Signposts To Chiral Drugs

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Signposts to Chiral Drugs

Author : Vitomir Sunjic
Publisher : Springer Science & Business Media
ISBN 13 : 3034801254
Total Pages : 249 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Signposts to Chiral Drugs by : Vitomir Sunjic

Download or read book Signposts to Chiral Drugs written by Vitomir Sunjic and published by Springer Science & Business Media. This book was released on 2011-05-10 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry. The book starts with an introduction treating the discovery and development of a new drug entity. Each of the 15 subsequent chapters presents one of the target structures and begins with a description of its biological profile as well as any known molecular mechanisms of action, underlining the importance of its structural and stereochemical features. This section is followed by detailed discussions of synthetic approaches to the chiral target structure, highlighting creative ideas, the scaling-up of laboratory methods and their replacement by efficient modern technologies for large-scale production. Nearly 60 synthetic reactions, most of them stereoselective, catalytic or biocatalytic, as well as chiral separating methodologies are included in the book. Vitomir Sunjic and Michael J. Parnham provide an invaluable source of information for scientists in academia and the pharmaceutical industry who are actively engaged in the interdisciplinary development of new drugs, as well as for advanced students in chemistry and related fields.

Stereoselective Synthesis of Drugs and Natural Products

Author : Vasyl Andrushko
Publisher : John Wiley & Sons
ISBN 13 : 1118628330
Total Pages : 1836 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Stereoselective Synthesis of Drugs and Natural Products by : Vasyl Andrushko

Download or read book Stereoselective Synthesis of Drugs and Natural Products written by Vasyl Andrushko and published by John Wiley & Sons. This book was released on 2013-08-16 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.

Medicinal and Environmental Chemistry: Experimental Advances and Simulations (Part I)

Author : Tahmeena Khan
Publisher : Bentham Science Publishers
ISBN 13 : 9814998281
Total Pages : 270 pages
Book Rating : 4.8/5 (149 download)

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Book Synopsis Medicinal and Environmental Chemistry: Experimental Advances and Simulations (Part I) by : Tahmeena Khan

Download or read book Medicinal and Environmental Chemistry: Experimental Advances and Simulations (Part I) written by Tahmeena Khan and published by Bentham Science Publishers. This book was released on 2021-09-02 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal and Environmental Chemistry: Experimental Advances and Simulations is a collection of topics that highlight the use of pharmaceutical chemistry to assess the environment or make drug design and chemical testing more environment friendly. The ten chapters included in the first part of this book set cover diverse topics, blending the fields of environmental chemistry and medicinal chemistry and have been authored by experts, scientists and academicians from renowned institutions. The book introduces the reader to environmental contaminants and techniques for their quantification and removal. A medicinal perspective for effects and remediation of environmental hazards, and therapeutic strategies available to design new and safer drugs, is addressed with a focus on knowledge about experimental and simulation methods. To further elaborate the importance of environmentally safe chemical practice, the concept of green chemistry has also been covered. Specialized chapters have been included in the book about persistent organic pollutants, heavy metal and plastic pollutants, the effect of environmental xenoesterogens on human health and the potential of natural products to combat ecotoxicity. Key Features: 1. 10 topics which blend environmental chemistry and medicinal chemistry 2. Contributions from more than 30 experts 3. Includes introductory topics on environmental pollutants, investigative techniques in drug design and environmental risk assessment and green chemistry 4. Includes specialized topics on persistent pollutants, ecotoxicity remediation and xenoestrogens 5. Bibliographic references This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.

Biotechnology and Biological Sciences

Author : Ramkrishna Sen
Publisher : CRC Press
ISBN 13 : 1000044408
Total Pages : 453 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Biotechnology and Biological Sciences by : Ramkrishna Sen

Download or read book Biotechnology and Biological Sciences written by Ramkrishna Sen and published by CRC Press. This book was released on 2019-11-20 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of Biotechnology dates back to the early era of civilization, when people first started to cultivate food crops. While the early applications are certainly still relevant, modern biotechnology is primarily associated with molecular biology, cloning and genetic engineering not only to increase the yield and to improve the quality of the crop but also its potential impact has touched upon virtually all domains of human interactions. Within the last 50 years, several key scientific discoveries revolutionized the biological sciences that facilitated the rapid growth of the biotechnology industry. 'Biotechnology and Biological Sciences III' contains the contributions presented at the 3rd International Conference on Biotechnology and Biological Sciences (BIOSPECTRUM 2019, Kolkata, India, 8-10 August 2019). The papers discuss various aspects of Biotechnology such as: microbial biotechnology, bioinformatics and drug designing, innovations in pharmaceutical industries and food processing industries, bioremediation, nano-biotechnology, and molecular-genetics, and will be of interest to academics and professionals involved or interested in these subject areas.

Advances in Heterocyclic Chemistry

Author : Alan R. Katritzky
Publisher : Academic Press
ISBN 13 : 0124202098
Total Pages : 293 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis Advances in Heterocyclic Chemistry by : Alan R. Katritzky

Download or read book Advances in Heterocyclic Chemistry written by Alan R. Katritzky and published by Academic Press. This book was released on 2013-12-13 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. - One of great importance to organic chemists, polymer chemists and many biological scientists - Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties

Signposts to Chiral Drugs

Author : Vitomir Sunjic
Publisher : Springer
ISBN 13 : 9783034801263
Total Pages : 232 pages
Book Rating : 4.8/5 (12 download)

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Book Synopsis Signposts to Chiral Drugs by : Vitomir Sunjic

Download or read book Signposts to Chiral Drugs written by Vitomir Sunjic and published by Springer. This book was released on 2013-01-02 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry. The book starts with an introduction treating the discovery and development of a new drug entity. Each of the 15 subsequent chapters presents one of the target structures and begins with a description of its biological profile as well as any known molecular mechanisms of action, underlining the importance of its structural and stereochemical features. This section is followed by detailed discussions of synthetic approaches to the chiral target structure, highlighting creative ideas, the scaling-up of laboratory methods and their replacement by efficient modern technologies for large-scale production. Nearly 60 synthetic reactions, most of them stereoselective, catalytic or biocatalytic, as well as chiral separating methodologies are included in the book. Vitomir Sunjic and Michael J. Parnham provide an invaluable source of information for scientists in academia and the pharmaceutical industry who are actively engaged in the interdisciplinary development of new drugs, as well as for advanced students in chemistry and related fields.

Dynamic Stereochemistry of Chiral Compounds

Author : Christian Wolf
Publisher : Royal Society of Chemistry
ISBN 13 : 0854042466
Total Pages : 534 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Dynamic Stereochemistry of Chiral Compounds by : Christian Wolf

Download or read book Dynamic Stereochemistry of Chiral Compounds written by Christian Wolf and published by Royal Society of Chemistry. This book was released on 2008 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1930 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Author : Andrea Bonetti
Publisher : Springer Science & Business Media
ISBN 13 : 1603274596
Total Pages : 381 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy by : Andrea Bonetti

Download or read book Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy written by Andrea Bonetti and published by Springer Science & Business Media. This book was released on 2009-01-09 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH platinum compound oxaliplatin has broadened the spectrum of activity of the platinums to include gastro-intestinal cancers, especially colorectal cancer. The clinical importance of this family of drugs continues to drive investigation into how these drugs work and how to improve their efficacy and reduce their toxicity. The papers in this volume were presented in Verona, Italy, during the tenth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. The symposium was jointly organized by the Department of Oncology of the Mater Salutis Hospital – Azienda Sanitaria Locale 21 of the Veneto Region – and by the Department of Medicine and Public Health, Section of Pharmacology, the University of Verona. They reflect the vitality of this field and the increasing use of new molecular and cell biologic, genetic, and biochemical tools to identify approaches to further improve their use.

360-Degree Waste Management, Volume 2

Author : Nishikant A. Raut
Publisher : Elsevier
ISBN 13 : 0323910394
Total Pages : 356 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis 360-Degree Waste Management, Volume 2 by : Nishikant A. Raut

Download or read book 360-Degree Waste Management, Volume 2 written by Nishikant A. Raut and published by Elsevier. This book was released on 2023-07-01 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: 360 Degree Waste Management, Volume Two: Biomedical, Pharmaceutical, and Industrial Waste and Remediation presents an interdisciplinary approach to understanding various types of biomedical, pharmaceutical, and industrial waste, including their origin, management, recycling, disposal, effects on ecosystems, and social and economic impacts. By applying the concepts of sustainable, affordable and integrated approaches for the improvement of waste management, the book confronts social, economic and environmental challenges. Thus, researchers, waste managers and environmental engineers will find critical information to identify long-term answers to problems of waste management that require complex understanding and analysis.Presenting key concepts in the management of biomedical and industrial waste, Volume Two of this two volume series includes aspects on microbiology of waste management, advanced treatment processes, environmental impacts, technological developments, economics of waste management and future implications. - Provides a critical assessment of economic, social and environmental challenges due to solid wastes, highlighting sustainable management approach - Describes various factors to be considered while developing waste management strategies, including techniques for reuse, reduce, recycle or recovery of solid waste and management of other wastes, such as wastes from pharmaceuticals, aluminum industry, heavy metal, and other metallurgical waste - Addresses contemporary issues such as the transformation of waste into value-added products - Presents an interdisciplinary approach to the management of various types of biomedical, pharmaceutical and industrial waste

Innovative Approaches in Drug Discovery

Author : Bhushan Patwardhan
Publisher : Academic Press
ISBN 13 : 0128018224
Total Pages : 482 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Innovative Approaches in Drug Discovery by : Bhushan Patwardhan

Download or read book Innovative Approaches in Drug Discovery written by Bhushan Patwardhan and published by Academic Press. This book was released on 2016-10-03 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. - Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned - Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines - Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

Natural Products

Author : Lixin Zhang
Publisher : Springer Science & Business Media
ISBN 13 : 1592599761
Total Pages : 380 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Natural Products by : Lixin Zhang

Download or read book Natural Products written by Lixin Zhang and published by Springer Science & Business Media. This book was released on 2007-11-17 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Prediction of Protein Structure and the Principles of Protein Conformation

Author : G.D. Fasman
Publisher : Springer Science & Business Media
ISBN 13 : 1461315719
Total Pages : 796 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Prediction of Protein Structure and the Principles of Protein Conformation by : G.D. Fasman

Download or read book Prediction of Protein Structure and the Principles of Protein Conformation written by G.D. Fasman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged.

Membrane Organization and Dynamics

Author : Amitabha Chattopadhyay
Publisher : Springer
ISBN 13 : 3319666010
Total Pages : 387 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Membrane Organization and Dynamics by : Amitabha Chattopadhyay

Download or read book Membrane Organization and Dynamics written by Amitabha Chattopadhyay and published by Springer. This book was released on 2017-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contemporary interest. The chapters cover various aspects of membrane lipid and protein dynamics, explored using a battery of experimental and theoretical approaches. The synthesis of information and knowledge gained by utilizing multiple approaches will provide the reader with a comprehensive understanding of the underlying membrane dynamics and function, which will help to develop robust dynamic models for the understanding of membrane function in healthy and diseased states. In the last few years, crystal structures of an impressive number of membrane proteins have been reported, thanks to tremendous advances in membrane protein crystallization techniques. Some of these recently solved structures belong to the G protein-coupled receptor (GPCR) family, which are particularly difficult to crystallize due to their intrinsic flexibility. Nonetheless, these static structures do not provide the necessary information to understand the function of membrane proteins in the complex membrane milieu. This volume will address the dynamic nature of membrane proteins within the membrane and will provide the reader with an up-to date overview of the theory and practical approaches that can be used. This volume will be invaluable to researchers working in a wide range of scientific areas, from biochemistry and molecular biology to biophysics and protein science. Students of these fields will also find this volume very useful. This book will also be of great use to those who are interested in the dynamic nature of biological processes.

Gold Chemistry

Author : Fabian Mohr
Publisher : John Wiley & Sons
ISBN 13 : 3527320865
Total Pages : 425 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Gold Chemistry by : Fabian Mohr

Download or read book Gold Chemistry written by Fabian Mohr and published by John Wiley & Sons. This book was released on 2009-04-20 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-class authors, this most recent major book on the topic highlights new and current trends as well as future directions. It is comprehensive in its scope, covering all aspects of gold chemistry -- from homogeneous to heterogeneous catalysis, from supramolecular assemblies to sensors and medicinal applications. The result is an invaluable work for both organic and inorganic chemists working in universities and industry, as well as material scientists.

Fundamentals of Ionic Liquids

Author : Douglas R. MacFarlane
Publisher : John Wiley & Sons
ISBN 13 : 352733999X
Total Pages : 275 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Fundamentals of Ionic Liquids by : Douglas R. MacFarlane

Download or read book Fundamentals of Ionic Liquids written by Douglas R. MacFarlane and published by John Wiley & Sons. This book was released on 2017-12-04 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts who have been part of this field since its beginnings in both research and academia, this textbook introduces readers to this evolving topic and the broad range of applications that are being explored. The book begins by examining what it is that defines ionic liquids and what sets them apart from other materials. Chapters describe the various types of ionic liquids and the different techniques used to synthesize them, as well as their properties and some of the methods used in their measurement. Further chapters delve into synthetic and electrochemical applications and their broad use as "Green" solvents. Final chapters examine important applications in a wide variety of contexts, including such devices as solar cells and batteries, electrochemistry, and biotechnology. The result is a must-have resource for any researcher beginning to work in this growing field, including senior undergraduates and postgraduates.

Periodic Precipitation

Author : H. K. Henisch
Publisher : Elsevier
ISBN 13 : 1483296806
Total Pages : 137 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Periodic Precipitation by : H. K. Henisch

Download or read book Periodic Precipitation written by H. K. Henisch and published by Elsevier. This book was released on 2014-06-28 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Containing illustrations, worked examples, graphs and tables, this book deals with periodic precipitation (also known as Liesegang Ring formation) in terms of mathematical models and their logical consequences, and is entirely concerned with microcomputer analysis and software development. Three distinctive periodic precipitation mechanisms are included: binary diffusion-reaction; solubility modulation, and competitive particle growth. The book provides didactic illustrations of a valuable investigational procedure, in the form of hypothetical experimentation by microcomputer. The development of appropriate software is described and the resulting programs are available separately on disk. The software (for IBM compatible microcomputers; 5 1/4 and 3 1/2 inch disks available) will be sold separately by, The Carnation Press, PO Box 101, State College, PA 16804, USA.