J. Mulzer: Marine Natural Products from Pseudopterogorgia Elisabethae: Structures, Biosynthesis, Pharmacology and Total Synthesis .-M. Kalesse: Recent Advances in Vinylogous Aldol Reactions and their Applications in Natural Product Synthesis .- U. Beifuss and M. Tietze: Methanophenazine and Other Biologically Active Phenazines .-H.-J. Knoelker: Occurrence, Biological Activity, and Convergent Organometallic Synthesis of Carbazole Alkaloids .-U. Nubbemeyer: Recent Advances in Charge Accelerated Aza-Claisen Rearrangements.- P. Metz: Synthetic Studies on the Pamamycin Macrodiolides
Author : Alexander Hillisch
Publisher : Birkhäuser
ISBN 13 : 3034879970
Total Pages : 294 pages
Book Rating : 4.0/5 (348 download)
Download or read book Modern Methods of Drug Discovery written by Alexander Hillisch and published by Birkhäuser. This book was released on 2012-11-28 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.
Author : John ApSimon
Publisher : John Wiley & Sons
ISBN 13 : 9780471545071
Total Pages : 726 pages
Book Rating : 4.5/5 (45 download)
Download or read book The Total Synthesis of Natural Products, Volume 8 written by John ApSimon and published by John Wiley & Sons. This book was released on 1992-04-16 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic chemistry's innovative breadth is especially noteworthy in the area of natural products synthesis. Since the early 1970s, this landmark chemical reference has been documenting the newest and most important of these, in a readily understood format, that clearly traces each of their synthetic routes. Volume Eight, the latest in the series, contains a long-awaited look at the synthesis of tri- and tetracyclic diterpenes, along with the synthesis of naturally occurring quinones. Recent interest in the biologically important polysaccharides has led to a detailed consideration of that compound class. Finally, this new volume contains a look at the strategies and methods specific to natural products containing the spiroketal functional group. The Total Synthesis of Natural Products, Volume Eight, continues the meticulous work of the series, providing chemists with an entirely up-to-date and convenient guide to the critical new syntheses essential to organic chemistry's continuing evolution.
Author : Thomas Elliott Jacks
Publisher :
ISBN 13 :
Total Pages : 406 pages
Book Rating : 4.:/5 (323 download)
Download or read book Studies Directed Towards the Total Synthesis of the Natural Products Avarol and Capentin written by Thomas Elliott Jacks and published by . This book was released on 1993 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : K. C. Nicolaou
Publisher : John Wiley & Sons
ISBN 13 : 3527292314
Total Pages : 826 pages
Book Rating : 4.5/5 (272 download)
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Author : Anthony Fers-Lidou
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (138 download)
Download or read book Studies Towards the Total Synthesis of Eleutherobin and Biologically Active Carbasugars written by Anthony Fers-Lidou and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Efforts have been directed towards the total synthesis of eleutherobin, a natural product with promising anticancerous properties. Indeed, Taxol-like activity of eleutherobin could provide an interesting alternative to Taxol-resistant cancers. The generation of the 10-membered ring has been performed via an exotic Knoevenagel condensation and paves the path for a concise, robust and efficient synthesis of the marine natural product. An additional study describes the synthesis of several inhibitors for the production of afucosylated antibodies that will ultimately provide a considerable enhancement of their antibody-dependent cell-mediated cytotoxicity. Alone or combined with toxic payloads (i.e., ADC), these antibodies will contribute to better and cheaper immunotherapies for cancer.
