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Author : Dirk Adrianus Kleinjan
Publisher :
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.:/5 (466 download)
Download or read book Regulation of the Gene for Cellular Retinoic Acid Binding Protein Type 1 written by Dirk Adrianus Kleinjan and published by . This book was released on 1998 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0128201479
Total Pages : 612 pages
Book Rating : 4.1/5 (282 download)
Download or read book Retinoid Signaling Pathways written by and published by Academic Press. This book was released on 2020-04-29 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Author : Katayoun Alavi Jessen
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.:/5 (59 download)
Download or read book Regulation of Retinol Binding Protein Gene Expression written by Katayoun Alavi Jessen and published by . This book was released on 1999 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Leslie Jo Willmert
Publisher :
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.E/5 ( download)
Download or read book The Retinoic Acid Receptors and Cellular Retinoic Acid Binding Protein II written by Leslie Jo Willmert and published by . This book was released on 2006 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ding Dong
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.E/5 ( download)
Download or read book Retinoid Receptors and Cellular Retinoic Acid Binding Proteins written by Ding Dong and published by . This book was released on 2000 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Emma Magna
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book The Biochemical Characterization of Cellular Retinoic Acid Binding Protein Type 1 (CRABP1) written by Emma Magna and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rune Blomhoff
Publisher : CRC Press
ISBN 13 : 9780824791209
Total Pages : 714 pages
Book Rating : 4.7/5 (912 download)
Download or read book Vitamin A in Health and Disease written by Rune Blomhoff and published by CRC Press. This book was released on 1994-02-01 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews the recent breakthroughs in vitamin A research. Discusses the metabolism of vitamin A; the mechanism of action of vitamin A and the provitamin A carotenoids; the role of retinoids in embryonic development, skin and epithelial cells, blood cells, vision, and reproduction; vitamin A deficiency and teratogenicity; and the anticancer role of vitamin A from an epidemiological point of view. Intended as a source of information for scientists engaged in research in the field of vitamin A.
Author : Mary Ann Asson-Batres
Publisher : Springer
ISBN 13 : 9402409459
Total Pages : 267 pages
Book Rating : 4.4/5 (24 download)
Download or read book The Biochemistry of Retinoid Signaling II written by Mary Ann Asson-Batres and published by Springer. This book was released on 2016-11-09 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Michel Neidhart
Publisher : Academic Press
ISBN 13 : 0127999205
Total Pages : 546 pages
Book Rating : 4.1/5 (279 download)
Download or read book DNA Methylation and Complex Human Disease written by Michel Neidhart and published by Academic Press. This book was released on 2015-08-11 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases
Author :
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (644 download)
Download or read book Cellular Retinoic Acid Binding Protein and Breast Cancer written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: In attempts to understand how the signaling by retinoic acid (the active vitamin A metabolite) is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand. The first aim is to determine the extent to which CRABP-II acts in activating different isotypes of RAR. The second aim is to dissect the mechanism by which RA-induced growth inhibition is mediated. This will then allow for closer inspection of particular target genes that are under such control. The third aim is to understand the basis for RA-resistance of mammary carcinoma cells and how CRABP-II functions to overcome this resistance.
Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527322817
Total Pages : 678 pages
Book Rating : 4.5/5 (273 download)
Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Author : Anuradha Samantha Budhu
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.E/5 ( download)
Download or read book The Retinoid Receptors and Cellular Retinoic Acid Binding Proteins written by Anuradha Samantha Budhu and published by . This book was released on 2002 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kelly Elane Radtke
Publisher :
ISBN 13 : 9781303102790
Total Pages : 175 pages
Book Rating : 4.1/5 (27 download)
Download or read book Retinoic Acid Signaling Regulation and Its Contribution to Robust, Precise, and Complex Zebrafish Hindbrain Development written by Kelly Elane Radtke and published by . This book was released on 2013 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development is an orchestrated series of molecular interactions, each of which must occur in the right place, at the correct time, and of a particular amplitude. In order for each of these interactions to fulfill their necessary function, they must be regulated. This regulation is required so that development of the organism is robust to variation, precise in determining cell fates, and ultimately produces a complex, patterned organism. Development uses many different mechanisms for achieving the correct regulation of each step in each pathway. To begin to understand some of these mechanisms, we have studied the retinoic acid signaling pathway and how it is regulated in patterning the zebrafish hindbrain. Retinoic acid (RA) is a unique signaling molecule due to its synthesis from the dietary precursor vitamin A, and either too much or too little vitamin A leads to developmental defects. Despite this, retinoic acid is used in multiple ways during embryonic development over a large, but finite, concentration range. This suggests that synthesis, signaling, and degradation of retinoic acid must be regulated in such a way to account for differences in vitamin A availability. In my thesis, I investigate mechanisms by which RA is regulated during development. Facilitated transport of RA by cellular retinoic acid binding proteins (Crabps) is one mechanism that maintains robust hindbrain patterning despite variation in RA concentration. Noise in intracellular RA, due to small variations in synthesis, diffusion and degradation, combined with noise from transcription and translation of RA target genes, provides a mechanism for cell fate reversibility, which drives precise gene expression boundaries. RA is known to induce many cell fate decisions, and one potential mechanism that explains that ability is RA activation of two different receptor sub-types, leading to complex cell fates from a single signaling molecule. When examined as a whole, my thesis work provides insight into diverse mechanisms that regulate RA to achieve robust, precise, and complex development.
Author :
Publisher : Elsevier
ISBN 13 : 0080552110
Total Pages : 630 pages
Book Rating : 4.0/5 (85 download)
Download or read book Osmosensing and Osmosignaling written by and published by Elsevier. This book was released on 2007-10-01 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over fifty years the Methods in Enzymology series has been the critically acclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume features articles on the topic of osmosensing and osmosignaling written by experts in the field.
Author : Maria Josephina Vaessen
Publisher :
ISBN 13 :
Total Pages : 147 pages
Book Rating : 4.:/5 (656 download)
Download or read book Cellular Retinoic Acid Binding Protein: Cloning and Expression of the Gene written by Maria Josephina Vaessen and published by . This book was released on 1991 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lindsay Allen
Publisher : Springer Science & Business Media
ISBN 13 : 1489925759
Total Pages : 300 pages
Book Rating : 4.4/5 (899 download)
Download or read book Nutrient Regulation during Pregnancy, Lactation, and Infant Growth written by Lindsay Allen and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost every aspect of energy and nutrient metabolism is altered by hormonal and other physiological changes during pregnancy and lactation. While it is evident that hormonal adjustments affect nutrient requirements, these are rarely considered when nutrient recommen dations are made for pregnant or lactating women, and often neglected during evaluation of nutritional status. In addition, changes in nutrient metabolism during the stages of pregnancy and oflactation are usually considered separately, while in reality events during pregnancy can have a major influence on nutritional status and nutrient requirements during lactation. The purpose of this volume is to describe changes in the metabolism of important nutrients during pregnancy and lactation, including the physiological basis for these changes and their implications for nutrient requirements and assessment. Authors have considered such issues as inter-relationships between endocrine changes and nutrient metabolism at the tissue, cellular and molecular level; alterations in nutrient binding proteins; the efficiency of nutrient absorp tion and retention; and the impact on maternal as well as fetal nutritional status. Another unique aspect of this book is the focus on pregnancy and lactation as a continuum.
