Spinal Interneurons

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Spinal Interneurons

Author : Lyandysha Viktorovna Zholudeva
Publisher : Academic Press
ISBN 13 : 0128192615
Total Pages : 476 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Spinal Interneurons by : Lyandysha Viktorovna Zholudeva

Download or read book Spinal Interneurons written by Lyandysha Viktorovna Zholudeva and published by Academic Press. This book was released on 2022-11-29 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spinal cord is comprised of four types of neurons: motor neurons, pre-ganglionic neurons, ascending projection neurons, and spinal interneurons. Interneurons are neurons that process information within local circuits, and have an incredible ability for neuroplasticity, whether due to persistent activity, neural injury, or in response to disease. Although, by definition, their axons are restricted to the same structure as the soma (in this case the spinal cord), spinal interneurons are capable of sprouting and rewiring entire neural circuits, and contribute to some restoration of disrupted neural communication after injury to the spinal cord (i.e., "bypassing the lesion site). Spinal Interneurons provides a focused overview of how scientists classify interneurons in general, the techniques used to identify subsets of interneurons, their roles in specific neural circuits, and the scientific evidence for their neuroplasticity. Understanding the capacity for neuroplasticity and identity of specific spinal interneurons that are optimal for recovery, may help determine cellular candidates for developing therapies. Spinal Interneurons provides neuroscientists, clinicians, and trainees a reference book exclusively concentrating on spinal interneurons, the techniques and experiments employed to identify and study these cells as part of normal and compromised neural circuits, and highlights the therapeutic potential of these cells by presenting the relevant pre-clinical and clinical work to date. People in industry will also benefit from this book, which compiles the latest in therapeutic strategies for targeting spinal interneurons, what considerations there are for the development and use of treatments, and how such treatments can not only be translated to the clinic, but how existing treatments should be appropriately reverse-translated to the bench. - Comprehensive overview of techniques used to identify, characterize, and classify spinal interneurons and their role in neural circuits - Description of the role that spinal interneurons play in mediating plasticity after compromise to spinal neural networks - In-depth discussion of therapeutic potential of spinal interneurons for spinal cord injury and/or disease

Neuroscience in the 21st Century

Author : Donald W. Pfaff
Publisher : Springer
ISBN 13 : 9781493934737
Total Pages : 0 pages
Book Rating : 4.9/5 (347 download)

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Book Synopsis Neuroscience in the 21st Century by : Donald W. Pfaff

Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer. This book was released on 2016-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

The Circuitry of the Human Spinal Cord

Author : Emmanuel Pierrot-Deseilligny
Publisher : Cambridge University Press
ISBN 13 : 9781139445641
Total Pages : 676 pages
Book Rating : 4.4/5 (456 download)

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Book Synopsis The Circuitry of the Human Spinal Cord by : Emmanuel Pierrot-Deseilligny

Download or read book The Circuitry of the Human Spinal Cord written by Emmanuel Pierrot-Deseilligny and published by Cambridge University Press. This book was released on 2005-06-08 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of human movement have proliferated in recent years, and there have been many studies of spinal pathways in humans, their role in movement, and their dysfunction in neurological disorders. This comprehensive reference surveys the literature related to the control of spinal cord circuits in human subjects, showing how they can be studied, their role in normal movement, and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks, and changes in patients with CNS lesions. Each chapter concludes with a helpful resume that can be used independently of the main text to provide practical guidance for clinical studies. This will be essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.

Breathe, Walk and Chew

Author :
Publisher : Elsevier
ISBN 13 : 044453623X
Total Pages : 243 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Breathe, Walk and Chew by :

Download or read book Breathe, Walk and Chew written by and published by Elsevier. This book was released on 2010-12-03 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the interplay of mind and motion-the bidirectional link between thought and action. In particular, it investigates the implications that this coupling has for decision making. How do we anticipate the consequences of choices and how is the brain able to represent these choice options and their potential consequences? How are different options evaluated and how is a preferred option selected and implemented? This volume addresses these questions not only through an extensive body of knowledge consisting of individual chapters by international experts, but also through integrative group reports that pave a runway into the future. The understanding of how people make decisions is of common interest to experts working in fields such as psychology, economics, movement science, cognitive neuroscience, neuroinformatics, robotics, and sport science. So far, however, it has mainly been advanced in isolation within distinct research disciplines; in contrast, this book results from a deliberate assembly of multidisciplinary teams. It offers intense, focused, and genuine interdisciplinary perspective. It conveys state-of-the-art and outlines future research directions on the hot topic of Mind and Motion (or embodied cognition). It includes contributions from psychologists, neuroscientists, movement scientists, economists, and others.

The Rat Nervous System

Author : George Paxinos
Publisher :
ISBN 13 : 9780125476355
Total Pages : 1136 pages
Book Rating : 4.4/5 (763 download)

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Book Synopsis The Rat Nervous System by : George Paxinos

Download or read book The Rat Nervous System written by George Paxinos and published by . This book was released on 1995 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a description of the cytoarchitecture, chemoarchitecture, and connectivity of the rat nervous system. In addition it offers updated and supplemented information on the peripheral motor, peripheral somatosensor, vascular, central motor, pain, and additional neurotransmitter systems.

Spinal Muscular Atrophy

Author : Charlotte J Sumner
Publisher : Academic Press
ISBN 13 : 0128036869
Total Pages : 508 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Spinal Muscular Atrophy by : Charlotte J Sumner

Download or read book Spinal Muscular Atrophy written by Charlotte J Sumner and published by Academic Press. This book was released on 2016-10-24 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. - Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development - Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA - Includes outstanding questions and perspectives for future investigations and key references for additional detailed study

Itch

Author : E. Carstens
Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

The Spinal Cord

Author : Ciba Foundation
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis The Spinal Cord by : Ciba Foundation

Download or read book The Spinal Cord written by Ciba Foundation and published by . This book was released on 1953 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cortical Development

Author : Ryoichiro Kageyama
Publisher : Springer Science & Business Media
ISBN 13 : 4431544968
Total Pages : 283 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Cortical Development by : Ryoichiro Kageyama

Download or read book Cortical Development written by Ryoichiro Kageyama and published by Springer Science & Business Media. This book was released on 2013-09-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and connections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain regions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.

Neuroproteomics

Author : Oscar Alzate
Publisher : CRC Press
ISBN 13 : 1420076264
Total Pages : 356 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neuroproteomics by : Oscar Alzate

Download or read book Neuroproteomics written by Oscar Alzate and published by CRC Press. This book was released on 2009-10-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Neurology of Sexual and Bladder Disorders

Author : David B. Vodusek
Publisher : Elsevier
ISBN 13 : 0444632549
Total Pages : 518 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurology of Sexual and Bladder Disorders by : David B. Vodusek

Download or read book Neurology of Sexual and Bladder Disorders written by David B. Vodusek and published by Elsevier. This book was released on 2015-05-21 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neurology of sex and bladder disorders requires specialized knowledge and represents a challenge for clinical neurologists focused on the neurological condition. Sex and bladder disorders are often related to more general neurological disorders like Parkinson's disease and multiple sclerosis, and often the sex and bladder disorders are passed to specialists in urology. Neurology of Sexual and Bladder Disorders: Handbook of Clinical Neurology is a focused, yet comprehensive overview that provides complete tutorial reference to the science, diagnosis and treatment of sex and bladder disorders from a neurologic perspective. - Comprehensive coverage of the neurology of sex and bladder disorders - Details the latest techniques for the study, diagnosis and treatment of sex and bladder dysfunction from a neurological perspective - A focused reference for clinical practitioners and neurology research communities

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309212219
Total Pages : 74 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Spinal Afferent Processing

Author : T.L. Yaskh
Publisher : Springer Science & Business Media
ISBN 13 : 146844994X
Total Pages : 564 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Spinal Afferent Processing by : T.L. Yaskh

Download or read book Spinal Afferent Processing written by T.L. Yaskh and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some 29 scientists from the fields of neuroanatomy, neurochemistry, neu rophysiology, neuropharmacology, and behavior have contributed their ef forts to this testimonial on behalf of the contributions made by Dr. F. W. L. Kerr to science and to those with whom he interacted. The intention of the contributors to this volume was to deal with the manifold advances that pertain to the substrates in spinal cord relating to the processing of sensory infor mation, a subject that in one form or another provoked time and again Kerr's native enthusiasm for research. The organization of the book follows a natural course from the peripheral innervation of the somatic and visceral organs (Winkelmann, Chapter 2) to the effective stimuli that activate these fibers and give rise to sensation under normal and pathological conditions (Campbell and Meyer, Chapter 3; Dubner and colleagues, Chapter 13; Dyck, Chapter 14) to the course these afferent systems take to enter the spinal cord (Coggeshall, Chapter 4) and to the organization of the systems through which this afferent information reaches the brain (Willis, Chapter 11; Vierck and colleagues, Chapter 12).

Neurobiology of Vertebrate Locomotion

Author : Sten Grillner
Publisher : Springer
ISBN 13 : 1349091480
Total Pages : 719 pages
Book Rating : 4.3/5 (49 download)

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Book Synopsis Neurobiology of Vertebrate Locomotion by : Sten Grillner

Download or read book Neurobiology of Vertebrate Locomotion written by Sten Grillner and published by Springer. This book was released on 2016-01-03 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pain Modulation

Author : Howard L. Fields
Publisher : Elsevier Publishing Company
ISBN 13 : 9780444809841
Total Pages : 454 pages
Book Rating : 4.8/5 (98 download)

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Book Synopsis Pain Modulation by : Howard L. Fields

Download or read book Pain Modulation written by Howard L. Fields and published by Elsevier Publishing Company. This book was released on 1988-01-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.

Neurons, Networks, and Motor Behavior

Author : Paul S. G. Stein
Publisher : MIT Press
ISBN 13 : 9780262692274
Total Pages : 330 pages
Book Rating : 4.6/5 (922 download)

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Book Synopsis Neurons, Networks, and Motor Behavior by : Paul S. G. Stein

Download or read book Neurons, Networks, and Motor Behavior written by Paul S. G. Stein and published by MIT Press. This book was released on 1997 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in motor behavior research rely on detailed knowledge of the characteristics of the neurons and networks that generate motor behavior. At the cellular level, Neurons, Networks, and Motor Behavior describes the computational characteristics of individual neurons and how these characteristics are modified by neuromodulators. At the network and behavioral levels, the volume discusses how network structure is dynamically modulated to produce adaptive behavior. Comparisons of model systems throughout the animal kingdom provide insights into general principles of motor control. Contributors describe how networks generate such motor behaviors as walking, swimming, flying, scratching, reaching, breathing, feeding, and chewing. An emerging principle of organization is that nervous systems are remarkably efficient in constructing neural networks that control multiple tasks and dynamically adapt to change.The volume contains six sections: selection and initiation of motor patterns; generation and formation of motor patterns: cellular and systems properties; generation and formation of motor patterns: computational approaches; modulation and reconfiguration; short-term modulation of pattern generating circuits; and sensory modification of motor output to control whole body orientation.