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Steroid Receptors Functions In Vivo And Breast Cancer
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Book Synopsis Steroid Receptors Functions In Vivo and Breast Cancer by :
Download or read book Steroid Receptors Functions In Vivo and Breast Cancer written by and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Women with estrogen receptor positive breast tumors respond to adjuvant hormonal therapy with an enhancement of disease free survival and overall survival. A substantial fraction of tumors are dependent upon estrogen for growth, and antiestrogen has been shown to be effective for the treatment of breast cancer. The precise mechanism of estrogen and anti-estrogen action in breast tumors still remain unclear. We postulated that estrogen and anti-estrogen act by activating the function of the endogenous estrogen receptor. Using rat mammary gland as the model, we examined the function of ER in response to estrogen and antiestrogen. Our data suggested that estrogen and anti-estrogen are able to activate and regulate the function of estrogen receptor in a cell context dependent fashion. We conclude that estrogen and anti-estrogen may exert their effects on the growth of target tissues, at least in part, by increasing the functional activity of the endogenous estrogen receptor. Abstracts for the research done in this funding period were submitted to the Annual Endocrine Meeting in June, 1997 and Era of Hope DOD BCRP Meeting in October, 1997 for presentation.
Book Synopsis Steroid Receptors in Health and Disease by : Virinder Moudgil
Download or read book Steroid Receptors in Health and Disease written by Virinder Moudgil and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and cancers. Although significant advances have been made in the purification, characterization, immunochemistry and molecular biology of steroid receptors, the precise molecular mechanism of steroid hormone action has remained obscure. This book captures the detailed presentations made at the first conference on Steroid Receptors in Health and Disease held at Meadow Brook Hall, Oakland University in the fall of 1987. The purpose of this international con ference was to facilitate scientific exchange toward a better understand ing of the mode of action of steroid hormones. The scientific sessions consisted of poster presentations and state-of-the-art lectures, the latter of which make up this volume. The first chapter is meant to provide the reader with a more general background of the topics covered in the book, as well as to discuss certain theme-related issues that are either not yet well-established or accepted or are in the stage of infancy. It is hoped that this volume will serve as a useful treatise for students and investigators interested in basic and clinical aspects of biological regulation by steroid hormones. A task of this magnitude could not have been undertaken without the encouragement, advice and continued generous assistance of the members of the scientific committee. I am gratefully indebted to Drs.
Book Synopsis Steroid Hormones and Cell Cycle Regulation by : Kerry L. Burnstein
Download or read book Steroid Hormones and Cell Cycle Regulation written by Kerry L. Burnstein and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.
Book Synopsis The Role of Steroid Receptor Coactivator-1 in Breast Cancer by :
Download or read book The Role of Steroid Receptor Coactivator-1 in Breast Cancer written by and published by . This book was released on 1999 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt: The steroid hormones estrogen and progesterone and their intracellular receptors have been Implicated in the development and progression of primary epithelial breast cancer. Regulation of gene expression by hormone-bound steroid receptors Is mediated by members of the steroid receptor coactivator (SRC) family. The purpose of this study was to examine the role of SRC-1 in the regulation of gene expression by steroid receptors. In breast cancer SRC-1 was found to exist in a multifactor complex which was stably associated with liganded progesterone receptor, implicating an active SRC-1 complex as a primary target of liganded PR in breast cancer cells. In an effort to further define the role of SRC-1 in breast cancer, we characterized a member of the active SRC-1 complex, SRA (steroid receptor RNA coactivator), which was shown to function as an RNA. Significantly, SRA Is a limiting factor required for efficient transcriptional activation by steroid hormone receptors in breast cancer cells.
Book Synopsis Steroid Receptors: Advances in Research and Application: 2011 Edition by :
Download or read book Steroid Receptors: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroid Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Steroid Receptors. The editors have built Steroid Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Steroid Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Steroid Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Regulatory Mechanisms in Breast Cancer by : Marc E. Lippman
Download or read book Regulatory Mechanisms in Breast Cancer written by Marc E. Lippman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.
Book Synopsis Advances in Rapid Sex-Steroid Action by : Gabriella Castoria
Download or read book Advances in Rapid Sex-Steroid Action written by Gabriella Castoria and published by Springer Science & Business Media. This book was released on 2011-12-14 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.
Book Synopsis Steroid Receptors—Advances in Research and Application: 2013 Edition by :
Download or read book Steroid Receptors—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroid Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Mineralocorticoid Receptors. The editors have built Steroid Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mineralocorticoid Receptors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Steroid Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Steroid Receptors in Breast Cancer by :
Download or read book Steroid Receptors in Breast Cancer written by and published by . This book was released on 1983 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Steroid Receptors—Advances in Research and Application: 2012 Edition by :
Download or read book Steroid Receptors—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroid Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Steroid Receptors. The editors have built Steroid Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Steroid Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Steroid Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Hormone Receptors in Breast Cancer by : Suzanne A. W. Fuqua
Download or read book Hormone Receptors in Breast Cancer written by Suzanne A. W. Fuqua and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.
Book Synopsis Role of Sex Steroids and Their Receptors in Cancers by : Pia Giovannelli
Download or read book Role of Sex Steroids and Their Receptors in Cancers written by Pia Giovannelli and published by Frontiers Media SA. This book was released on 2022-11-22 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Steroid Receptors and Disease by : Peter J. Sheridan
Download or read book Steroid Receptors and Disease written by Peter J. Sheridan and published by . This book was released on 1988 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Steroid Hormone Receptors: Basic and Clinical Aspects by : V. K. Moudgil
Download or read book Steroid Hormone Receptors: Basic and Clinical Aspects written by V. K. Moudgil and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have witnessed the emergence of steroid hormones as the wonder molecules which generate as much discussion in the scientific literature as they do in a typical living room. This transition has been a result of the tremendous public and scientific interest in the normal functioning of the hor mones as well their suggested involvement in several clinical conditions. In the recent past, notable scientific and technological advances have been made in the areas of contraception and regulation of fertility. Steroid receptors are the indis pensable mediators of hormonal responses and are complex protein molecules which appear to exist in association with other, yet undefined, proteins and/or factors. Receptors for vitamin D, retinoic acid and the thyroid hormones share structural similarities with steroid receptors, and the roster of this superfamily is still expanding. While our knowledge of the diversity and magnitude of steroid effects has advanced, the precise mode of steroid hormone action has alluded investigators. This volume brings together an international team of prominent investigators who discuss their most recent work on the basic and clinical aspects of steroid/nuclear receptors. The contributions represent updated versions of the invited presentations made at The Second Meadow Brook Conference on Steroid Receptors in Health and Disease. I am grateful to my colleagues on the Scientific Committee: Etienne Baulieu, Jack Gorski, Benita Katzenellenbogen, David Toft and James WittJiff, who provided the vision and guidance in formulating an out standing program.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis The Regulation and Function of Nuclear Receptor Corepressor SMRT in Human Breast Cancer Cells by :
Download or read book The Regulation and Function of Nuclear Receptor Corepressor SMRT in Human Breast Cancer Cells written by and published by . This book was released on 2001 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Members of the steroid receptor coactivator family have been implicated in the regulation of nuclear receptor function by enhancing ligand-dependent transcriptional activation of target genes. We have previously isolated the third member of the SRC family, receptor-associated coactivator 3 (RAC3). In this study, we investigated the mechanisms by which RAC3 may interact with and modulate the transcriptional activity of nuclear receptors. We found that VDR, ERBeta, and retinoid receptors interact with different a-helical LXXLL motifs of RAC3. Peptides corresponding to these motifs have diverse affinities for the VDR and ERBeta and mutation of specific motifs differentially impairs the ability of RAC3 to interact with receptors in vitro. Consequently, these mutations inhibit the enhancement of transcriptional activation by these receptors in vivo. Furthermore, we found that the activation function-2 (AF-2) domain of RXR interferes with RAC3 binding to DNA-bound VDR/RXR or RAR/RXR heterodimers, while the VDR or RAR AF-2 domains are required for this interaction. Finally, we demonstrated that RAR and RXR differentially contribute to coactivator recruitment and transcriptional regulation by the RAR/RXR heterodimer. These results suggest a receptor-specific binding preference for the different LXXLL motifs of RAC3, which may provide flexibility for RAC3 to regulate the function of different receptors.
Book Synopsis Steroid Receptors and the Management of Cancer by :
Download or read book Steroid Receptors and the Management of Cancer written by and published by . This book was released on 1979 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
