Seizures And The Developing Brain

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Seizures and the Developing Brain

Author : Aristea S. Galanopoulou
Publisher : Biota Publishing
ISBN 13 : 1615043551
Total Pages : 72 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Seizures and the Developing Brain by : Aristea S. Galanopoulou

Download or read book Seizures and the Developing Brain written by Aristea S. Galanopoulou and published by Biota Publishing. This book was released on 2011-10-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seizures are more common early in life than in adulthood. Bidirectional interactions between seizures and normal developmental processes define their expression and outcomes. Several developmentally regulated factors control neuronal excitability. GABAA receptors hold a central role as they control neuronal activity in an age-specific manner. Early in development, GABAA receptors have depolarizing effects, which contribute to the increased susceptibility of immature neurons to seizures but they are also essential for normal brain development. During development, there is a gradual shift to the "adult-type" hyperpolarizing GABAA receptor signaling, creating more efficient inhibition. Seizures may disrupt GABAA receptor signaling by changing the expression of their subunits and by changing the direction of GABAA responses, which, in certain situations, may be detrimental for brain development. Furthermore, subcortical nuclei, such as the substantia nigra, control the expression and propagation of seizures in an age- and sex-dependent manner. These endogenous control centers and signaling pathways are further modified by independent genetic epigenetic, biologic, or other factors, which further increase the heterogeneity in presentation of seizures, their treatment, and their comorbidities. Elucidation of these complex interactions and identification of biomarkers guiding therapeutic interventions will be necessary to improve our ability to treat early-life epilepsies.

Pediatric Epilepsy

Author : Blaise F. Bourgeois, MD
Publisher : Demos Medical Publishing
ISBN 13 : 1934559865
Total Pages : 922 pages
Book Rating : 4.9/5 (345 download)

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Book Synopsis Pediatric Epilepsy by : Blaise F. Bourgeois, MD

Download or read book Pediatric Epilepsy written by Blaise F. Bourgeois, MD and published by Demos Medical Publishing. This book was released on 2007-12-16 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extensively updated third edition of Pediatric Epilepsy: Diagnosis and Therapy continues to be the definitive volume on the diagnosis, treatment, classification, and management of the childhood epilepsies. Written by nearly 100 international leaders in the field, this new edition progresses logically with major sections on the basic mechanisms of the disease, classification, epidemiology, etiology, diagnosis, and age-related syndromes of epilepsy. The core of the new third edition is its completely updated section on antiepileptic drugs, including an in-depth discussion of dosage considerations, drug toxicity, teratogenicity, and drug interactions, with recommendations for optimal combinations when multiple drug therapy is required. Features unique to the third edition include: Expanded section on the basic science and mechanism of epilepsy Completely updated drug chapters, including newly released drugs and those in development Expanded chapters on vagus nerve stimulation and surgical treatment Expanded section on co-morbidities The third edition includes 21 new chapters, including discussions of: epileptic channelopathies; epileptogenic cerebral cortical malformation; epilepsy genes; etiologies and workup; evidence-based medicine issues related to drug selection; Levetiracetam; Sulthiame; Pregabalin; herbal medications; basic and advanced imaging; immunotherapy issues; vagus nerve stimulation therapy; cognitive and psychiatric co-morbidities and educational placement; and psychosocial aspects of epilepsy.

The Epilepsies

Author : Chrysostomos P. Panayiotopoulos
Publisher : Springer
ISBN 13 :
Total Pages : 570 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Epilepsies by : Chrysostomos P. Panayiotopoulos

Download or read book The Epilepsies written by Chrysostomos P. Panayiotopoulos and published by Springer. This book was released on 2005 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.

Epilepsy Across the Spectrum

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309259533
Total Pages : 568 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Epilepsy Across the Spectrum by : Institute of Medicine

Download or read book Epilepsy Across the Spectrum written by Institute of Medicine and published by National Academies Press. This book was released on 2012-07-29 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2.2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living. The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource.

Pediatric Neurology Part I

Author : Claude G. Wasterlain
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128077514
Total Pages : 892 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Pediatric Neurology Part I by : Claude G. Wasterlain

Download or read book Pediatric Neurology Part I written by Claude G. Wasterlain and published by Elsevier Inc. Chapters. This book was released on 2013-04-24 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neonatal brain has poorly developed GABAergic circuits, and in many of them GABA is excitatory, favoring ictogenicity. Frequently repeated experimental seizures impair brain development in an age-dependent manner. At critical ages, they delay developmental milestones, permanently lower seizure thresholds, and can cause very specific cognitive and learning deficits, such as the permanent impairment of neuronal spatial maps. Some types of experimental status epilepticus cause neuronal necrosis and apoptosis, and are followed by chronic epilepsy with spontaneous recurrent seizures, others appear relatively benign, so that seizure-induced neuronal injury and epileptogenesis are highly age-, seizure model-, and species-dependent. Experimental febrile seizures can be epileptogenic, and hyperthermia aggravates both neuronal injury and epileptogenicity. Antiepileptic drugs, the mainstay of treatment, have major risks of their own, and can, at therapeutic or near-therapeutic doses, trigger neuronal apoptosis, which is also age-, drug-, cell type-, and species-dependent. The relevance of these experimental results to human disease is still uncertain, but while their brains are quite different, the basic biology of neurons in rodents and humans is strikingly similar. Further research is needed to elucidate the molecular mechanisms of epileptogenesis and of seizure- or drug-induced neuronal injury, in order to prevent their long-term consequences.

Childhood Epilepsies and Brain Development

Author : Astrid Nehlig
Publisher :
ISBN 13 :
Total Pages : 330 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Childhood Epilepsies and Brain Development by : Astrid Nehlig

Download or read book Childhood Epilepsies and Brain Development written by Astrid Nehlig and published by . This book was released on 1999 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epilepsies are quite frequent among the general population and particularly during childhood. Many childhood epilepsies are associated with abnormalities of brain development as well as with learning abilities. This book brings together contributions from many international eminent scientists and clinicians involved in the diagnosis, treatment and research on childhood epilepsies and in the study of specific features of brain development in relation to the pathophysiology of childhood epilepsies. This book is recommended to all clinicians who would like up-to-date knowledge of the basic aspects of brain development and seizures of the developing brain.

Brain Development and Epilepsy

Author : Philip A. Schwartzkroin
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Brain Development and Epilepsy by : Philip A. Schwartzkroin

Download or read book Brain Development and Epilepsy written by Philip A. Schwartzkroin and published by . This book was released on 1995 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, developmental neurobiologists have made significant progress toward understanding the processes that determine normal organization and function of the central nervous system. Although this research provides the necessary basis for examining the factors that contribute to the age-dependent expression of seizures, there has been surprisingly little communication between developmental neurobiologists and the clinicians who deal with pediatric epilepsy patients. An understanding of normal and pathological functions in the immature central nervous system requires a special appreciation of developmentally unique mechanisms. This integrated volume applies the emerging concepts in developmental neurobiology to an understanding of the origins of the epilepsies of childhood. Early chapters give a picture of the age-specific epileptic syndromes and their associated pathologies, and describe experimental approaches toward understanding the basic mechanisms underlying these clinical phenomena. The following chapters provide an outline of developmental properties that may be critical to the generation of abnormal excitability, and pose hypotheses about pathological consequences of "mistakes" in key developmental processes. The final chapters attempt to integrate our knowledge of both maturational and epileptogenic mechanisms as a means not only for understanding epilepsies of the immature organism, but also for developing more effective treatment of these often devastating syndromes.

Cognitive Plasticity in Neurologic Disorders

Author : Joseph I. Tracy
Publisher : Oxford University Press, USA
ISBN 13 : 0199965242
Total Pages : 433 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Cognitive Plasticity in Neurologic Disorders by : Joseph I. Tracy

Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey L. Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey L. Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey L. Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

The Causes of Epilepsy

Author : Simon Shorvon
Publisher : Cambridge University Press
ISBN 13 : 1108420753
Total Pages : 1013 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis The Causes of Epilepsy by : Simon Shorvon

Download or read book The Causes of Epilepsy written by Simon Shorvon and published by Cambridge University Press. This book was released on 2019-05-02 with total page 1013 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.

Encyclopedia of Basic Epilepsy Research

Author :
Publisher : Academic Press
ISBN 13 : 0123739616
Total Pages : 1853 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Encyclopedia of Basic Epilepsy Research by :

Download or read book Encyclopedia of Basic Epilepsy Research written by and published by Academic Press. This book was released on 2009-05-27 with total page 1853 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research

Developmental Epilepsy: From Clinical Medicine To Neurobiological Mechanisms

Author : Carl E Stafstrom
Publisher : World Scientific
ISBN 13 : 9813277742
Total Pages : 436 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Developmental Epilepsy: From Clinical Medicine To Neurobiological Mechanisms by : Carl E Stafstrom

Download or read book Developmental Epilepsy: From Clinical Medicine To Neurobiological Mechanisms written by Carl E Stafstrom and published by World Scientific. This book was released on 2019-06-24 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'It is a small treasure chest of information presented in a compact textbook format. The unique contribution of this volume is the authors' ability to seamlessly bridge our current understanding of the basic science and genetics of this group of disorders to the clinical aspects of each epilepsy ... In short, those who practice in the field of epilepsy will find this text an easily accessible mini encyclopedia of reviews of our current understanding of the mechanisms that underlie the various childhood epilepsies. Readers will appreciate the digestible length and level of detail of each chapter and enjoy grabbing this book off the shelf.'Journal of Paediatric Epilepsy This is a collection of chapters from renowned authors focused on the contemporary issues in developmental epilepsy, from both clinical and basic science perspectives. Developmental epilepsy (or epilepsy syndromes), while receiving much more attention than 20 years ago, is still not well understood. This lag in research is reflected in the challenges of treating developmental epilepsy. The book discusses these challenges in the clinic and brings them back to the laboratory bench (and in some cases back to the bedside). This book fills a gap in the literature on developing epilepsy by bridging current clinical knowledge with basic and translational research in the developing brain relevant for developmental epilepsy.The book is introduced by a chapter on brain development to provide a background for understanding when and how seizures and epilepsy can emerge. Recent clinical research indicates strong relationship between childhood epilepsy and developmental cognitive impairment. This connection can be studied in experimental animals and can uncover developmental mechanisms common to both conditions. Targeting those mechanisms might reveal disease-modifying treatments. Febrile seizures are very common in the pediatric population and their impact on further epilepsy development is explored. The link between immunity, inflammation and epileptogenesis in the developing brain is explored. Many developmental epilepsies arise from brain malformations or neuronal migration deficits; some juvenile epilepsies have a clear genetic basis while the etiology of others is less certain. Recently, the involvement of the mTOR pathway in certain childhood epilepsy syndromes was recognized, prompting the repurposing of drugs used in cancer treatment for therapy of these specific epilepsy syndromes. Steroid hormones have significant hormonal effects on neurotransmitter receptors and function, and therefore have an impact on childhood epilepsy; sex steroids may have long term organizational effects on brain structure and epilepsy development. Stress, even early in development, may affect the developing brain and lead to behavioral changes as well as increased susceptibility to seizures.

Do Seizures Damage the Brain

Author : Thomas Sutula
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 548 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Do Seizures Damage the Brain by : Thomas Sutula

Download or read book Do Seizures Damage the Brain written by Thomas Sutula and published by Elsevier Publishing Company. This book was released on 2002 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the consequences, if any, of repeated brief seizures that are the defining feature of epilepsy? A firm answer to this question has been surprisingly elusive for a variety of reasons. Clearly there is a subset of patients who appear to tolerate seizures with relatively limited long-term consequences, and not all patients are destined to progress to intractability with frequent seizures and disability. This variability and individual susceptibility has made it difficult to make statements that fairly apply to the full range of people with epileptic disorders, whose disorders span a broad spectrum from mild with excellent control and few limitations, to severe with multiple daily seizures and pronounced disability that affects employment, educational performance, an personal life. This volume seeks to explore the spectrum of severe to more subtle damage that may be a consequence of seizures. The contributing authors have addressed these questions and related issues using a variety of methods in experimental models and in patients with epilepsy.

Seizures and Epilepsy

Author : Jerome Engel Jr
Publisher : Oxford University Press
ISBN 13 : 019532854X
Total Pages : 737 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Seizures and Epilepsy by : Jerome Engel Jr

Download or read book Seizures and Epilepsy written by Jerome Engel Jr and published by Oxford University Press. This book was released on 2013-01-31 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

Mammalian Brain Development

Author : Damir Janigro
Publisher : Springer Science & Business Media
ISBN 13 : 1607612879
Total Pages : 227 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Mammalian Brain Development by : Damir Janigro

Download or read book Mammalian Brain Development written by Damir Janigro and published by Springer Science & Business Media. This book was released on 2009-09-18 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Denis Noble Nearly a decade after completion of the first draft of the entire Human Genome sequence we are in a better position to assess the nature and the consequences of that heroic achievement, which can be seen as the culmination of the molecular biological revolution of the second half of the twentieth century. The achievement itself was celebrated at the highest levels (President and Prime Minister) on both sides of the Atlantic, and rightly so. DNA sequencing has become sufficiently c- mon now, even to the extent of being used in law courts, that it is easy to forget how technically difficult it was and how cleverly the sequencing teams solved those problems in the exciting race to finish by the turn of the century [1, 2]. The fanfares were misplaced, however, in an important respect. The metaphors used to describe the project and its biological significance gave the impression to the public at large, and to many scientists themselves, that this sequence would reveal the secrets of life. DNA had already been likened to a computer program [3]. The “genetic program” for life was therefore to be found in those sequences: A kind of map that had simply to be unfolded during development. The even more colo- ful “book of life” metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.

Indexes to the Epilepsy Accessions of the Epilepsy Information System

Author : J. Kiffin Penry
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (796 download)

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Book Synopsis Indexes to the Epilepsy Accessions of the Epilepsy Information System by : J. Kiffin Penry

Download or read book Indexes to the Epilepsy Accessions of the Epilepsy Information System written by J. Kiffin Penry and published by . This book was released on 1978 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Limbic Seizures in Children

Author : G. Avanzini
Publisher : John Libbey Eurotext
ISBN 13 : 9780861965953
Total Pages : 272 pages
Book Rating : 4.9/5 (659 download)

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Book Synopsis Limbic Seizures in Children by : G. Avanzini

Download or read book Limbic Seizures in Children written by G. Avanzini and published by John Libbey Eurotext. This book was released on 2001 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the colloquium from which this multi-author book derives, was to outline the specific expression of epilepsies involving the limbic structures in children and to establish a consensus on the evidence relevant to the clinical management of these epilepsies. The book addresses basic questions such as age-related aetiologic, pathogenetic and prognostic factors relevant to the course of infantile epilepsies with limbic seizures, and enlightens the criteria for their clinical and laboratory assessment. The interaction between basic scientists, neuropaediatricians and neurosurgeons contributes to define suitable strategies aimed at preventing the unfavourable course of these often severe infantile epilepsies and their optimal timing.