Dna Methylation And Complex Human Disease

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DNA Methylation and Complex Human Disease

Author : Michel Neidhart
Publisher : Academic Press
ISBN 13 : 0127999205
Total Pages : 552 pages
Book Rating : 4.1/5 (279 download)

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Book Synopsis DNA Methylation and Complex Human Disease by : Michel Neidhart

Download or read book DNA Methylation and Complex Human Disease written by Michel Neidhart and published by Academic Press. This book was released on 2015-08-11 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

Computational Epigenetics and Diseases

Author :
Publisher : Academic Press
ISBN 13 : 0128145145
Total Pages : 450 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Computational Epigenetics and Diseases by :

Download or read book Computational Epigenetics and Diseases written by and published by Academic Press. This book was released on 2019-02-06 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

DNA Methylation: Development, Genetic Disease and Cancer

Author : Walter Doerfler
Publisher : Springer
ISBN 13 : 9783642068300
Total Pages : 0 pages
Book Rating : 4.0/5 (683 download)

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Book Synopsis DNA Methylation: Development, Genetic Disease and Cancer by : Walter Doerfler

Download or read book DNA Methylation: Development, Genetic Disease and Cancer written by Walter Doerfler and published by Springer. This book was released on 2010-11-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.

Epigenetic Epidemiology

Author : Karin B. Michels
Publisher : Springer Science & Business Media
ISBN 13 : 9400724950
Total Pages : 450 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Epigenetic Epidemiology by : Karin B. Michels

Download or read book Epigenetic Epidemiology written by Karin B. Michels and published by Springer Science & Business Media. This book was released on 2012-01-02 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored.This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Epigenetics in Human Disease

Author : Trygve O. Tollefsbol
Publisher : Academic Press
ISBN 13 : 0123884152
Total Pages : 618 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Epigenetics in Human Disease by : Trygve O. Tollefsbol

Download or read book Epigenetics in Human Disease written by Trygve O. Tollefsbol and published by Academic Press. This book was released on 2012-07-26 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

DNA Methylation Dynamics and Human Diseases

Author : Li Tan
Publisher : Frontiers Media SA
ISBN 13 : 2889765857
Total Pages : 130 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis DNA Methylation Dynamics and Human Diseases by : Li Tan

Download or read book DNA Methylation Dynamics and Human Diseases written by Li Tan and published by Frontiers Media SA. This book was released on 2022-07-18 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Epigenetics: How Science Works

Author : Carsten Carlberg
Publisher : Springer Nature
ISBN 13 : 3030229076
Total Pages : 153 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Human Epigenetics: How Science Works by : Carsten Carlberg

Download or read book Human Epigenetics: How Science Works written by Carsten Carlberg and published by Springer Nature. This book was released on 2019-09-24 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Epigenetic Biomarkers and Diagnostics

Author : José Luis García-Giménez
Publisher : Academic Press
ISBN 13 : 0128019212
Total Pages : 696 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Epigenetic Biomarkers and Diagnostics by : José Luis García-Giménez

Download or read book Epigenetic Biomarkers and Diagnostics written by José Luis García-Giménez and published by Academic Press. This book was released on 2015-12-07 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Epigenetics

Author : C. David Allis
Publisher : CSHL Press
ISBN 13 : 0879697245
Total Pages : 503 pages
Book Rating : 4.8/5 (796 download)

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Book Synopsis Epigenetics by : C. David Allis

Download or read book Epigenetics written by C. David Allis and published by CSHL Press. This book was released on 2007 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Epigenetic Mechanisms of Gene Regulation

Author : Vincenzo E. A. Russo
Publisher :
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Epigenetic Mechanisms of Gene Regulation by : Vincenzo E. A. Russo

Download or read book Epigenetic Mechanisms of Gene Regulation written by Vincenzo E. A. Russo and published by . This book was released on 1996 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Epigenetics in Human Disease

Author : Trygve Tollefsbol
Publisher : Academic Press
ISBN 13 : 0123884160
Total Pages : 617 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Epigenetics in Human Disease by : Trygve Tollefsbol

Download or read book Epigenetics in Human Disease written by Trygve Tollefsbol and published by Academic Press. This book was released on 2012-07-26 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Environmental Epigenetics

Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 321 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Environmental Epigenomics in Health and Disease

Author : Randy L. Jirtle
Publisher : Springer Science & Business Media
ISBN 13 : 3642368271
Total Pages : 361 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Environmental Epigenomics in Health and Disease by : Randy L. Jirtle

Download or read book Environmental Epigenomics in Health and Disease written by Randy L. Jirtle and published by Springer Science & Business Media. This book was released on 2013-05-13 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this two volume book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Consequently, epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. This volume highlights the correlation between environmental factors and complex diseases, such as autism, addiction, neurological diseases, diabetes, obesity and cancer. It concludes with a chapter on legal and ethical implications of epigenetics.

Methylation

Author : Anica Dricu
Publisher : Inst za onkologiju i radiol
ISBN 13 : 9535108816
Total Pages : 311 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Methylation by : Anica Dricu

Download or read book Methylation written by Anica Dricu and published by Inst za onkologiju i radiol. This book was released on 2012-11-28 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area. The textbook chapters provide background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain.

Epigenetics and Complex Traits

Author : Anna K. Naumova
Publisher : Springer Science & Business Media
ISBN 13 : 1461480787
Total Pages : 341 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Epigenetics and Complex Traits by : Anna K. Naumova

Download or read book Epigenetics and Complex Traits written by Anna K. Naumova and published by Springer Science & Business Media. This book was released on 2013-09-17 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance. Epigenetic states may contribute to the penetrance of genetic polymorphisms or mutations and thereby modify inheritance patterns. This may result in non‐Mendelian inheritance of genetic traits such as observed in common human disease. The relationship between epigenetics and genetics, however, has not been comprehensively summarized yet. The topic is being more and more appreciated lately due to considerable advances in genomic and epigenomic approaches to study the origins of human disease. The editors will focus not only on describing epigenetic characteristics, mechanisms and results, but also on how considerations of epigenetics can alter interpretation and analysis of risks for complex traits. This book will be a resource for those who have been working in human genetics or analysis of human genetic data and are studying the impact of epigenetics on inheritance. An overview will be given of the impacts of inter‐individual variation in epigenetic states from major changes (errors in genomic imprinting) that cause congenital developmental defects to subtle changes and their impact on complex traits. The editors will discuss the relationship between epigenetic changes and genetic changes in human disease. Several chapters will also focus on statistical analysis of epigenetics effects, either in human disease genetic studies, or in population genetics.

Introduction to Epigenetics

Author : Renato Paro
Publisher : Springer Nature
ISBN 13 : 3030686701
Total Pages : 215 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Introduction to Epigenetics by : Renato Paro

Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Epigenetics

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470515511
Total Pages : 238 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Epigenetics by : Derek J. Chadwick

Download or read book Epigenetics written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.